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Rodrigo Morales

Assistant Professor

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

Líneas de Investigación


- Strain diversity and species barriers in prion diseases - Chronic Wasting disease (prion diseases in deer) - Diagnosis of prion diseases - Prion-like transmission of amyloid-beta - Cross-seeding between heterologous amyloids

Educación

  •  Sciences with mention in Biology, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2003

Experiencia Académica

  •   Graduate Research Assistant Full Time

    The University of Texas Medical Branch at Galveston

    Galveston, Estados Unidos

    2004 - 2009

  •   Post-doctoral Fellow Full Time

    The University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    2009 - 2012

Experiencia Profesional

  •   Instructor Full Time

    The University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    2012 - 2012

  •   Assistant Professor Full Time

    The University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    2012 - 2018

  •   Associate Professor Full Time

    The University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    2018 - At present


 

Article (32)

Efficient prion disease transmission through common environmental materials
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo
Detection of Prions in Blood of Cervids at the Asymptomatic Stage of Chronic Wasting Disease
Prion strains in mammals: Different conformations leading to disease
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo
Role of Prion Replication in the Strain-dependent Brain Regional Distribution of Prions
Strain-dependent profile of misfolded prion protein aggregates
Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions
Prion-like features of misfolded A beta and tau aggregates
Titration of biologically active amyloid-beta seeds in a transgenic mouse model of Alzheimer's disease
Aggregate-Depleted Brain Fails to Induce A beta Deposition in a Mouse Model of Alzheimer's Disease
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate A? deposition in vivo
Peripherally administrated prions reach the brain at sub-infectious quantities in experimental hamsters
Agregados amiloides: rol en desórdenes de conformación proteica
Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases
Lack of prion transmission by sexual or parental routes in experimentally infected hamsters
De novo induction of amyloid-beta deposition in vivo
Protein misfolding cyclic amplification of infectious prions
Initial fate of prions upon peripheral infection: half-life, distribution, clearance, and tissue uptake
Cellular factors implicated in prion replication
Estimating prion concentration in fluids and tissues by quantitative PMCA
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases
Are Amyloids Infectious?
Cross Currents in Protein Misfolding Disorders: Interactions and Therapy
De Novo Generation of Infectious Prions In Vitro Produces a New Disease Phenotype
Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism
Cell-free propagation of prion strains
Crossing the species barrier by PrPSc replication in vitro generates unique infectious Prions
Detection of infectious prions in urine
Reduction of prion infectivity in packed red blood cells
Isolation and characterization of a proteinase K-sensitive PrPSc fraction
Protein misfolding cyclic amplification for diagnosis and prion propagation studies

BookSection (1)

Amyloid-beta Transmissibility

BookWhole (2)

Role of prion protein oligomers in the pathogenesis of transmissible spongiform encephalopathies
Signaling pathways controling prion neurotoxicity: Role of endoplasmic reticulum stress-mediated apoptosis

Review (2)

Amyloid aggregates: role in protein misfolding disorders
The prion strain phenomenon: Molecular basis and unprecedented features
37
Rodrigo Morales

Assistant Professor

Neurology

The University of Texas Health Science Center at Houston

Houston, Estados Unidos

9
Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

2
lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

1
RODRIGO DIAZ

Profesor Asistente

Universidad de Santiago de Chile

Santiago, Chile