Man

Maria Loreto Massardo Vega

Docente Investigador

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Estudio de la patogenia de autoanticuerpos en enfermedades autoinmunes

Educación

  •  Médico-Cirujano, UNIVERSIDAD DE CHILE. Chile, 1979
  •  Reumatología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1982
  •  Rheumatology, University of Bristol. Reino Unido, 1988

Experiencia Académica

  •   Profesor titular Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Chile

    1985 - 2017

  •   Docente Investigador Full Time

    Universidad San Sebastián

    Medicina y Ciencia

    Santiago, Chile

    2017 - At present

Formación de Capital Humano


Participación en la formación de médicos en su etapa formativa en medicina en reumatologia y en la especialidad de reumatologia y apoyo en la formación de tesistas y magisteres de pre y pos titulo en biologia celular


Difusión y Transferencia


Difusion
En los media:
Sitio web educativo para pacientes con artritis reumatoide de PANLAR: www.artritisreumatoide.cl. Fan page 2017
SItio web educativo y face book: Hablemos de Lupus
Vinculación con el medio
Charlas a los pacientes y familiares de la Agrupación Lupus Chile 10 Agosto 2019: Lupus y Memoria y 2017 Qué es el lupus


Premios y Distinciones

  •   PANLAR-Merck Rheumatology Prize for LatinAmerican Rheumatologists 2002

    Pan American Associations for Rheumatology PANLAR

    Estados Unidos, 2002

    PANLAR-Merck Rheumatology Prize for LatinAmerican Rheumatologists 2002

  •   Premio Academia de Medicina 2012

    Instituto de Chile. Academia de Medicina

    Chile, 2012

    Premio Academia de Medicina 2012 en reconocimiento a la calidad de su investigación científica

  •   Premio Conferencia Sociedad Médica de Santiago

    SOCIEDAD MEDICA DE SANTIAGO

    Chile, 2017

    Premio Conferencia Sociedad Médica de Santiago "El compromiso cognitivo en el Lupus Neuro-Psiquiatrico"


 

Article (72)

