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Diego Antonio Mezzano Abedrapo

Director

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Platelet Physiology and Pathophysiology; Platelet Tissue Factor; Platelet Pro-coagulant Activity; Mechanisms of Atherothrombosis; Primary Hemostasis Disorders; Functions of Neo-synthesized Proteins by Platelets; Platelet Aging in Circulation.

Medical Doctor, Pontificia Universidad Católica de Chile. Chile, 1969

Professor Full Time

Physician, Sótero del Río Hospital

Medicine

Santiago, Chile

1974 - At present
Medical Doctor Full Time

Hospital Sótero del Río

Medicine, P. Catholic University of Chile

Santiago, Chile

1972 - 1974
Hematology Fellowship Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

1974 - 1976
National Institutes of Health, Fogarty Center, Research Fellowship Full Time

Blood Center of South-Eastern Milwaukee

Associated with Medical College of Wisconsin

Milwaukee, Estados Unidos

1978 - 1980

Research fellowship Full Time

Blood Ctr. South-Eastern Milwaukee

Milwaukee, Estados Unidos

1978 - 1980
Attending Physician, Internal Medicine Full Time

Hospital Sótero del Río

Santiago, Chile

1972 - 1974
Internal Medicine Fellowship Full Time

School of Medicine, Catholic Univ of Chile

Santiago, Chile

1969 - 1972
Hematology Fellowship Full Time

School of Medicine, Catholic Univ of Chile

Santiago, Chile

1974 - 1976
Associate Editor Other

Journal of Thrombosis and Haemostasis

Leiden, Holanda

2014 - At present
Co-Chairman, Platelet Physiology Sub-Committee Other

International Society for Thrombosis and Haemostasis

Chapel Hill, Estados Unidos

2012 - At present
Member, Lectures and Awards Committee Other

International Society for Thrombosis and Haemostasis

Chapel Hill, Chile

2012 - At present

Medical Students.
1997-2004: Director, Organizer and Lecturer in the course of Pathophysiology: Cellular and Molecular Basis of the Disease. For 3rd grade students of Medicine. First semester
2005-2009: Co-Direction of the Integrated Course "Functional and Morphological Pathology". First semester. Lecturer in this course until now.
1997-2006: Lectures and Bibliographic Seminars in the Course Molecular Biology of the Cell, for 2nd grade students of Medicine. First Semester.
1983-1985 and 1988-2009: Director of the chapter of Blood Physiology. Collaborator since 2010 in the same course, for 2nd grade students of Medicine.2nd Semester.
1976-2011: Lectures in Thrombosis, Hemostasis and Transfusion Medicine in the Chapter of Clinical Hematology in the Integrated Medical-Surgical Course for Medical Students, 4th grade.
1990-1999: Programmed Hematology, Hemostasis-Thrombosis and Transfusion Medicine Rounds with groups of students during their Internship.
1985-1989: Optative Course: Training Program in Blood Banking for Pre-Graduate Medical Students. 1 semester.

Pre-Graduate Students in other Health-Related Careers.
1983-1986: Coordinator of the Course Pathophysiology for Nursery Students. 2nd Semester.
1998-2014: Lectures in Hemostasis in the Course Introduction to Clinical Laboratory, for Biochemistry and Biology Students (Faculty of Biological Sciences)
1998-2014: Lectures in Hemostasis in the Course Introduction to Clinical Laboratory, for Chemistry and Pharmacy Students (Faculty of Chemistry)
2012-2014: Lectures in Pathophysiology of the Blood for Dentistry Students (Health Sciences Faculty)

Post-Graduate Students.
1997-2003: Director, Subspecialty Clinical and Laboratory Training in Hemostasis-Thrombosis and Transfusion Medicine. Duration: 1 year. or Hematologists, Pediatricians, Clinical Pathologists, Internists,
2004-2014: Director, Subspecialty Clinical and Laboratory Training in Hemostasis-Thrombosis, 1 year duration for Hematologists, Pediatricians, Clinical Pathologists, Internists,
1995-2014: Medical Sciences PhD Program: Lectures and Seminars in successive courses of this program: Integrative Physiology, Basic Biologic Processes in Human Diseases, Cell-cell interactions in disease: mechanisms and functions.
1997-2013: Magister of Nutrition. Lectures on pathophysiology of disorders related with nutrition and metabolism (atherosclerosis, thrombosis, hemostatic disorders associated with vitamin K deficiency, diabetes, homocysteine metabolism)

Tutorship of Pre-Graduate Students in the Hemostasis and Thrombosis Laboratory.
1992-2014: Pre-Graduate Students of Medical Technology (Internship), Biochemistry and Biology (Clinical Lab Courses) rotate permanently in our Laboratories. These include students of our and other Universities: Universidades Andrés Bello, Mayor, San Sebastián.
1985-2009: Tutorship of 31 Medical Students to help in teaching activities, consultative functions in the courses I directed.
1985-1996: Tutorship of 18 medical students to participate in specific areas of our research projects. Six of them are co-authors in our papers.

Tutorship of Post-Graduate Students in the Hemostasis and Thrombosis Laboratory.
1982-2014: more than 50 physicians, mainly hematologists and clinical pathologists, either during their specialty fellowships or for further training, have spent from 1 to 3 months of stay in our Laboratories for training. We receive fellows or hematologists from all along the country, and almost all the accredited Hematology Fellowship Programs are trained by us.
1982-2014: all the Hematology and Hematology-Oncology Fellows (Adults and Pediatricians) of our Institution are trained in Hemostasis and Thrombosis in our Laboratory

Thesis.
1982-2014: I have tutored or co-tutored the Pre-Graduate Thesis of 30 students of Biochemistry, Biology, Chemistry and Pharmacy, from other Faculties or Universities. The results of the Thesis of almost all of them have been presented in scientific meetings and most of them have co-authored the publications of our laboratory.
2007-2010: co-tutor of the PhD Thesis in Medical Sciences of Sebastián Cabrera,, from the University of Chile: “Transport of L-Arginina in Human Platelets. Role of platelet dysfunction in chronic renal failure".

