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lisbell dianne estrada apablaza

Decana Facultad Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

Alzheimer disease; Protein misfolding; Molecular and cell Biology

Ciencias mención Biología, UNIVERSIDAD DE CHILE. Chile, 2010
Ingeniero en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2005

Directora de Investigacion y Doctorados Full Time

UNIVERSIDAD BERNARDO O'HIGGINS

Salud

santiago, Chile

2015 - 2019
Investigador Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Santiago, Chile

2010 - 2015
Decana Full Time

UNIVERSIDAD BERNARDO O'HIGGINS

Ciencias de la Salud

Santiago, Chile

2020 - At present

research associate Full Time

University of texas medical branch

Galveston, Estados Unidos

2003 - 2008

2016-Tesista de Pregrado Universidad Bernardo O Higgins. Srta. Nicole Mundaca. Fondecyt 11130561.
2017-Tesista de Pregrado Universidad Bernardo O Higgins. Sr. Pablo Ahumada. Fondecyt 11130561.
2017-Tesista de Postgrado Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Srta. Elizabeth Durán. Fondecyt 11130561.
2018-Tesista de Postgrado Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Srta. Elena Castañeda. Fondecyt 11130561.
2019-Tesista de Postgrado Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Sr. Pablo Ahumada Fondecyt 11130561.
2019-Tesista de Postgrado (en curso) Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Sr. Luis Astete.
2019-Tesista de Postgrado (en curso) Programa Magister en Ciencias Químico-Biológicas Universidad Bernardo O Higgins. Srta. María Celis.


Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer's disease Morales, Rodrigo; Duran-Aniotz, Claudia; Bravo-Alegria, Javiera; Estrada, Lisbell D.; Shahnawaz, Mohammad; Hu, Ping-Ping; Kramm, Carlos; Morales-Scheihing, Diego; Urayama, Akihiko; Soto, Claudio Article ISI ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
Liver Dysfunction as a Novel Player in Alzheimer’s Progression: Looking Outside the Brain Estrada, Lisbell D.; Ahumada, Pablo.; Cabrera, Daniel Alejandro; Arab, Juan Pablo Article Indexed in: PubMed, PubMed Central (PMC), Scopus, Web of Science Citation Index Expanded (SCIE), Google Scholar, DOAJ, CrossRef, PsycINFO, Chemical Abstracts Service (CAS), EMBASE, Semantic Scholar, Ulrich's Periodicals Directory, Science Citation Index Expanded, CLOCKSS, EBSCO, OpenAIRE, Zetoc FRONTIERS IN AGING NEUROSCIENCE (2019)
Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimers disease Morales-Zavala, Francisco; Casanova-Morales, Nathalie; Gonzalez, Raul B.; Chandia-Cristi, America; Estrada, Lisbell D.; Alvizu, Ignacio; Waselowski, Victor; Guzman, Fanny; Guerrero, Simon; Oyarzun-Olave, Marisol; Rebolledo, Cristian; Rodriguez, Enrique; Armijo, Julien; Bhuyan, Heman; Favre, Mario; Alvarez, Alejandra R.; Kogan, Marcelo J.; Maze, Jeronimo R. Article ISI SCOPUS JOURNAL OF NANOBIOTECHNOLOGY (2018)
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia. Ábrigo, Johanna; Elorza, Alvaro A; Riedel, Claudia A; Vilos, Cristian; Simon, Felipe; Cabrera, Daniel; Estrada, Lisbell; Cabello-Verrugio, Claudio Article Oxidative medicine and cellular longevity (2018)
The cluster [ReSeI] penetrates biological membranes=> drug-like properties for CNS tumor treatment and diagnosis. Estrada, Lisbell D; Duran, Elizabeth; Cisterna, Matias; Echeverria, Cesar; Zheng, Zhiping; Borgna, Vincenzo; Arancibia-Miranda, Nicolas; Ramírez-Tagle, Rodrigo Article Biometals => an international journal on the role of metal ions in biology, biochemistry, and medicine (2018)
Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for AlzheimerÂ´s Disease. Estrada, Lisbell Dianne; Oliveira Cruz, Luciana; Cabrera, Daniel Alejandro Article wos ISI CURRENT PROTEIN AND PEPTIDE SCIENCE (2018)
c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease Yáñez, M.J.; Belbin, O.; Estrada, L.D.; Leal, N.; Contreras, P.S.; Lleó, A.; Burgos, P.V.; Zanlungo, S.; Alvarez, A.R. Article BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1. Cabrera, Daniel; Ruiz, Alex; Cabello-Verrugio, Claudio; Brandan, Enrique; Estrada, Lisbell; Pizarro, Margarita; Solis, Nancy; Torres, Javiera; Barrera, Francisco; Arrese, Marco Article Digestive diseases and sciences (2016)
Reduction of Blood Amyloid-Î² Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition. Estrada, Lisbell D; Chamorro, David; Yañez, María José; Gonzalez, Marcelo; Leal, Nancy; von Bernhardi, Rommy; Dulcey, Andrés E; Marugan, Juan; Ferrer, Marc; Soto, Claudio; Zanlungo, Silvana; Inestrosa, Nibaldo C; Alvarez, Alejandra R Article Journal of Alzheimer's disease : JAD (2016)
c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer's Disease Gonzalez-Zuñiga, Marcelo; Contreras, Pablo S.; Estrada, Lisbell D.; Chamorro, David; Villagra, Alejandro; Zanlungo Silvana, Seto; Edward, Alvarez Article Molecular Cell (2014)
EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-beta Oligomers M. Vargas, Lina; Leal, Nancy.; Estrada, Lisbell D.; Gonzlez, Adrian; Serrano, Felipe; Araya, Katherine; Gysling, Katia; Inestrosa, Nibaldo C; Pasquale, Elena B.; Alvarez, Alejandra R.; Arendt, Thomas Article ISI SCOPUS PLOS ONE (2014)
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer´s disease. Moreno-Gonzalez I.; Estrada LD.; Sanchez-Mejias E.; Soto C. Article Nature communications (2013)
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease Ines Moreno-Gonzalez* and Lisbell D. Estrada* (first author), Elisabeth Sanchez-Mejias & Claudio Soto Article Nature Communications (2013)
De novo induction of amyloid-beta deposition in vivo Morales R.; Duran-Aniotz, C; Castilla J.; Estrada L.D.; Soto C. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2012)
Induction of amyloid deposition and memory impairments in animal models of Alzheimer disease by blood transfusion Duran-Aniotz C.; Morales R.; Estrada L.; Urayama A.; Morales-Scheihing D.; SOTO, C Article PRION (2012)
C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology Estrada, LD; Zanlungo, SM; Alvarez, AR Article ISI CURRENT ALZHEIMER RESEARCH (2011)
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases Morales R.; Estrada, LD; Diaz-Espinoza, R; Morales-Scheihing, D; Jara, MC; Castilla J.; Soto C. Article ISI SCOPUS Journal of Neuroscience (2010)
Protein misfolding and neurodegeneration SOTO, C; Estrada L.D. Article Archives of Neurology (2008)
Disrupting beta-amyloid aggregation for Alzheimer disease treatment. Estrada, L D; Soto, C Article Current topics in medicinal chemistry (2007)
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates. Soto C., Estrada L.D., Castilla J. Article Trends Biochem Sci. (2006)
Inhibition of protein misfolding and aggregation by small rationally-designed peptides. Estrada, L D; Soto, C Article Current pharmaceutical design (2006)
Protein misfolding disorders and rational design of antimisfolding agents. Estrada, Lisbell D; Yowtak, June; Soto, Claudio Article Methods in molecular biology (Clifton, N.J.) (2006)
Amyloid formation modulates the biological activity of a bacterial protein Bieler, S; Estrada L.; Lagos R.; Baeza, M.; Castilla J.; Soto C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Amyloid inhibitors and beta-sheet breakers Soto, C. and Estrada, L.D. Article Subcell Biochem (2005)


