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Rodrigo Morales

Assistant Professor

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

- Strain diversity and species barriers in prion diseases - Chronic Wasting disease (prion diseases in deer) - Diagnosis of prion diseases - Prion-like transmission of amyloid-beta - Cross-seeding between heterologous amyloids

Sciences with mention in Biology, UNIVERSIDAD DE CHILE. Chile, 2009
Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2003

Graduate Research Assistant Full Time

The University of Texas Medical Branch at Galveston

Galveston, Estados Unidos

2004 - 2009
Post-doctoral Fellow Full Time

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

2009 - 2012

Instructor Full Time

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

2012 - 2012
Assistant Professor Full Time

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

2012 - 2018
Associate Professor Full Time

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

2018 - At present


Efficient prion disease transmission through common environmental materials Soto, Claudio; Concha-Marambio, Luis; Pritzkow, Sandra; Urayama, Akihiko; Lyon, Adam; Morales, Rodrigo Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo Soto, C.; Moreno-Gonzalez, I.; Diaz-Espinoza, R.; Moda, F.; Concha-Marambio, L.; Morales, R. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2018)
Detection of Prions in Blood of Cervids at the Asymptomatic Stage of Chronic Wasting Disease Kramm, C; Pritzkow, S; Lyon, A; Nichols, T; Morales, R; Soto, C Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Prion strains in mammals: Different conformations leading to disease Morales, Rodrigo Article ISI PLOS PATHOGENS (2017)
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo Park K.-W.; Eun Kim G.; Morales R.; Moda F.; Moreno-Gonzalez I.; Concha-Marambio L.; Lee A.S.; Hetz C.; Soto C. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Role of Prion Replication in the Strain-dependent Brain Regional Distribution of Prions Hu P.P.; Morales R.; Duran-Aniotz C.; Moreno-Gonzalez I.; Khan U.; Soto C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Strain-dependent profile of misfolded prion protein aggregates Morales R.; Hu PP; Duran-Aniotz, C; Moda F; Diaz-Espinoza, R; Chen, BA; Bravo-Alegria, J; Makarava N; Baskakov IV; Soto C. Article ISI SCOPUS SCIENTIFIC REPORTS (2016)
Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions Soto, Claudio; Khan, Uffaf; Pritzkow, Sandra; Telling, Glenn C.; Moda, Fabio; Hoover, Edward; Morales, Rodrigo Article ISI CELL REPORTS (2015)
Prion-like features of misfolded A beta and tau aggregates Soto, Claudio; Callegari, Keri; Morales, Rodrigo Article ISI VIRUS RESEARCH (2015)
Titration of biologically active amyloid-beta seeds in a transgenic mouse model of Alzheimer's disease Morales R.; Bravo-Alegria, J; Duran-Aniotz, C; Soto C. Article ISI SCOPUS SCIENTIFIC REPORTS (2015)
Aggregate-Depleted Brain Fails to Induce A beta Deposition in a Mouse Model of Alzheimer's Disease Duran-Aniotz, C; Morales R.; Moreno-Gonzalez, I; Hu PP; Fedynyshyn J; Soto C. Article ISI SCOPUS PLOS ONE (2014)
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate A? deposition in vivo Duran-Aniotz C.; Morales R.; Moreno-Gonzalez I.; Hu P.P.; Soto C. Article ISI SCOPUS Acta Neuropathologica Communications (2014)
Peripherally administrated prions reach the brain at sub-infectious quantities in experimental hamsters Morales, Rodrigo; Soto, Claudio; Chen, Baian Article ISI FEBS LETTERS (2014)
Agregados amiloides: rol en desórdenes de conformación proteica Claudia Duran-Aniotz; In Moreno-Gonzalez; Rodrigo Morales Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2013)
Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases Soto, Claudio; Moreno-Gonzalez, Ines; Morales, Rodrigo Article ISI PLOS PATHOGENS (2013)
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters Morales R.; Pritzkow, S; Hu PP; Duran-Aniotz, C; Soto C. Article ISI SCOPUS Prion (2013)