IV Latin-american Scientific Meeting of Medical Students

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Venezuela, 1991

I was the tutor of the students Mariela Torrente and Ignacio Campos. First Prize in Clinical Sciences. "Tubular Necrosis and Acute Renal Failure in Rats Treated with 5-Hydroxi tryptofan .
X Chilean Congress of Hematology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1994

Prize to the Best Scientific Work: "Inhibition of fibrinolysis corrects the bleeding time (BT) in patients with terminal renal failure. Mezzano D, Tagle R, Downey P, Thambo S, González F, Mezzano S, Barja P, Pérez M, Panes O, Rodríguez MS, Muñoz B, Pereira J.
Chilean Meeting of the Societies of Hypertension, Nephrology and Transplantation

Societies of Hypertension, Nephrology and Transplantation

Chile, 1994

Prize to the Best Scientific Work. Fibrinolysis inhibition corrects the bleeding time in most patients with terminal chronic renal failure" Tagle R, Downey P, González F, Pais E, Mezzano S, Thambo S, Barja P, Pérez M, Panes O, Pereira J, Mezzano D. La Serena, 1994.
Faculty of Medicine Scientific Meeting of Residents and Fellows

Faculty of Medicine, P. Catholic University of Chile

Chile, 1995

First Prize to the Best Abstract. "Fibrinolysis inhibition corrects the bleeding time in most patients with terminal chronic renal failure" Fellow: Rodrigo Tagle, M.D. Tutor: D. Mezzano, M.D.
IX Chilean Congress of Clinical Chemistry

Chilean Society of Clinical Chemistry

Chile, 1995

"Disorders of primary hemostasis can be the consequence of clotting and fibrinolysis activation in terminal chronic renal failure" O. Panes, B. Muñoz, M. Pérez, J. Pereira, D. Mezzano.
Best Publication 1996

Sociedad Médica de Santiago

Chile, 1996

"Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis". Thromb Haemostas 1996; 76: 312-321. Mezzano D, Tagle R, Panes O, Pérez M, Downey P, Muñoz B, Aranda E, Barja P, Thambo S, González F, Mezzano S, Pereira J.
Best Professor 3rd Grade of Medicine, 1997

School of Medicine, P. Catholic University of Chile

Chile, 1997

Voted by the Students of 3rd Grade of Medicine
Prize Araucaria Foundation on Coronary Artery Disease

Chilean Society of Cardiology and cardiovascular Surgery

Chile, 1998

“Coronary Heart Disease: asociation with C677T gene mutation of 5,10-methylen-tetrahydrofolate reductase and plasma levels of folic acid and homocysteine". Mezzano D, Guarda E, Villagrán C, Goycoolea M, Aranda E, Quiroga T, Fajuri A, Marchant E, Martínez A, Maiz A, Pereira J.
Best Professor 3rd Grade Medicine 1998

School of Medicine, P. Catholic University of Chile

Chile, 1998

Voted by the 3rd Grade students
Prize Senior Investigator 1999

Faculty of Medicine, P. Catholic University of Chile

Chile, 1999

Elected by the Faculty Council.
Prize Second Best Publication XIII Congress Chilean Society of Hematology

Chilean Society of Hematology

Chile, 2000

Selected by the Scientific Committee and the Society Directors.
Prize Best Professor 3rd Grade of Medicine 2000

School of Medicine, P. Catholic University of Chile

Chile, 2000

Voted by the 3rd Grade Students of Medicine.
Prize Medical Society of Santiago 1999 to the Best Publication during 1999.

Medical Society of Santiago

Chile, 1999

“Complementary Benefits of Mediterranean diet and red wine on hemostatic factors with cardiovascular risk". Mezzano D, Martínez C, Marshall G, Muñoz B, Rodríguez S, San Martín A, Pereira J, Leighton F.
Prize Academy of Medicine 2000 to a Research Career

Chilean Academy of Medicine

Chile, 2000

Physiology, Pathophysiology and Clinical Aspects of Primary Hemostasis", granted during the XXII Congress of the Chilean Congress of Internal Medicine.
Prize Chilean Society of Clinical Chemistry to the Best Oral Presentacion.

Chilean Society of Clinical Chemistry

Chile, 2001

“Prevalence of heparin-induced anti-phospholipid and anti-platelet antibodies in patients on hemodialysis”. Palomo I, Pereira J, Jara E, Alarcón M, Espinoza M, Moore R, Hernández A, Hernández E, Díaz G, Quiroga G, Rojas P, Vásquez M, Mezzano D, Arce I.
Prize Best Professor 3rd Grade 2002 of Medicine

School of Medicine, P. Catholic University of Chile

Chile, 2002

Voted by the 3rd Grade Students of Medicine.
Prize Dr. Germán Ducach Grinberg 2003 to the Best Publication in Clinical Hematology.

Chilean Society of Internal Medicine

Chile, 2003

“Mediterranean diet, but not red wine, is associated with beneficial changes on primary haemostasis”. Mezzano D, Leighton F, Strobel P, Martínez C, Marshall G, Cuevas A, Castillo O, Panes O, Muñoz B, Rozowski J, Pereira J. Eur J Clin Nutr 2003; 57: 439-446.
Prize Dr. Germán Ducach Grinberg 2005 to the Best Publication in Clinical Hematology.

Chilean Society of Internal Medicine

Chile, 2005

“Template bleeding time and PFA-100® have low sensitivity to screen patients with hereditary mucocutaneous haemorrhages: comparative study in 148 patients. Quiroga T, Goycoolea M, Muñoz B, Morales M, Aranda E, Panes O, Pereira J, Mezzano D. J Thromb Haemost 2004; 2: 892-8.
Prize Medical Society of Santiago 2007 to the Best Scientific Work in the XXIX Congress of the Chilean Society of Internal Medicine

Medical Society of Santiago

Chile, 2007

Cerebral perfusion defects associated with hemostasis activation in chronic cocain consumers". Massardo T, Jaimovich R, Pallavicini J, Quintana JC, Panes O, Hidalgo P, Mezzano D, Sáez C, Pereira J.
Prize Dr. Germán Ducach Grinberg 2009 to the Best Publication in Clinical Hematology

Chilean Society of Internal Medicine

Chile, 2009

“High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. Prospective study of 280 patients and 299 controls”. Quiroga T, Goycoolea M, Panes O, Aranda E, Martínez C, Belmont S, Muñoz B, Zúñiga P, Pereira J, Mezzano D. Haematologica 2007, 92:357-365.
Prize Eduardo Bunster Montero 2012, Chilean Society of Hematology

Chilean Society of Hematology

Chile, 2012

Prize to the Professional Career, Elected by the Directors of the Chilean Society of Hematology. Plenary Conference 2012, Congress of the Chilean Society of Hematology.
Prize Germán Ducach Grinberg 2014 to the Best Publication in Clinical Hematology.