Applying the 2019 EULAR/ACR lupus criteria to patients from an established cohort: A Latin American perspective
Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort
Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale – Depression subscale scores: An individual participant data meta-analysis of 73 primary studies
A Consensus Position Paper From REAL-PANLAR Group About the Methodological Approach for the Accreditation Process of Centers of Excellence in Rheumatoid Arthritis in Latin America
Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies.
Predictors of damage accrual in systemic lupus erythematosus: a longitudinal observational study with focus on neuropsychological factors and anti-neuronal antibodies
Antibodies and the brain: antiribosomal P protein antibody and the clinical effects in patients with systemic lupus erythematosus
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus=> Latin American Group for the Study of Lupus (GLADEL, )-Pan-American League of Associations of Rheumatology (PANLAR).
Predictive factors of flares in systemic lupus erythematosus patients: data from a multiethnic Latin American cohort
Renal involvement in antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides. Recommendations of the Chilean Societies of Nephrology and Rheumatology
Therapeutic Guidelines for Latin American Lupus Patients Methodology
Impact of cognitive impairment, depression, disease activity, and disease damage on quality of life in women with systemic lupus erythematosus.
Remission and Low Disease Activity Status (LDAS) protect lupus patients from damage occurrence=> data from a multiethnic, multinational Latin American Lupus Cohort (GLADEL).
Features associated with hematologic abnormalities and their impact in patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort
A consensus of the Chilean Nephrology and Rheumatology Societies on renal involvement in systemic lupus erythematosus
Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus
Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus.
Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice
Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice.
Beginning to Explore the High Rate of Work Limitation in Patients With Rheumatoid Arthritis in Chile
Late-onset systemic lupus erythematosus in Latin Americans: a distinct subgroup?
Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model
Pathogenicity of lupus anti-ribosomal P antibodies=> role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model.
REAL-PANLAR Project for the Implementation and Accreditation of Centers of Excellence in Rheumatoid Arthritis Throughout Latin America A Consensus Position Paper From REAL-PANLAR Group on Improvement of Rheumatoid Arthritis Care in Latin America Establishing Centers of Excellence
Recomendaciones sobre el manejo del compromiso renal del lupus eritematoso sistémico: Documento de Consenso de las Sociedades Chilenas de Nefrología y Reumatología
The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus: data from a multiethnic Latin American cohort
The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus=> data from a multiethnic Latin American cohort.
Primary cardiac disease in systemic lupus erythematosus patients: protective and risk factors-data from a multi-ethnic Latin American cohort
Primary cardiac disease in systemic lupus erythematosus patients=> protective and risk factors--data from a multi-ethnic Latin American cohort.
Systemic lupus erythematosus impairs memory cognitive tests not affected by depression
Systemic lupus erythematosus impairs memory cognitive tests not affected by depression.
Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients
Mestizos with systemic lupus erythematosus develop renal disease early while antimalarials retard its appearance: Data from a Latin American cohort
An update on neuropsychiatric lupus with emphasis in cognitive dysfunction
Early Rheumatoid Arthritis in Latin America: Low Socioeconomic Status Related to High Disease Activity at Baseline
The impact of rural residency on the expression and outcome of systemic lupus erythematosus: data from a multiethnic Latin American cohort
Treatment of Early Rheumatoid Arthritis in a Multinational Inception Cohort of Latin American Patients The GLADAR Experience
Common mental disorders and psychological distress in systemic lupus erythematosus are not associated with disease activity
Antimalarial Treatment May Have a Time-Dependent Effect on Lupus Survival
Extensive cerebral vein thrombosis as first manifestation of Behcet's disease. Report of one case
Extensive cerebral vein thrombosis as first manifestation of Behçet's disease. Report of one case Trombosis de senos venosos encefálicos como posible primera manifestación de enfermedad de Behçet: Caso clínico
Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation
Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation
Management of Patients With Rheumatoid Arthritis in Latin America A Consensus Position Paper From Pan-American League of Associations of Rheumatology and Grupo Latino Americano De Estudio de Artritis Reumatoide
Early rheumatoid arthritis Artritis reumatoide temprana
Use of rituximab for the treatment of rheumatoid arthritis: the Latin American context
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis
Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus - An international meta-analysis
Antibodies against galectin-8 in patients with systemic lupus erythematosus
Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
Circulating platelet-derived microparticles in systemic lupus erythematosus - Association with increased thrombin generation and procoagulant state
Circulating Platelet-Derived Microparticles in Systemic Lupus Erythematosus. Association With Increased Thrombin Generation and Procoagulant State
Effectiveness of infliximab in patients with Behcet syndrome and severe uveoretinitis. Report of five cases
Galectin-8 binds specific beta 1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells
Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort
Effectiveness of infliximab in patients with inflammatory arthritis refractory to conventional treatment
Outcome of Chilean Patients with Lupus Nephritis and Response to Intravenous Cyclophosphamide
Paget disease of bone. Report of 15 cases
A population based assessment of the use of orthopedic surgery in patients with rheumatoid arthritis
Antiribosomal P protein antibodies in Chilean SLE patients: no association with renal disease
The presence of the HLA-DRB1 shared epitope correlates with erosive disease in Chilean patients with rheumatoid arthritis
Prevalence and isotype distribution of antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus (SLE)
Increased expression of c-rel, from the NF-?B/Rel family, in T cells from patients with systemic lupus erythematosus
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus
Influence of the HLA-DRbeta shared epitope on susceptibility to and clinical expression of rheumatoid arthritis in Chilean patients
Occasional Series: Lupus Around the World The Chilean experience of systemic lupus erythematosus
High-Dose Intravenous Methylprednisolone Therapy Associated with Osteonecrosis in Patients with Systemic Lupus Erythematosus
Novel genetic markers of rheumatoid arthritis in chilean patients, by dr serotyping and restriction fragment length polymorphism analysis
Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients.
Osteoarthritis of the knee joint: an eight year prospective study.
Inspiratory muscle dysfunction and unexplained dyspnea in systemic lupus erythematosus

Abstract (20)