De novo induction of amyloid-beta deposition in vivo Morales R.; Duran-Aniotz, C; Castilla J.; Estrada L.D.; Soto C. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2012)
Protein misfolding cyclic amplification of infectious prions Morales R.; Duran-Aniotz, C; Diaz-Espinoza, R; Camacho, MV; Soto C. Article ISI NATURE PROTOCOLS (2012)
Initial fate of prions upon peripheral infection: half-life, distribution, clearance, and tissue uptake Soto, Claudio; Niehoff, Michael L.; Urayama, Akihiko; Banks, William A.; Morales, Rodrigo Article ISI FASEB JOURNAL (2011)
Cellular factors implicated in prion replication Soto, Claudio; Morales, Rodrigo; Abid, Karim Article ISI FEBS LETTERS (2010)
Estimating prion concentration in fluids and tissues by quantitative PMCA Soto, Claudio; Barria, Marcelo A.; Chen, Baian; Morales, Rodrigo Article ISI NATURE METHODS (2010)
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases Morales R.; Estrada, LD; Diaz-Espinoza, R; Morales-Scheihing, D; Jara, MC; Castilla J.; Soto C. Article ISI SCOPUS Journal of Neuroscience (2010)
Are Amyloids Infectious? Perry, G; Soto, Claudio; Morales, Rodrigo; Maccioni, RB; Chen, Baian Article ISI CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)
Cross Currents in Protein Misfolding Disorders: Interactions and Therapy Soto, Claudio; Green, Kristi M.; Morales, Rodrigo Article ISI CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2009)
De Novo Generation of Infectious Prions In Vitro Produces a New Disease Phenotype Barria, MA; Mukherjee, A; Gonzalez-Romero, D; Morales R.; Soto C. Article ISI SCOPUS PLOS PATHOGENS (2009)
Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism Supattapone, Surachai; Soto, Claudio; Piro, Justin R.; Morales, Rodrigo; Nishina, Koren; Rees, Judy R.; Harris, Brent T. Article ISI JOURNAL OF VIROLOGY (2009)
Cell-free propagation of prion strains Castilla J.; Morales R.; Saa, P; Barria, M.; Gambetti, P; Soto C. Article ISI SCOPUS EMBO JOURNAL (2008)
Crossing the species barrier by PrPSc replication in vitro generates unique infectious Prions Soto, Claudio; Morales, Rodrigo; Castilla, Joaquin; De Castro, Jorge; Saa, Paula; Gonzalez-Romero, Dennisse Article ISI CELL (2008)
Detection of infectious prions in urine Soto, Claudio; Leon, Patricia; Gonzalez-Romero, Dennisse; Morales, Rodrigo; Barria, Marcelo A. Article ISI FEBS LETTERS (2008)
Reduction of prion infectivity in packed red blood cells Morales R.; Buytaert-Hoefen, KA; Gonzalez-Romero, D; Castilla J.; Hansen, ET; Hlavinka, D; Goodrich, RP; Soto C. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Isolation and characterization of a proteinase K-sensitive PrPSc fraction Requena, Jesus R.; Castilla, Joaquin; Pastrana, Miguel A.; Morales, Rodrigo; Onisko, Bruce; Soto, Claudio; Sajnani, Gustavo Article ISI BIOCHEMISTRY (2006)
Protein misfolding cyclic amplification for diagnosis and prion propagation studies Wetzel, R; Maundrell, Kinsey; Castilla, Joaquin; Soto, Claudio; Morales, Rodrigo; Kheterpal, I; Saa, Paula; Abid, Karim Article ISI ION CHANNELS: CHANNEL PRODUCTION AND OPTICAL METHODS (2006)


Amyloid-beta Transmissibility Duran-Aniotz, Claudia; Morales, Rodrigo; Moreno-Gonzalez, Ines; Soto, Claudio; Jucker, Mathias; Chrisen, Y BookSection (2013)


Role of prion protein oligomers in the pathogenesis of transmissible spongiform encephalopathies Morales R.; Duran-Aniotz C.A.; Soto C. BookWhole SCOPUS Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases (2012)
Signaling pathways controling prion neurotoxicity: Role of endoplasmic reticulum stress-mediated apoptosis Morales R.; Hetz C.; Soto C. BookWhole SCOPUS Neurodegeneration and Prion Disease (2005)


Amyloid aggregates: role in protein misfolding disorders Duran-Aniotz, C; Moreno-Gonzalez, I; Morales R. Review ISI REVISTA MEDICA DE CHILE (2013)
The prion strain phenomenon: Molecular basis and unprecedented features Morales R.; Abid, K; Soto C. Review ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)