Chilean Society of Internal Medicine

Chile, 2014

An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in 4 Chilean families. V. Matus, G. Valenzuela, C. G. Sáez, P. Hidalgo, M. Lagos, E. Aranda, O. Panes, J. Pereira, X. Pillois, A.T. Nurden and D. Mezzano. J Thromb Haemost 2013; 11(9):1751-9.


Atorvastatin Reduces the Proadhesive and Prothrombotic Endothelial Cell Phenotype Induced by Cocaine and Plasma From Cocaine Consumers In Vitro. Saez CG; Pereira-Flores, K; Ebensperger, R; Panes O.; Massardo, T; Hidalgo, P.; Mezzano D.; Pereira J. Article ISI Arterioscler Thromb Vasc Biol (2014)
Diagnosing type 1 von Willebrand disease: good for patient's health or for doctor's prestige? Comment. Mezzano D.; Zúñiga P; Pereira J.; Quiroga T. Article ISI J Thromb Haemost. 2014 Sep 12. [Epub ahead of print] (2014)
Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey. Gresele P.; Harrison, P; Bury L.; Falcinelli, E; Gachet C.; Hayward, C.; Kenny D.; Mezzano D.; Mumford A.D.; Nugent D.; Nurden A.T.; Orsini, S; Cattaneo M. Article JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)
Quantitative impact of using different criteria for the laboratory diagnosis of type 1 VWD. Quiroga T.; Goycoolea M.; Panes O.; Belmont, S; Aranda, E; Zúñiga P; Pereira J.; Mezzano D. Article ISI JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)
An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families Matus, V.; Valenzuela, G; Saez CG; Hidalgo, P.; Lagos, M; Aranda, E; Panes O.; Pereira J.; Pillois, X; Nurden, AT; Mezzano D. Article ISI SCOPUS Journal of Thrombosis and Haemostasis (2013)
Is my patient a bleeder? A diagnostic framework for mild bleeding disorders Quiroga T.; Mezzano D. Article ISI HEMATOLOGY-AMERICAN SOCIETY HEMATOLOGY EDUCATION PROGRAM (2012)
Clot lysis time in platelet-rich plasma: Method assessment, comparison with assays in platelet-free and platelet-poor plasmas, and response to tranexamic acid Panes O.; Padilla, O; Matus, V.; Saez CG; Berkovits, A; Pereira J.; Mezzano D. Article ISI PLATELETS (2011)
Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users Saez CG; Olivares, P; Pallavicini, J; Panes O.; Moreno, N; Massardo, T; Mezzano D.; Pereira J. Article ISI SCOPUS Thrombosis Research (2011)
Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children Guerrero, JA; Rivera J.; Quiroga T.; Martinez-Perez, A; Anton, AI; Martínez C; Panes O.; Vicente, V; Mezzano D.; Soria, JM; Corral, J Article ISI SCOPUS Haematologica (2011)
Platelet activation in chronic cocaine users: Effect of short term abstinence Pereira J.; Saez CG; Pallavicini, J; Panes O.; Pereira-Flores, K; Cabreras, MJ; Massardo, T; Mezzano D. Article ISI SCOPUS Platelets (2011)
Rare homozygous status of P43 beta 1-tubulin polymorphism causes alterations in platelet ultrastructure Navarro-Nunez, L; Teruel, R; Anton, AI; Nurden, P; Martinez-Martinez I.; Lozano, ML; Rivera J.; Corral, J; Mezzano D.; Vicente, V; Martínez C Article ISI SCOPUS Thrombosis and Haemostasis (2011)
Daño endotelial y activación del sistema hemostático asociado al uso crónico de cocaína: estudios ex vivo e in vitro Pereira, Jaime; Saez, Claudia; Olivares, Paulina; Moreno, Natalia; Cabrera, Manuel J; Panes Olga; Belmont, Sabine; Hidalgo, Patricia; Massardo, Teresa; Pallavicini, Julio; Mezzano, Diego Article SCIELO Revista chilena de cardiología (2010)
Influence of the F12-4 C > T polymorphism on hemostatic tests Corral, J; Anton, AI; Quiroga T.; Gonzalez-Conejero, R; Pereira J.; Roldan, V; Vicente, V; Mezzano D. Article ISI SCOPUS Blood Coagulation and Fibrinolysis (2010)
Inherited disorders of platelet function and challenges to diagnosis of mucocutaneous bleeding Israels, SJ; El-Ekiaby, M; Quiroga T.; Mezzano D. Article SCOPUS Haemophilia (2010)
La atorvastatina no modifica el incremento agudo de los niveles de p-selectina y fibrinógeno inducido con esfuerzo físico máximo Lindefjeld, Dante; Acevedo, Monica; Chamorro, Gaston; Mezzano, Diego; Panes Olga; Aranis, Carolina; Oporto, Jorge Article SCIELO Revista chilena de cardiología (2010)
Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders Anton, AI; Gonzalez-Conejero, R; Roldan, V; Quiroga T.; Sanchez-Vega, B; Corral, J; Vicente, V; Mezzano D. Article ISI SCOPUS Annals of Hematology (2010)
Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays Quiroga T.; Goycoolea M.; Matus, V.; Zúñiga P; Martínez C; Garrido M.; Aranda, E; Leighton F.; Panes O.; Pereira J.; Mezzano D. Article ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2009)
Genotype-phenotype relationship for six common polymorphisms in genes affecting platelet function from 286 healthy subjects and 160 patients with mucocutaneous bleeding of unknown cause Martínez C; Anton, AI; Corral, J; Quiroga T.; Panes O.; Lozano, ML; Gonzalez-Conejero, R; Teruel, R; Navarro-Nunez, L; Pereira J.; Mezzano D.; Vicente, V; Rivera J. Article ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2009)
Health impact of Mediterranean diets in food at work Leighton F.; Polic, G; Strobel P.; Pérez D.; Martínez C; Vásquez, L.; Castillo O.; Villarroel L.; Echeverría G.; Urquiaga, I; Mezzano D.; Rozowski J. Article ISI SCOPUS International Journal of Environmental Research and Public Health (2009)
Platelet Tissue Factor: Fast and Specific Clotting Activation Pathway Mediated by VWF-GPIba Interaction and Platelet Membrane FVII. Human Platelets Contain All the Components for Assembling the Prothrombinase Complex and Their Procoagulant Function Is Ind Panes O.; Matus, V.; Saaez, CG; Pereira J.; Mezzano D. Article BLOOD (2009)
Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages Matus, V.; Willemse, J; Quiroga T.; Goycoolea M.; Aranda, E; Panes O.; Pereira J.; Hendriks, D; Mezzano D. Article ISI SCOPUS CLINICA CHIMICA ACTA (2009)
Laboratory Assessment of Familial, Nonthrombocytopenic Bleeding: A Definitive Not Possible Mucocutaneous Diagnosis Is Often Not Possible Pereira J.; Quiroga T.; Mezzano D. Article ISI SEMINARS IN THROMBOSIS AND HEMOSTASIS (2008)
Tissue factor storage, synthesis and function in normal and activated human platelets Mezzano D.; Matus, V.; Saez CG; Pereira J.; Panes O. Article ISI THROMBOSIS RESEARCH (2008)
High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls Quiroga T.; Goycoolea M.; Panes O.; Aranda, E; Martínez C; Belmont, S; Muñoz B.; Zúñiga P; Pereira J.; Mezzano D. Article ISI SCOPUS HAEMATOLOGICA (2007)
Human platelets synthesize and express functional tissue factor Panes O.; Matus, V.; Saez CG; Quiroga T.; Pereira J.; Mezzano D. Article ISI SCOPUS BLOOD (2007)
Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels Salas, SP; Giacaman, A; Romero W.; Downey P.; Aranda, E; Mezzano D.; Vio, CP Article ISI HYPERTENSION (2007)
Circulating platelet-derived microparticles in systemic lupus erythematosus - Association with increased thrombin generation and procoagulant state Pereira J.; Alfaro G.; Goycoolea M.; Quiroga T.; Ocqueteau, M; Massardo, L; Pérez, C.; Sáez C.; Panes O.; Matus, V.; Mezzano D. Article ISI SCOPUS THROMBOSIS AND HAEMOSTASIS (2006)
Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia von Bernhardi R.; Alarcon, R; Mezzano D.; Fuentes P.; Inestrosa, NC Article ISI SCOPUS DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2005)
Distinctive Effects of Red Wine and Diet on Haemostatic Cardiovascular Risk Factors Mezzano D. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2004)
Primary thombophilia. Report of 93 cases and 12 asymptomatic relatives Srur E.; Vargas C.; SALAS, S.; Parra, JA; Bianchi, V; Mezzano D.; Muñoz B.; Vásquez M; Pacheco, E Article ISI REVISTA MEDICA DE CHILE (2004)
Template bleeding time and PFA-100 (R) have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients Quiroga T.; Goycoolea M.; Muñoz B.; Morales M.; Aranda, E; Panes O.; Pereira J.; Mezzano D. Article ISI SCOPUS JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Template bleeding time and PFA-100® have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: Comparative study of 148 patients - A rebuttal (multiple letters) [13] Hajdenberg J.; Quiroga T.; Pereira J.; Mezzano D. Article JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Haemostatic cardiovascular risk factors: Differential effects of red wine and diet on healthy young population Mezzano D.; Leighton F. Article ISI PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS (2003)
Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis Mezzano D.; Leighton F.; Strobel P.; Martínez C; Marshall G.; Cuevas, A.; Castillo O.; Panes O.; Muñoz B.; Rozowski J.; Pereira J. Article ISI EUROPEAN JOURNAL OF CLINICAL NUTRITION (2003)
Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type I Pereira J.; Quiroga T.; Pereira, ME; Morales M.; Goycoolea M.; Hidalgo, P.; Prieto, C; Mezzano D. Article ISI THROMBOSIS AND HAEMOSTASIS (2003)
Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucoputaneous haemorrhages Quiroga T.; Goycoolea M.; Giesen, PLA; Morales M.; Muñoz B.; Aranda, E; Rodríguez, S.; Panes O.; Martínez C; Pereira J.; Mezzano D. Article ISI SCOPUS PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS (2003)
Platelet aging in vivo is associated with activation of apoptotic pathways: Studies in a model of suppressed thrombopoiesis in dogs Pereira J.; Soto M.; Palomo I.; Ocqueteau, M; Coetzee, LM; Astudillo S.; Aranda, E; Mezzano D. Article ISI SCOPUS THROMBOSIS AND HAEMOSTASIS (2002)
Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors Mezzano D.; Leighton F.; Martínez C; Marshall G.; Cuevas, A.; Castillo O.; Panes O.; Muñoz B.; Perez, DD; Mizon, C; Rozowski J.; San Martin, A; Pereira J. Article ISI SCOPUS EUROPEAN JOURNAL OF CLINICAL NUTRITION (2001)
Increased activation of protein C, but lower plasma levels of free, activated protein C in uraemic patients: relationship with systemic inflammation and haemostatic activation Mezzano D.; Espana F.; Panes O.; Medina, P; Pais, E; Marshall G.; Tagle, R; Downey P.; Caceres, S; González F; Quiroga T.; Pereira J. Article ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2001)
Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia Mezzano D.; Pais, EO; Aranda, E; Panes O.; Downey P.; Ortiz, M; Tagle, R; González F; Quiroga T.; Caceres, MS; Leighton F.; Pereira J. Article ISI SCOPUS KIDNEY INTERNATIONAL (2001)
Cardiovascular risk factors in vegetarians: Normalization of hyperhomocysteinemia with vitamin B-12 and reduction of platelet aggregation with n-3 fatty acids Mezzano D.; Kosiel, K; Martínez C; Cuevas, A.; Panes O.; Aranda, E; Strobel P.; Perez, DD; Pereira J.; Rozowski J.; Leighton F. Article ISI THROMBOSIS RESEARCH (2000)
EL ENVEJECIMIENTO DE LAS PLAQUETAS EN LA CIRCULACION SE ASOCIA A CAMBIOS PROPIOS DE LA MUERTE CELULAR PROGRAMADA (APOPTOSIS) Soto, Monica; Pereira, Jaime; Palomo, Iván; Ocqueteau, Mauricio; Mezzano, Diego; Astudillo S.; Aranda, Eduardo Article REVISTA CHILENA DE CANCEROLOGIA Y HEMATOLOGIA (2000)
Glycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia Pereira J.; Hidalgo, P.; Ocqueteau, M; Blacutt, M; Marchesse, M; Nien, Y; Letelier, L.; Mezzano D. Article ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2000)
Systemic inflammatory reaction may explain the activation of coagulation and fibrinolysis in patients with chronic renal failure (CRF) Mezzano D.; Paneso; Paise; Tagle, R; Gonzalez Á.; Mezzano S.; Jalil, R; Aranda, E; Munozb; Pereira J. Article Fibrinolysis and Proteolysis (1998)
Endothelial cell markers in chronic uremia: Relationship with hemostatic defects and severity of renal failure Mezzano D.; Panes O.; Perez M.; Muñoz B.; Aranda, E; Pereira J.; Tagle, R; Pais, E; Downey P.; Barja P.; Thambo, S; González F; Mezzano S. Article THROMBOSIS RESEARCH (1997)
Hemostatic disorder of uremia: The platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis Mezzano D.; Panes O.; Perez M.; Muñoz B.; Aranda, E; Pereira J.; Tagle, R; Downey P.; González F; Barja P.; Thambo, S; Mezzano S. Article THROMBOSIS AND HAEMOSTASIS (1996)
Human intraplatelet 5-hydroxytryptamine is correlated with mean platelet survival time Aranda, E; Pereira J.; Ajenjo, C; Prieto, C; Sepùlveda S.; Mezzano D. Article THROMBOSIS RESEARCH (1996)
In vivo effect of bile salts on platelet aggregation in rats. Pereira J.; Accatino L.; Pizarro M.; Mezzano, V; Ibáñez A.; Mezzano D. Article ISI Thromb Res (1995)
[Determination of IgG associated with platelets by immunoelectroassay] Pereira J.; Mezzano D.; Aranda, E; Lira, P; Grebe, G Article ISI Rev Med Chil. 1984
[Diagnosis of von Willebrand's disease subtypes by the analysis of multimeric composition of plasma von Willebrand factor]. Quiroga T.; Perez M.; Pereira J.; Mezzano D. Article ISI Rev Med Chil. 1990
[Kinetic studies of platelets labeled with 51Cr] Mezzano D.; Foradori, A. C.; Lira, P; Grebe, G; Vergara M. Article ISI Rev Med Chil. 1976
[Neonatal autoimmune purpura: laboratory study of 5 cases]. Pereira J.; Pizarro, I ; Winter, A.; Mezzano D. Article ISI Rev Med Chil. 1992
[Skin and mucous membrane hemorrhages: clinical assessment, study sequence and relative frequency of hereditary diseases of the hemostasis in a Chilean population]. Quiroga T.; Perez M.; Rodríguez, S.; Muñoz B.; Aranda, E; Morales M.; Verdugo, P; Pereira J.; Mezzano D. Article ISI Rev Med Chil. 1997
Endothelial damage and activation of the haemostatic system associated to chronic use of cocaine: an ex vivo and in vitro study. Pereira J.; Sáez C.; Olivares, P; Moreno, N; Cabrera, M. J.; Panes O.; Belmont, S; Hidalgo, P.; Massardo, T; Pallavicini, J; Mezzano D. Article Scielo Rev Chilena Cardiol 2010
[A study of blood clearance and spleen sequestration of heat-damaged erythrocytes in patients with hypersplenism] Del Fávero, H.; Mezzano D.; Foradori, A. C.; Lira, P; Grebe, G Article ISI Sangre (Barc). 1980
[Acquired inhibition of coagulation factor VIII]. Figueroa H.; Lira, P; Grebe, G; Mezzano D.; Legues, M. E. Article ISI Rev Med Chil. 1984
[Activated C protein resistance: laboratory study and prevalence of the defect in the Chilean population]. Pereira J.; Quiroga T.; Goycoolea M.; Muñoz B.; Hidalgo, P.; KALTWASSER, G; Mezzano D. Article ISI Rev Med Chil. 1996
[Chloramphenicol induced sideroblastic anemia] Del Fávero, H.; Grebe, G; Lira, P; Mezzano D. Article ISI Rev Med Chil. 1977
