Man

RODRIGO CARLOS DIAZ ESPINOZA

Profesor Asistente

Universidad de Santiago de Chile

Santiago, Chile

Líneas de Investigación


Design, development and characterization of catalytic peptide amyloid assemblies for diverse applications (bio-nanotechnology, disease and prebiotic chemistry)

Educación

  •  Ingeniero en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Protein Aggregation, UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON. Estados Unidos, 2011

Experiencia Académica

  •   Postdoctoral Researcher Full Time

    UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON

    HOUSTON, Estados Unidos

    2011 - 2014

  •   Postdoctoral researcher Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2014 - 2016

Experiencia Profesional

  •   Undergraduate Research Assistant

    Universidad de Chile

    Chile

    2002 - 2005

  •   Graduate Research Assistant

    The University of Texas Medical Branch

    Estados Unidos

    2005 - 2011

  •   Postdoctoral Researcher

    The University of Texas Health Science Center

    Estados Unidos

    2011 - At present


 

Article (17)

Catalytic Amyloids as Novel Synthetic Hydrolases
Functional characterization of the ATPase-like activity displayed by a catalytic amyloid
Recent High-Resolution Structures of Amyloids Involved in Neurodegenerative Diseases
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo
Development of a novel catalytic amyloid displaying a metal-dependent ATPase-like activity
Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding
Overcoming Electrostatic Repulsions During Amyloid Assembly: Effect of pH and Interaction With Divalent Metals Using Model Peptides
Prion-like characteristics of the bacterial protein Microcin E492
Strain-dependent profile of misfolded prion protein aggregates
The extent of protease resistance of misfolded prion protein is highly dependent on the salt concentration.
High-resolution structure of infectious prion protein: the final frontier.
Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form.
Protein misfolding cyclic amplification of infectious prions.
Generation of prions in vitro and the protein-only hypothesis.
Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases.
Transport of prion protein across the blood-brain barrier.
Domain folding and flexibility of Escherichia coli FtsZ determined by tryptophan site-directed mutagenesis.

BookSection (1)

Design and Testing of Synthetic Catalytic Amyloids Based on the Active Site of Enzymes

Proyecto (5)

An Experimental Study of the Involvement of Catalytic Amyloids on Prebiotic Chemistry
Fortalecimiento de la docencia de pregrado en Bioquímica, e implementación de una nueva línea de investigación en Biología Estructural y Computacional orientadas a los Doctorados de Neurociencias y Biotecnología
AN EXPLORATORY APPROACH TO STUDY THE CATALYTIC PROPERTIES OF AMYLOIDS AND THEIR BIOLOGICAL IMPLICATIONS
EMERGENCE OF NUCLEOTIDYLTRANSFERASE ACTIVITY FROM SELF-ASSEMBLED PEPTIDE AMYLOIDS
ESTABILIDAD Y MECANISMO DE PLEGAMIENTO DE FTSZ Y TUBULINA, Y SU RELACION CON LA ACTIVIDAD GTPASICA EN EL CONTROL DE LA POLIMERIZACION
11
RODRIGO DIAZ

Profesor Asistente

Universidad de Santiago de Chile

Santiago, Chile

1
Raul Araya

Profesor Asistente

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

1
Rodrigo Morales

Assistant Professor

Neurology

The University of Texas Health Science Center at Houston

Houston, Estados Unidos