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Patricio Andres Manque Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

Genomics, Neurodegeneration, Vaccine Development, Systems Biology, Genetics

Medical Technologist, UNIVERSIDAD DE ANTOFAGASTA. Chile, 1995
Microbiology and Immunology, ESCOLA PAULISTA DE MEDICINA. Brasil, 2001

Post Doctoral Fellow Full Time

ESCOLA PAULISTA DE MEDICINA

Medicine

Sao Paulo, Brasil

2001 - 2002
Post Doctoral Fellow Full Time

VIRGINIA COMMONWEALTH UNIVERSITY

Medicine

Richmond, Estados Unidos

2002 - 2006
Senior Research Associate Full Time

VIRGINIA COMMONWEALTH UNIVERSITY

Medicine

Richmond, Chile

2006 - 2009
Fellow Other

VIRGINIA COMMONWEALTH UNIVERSITY

Center for the Study of Biological Complexity

Richmond, Chile

2002 - 2009

Associate Professor, Director Center for Genomics and Bioinformatics Full Time

Universidad Mayor

Santiago, Chile

2009 - 2015
Dean, Faculty of Sciences Full Time

Universidad Mayor

Santiago, Chile

2013 - At present
FULL PROFESSOR, CENTER FOR INTEGRATIVE BIOLOGY Full Time

UNIVERSIDAD MAYOR

Chile

2016 - At present
VICE PRESIDENT OF RESEARCH Full Time

UNIVERSIDAD MAYOR

Chile

2016 - At present

Undergraduate Thesis:
Camila Gherardelli and Emiliano Vicencio (2011-?2012). Biotechnology thesis. Universidad Mayor
Javiera Quintana and Romina Paillao (2011-?2012). Biotechnology thesis. Universidad Mayor
Jose Escalona and Michel Leiva (2011). Medical technology thesis. Universidad Mayor

Undergradate Research Program (Pre thesis)
Valeria Labra, Biotechnology major, Universidad Mayor
Javiera Arcos, Biotechnology major, Universidad Mayor

Ph.D. Students:
Jose Manuel Matamala (2011-?present, co-?advisor with Claudio Hetz). Ph.D. program in medical sciences, neurology. Department of Neurological sciences. University of Chile
Sebastian Beltran, Ph.D. Program in Integrative Genomics, Universidad Mayor (2014-2018)
Cristian Muñoz, Ph.D. Program in Integrative Genomics, Universidad Mayor (2014-2018)

Post-doctoral fellows
Dr. Fernando Tenjo (2006-2009)
Dr. Nicole Trombert (2011-?2012)
Dr.Melissa Calegaro Nassif (2013-2016)


Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis Beltran, S; Nassif M.; Vicencio E.; Arcos J.; Labrador L.; Cortes B.I.; Cortez C.; Bergmann C.A.; Espinoza S.; Hernandez M.F.; Matamala, J. M.; Bargsted L.; Matus S.; Rojas-Rivera D.; Bertrand M.J.M.; Medinas D.B.; Hetz C.; Manque P.A.; Woehlbier U. Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2019)
Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Matamala, José Manuel; Arias-Carrasco, Raul; Sanchez, Carolina; Uhrig, Markus; Bargsted, Leslie; Matus, Soledad; Maracaja-Coutinho, Vinicius; Abarzua, Sebastian; van Zundert, Brigitte; Verdugo, Renato; Manque, Patricio; Hetz, Claudio Article Neurobiology of aging (2018)
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs. De Gregorio, Cristian; Díaz, Paula; López-Leal, Rodrigo; Manque, Patricio; Court, Felipe A Article Methods in molecular biology (Clifton, N.J.) (2018)
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders. Salvadores, Natalia; Sanhueza, Mario; Manque, Patricio; Court, Felipe A Article Frontiers in neuroscience (2017)
The Enigmatic Role of C9ORF72 in Autophagy. Nassif, Melissa; Woehlbier, Ute; Manque, Patricio A Article Frontiers in neuroscience (2017)
High quality RNA extraction from Maqui berry for its application in next-generation sequencing. Sánchez, Carolina; Villacreses, Javier; Blanc, Noelle; Espinoza, Loreto; Martinez, Camila; Pastor, Gabriela; Manque, Patricio; Undurraga, Soledad F; Polanco, Victor Article SpringerPlus (2016)
Deep Sequencing Reveals the Complete Genome and Evidence for Transcriptional Activity of the First Virus-Like Sequences Identified in Aristotelia chilensis (Maqui Berry) Villacreses, J; Rojas-Herrera, M; Sánchez C; Hewstone, N; Undurraga, SF; Alzate, JF; Manque P.; Maracaja-Coutinho, V; Polanco V. Article ISI SCOPUS Viruses (2015)
Revisiting the reference genomes of human pathogenic Cryptosporidium species: reannotation of C. parvum Iowa and a new C. hominis reference Isaza, JP; Galvan, AL; Polanco V.; Huang B.; Matveyev, AV; Serrano, MG; Manque P.; Buck, GA; Alzate, JF Article ISI SCOPUS SCIENTIFIC REPORTS (2015)
Draft Genome Sequence of Virulent Strain AUSTRAL-005 of Piscirickettsia salmonis, the Etiological Agent of Piscirickettsiosis. Yañez, Alejandro J; Molina, Cristian; Haro, Ronie E; Sanchez, Patricio; Isla, Adolfo; Mendoza, Julio; Rojas-Herrera, Marcelo; Trombert, Annette; Silva, Andrea X; Cárcamo, Juan G; Figueroa, Jaime; Polanco, Victor; Manque, Patricio; Maracaja-Coutinho, Vinicius; Olavarría, Víctor H Article Genome announcements (2014)
Draft Genome Sequence of Virulent Strain AUSTRAL-005 of Piscirickettsia salmonis, the Etiological Agent of Piscirickettsiosis. Yañez, Alejandro J; Molina, Cristian; Haro, Ronie E; Sanchez, Patricio; Isla, Adolfo; Mendoza, Julio; Rojas-Herrera, Marcelo; Trombert, Annette; Silva, Andrea X; Cárcamo, Juan G; Figueroa, Jaime; Polanco, Victor; Manque, Patricio; Maracaja-Coutinho, Vinicius; Olavarría, Víctor H Article Genome announcements (2014)
The Effect of Tunicamycin on the Glucose Uptake, Growth, and Cellular Adhesion in the Protozoan Parasite Crithidia fasciculata Rojas, R.; Segovia, C; Trombert, AN; Santander, J; Manque P. Article ISI SCOPUS CURRENT MICROBIOLOGY (2014)
Intranasal vaccination in mice with an attenuated Salmonella enterica Serovar 908htr A expressing Cp15 of Cryptosporidium: impact of malnutrition with preservation of cytokine secretion Roche, JK; Rojo, AL; Costa, LB; Smeltz, R; Manque P.; Woehlbier, U; Bartelt, L; Galen, J; Buck G.; Guerrant, RL Article SCOPUS Vaccine (2013)
Results of external quality assessment for proviral DNA testing of HIV tropism in the Maraviroc Switch collaborative study Tu, E; Swenson, LC; Land, S; Pett, S; Emery, S.; Marks, K; Kelleher, AD; Kaye, S; Kaiser, R.; Schuelter, E; Harrigan, R; Manque P.; MARCH Laboratory Group and the MARCH Study Group Article ISI J. CLIN. MICROBIOL. (2013)
Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis Manque, Patricio A.; Woehlbier, Ute*; Lara, Ana M.; Tenjo, Fernando; Alves, Joao M.; Buck, Gregory A. Article ISI PLOS ONE (2012)
Identification and characterization of a novel calcium-activated apyrase from Cryptosporidium parasites and its potential role in pathogenesis. Manque, PA; Woehlbier, U; Lara, AM; Tenjo, F; Alves, JM; Buck, GA Article ISI PLoS One (2012)
Identification and immunological characterization of three potential vaccinogens against Cryptosporidium species Manque P.A.; Tenjo, F; Woehlbier, U; Lara A.M.; Serrano M.G.; Xu, P; Alves J.M.; Smeltz R.B.; Conrad D.H.; Buck G.A. Article SCOPUS Clinical and Vaccine Immunology (2011)