Factors Predictive of Flares in Systemic Lupus Erythematosus Patients: Data from a Multiethnic Latin American Cohort
Cognitive impairment in lupus erythematosus: contribution of depression and intrinsic disease factors
Hemorrhagic emergency due to intrahepatic aneurism rupture in a patient with Polyateritis Nodosa after long time of episodic fever: A case report
THE MEANING OF LIVING WITH SYSTEMIC LUPUS ERYTHEMATOSUS: QUALITATIVE STUDY IN CHILEAN WOMEN
Use of rituximab in Hispanic patients with severe ANCA associated vasculitis: A 6 years experience in a tertiary centre in Chile
Anti NMDAR and Anti-P/NSPA Antibodies Contribute to Cognitive Dysfunction in Lupus Patients.
Anti-P Autoantibodies Enhance Cytosolic Calcium and Neurotransmission in Hippocampal Neurons by Cross-Reacting with Cell Surface NSPA
Cognitive impairment in Chilean patients with systemic lupus erythematosus (sle) is not related to depression
Early Rheumatoid Arthritis in Latin America. Low Socioeconomic Status Relates to High Disease Activity At Baseline
Latinamerican Survey on the Use of Glucocorticoids in Rheumatoid Arthritis. Patients' and Rheumatologists' Perspective
APPLIANCE OF A HEALTH CARE REFORM IN CHILE OFFERING MEDICAL BENEFITS FOR RHEUMATOID ARTHRITIS (RA)
HEALTH RELATED VARIABLES IN RHEUMATOID ARTHRITIS (RA) PATIENTS TREATED IN DIFFERENT HEALTH CARE SETTINGS (DHCS); SANTIAGO DE CHILE
INFLUENCE OF CLINICAL AND SOCIOECONOMIC VARIABLES ON QUALITY OF LIFE OF RHEUMATOID ARTHRITIS PATIENTS TREATED IN DIFFERENT HEALTH CARE SETTINGS (DHCS)
Anti-P antibodies impair memory in mice
Detection of bone erosions in rheumatoid arthritis wrist and meta-carpophalangeal joints: A comparison of ultrasonography, computed tomography and magnetic resonance imaging.
Autoantibodies against galectin-8 block adhesion and lamellipodia formation induced by galectin-8 in Jurkat cells
Loss of platelet membrane phospholipid asymmetry in systemic lupus erythematosus: Association with disease activity and hypercoagulable state.
Autoantibodies against ribosomal P proteins recognize a novel surface protein in brain neurons
Blocking autoantibodies against the dopamine transporter in a SLE patient with psychosis
Novel proteins of the synaptic region are autoantigens associated with lupic neuropsychiatric manifestations

BookSection (3)

Lupus eritematoso sistémico y psiquiatría
Síndrome metabólico en Lupus eritematoso sistémico.
Rheumatoid Arthritis.

CaseReport (2)

Trombosis de senos venosos encefálicos como posible primera manifestación de enfermedad de Behçet: Caso clínico
Eficacia del infliximab en pacientes con síndrome de Behçet portadores de úveo-retinitis grave

Errata (1)

Clinical predictors of remission and low disease activity in Latin American early rheumatoid arthritis: data from the GLADAR cohort (vol 38, pg 2737, 2019)

Proyecto (15)