[Effect of 1-deamino-8-D-arginine vasopressin (DDAVP) on bleeding time in uremic patients]. Alarcón F; Mezzano D.; Vial, S; Pereira J. Article ISI Rev Med Chil. 1985
[Enough, timely, safe and cheap, blood: how?] Mezzano D. Article ISI Rev Med Chil. 1992
[Essential thrombocythemia: clinical and laboratory study of 6 cases]. Grebe, G; Alvo M; Lira, P; Barria, C; Mezzano D.; Monsalve, V. Article ISI Rev Med Chil. 1983
[Evaluation of commercial kits used for Chagas disease diagnosis in blood banks in Chile. II. Routine application]. Lorca M.; Child, R; Garcia, A.; Silva M.; Martinez L.; Jerez G.; Toledo, I; Mezzano D. Article ISI Rev Med Chil. 1994
[Frequency of platelet specific alloantigens HPA-1a (P1A1) and HPA-4a (Pen(a)) expression in Chilean population]. Pereira J.; Rodríguez, S.; Pizarro, I ; Mezzano D. Article ISI Rev Med Chil. 1992
[Glanzmann's disease: diagnostic study of 6 patients]. Quiroga T.; Mezzano D.; Aranda, E; Montesinos, M; Foradori, A. C.; Bull, P; Schuh, W.; Morales M.; Vargas L. Article ISI Rev Med Chil. 1985
[Hemophilia A: analysis of intron 18 and intron 7 of factor VIII gene and their role in a diagnostic strategy for carrier detection in a Chilean population]. Quiroga T.; Goycoolea M.; KALTWASSER, G; Morales M.; Vildósola, J; Mezzano D.; Muñoz B.; Pereira J. Article ¿
[Platelet alloimmunization in patients with oncologic blood disorders treated with multiple transfusions: prospective study in adults and children]. Pereira J.; Bronfman, L.; Bertín P.; Marzouka E.; Hidalgo, P.; Amaya, S.; Mezzano D. Article ISI Rev Med Chil. 1997
[Platelet consumption and platelet dysfunction during and after surgery with extracorporeal circulation] Mezzano D.; Habash, J.; Aranda, E; Urzúa J.; Lema, G; Irarrázabal, M. J.; Brebe, G. Article ISI Sangre (Barc). 1986
[Sjogren's syndrome associated with lymphoproliferative syndrome and monoclonal mixed cryoglobulinemia]. Mezzano D.; Rosenberg H.; Sörensen R.; Grebe, G Article ISI Rev Med Chil. 1977
[The patient with hemorrhage and prolonged bleeding time: classification and differential diagnosis]. Marzouka E.; Rios E.; Mezzano D.; Schuh, W.; Aranda, E; Cataldo C.; Legues, M. E. Article ISI Rev Chil Pediatr. 1985
[Transplacental alloimmunization against specific platelet antigens: prevalence and features in a Chilean population]. Pereira J.; Soto M.; Hidalgo, P.; Amaya, S.; Mezzano D. Article ISI Rev Med Chil. 1997
[von Willebrand's disease: study of 58 patients]. Mezzano D.; Grebe, G; Vargas L.; Lira, P; Pereira J.; Muñoz B.; Aranda, E Article ISI Rev Med Chil. 1986
[von Willebrand's disease]. Mezzano D.; Pereira J.; Quiroga T. Article ISI Rev Med Chil. 1990
Accumulation of 5-hydroxytryptamine by aging platelets: studies in a model of suppressed thrombopoiesis in dogs Aranda, E; Pizarro M.; Pereira J.; Mezzano D. Article ISI Thromb Haemost
Activación Plaquetaria en el Síndrome Hipertensivo Inducido por el Embarazo Ivankovic, M; Oyarzún E.; Werth, P.; Aranda, E; Mezzano D. Article Scielo Rev Chil Obstet Ginecol 1987
Anticuerpos antiplaquetarios inducidos por heparina: prevalencia en pacientes portadores de insuficiencia renal crónica en hemodiálisis Palomo I.; Pereira J.; Alarcon M.; Quiroga G; Diaz G.; Vásquez M; Mezzano D. Article Scielo Rev Chil Cancerol y Hematol
Bleeding time in preeclampsia. Ivankovic, M; Pereira J.; Bianchi, M.; Germain A.; Mezzano D. Article ISI ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Changes in platelet beta-thromboglobulin, fibrinogen, albumin, 5-hydroxytryptamine, ATP, and ADP during and after surgery with extracorporeal circulation in man. Mezzano D.; Aranda, E; Urzúa J.; Lema, G; Habash, J.; Irarrázabal, M. J.; Pereira J. Article ISI American Journal of Hematology
Characteristics of total platelet populations and of platelets isolated in platelet-rich plasma. Mezzano D.; Hwang, K.; Aster, R. H. Article ISI Transfusion
Comparative study of size, total protein, fibrinogen and 5-HT content of human and canine platelet density subpopulations Mezzano D.; Aranda, E; Foradori, A. C. Article ISI Thromb Haemost 1986
Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. Mezzano S.; Kinick, M.; OLAVARRIA, F; Ardiles L.; Aranda, E; Mezzano D. Article ISI Nephron
Determinación de los antígenos grupo ABO y factor Rh de pacientes con cáncer vesicular y colelitiasis y de pacientes con colelitiasis sin cáncer. Cubillos, L; Gonzalez S.; Mezzano D.; Bergoing, M.; Martínez I. Article Scielo Rev Chilena de Cirugía 1997
Diagnosis of Type 1-Von Willebrand Disease: Investigators, Not Clinical Doctors Prestige Stays in Debt. A Rebuttal. Letter to the Editor. Mezzano D.; Quiroga T. Article ¿
Effects of diterpene forskolin on the release reaction and protein phosphorylation of human platelets. Mezzano D.; Aranda, E; Foradori, A. C.; Rodríguez, S.; Lira, P Article ISI Cell Biochem Funct. 1983
Evaluación pre operatoria de la hemostasia. Mezzano D.; Pereira J. Article Scielo Cuadernos de Cirugía 1992
Increase in density and accumulation of serotonin by human aging platelets. Mezzano D.; Aranda, E; Rodríguez, S.; Foradori, A. C.; Lira, P Article ISI American Journal of Hematology
Kinetics of platelet density subpopulations in splenectomized mongrel dogs. Mezzano D.; Aranda, E; Foradori, A. C.; Rodríguez, S.; Lira, P Article ISI American Journal of Hematology
La atorvastatina no modifica el incremento agudo de los niveles de P-selectina y fibrinógeno inducido con esfuerzo físico máximo. Lindefjeld, D; Acevedo M.; Chamorro, G; Mezzano D.; Panes O.; Aranis, C; Oporto J. Article Scielo Rev Chil Cardiol 2010
Manejo intraparto de embarazadas con trastornos hereditarios de la coagulación. Merino, P; Zúñiga P; Carvajal, J.; Mezzano D. Article Scielo Rev Chil Obstet Ginecol 2006
Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme. Orellana, A; Hidalgo, P. C.; Morales M.N.; Mezzano D.; Bronfman, M Article ISI EUROPEAN JOURNAL OF BIOCHEMISTRY
Polimorfismo del receptor de ADP plaquetario en pacientes con enfermedad coronaria y variabilidad en agregación plaquetaria. Baraona F.; Guarda E.; Ocaranza M.; Marchant, E; Mezzano D.; Tala P.; Lazen, R Article Scielo Rev Chil Cardiol 2006
Screening tests and platelet function assays in the workup of bleeding disorders: Evidence from studies of South American patients. Mezzano D.; Quiroga T. Article Int J Lab Hematol
Sex-related difference in plasma von Willebrand factor (vWF:Ag and vWF:RiCof) levels in adolescents Quiroga T.; Tagle, R; Pereira J.; Mezzano D. Article ISI Thromb Haemost
Tissue Factor-Dependent Pro-Coagulant Activity Of Human Platelets Is Directly Related To Membrane Cholesterol Content. Rosuvastatin, But Not Atorvastatin, Reduces The Platelet Cholesterol, Tissue Factor Protein and Clotting Activity In Hypercholesterolemic Patients. Panes O.; Valderas, JP; Acevedo M.; Contreras S.; Pereira J.; Rigotti, A.; Mezzano D. Article BLOOD
Total sialic acid in human and canine platelets does not change with the platelet age. Mezzano D.; Aranda, E; García, M. E.; Pereira J.; Quiroga T.; Perez M. Article ISI American Journal of Hematology


