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Diego Andrés Rojas Rivera

Assistant Professor

Universidad Mayor

Santiago, Chile

Cell Death, ER stress, TNF signaling pathway, Apoptosis, Necroptosis. Pharmacology, Bioassays.

Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2012
Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2006

Postdoctoral Researcher Full Time

UNIVERSITY OF GENT

Inflammation Research Center

Gent, Bélgica

2016 - 2018
Postdoctoral Researcher Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2013 - 2015
Assistant professor Full Time

Universidad Mayor

Ciencias

Santiago, Chile

2018 - At present
Phd student Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2007 - 2012

Assistant Professor Full Time

Universidad Mayor

Santiago, Chile

2018 - At present

2016 Study of the contribution of the UPR to TNF-mediated inflammatory response and cell death induction. Scientific supervisor of Master thesis of Science in Biochemistry and Biotechnology, Ghent University. Belgium.

2014-2018 Role of HSP47 on the regulation of IRE1alfa. Co-Advisor of Ph.D. thesis in Biomedical Sciences, University of Chile, Chile.

2019 chairman of self-evaluation committee for the Neurobiology doctoral program, Universidad Mayor, Chile.

2013-2014: Coordinator of Seminars “Talks about Neuromedicine” at the Biomedical Neuroscience Institute, Medicine Faculty. University of Chile.

Mejor Tesis Doctoral

ACADEMIA CHILENA DE CIENCIAS

Chile, 2015

Doctoral thesis: “TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis”.
Mejor tesis doctoral en biologia celular de Chile

Fundación Allende-Connelly

Chile, 2013

Doctoral thesis: “TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis”.
Young Scientist Program award

IUBMB & FEBS

Chile, 2012

Premio otorgado por IUBMB & FEBS, 2012
Keystone Symposia Award

Keystone Symposia

Chile, 2010

For assisting “Cell Death Pathways: Apoptosis, Autophagy and Necrosis (X3)”. Vancouver, British Columbia, Canadá.


Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis Beltran, S; Nassif M.; Vicencio E.; Arcos J.; Labrador L.; Cortes B.I.; Cortez C.; Bergmann C.A.; Espinoza S.; Hernandez M.F.; Matamala, J. M.; Bargsted L.; Matus S.; Rojas-Rivera D.; Bertrand M.J.M.; Medinas D.B.; Hetz C.; Manque P.A.; Woehlbier U. Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2019)
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation Dondelinger Y.; Delanghe T.; Priem D.; Wynosky-Dolfi M.A.; Sorobetea D.; Rojas-Rivera D.; Giansanti P.; Roelandt R.; Gropengiesser J.; Ruckdeschel K.; Savvides S.N.; Heck A.J.R.; Vandenabeele P.; Brodsky I.E.; Bertrand M.J.M. Article ISI SCOPUS NATURE COMMUNICATIONS (2019)
ER stress sensing mechanism: Putting off the brake on UPR transducers Rojas-Rivera, Diego. Article Oncotarget (2018)
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha Sepulveda, D; Rojas-Rivera, D; Rodriguez, DA; Groenendyk, J; Kohler, A; Lebeaupin, C; Ito, S; Urra, H; Carreras-Sureda, A; Hazari, Y; Vasseur-Cognet, M; Ali, MMU; Chevet, E; Campos, G; Godoy, P; Vaisar, T; Bailly-Maitre, B; Nagata, K; Michalak, M; Sierralta, J; hetz, C Article ISI SCOPUS MOLECULAR CELL (2018)
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response (vol 30, pg 4465, 2011) Castillo,Karen; Rojas-Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamin; Nassif, Melissa;; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena.; Glavic, Alvaro.; Hetz, Claudio Article ISI EMBO JOURNAL (2017)
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death Dondelinger, Yves; Delanghe, Tom; Rojas-Rivera, Diego; Priem, Dario; Delvaeye, Tinneke; Bruggeman, Inge; Van Herreweghe, Franky; Vandenabeele, Peter; Bertrand, Mathieu J. M. Article ISI Nature Cell Biology (2017)
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157 Rojas-Rivera, Diego; Delvaeye, Tinneke; Roelandt, Ria; Nerinckx, Wim; Augustyns, Koen; Vandenabeele, Peter; Bertrand, Mathieu J. M. Article ISI CELL DEATH AND DIFFERENTIATION (2017)
A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress Aguileta, M. A.; Rojas-Rivera, D.; Goossens, V.; Estornes, Y.; Van Isterdael, G.; Vandenabeele, P.; Bertrand, M. J. M. Article ISI CELL DEATH AND DIFFERENTIATION (2016)
Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview Dufey E.; Sepulveda D.; Rojas-Rivera, D; hetz C. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis Groenendyk J.; Peng, ZL; Dudek, E; Fan X.; Mizianty, MJ; Dufey E.; Urra, H; Sepulveda D.; Rojas-Rivera, D; Lim, Y; Kim, DH; Baretta, K; Srikanth, S; Gwack, Y; Ahnn, J; Kaufman, RJ; Lee, SK; hetz C.; Kurgan L.; Michalak M. Article ISI SCOPUS SCIENCE SIGNALING (2014)
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis Nassif, M; Valenzuela, V.; Rojas-Rivera, D; Vidal, R; Matus, S; Castillo, K; Fuentealba Y.; Kroemer G.; Levine, B; hetz C. Article ISI SCOPUS AUTOPHAGY (2014)
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis. Kiviluoto, S.; Luyten, T.; Schneider, L.; Lisak, D.; Rojas-Rivera, D.; Welkenhuyzen, K.; Missaen, L.; De Smedt, H.; Parys, J.B.; Hetz, C.; Methner, A. Article Cell Calcium (2013)
When ER stress reaches a dead end Urra, H.; Dufey, E.; Lisbona, F.; Rojas-Rivera, D. Article BBA-Molecular Cell Research (2013)
BAX/BAK and Cyclophilin D-independent intrinsic apoptosis pathway Zamorano, S.; Rojas-Rivera, D.; Lisbona, F.; Parra, V.; Court, F.A.; Villegas, R.; Cheng, E.H.; Korsmeyer, S.J.; Lavandero, S. Article PLoS One (2012)
BH3-only proteins are part of a regulatory network that control the sustained signaling of the UPR sensor IRE1alpha. Rodriguez, D.A.; Zamorano, S.; Lisbona, F.; Rojas-Rivera, D.; Urra, H.; Cubillos-Ruiz, J.R.; Armisen, R.; Henriquez, D.R.; Cheng, E.; Letek, M.; Vaisar, T.; Irrazabal, T.; Gonzalez-Billault, C.; Letai, A.; Pimentel-Muiños, F.X.; Kroemer, G. Article EMBO Journal (2012)
TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Rojas-Rivera, D.; Armisen, R.; Colombo, A.; Eguigurren, M.L.; Martinez, G.; Diaz, A.; Patron, M.; Rizzuto, R.; Bultynck, G.; Concha, M.; Sierralta, A.; Hetz, C. Article Cell Death Differ (2012)
Alternative functions of the BCL-2 protein family at the endoplasmic reticulum Rojas-Rivera, D.; Caballero, B.; Zamorano, Z.; Lisbona, F. Article Adv Exp Med Biol (2011)
BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. Castillo, K.; Rojas-Rivera, D.; Lisbona, F.; Caballero, B.; Nassif, M.; Court, F.; Schuck, S.; Ibar, C.; Walter, P.; Sierralta, J.; Glavic, A. Article EMBO Journal (2011)
Integrating stress signals at the endoplasmic reticulum=> The BCL-2 protein family rheostat. Rodriguez, D.A.; Rojas-Rivera, D. Article Biochim Biophys Acta (2011)
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1 Lisbona, F.; Rojas-Rivera, D.; Thielen, P.; Zamorano, S.; Todd, D.; Martinon, F.; Glavic, A.; Kress, C.; Lin, J.H.; Walter, P.; Reed, J.C.; Glimcher, L.H. Article Molecular Cell (2009)
Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species. Rojas-Rivera, D.; Diaz-Elizondo, J.; Chiong, M.; Olea-Azar, C. Article FEBS Letters (2009)
Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas Miranda H, Rodrigo; Castro G, Pablo; Verdejo P, Hugo; Chiong, Mario; Diaz-Araya, Guillermo; Mellado, Rosemarie; Rojas, Diego.; Concepción, Roberto; Lavandera, Sergio Article SCIELO REVISTA MEDICA DE CHILE (2007)
Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes Diaz-Elizondo, J.; Chiong, M.; Rojas-Rivera, D.; Olea-Azar, C.; Kwon, H.M. Article Biochem biophys Res Comun (2006)


Alternative functions of the BCL-2 protein family at the endoplasmic reticulum. Rojas-Rivera, Diego.; Ceballero, Benjamin.; Zamorano, Sebastián. BookReview GLIAL CELLS IN HEALTH AND DISEASE OF THE CNS (2010)