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes Manque, PA; Probst, CM; Pereira MC.; Rampazzo, RC; Ozaki, LS.; Pavoni, DP; Silva Neto, DT; Carvalho, MR; Xu, P; Serrano, MG; Alves, JM; Meirelles, Mde N; Goldenberg, S; Krieger, MA; Buck, GA Article ISI INFECTION AND IMMUNITY (2011)
A genome-scale metabolic model of Cryptosporidium hominis Vanee, N; Roberts, SB; Fong, SS; Manque P.; Buck, GA Article ISI CHEMISTRY AND BIODIVERSITY (2010)
Protein and mRNA content of TcDHH1-containing mRNPs in Trypanosoma cruzi Holetz, FB; Alves, LR; Probst, CM; Dallagiovanna, B; Marchini, FK; Manque P.; Buck G.; Krieger, MA; Correa, A; Goldenberg, S Article ISI SCOPUS FEBS Journal (2010)
Proteomic analysis reveals the dynamic association of proteins with translated mRNAs in Trypanosoma cruzi Alves, LR; Avila, AR; Correa, A; Holetz, FB; Mansur, FC; Manque, PA; de Menezes, JP; Buck, GA; Krieger, MA; Goldenberg, S Article ISI GENE (2010)
Putative cis-regulatory elements associated with heat shock genes activated during excystation of Cryptosporidium parvum Cohn B.; Manque P.; Lara A.M.; Serrano M.; Buck G.; Sheth N. Article PLOS ONE (2010)
Sera of Chagasic patients react with antigens from the tomato parasite Phytomonas serpens Graça-de Souza, VK; Monteiro-Góes, V; Manque P.; Souza, TA; Corrêa, PR; Buck, GA; Avila, AR; Yamauchi, LM; Pinge-Filho, P; Goldenberg, S; Krieger, MA; Yamada-Ogatta, SF Article SCIELO BIOLOGICAL RESEARCH (2010)
Over-expression and localization of a host protein on the membrane of Cryptosporidium parvum infected epithelial cells Yang, YL; Serrano, MG; Sheoran, AS; Manque, PA; Buck, GA; Widmer, G Article ISI MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2009)
Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi Roberts, SB; Robichaux, JL; Chavali, AK; Manque, PA; Lee, V; Lara, AM; Papin, JA; Buck, GA Article ISI BMC SYSTEMS BIOLOGY (2009)
T-bet-dependent regulation of CD8+ T-cell expansion during experimental Trypanosoma cruzi infection Cobb, D; Guo, S; Lara, AM; Manque P.; Buck G.; Smeltz, RB Article ISI IMMUNOLOGY (2009)
The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages Gomes, IN; Palma, NC; Campos, GO; Lima, JG; De Almeida, TF; de Menezes, JP; Ferreira, CA; Santos, RR; Buck, GA; Manque, PA; Ozaki, LS.; Probst, CM; De Freitas, LA; Krieger, MA; Veras, PS Article ISI PARASITE IMMUNOLOGY (2009)
Cryptosporidium hominis infection of the human respiratory tract Mercado R.; Buck, GA; Manque, PA; Ozaki, LS. Article ISI SCOPUS EMERGING INFECTIOUS DISEASES (2007)
Genome of the opportunistic pathogen Streptococcus sanguinis Xu, P; Alves, JM; Kitten, T; Brown A.; Chen, Z; Ozaki, LS.; Manque P.; Ge, X; Serrano, MG; Puiu, D; Hendricks S.; Wang Y.; Chaplin, MD; Akan, D; Paik, S; Peterson, DL; Macrina, FL; Buck, GA Article ISI JOURNAL OF BACTERIOLOGY (2007)
The genome of Cryptosporidium hominis Xu, P; Widmer, G; Wang Y.; Ozaki, LS.; Alves, JM; Serrano, MG; Puiu, D; Manque P.; Akiyoshi, D; Mackey, AJ; Pearson, WR; Dear, PH; Bankier, AT; Peterson, DL; Abrahamsen, MS; Kapur, V; Tzipori, S; Buck, GA Article ISI NATURE (2004)
Cell adhesion and Ca2+ signaling activity in stably transfected Trypanosoma cruzi epimastigotes expressing the metacyclic stage-specific surface molecule gp82 Manque, PM; Neira, I; Atayde, VD; Cordero E.; Ferreira, AT; da Silveira, JF; Ramirez M.; Yoshida, N Article ISI INFECTION AND IMMUNITY (2003)
Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi Araya, JE; Neira, I; da Silva, S; Mortara, RA; Manque P.; Cordero E.; Sagua, H; Loyola, A.; Bórquez J.; Morales G.; Gonzalez, J Article ISI SCOPUS MEMORIAS DO INSTITUTO OSWALDO CRUZ (2003)
Characterization of the cell adhesion site of Trypanosoma cruzi metacyclic stage surface glycoprotein gp82 Manque P.M.; Araya J.E.; Yoshida, N; Juliano M.A.; Juliano L.; Eichinger D. Article SCOPUS INFECTION AND IMMUNITY (2000)
Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells Yoshida, N; Favoreto S, Jr; Ferreira, AT; Manque, PM Article ISI Brazilian Journal of Medical and Biological Reseach (2000)
Infectivity of Trypanosoma cruzi strains is associated with differential expression of surface glycoproteins with differential Ca2+ signalling activity. Ruiz, RC; Favoreto S, Jr; Dorta, ML; Oshiro, ME; Ferreira, AT; Manque, PM; Yoshida, N Article ISI BIOCHEMICAL JOURNAL (1998)
Serum antibodies to Trypanosoma cruzi antigens in Atacameños patients from highland of northern Chile Gonzalez, J; Neira, I; Gutierrez B.; ANACONA, D; Manque P.; Silva, X.; Marin, S; Sagua, H; Vergara, U. Article ACTA TROPICA (1996)
Levels of anti-Gal antibodies in persons infected and non-infected with Trypanosoma cruzi. Probably induced by bacteria and by the parasite Gonzalez, J; Ramírez C.; Seguel, X; Gutierrez B.; Manque P.; Porcile P.; Neira, I; Sagua, H Article ISI BOLETIN CHILENO DE PARASITOLOGIA (1995)