A beta oligomers affects Blood-brain-barrier integrity in Alzheimers disease. Estrada, LD; Ahumada, P; Cisterna, M; Morales-Loyola, R; Carrasco N. Abstract ISI (2017)
Induction of amyloid deposition and memory impairments in animal models of Alzheimer disease by blood transfusion Duran-Aniotz, C; Morales R.; Estrada L.; Urayama, A; Morales-Scheihing, D; Soto C. Abstract PRION (2012)
Regulation of HDAC2 by of the tyrosine kinase c-Abl, a new mechanism of regulation of the gene expression. GONZALEZ, MA; Contreras P.; Estrada L.; David, C; Seto E.; Villagra, A; Alvarez, AR Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)
c-Abl inhibition decreases the levels of Amyloid beta peptide in plasma of Alzheimer transgenic mice. Estrada, LD; Chamorro, D; Inestrosa, NC; Alvarez, AR Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2011)
Induction of A beta Amyloidogenesis In Vivo by Blood Transfusion Morales R.; Duran-Aniotz, C; Urayama, A; Estrada L.; Morales-Scheihing, D; Soto C. Abstract ISI PRION (2011)
Transmission of Alzheimer Disease and Type 2 Diabetes by a Prion Mechanism Soto C.; Salvadores-Bersezio, N; Moreno-Gonzalez, I; Duran-Aniotz, C; Urayama, A; Estrada L.; Morales-Scheihing, D; Morales R. Abstract ISI PRION (2011)


Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2018 Cabello-Verrugio, C; Vilos, C; Rodrigues-Diez, R; Estrada L. EditorialMaterial ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)


BLOOD BRAIN BARRIER INSIGHTS=> PATHOLOGICAL BREAKDOWN AND MODULATION AS A THERAPEUTIC APPROACH FOR ALZHEIMERÂ´S DISEASE FONDECYT (11130561) Proyecto 2013-2018 Inv. Responsable
Centro de envejecimiento y regeneracion CARE FONDAP (PROJECTO B) Proyecto 2013-2017 Postdoctorado
Identification of c-Abl inhibitors for the potential treatment of Alzheimer disease FONDEF (D10I1077) Proyecto 2011-2013 Postdoctorado
Uncovering the mechanisms of Amyloid clearence induced by STI571-treatment in Alzheimers disease=> the role of the Abl kinase FONDECYT (3110052) Proyecto 2010-2013 Inv. Responsable
Development of Blood biomarkers for early diagnosis and to track progression of Alzheimers disease Mitchell Foundation Grant Proyecto 2007-2009 Coinvestigador(a)
Detection of misfolded Aß oligomers for early diagnosis of Alzheimer’s diseases CART Foundation Proyecto 2006-2008 Investigador(a)
Small molecule ß-sheet breaker peptidemimetics for Alzheimer’s therapy National Institute of health (NIH) Proyecto 2006-2011 Investigador(a)
Smoking and amyloid formation in Alzheimer’s disease Tobacco Foundation Proyecto 2004-2004 Investigador(a)


Liver Dysfunction as a Novel Player in Alzheimer's Progression: Looking Outside the Brain Estrada, LD; Ahumada, P; Cabrera, D; Arab, JP Review ISI FRONTIERS IN AGING NEUROSCIENCE (2019)
TGF-? and hepatocellular carcinoma: When a friend becomes an enemy Arrese M.; Hernandez A.; Astete L.; Estrada L.; Cabello-Verrugio C.; Cabrera D. Review ISI SCOPUS (2018)
Protein misfolding and neurodegeneration Soto C.; Estrada, LD Review ISI ARCHIVES OF NEUROLOGY (2008)