Association between endothelial dysfunction markers and regional cerebral blood flow (rCBF) changes in cocaine dependent patients under recent abstinence. Massardo, T; Quintana, J; Jaimovich R.; Sáez C.; Pallavicini, J; Veliz, J; Ibáñez C; Cabreras, M; Pereira K; Mezzano D.; Pereira J. Abstract EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2013)
Human Platelets Express Functional Pannexin-1 Pereira J.; Shoji, KF; Vargas AA; Orellana, JA; Saez CG; Pereira K; Paddock, C; Kuckleburg, C; Newman, PJ; Mezzano D.; Sáez JC Abstract BLOOD (2011)
Tissue factor pathway inhibitor (TFPI) and tissue factor (TF) co-localize in lipid rafts of platelet membranes: mechanism to inhibit platelet procoagulant (PCA) activity? Olga, P; González C; Matus, V.; Pereira J.; Mezzano D. Abstract JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Clot lysis time (CLT) of PRP and PPP in hypercholesterolemia. Effect of atorvastatin and relationships with inflammatory markers Mezzano D.; Acevedo M.; Pereira J.; Matus, V.; Panes O. Abstract JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Effect of Short-Term Abstinence on Cocaine-Induced Endothelial Dysfunction and Platelet Activation Pereira J.; Saez CG; Pallavicini, J; Olivares, P; Moreno, N; Cabreras, M; Massardo, T; Mezzano D. Abstract BLOOD (2010)
Platelet Tissue Factor Activity In Patients with Hypercholesterolemia: Modulation of Procoagulant Activity by Statins Panes O.; Acevedo M.; Matus, V.; Saez CG; Pereira J.; Mezzano D. Abstract BLOOD (2010)
Evidence of Endothelial Dysfunction in Cocaine Users Pereira J.; Saez CG; Pallavicini, J; Olivares, P; Panes O.; Moreno, N; Belmont, S; Massardo, T; Mezzano D. Abstract BLOOD (2008)
Platelet Tissue Factor: Expression of Pro-Coagulant Activity depends on Gpib alpha Activation and Signaling through Lyn-Mediated Phosphorylation. A Platelet-Based Model of Hemostasis Panes O.; Ibarra P.; Matus, V.; Saez CG; Pereira J.; Mezzano D. Abstract BLOOD (2008)
Human platelet tissue factor is localized in lipid rafts and is associated with GPIb-IX-V complex in the membrane: Association between adhesive and procoagulant activities of platelets. Panes O.; Matus, V.; Saez CG; Garate, A.; Pereira J.; Mezzano D. Abstract BLOOD (2006)
Elevated levels of cell-derived microparticles with procoagulant activity in cocaine abusers: Association with increased thrombin generation and a prothrombotic state. Pereira J.; Alfaro G.; Massardo, T; Pallavicini, J; Sáez C.; Goycoolea M.; Panes O.; Mezzano D. Abstract BLOOD (2005)
Diagnostic assessment of patients with inherited mucocutaneous hemorrhages (IMCH): Opening a pandora box? Mezzano D.; Quiroga T.; Goycoolea M.; Muñoz B.; Aranda, E; Panes O.; Pereira J. Abstract BLOOD (2004)
Loss of platelet membrane phospholipid asymmetry in systemic lupus erythematosus: Association with disease activity and hypercoagulable state. Pereira J.; Quiroga T.; Massardo, L; Pérez, C.; Alfaro G.; Ocqueteau, M; Panes O.; Mezzano D. Abstract BLOOD (2004)
Amphotericin B induces premature apoptosis in stored platelets. Pereira J.; Soto M.; Ibáñez S.; Ocqueteau, M; Mezzano D. Abstract BLOOD (2001)