PATHOGENIC MECHANISMS OF ANTI-RIBOSOMAL P AND CROSS-REACTING ANTI-DOUBLE STRANDED DNA ANTIBODIES IN LUPUS NEPHRITIS=> ROLE OF NEURONAL-SURFACE-P-ANTIGEN (NSPA)
GAL-8 AS A NOVEL REGULATOR OF PROTEOSOMAL FUNCTION IN AUTOIMMUNITY AND CANCER
ROLE OF AUTOANTIBODIES IN COGNITIVE IMPAIRMENT IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
FUNCTION OF GALECTIN-8 IN THE IMMUNE SYSTEM AND AUTOIMMUNE DISEASES
POTENCIAL PATOGENICO DE AUTOANTICUERPOS EN LAS MANIFESTACIONES DIFUSAS DEL SISTEMA NERVIOSO CENTRAL DE PACIENTES CON LUPUS ERITEMATOSO SISTEMICO.
FUNCION DE LA GAL-8 Y LOS AUTOANTICUERPOS ANTI-GAL8 EN LINFOCITOS Y SU RELACION CON AUTOINMUNIDAD.
IDENTIFICACION Y CARACTERIZACION DE AUTOANTIGENOS DE LA SUPERFICIE CELULAR ASOCIADOS A LA PATOGENIA DEL LUPUS ERITEMATOSO GENERALIZADO
PAPEL DE LAS PLAQUETAS EN LA PATOGENIA DE ESTADOS DE HIPERCOAGULABILIDAD ADQUIRIDOS=> ESTUDIOS EN PACIENTES PORTADORES DE LUPUS ERITEMATOSO SISTEMICO Y SINDROME ANTIFOSFOLIPIDO.
ESTUDIOS SOBRE LOS FACTORES DE TRANSCRIPCION NF-KB/REL DEL LINFOCITO T EN PATOLOGIAS AUTOINMUNES.
ESTUDIO DE AUTOANTIGENOS EN ENFERMEDADES AUTOINMUNES
ESTUDIO DE LA FUNCION DE FACTORES DE TRANSCRIPCION DE LA FAMILIA NF-KAPPAR Y EL PROTO-ONCOGEN C-REL EN LINFOCITOS DE ENFERMEDADES AUTOINMUNES HUMANAS
ESTUDIO DE SECUENCIA DE GENOMA HUMANO Y DE LA EXPRESION DEL PROTO-ONCOGEN C-REL EN ARTRITIS REUMATOIDEA
EFECTOS DE LA SUPRESION DE PROLACTINA SOBRE LA FUNCION INMUNE CELULAR Y LA EVOLUCION CLINICA DE LA ENFERMEDAD EN ARTRITIS REUMATOIDEA ACTIVA
SECUENCIAS EN EL GENOMA HUMANO DETERMINANTES DE SUSCEPTIBILIDAD A LA ARTRITIS REUMATOIDEA. ESTUDIO MEDIANTE AMPLIFICACION GENICA (PCR)
ESTUDIO DE NUEVOS MARCADORES PARA ARTRITIS REUMATOIDEA MEDIANTE ANALISIS DEL DNA GENOMICO.

Review (5)

Education for patients with rheumatoid arthritis in Latin America and the Caribbean
Lupus in Latin-American patients: lessons from the GLADEL cohort
Actualización en lupus neuro-psiquiátrico con énfasis en déficit cognitivo
Artritis reumatoide temprana
Early rheumatoid arthritis
93
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

24
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

7
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

7
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

4
Jaime Leppe

Coordinador de Investigación Carrera de Kinesiología

Universidad del Desarrollo

Santiago, Chile

4
CLAUDIA CARCAMO

Profesor Asociado

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

4
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

3
Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

3
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

3
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

3
Gonzalo Valdivia

Division Head, Full Professor

Medical School

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Roxana Pincheira

Associate Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

2
Leopoldo Ardiles

Profesor Titular

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

2
Valeria Matus

Associate Researcher

Hematology-Oncology

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Sergio González

FACULTAD DE MEDICINA. PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Achurra

Cirujano Digestivo/ Instructor Adjunto

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Oscar Neira

Medico internista y reumatólogo

Medicina oriente

Hospital del Salvador

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Miguel Gutierrez

jefe servicio medicina

medicina

hospital naval almirante nef

viña del mar, Chile

1
Miriam Alvo

jefa de sección

de medicina

HOSPITAL CLÍNICO U. DE CHILE

Santiago, Chile

1
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
TOMAS LEON

Psiquiatra

Clinica de Memoria y Neuropsiquiatría

santiago , Chile

1
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
MARIO CALVO

Profesor Asociado

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Ana Guzman

MÉDICO JEFE LABORATORIO

LABORATORIO CLÍNICO

PONTIFICIA UNIVERSIDAD CATÓLICA

SANTAIGO, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Milena Mimica

Profesor Instructor

CEBICEM

Universidad San Sebastián

Santiago de Chile, Chile