ystems Biology-‐based Approaches Applied to Vaccine Development Manque, Patricio;; Woehlbier, Ute* BookSection (2011)
Cell co-‐ infections with non-‐viral pathogens and the construction of doubly infected phagosomes Ravinovitch, Michel; Freymuller, Edna; De Paula, Regina; Manque, Patricio;; Andreoli, Walter; Mortara, Renato BookSection (1999)


Systems biology-based approaches applied to vaccine development Manque P.A.; Woehlbier, U BookWhole SCOPUS Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications (2011)


DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY. FONDECYT (1150743) Proyecto 2015-2019 Coinvestigador(a)
LOSS OF KEY FUNCTIONS DRIVES SALMONELLA TYPHI ADAPTIVE PATHOGENESIS TO HUMANS FONDECYT (1151393) Proyecto 2015-2019 Coinvestigador(a)
ANALYSIS OF GENE REGULATORY NETWORKS THAT MODULATE BEHAVIOR UPON BACTERIAL PATHOGENESIS Manque, Patricio;; Calixto, Andrea.; Alkema, Mark Proyecto (2014)
Analysis of gene regulatory networks that modulate behavior upon bacterial pathogenesis. UMASS/Conicyt (USA-2013-0041) Proyecto 2014-2017 Inv. Principal
C13ORF18/BECLIN1-INTERACTING PROTEIN(BCI)=>DEFINING THE ROLE OF A NOVEL AUTOPHAGY-RELATED PROTEIN TO AMYOTROPHIC LATERAL SCLEROSIS FONDECYT (3140110) Proyecto 2013-2017 Inv. Patrocinante
DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS Calixto, Andrea.; Manque, Patricio; Proyecto (2013)
DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS. FONDECYT (1131038) Proyecto 2013-2017 Coinvestigador(a)
Neuronal network-based initiative (NBI): Understanding the causes of neuronal vulnerability in disease Manque, Patricio;; Court, Felipe; Henny, Pablo; Hetz, Claudio Proyecto (2013)
Iniciativa de Red Neuronal (IRN)=> Entendiendo las Causas de la Vulnerabilidad Neuronal Diferencial en Enfermedades PIA (act 1109) Proyecto 2012-2015 Inv. Principal
The usefulness of Maraviroc in patients with limited therapeutic options and current undetectable VL with previous failure. Genetic tropism by ultra-sequencing techniques ViiV Proyecto 2012-2014 Inv. Principal
Functional genomics of Cryptosporidium parvum NIH 1R01 AI55347 Proyecto 2004-2008 Coinvestigador(a)
Cryptosporidium parvum genomics, pathogenesis and vaccinology NIH U34 AI57168 Proyecto 2003-2008 Coinvestigador(a)
ryptosporidium parvum genomics, pathogenesis and vaccinology Buck, Gregory; Manque, Patricio; Proyecto (2003)
Functional genomics of metacyclogenesis in T. cruzi Buck, Gregory; Manque, Patricio; Proyecto (2002)
Functional genomics of Cryptosporidium parvum Buck, Gregory; Manque, Patricio; Proyecto (0)

Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Jorge Araya

Profesor Asociado

Departamento de Tecnología Médica

Universidad de Antofagasta

Antofagasta, Chile

Víctor Polanco

Vicerrector de Investigación, Creación Artística y Doctorado

Vicerrectoría de Investigación, Creación Artística y Doctorado

Universidad Finis Terrae

Santiago, Chile

Esteban Cordero

Assistant Professor

Universidad Mayor

Santiago, Chile

Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

sandra espinoza

asistente de investigacion

Laboratorio Neuroinmunologia

Fundacion Ciencias para la Vida/Universidad San Sebastian

Santiago, Chile

Ulises Vergara

Profesor Titular

Patología

Facultad de Ciencias Veterinarias y Pecuarias- Universidad de Chile

Santiago, Chile

Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

Carolina Sanchez

Assistant Professor, Faculty of Science; Principal Investigator of Advanced Genomics Laboratory; Head of DNA Sequencing Core of the Center for Genomics and Bioinformatics

Center for Genomics and Bioinformatics

Universidad Mayor

Santiago, Chile

IVAN NEIRA

Académico

Tecnología Médica

Universidad de Antofagasta

Antofagasta, Chile

RUBEN MERCADO

Academico

Pediatria y Cirugia Infantil Occidente

UNIVERSIDAD DE CHILE. FACULTAD DE MEDICINA. UNIDAD DOCENTE DE PARASITOLOGÍA.

Santiago, Chile

Patricio Andres Manque Manque

Líneas de Investigación

Educación

Medical Technologist, UNIVERSIDAD DE ANTOFAGASTA. Chile, 1995

Microbiology and Immunology, ESCOLA PAULISTA DE MEDICINA. Brasil, 2001

Experiencia Académica

Post Doctoral Fellow Full Time

Post Doctoral Fellow Full Time

Senior Research Associate Full Time

Fellow Other

Experiencia Profesional

Associate Professor, Director Center for Genomics and Bioinformatics Full Time

Dean, Faculty of Sciences Full Time

FULL PROFESSOR, CENTER FOR INTEGRATIVE BIOLOGY Full Time

VICE PRESIDENT OF RESEARCH Full Time

Formación de Capital Humano

Article (36)

BookSection (2)

BookWhole (1)

Proyecto (15)

DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY.

LOSS OF KEY FUNCTIONS DRIVES SALMONELLA TYPHI ADAPTIVE PATHOGENESIS TO HUMANS

Analysis of gene regulatory networks that modulate behavior upon bacterial pathogenesis.

C13ORF18/BECLIN1-INTERACTING PROTEIN(BCI)=>DEFINING THE ROLE OF A NOVEL AUTOPHAGY-RELATED PROTEIN TO AMYOTROPHIC LATERAL SCLEROSIS

DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS.

Iniciativa de Red Neuronal (IRN)=> Entendiendo las Causas de la Vulnerabilidad Neuronal Diferencial en Enfermedades

The usefulness of Maraviroc in patients with limited therapeutic options and current undetectable VL with previous failure. Genetic tropism by ultra-sequencing techniques

Functional genomics of Cryptosporidium parvum

Cryptosporidium parvum genomics, pathogenesis and vaccinology