Dieta Mediterránea, Vino y Factores de Riesgo Cardiovascular. Mezzano D.; Palomo I.; Leiva E.; Vásquez M BookSection
Disfunciones plaquetarias hereditarias y adquiridas. Chapter 43. Mezzano D.; Quiroga D.; Vicente, V. G.; Osorio G.; Liendo, F; Vargas L.; Pereira J. BookSection
Emergency Transfusion Therapy in Acute Hemorrhage. Chapter 24 Pereira J.; Mezzano D.; Cubillos, L BookSection
Hemostasis: General Principles. Mechanisms of Regulation. Chapter 8 Barja P.; Mezzano D.; Osorio G. BookSection
Transfusion Therapy in Intensive Care Units. Chapter 4 Soto, V.; Mezzano D.; Bugedo G.; Castillo L.; Dougnac, A BookSection
Trombocitopenias y trombocitopatías adquiridas. Chapter 3. Mezzano D.; Pereira J.; García-Conde, J.; San Miguel, J. F.; Sierra, J; Urbano-Espizúa, A.; Vicente, V. G.; Vives, J. L. BookSection
Blood Transfusion Support in Chemotherapy and Radiotherapy. Chapter 13. Liendo, F; Child, R; Mezzano D.; Osorio G.; Liendo, F; Anguita T.; Rios E.; Gutierrez J.; Vargas L. BookSection
Contenido de los gránulos plaquetarios Mezzano D.; López Borrasca, A.; Arocha-Piñango, C. L.; et al. BookSection
Emergency Blood Transfusion in Acute Hemorrhage. Mezzano D.; Pereira J.; Cubillos, L BookSection
Enfermedad de von Willebrand, Chapter 38 Quiroga D.; Pereira J.; Mezzano D.; Osorio G.; Liendo, F; Vargas L.; Pereira J. BookSection
Exploración clínica y de laboratorio de la hemostasia. Mezzano D.; Goic, A; Chamorro, G; Reyes, H. BookSection
Influence of Diet in Clotting and Thrombosis Mezzano D.; Martínez C; Leighton F.; Urquiaga, I BookSection
Radioinmunoensayo de Factor Plaquetario 4 (FP4). Aranda, E; Mezzano D.; Foradori, A. C.; Kordich, L. C.; Sánchez Ávalos, J. C.; Vidal, H. O.; De Campos Guerra, C. BookSection
Thrombocytopenias and Platelet Function Disorders. Chapter 21 Pereira J.; Mezzano D.; Vicente, V. G.; Palomo I.; Pereira J.; Palma J. BookSection
Von Willebrand Disease, Chapter 36. Pereir, J.; Mezzano D.; Quiroga T.; Osorio G.; Liendo, F; Anguita T.; Rios E.; Gutierrez J.; Vargas L. BookSection
Women and Thrombophilia, Chapter 28. Mezzano D.; Rodríguez, J. A.; López G. BookSection


Blood Physiology. 1993 Mezzano D.; Pereira J.; Mezzano D.; Pereira J. BookWhole
Transfusion Therapy. 1979 Mezzano D.; Mezzano D. BookWhole


Mediterranean Food and Diets, Global Resource for the Control of Metabolic Syndrome and Chronic Diseases Urquiaga, L; Echeverría G.; Polic, G; Castillo O.; Liberona, Y; Rozowski J.; Pérez D.; Martínez C; Vásquez, L.; Strobel P.; Mezzano D.; Leighton F. ConferencePaper NUTRITIONAL CARE OF PRETERM INFANTS: SCIENTIFIC BASIS AND PRACTICAL GUIDELINES (2008)


Influence of the Thr325Ile polymorphism on procarboxypeptidase U (thrombin-activable fibrinolysis inhibitor) activity-based assays Willemse, JL; Matus, V.; Heylen, E; Mezzano D.; Hendriks, DF Letter ISI JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
High plasma levels of lipoprotein(a) in uremic patients are related to markers of inflammation, and to activated, not impaired, fibrinolysis Gatica A.; Panes O.; Tagle, R; Pereira J.; Mezzano D. Letter THROMBOSIS AND HAEMOSTASIS (2002)
Fast decrease of bleeding time by tranexamic acid in uremia Mezzano D.; Muñoz B.; Pais, E; Downey P.; Pereira J. Letter THROMBOSIS AND HAEMOSTASIS (2000)


New oral anticoagulant drugs Berkovits, A; Aizman A.; Zúñiga P; Pereira J.; Mezzano D. Review REVISTA MEDICA DE CHILE (2011)
The Level of Laboratory Testing Required for Diagnosis or Exclusion of a Platelet Function Disorder Using Platelet Aggregation and Secretion Assays Mezzano D.; Quiroga T.; Pereira J. Review ISI SCOPUS Seminars in Thrombosis and Hemostasis (2009)

149

Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Valeria Matus

Associate Researcher

Hematology-Oncology

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

MONICA ACEVEDO

Titular Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

Ada Cuevas

Médico

Nutrición Clínica

CLINICA LAS CONDES

Santiago, Chile

Pamela Zúñiga

Profesor Asociado

Pediatria

Pontificia Universidad Católica de Chile

Santiago , Chile

Ines Urquiaga

Coordinador Cientifico

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Andres Aizman

Assitant Professor

Internal Medicine

Pontificia Universidad Católica de Chil

Santiago, Chile

Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

Dante Lindefjeld

Staff, Assistant Professor

Cardiology

Clinical Hospital of the Pontificia Universidad Católica de Chile

Santiago, Chile

Guadalupe Echeverría

Manager

Center for Molecular Nutrition and Chronic Diseases

Pontificia Universidad Católica de Chile

Santiago, Chile

Luz Letelier

Jefe de Departemento

Medicina Interna

Pontificia Universidad Catolica de Chile, Facultad de Medicina

Santiago, Chile

Edgard Pais

Director Médico

Nefrodiálisis San Lucas

Santiago, Chile

Patricio Fuentes

Medico Neurologo

Medicina

Hospital Clínico Universidad de Chile

Santiago, Chile

Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

Guillermo Marshall

MARCELA VASQUEZ

Prof. Asistente

Bioquímica Clínica e Inmunohematología

Universidad de Talca

Talca, Chile

ALEJANDRA SAN MARTIN

Professor

Medicine

Universidad Andrés Bello

Santiago, Chile

Diego Antonio Mezzano Abedrapo

Líneas de Investigación

Educación

Medical Doctor, Pontificia Universidad Católica de Chile. Chile, 1969

Experiencia Académica

Professor Full Time

Medical Doctor Full Time

Hematology Fellowship Full Time

National Institutes of Health, Fogarty Center, Research Fellowship Full Time

Experiencia Profesional

Research fellowship Full Time

Attending Physician, Internal Medicine Full Time

Internal Medicine Fellowship Full Time

Hematology Fellowship Full Time

Associate Editor Other

Co-Chairman, Platelet Physiology Sub-Committee Other

Member, Lectures and Awards Committee Other

Formación de Capital Humano

Premios y Distinciones

IV Latin-american Scientific Meeting of Medical Students

X Chilean Congress of Hematology

Chilean Meeting of the Societies of Hypertension, Nephrology and Transplantation

Faculty of Medicine Scientific Meeting of Residents and Fellows

IX Chilean Congress of Clinical Chemistry

Best Publication 1996

Best Professor 3rd Grade of Medicine, 1997

Prize Araucaria Foundation on Coronary Artery Disease

Best Professor 3rd Grade Medicine 1998

Prize Senior Investigator 1999

Prize Second Best Publication XIII Congress Chilean Society of Hematology

Prize Best Professor 3rd Grade of Medicine 2000

Prize Medical Society of Santiago 1999 to the Best Publication during 1999.

Prize Academy of Medicine 2000 to a Research Career

Prize Chilean Society of Clinical Chemistry to the Best Oral Presentacion.

Prize Best Professor 3rd Grade 2002 of Medicine

Prize Dr. Germán Ducach Grinberg 2003 to the Best Publication in Clinical Hematology.

Prize Dr. Germán Ducach Grinberg 2005 to the Best Publication in Clinical Hematology.

Prize Medical Society of Santiago 2007 to the Best Scientific Work in the XXIX Congress of the Chilean Society of Internal Medicine

Prize Dr. Germán Ducach Grinberg 2009 to the Best Publication in Clinical Hematology

Prize Eduardo Bunster Montero 2012, Chilean Society of Hematology

Prize Germán Ducach Grinberg 2014 to the Best Publication in Clinical Hematology.

Article (94)

Abstract (13)