Man

Diego Antonio Mezzano Abedrapo

Director

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Platelet Physiology and Pathophysiology; Platelet Tissue Factor; Platelet Pro-coagulant Activity; Mechanisms of Atherothrombosis; Primary Hemostasis Disorders; Functions of Neo-synthesized Proteins by Platelets; Platelet Aging in Circulation.

Educación

  •  Medical Doctor, Pontificia Universidad Católica de Chile. Chile, 1969

Experiencia Académica

  •   Professor Full Time

    Physician, Sótero del Río Hospital

    Medicine

    Santiago, Chile

    1974 - At present

  •   Medical Doctor Full Time

    Hospital Sótero del Río

    Medicine, P. Catholic University of Chile

    Santiago, Chile

    1972 - 1974

  •   Hematology Fellowship Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    1974 - 1976

  •   National Institutes of Health, Fogarty Center, Research Fellowship Full Time

    Blood Center of South-Eastern Milwaukee

    Associated with Medical College of Wisconsin

    Milwaukee, Estados Unidos

    1978 - 1980

Experiencia Profesional

  •   Research fellowship Full Time

    Blood Ctr. South-Eastern Milwaukee

    Milwaukee, Estados Unidos

    1978 - 1980

  •   Attending Physician, Internal Medicine Full Time

    Hospital Sótero del Río

    Santiago, Chile

    1972 - 1974

  •   Internal Medicine Fellowship Full Time

    School of Medicine, Catholic Univ of Chile

    Santiago, Chile

    1969 - 1972

  •   Hematology Fellowship Full Time

    School of Medicine, Catholic Univ of Chile

    Santiago, Chile

    1974 - 1976

  •   Associate Editor Other

    Journal of Thrombosis and Haemostasis

    Leiden, Holanda

    2014 - At present

  •   Co-Chairman, Platelet Physiology Sub-Committee Other

    International Society for Thrombosis and Haemostasis

    Chapel Hill, Estados Unidos

    2012 - At present

  •   Member, Lectures and Awards Committee Other

    International Society for Thrombosis and Haemostasis

    Chapel Hill, Chile

    2012 - At present

Formación de Capital Humano


Medical Students.
1997-2004: Director, Organizer and Lecturer in the course of Pathophysiology: Cellular and Molecular Basis of the Disease. For 3rd grade students of Medicine. First semester
2005-2009: Co-Direction of the Integrated Course "Functional and Morphological Pathology". First semester. Lecturer in this course until now.
1997-2006: Lectures and Bibliographic Seminars in the Course Molecular Biology of the Cell, for 2nd grade students of Medicine. First Semester.
1983-1985 and 1988-2009: Director of the chapter of Blood Physiology. Collaborator since 2010 in the same course, for 2nd grade students of Medicine.2nd Semester.
1976-2011: Lectures in Thrombosis, Hemostasis and Transfusion Medicine in the Chapter of Clinical Hematology in the Integrated Medical-Surgical Course for Medical Students, 4th grade.
1990-1999: Programmed Hematology, Hemostasis-Thrombosis and Transfusion Medicine Rounds with groups of students during their Internship.
1985-1989: Optative Course: Training Program in Blood Banking for Pre-Graduate Medical Students. 1 semester.

Pre-Graduate Students in other Health-Related Careers.
1983-1986: Coordinator of the Course Pathophysiology for Nursery Students. 2nd Semester.
1998-2014: Lectures in Hemostasis in the Course Introduction to Clinical Laboratory, for Biochemistry and Biology Students (Faculty of Biological Sciences)
1998-2014: Lectures in Hemostasis in the Course Introduction to Clinical Laboratory, for Chemistry and Pharmacy Students (Faculty of Chemistry)
2012-2014: Lectures in Pathophysiology of the Blood for Dentistry Students (Health Sciences Faculty)

Post-Graduate Students.
1997-2003: Director, Subspecialty Clinical and Laboratory Training in Hemostasis-Thrombosis and Transfusion Medicine. Duration: 1 year. or Hematologists, Pediatricians, Clinical Pathologists, Internists,
2004-2014: Director, Subspecialty Clinical and Laboratory Training in Hemostasis-Thrombosis, 1 year duration for Hematologists, Pediatricians, Clinical Pathologists, Internists,
1995-2014: Medical Sciences PhD Program: Lectures and Seminars in successive courses of this program: Integrative Physiology, Basic Biologic Processes in Human Diseases, Cell-cell interactions in disease: mechanisms and functions.
1997-2013: Magister of Nutrition. Lectures on pathophysiology of disorders related with nutrition and metabolism (atherosclerosis, thrombosis, hemostatic disorders associated with vitamin K deficiency, diabetes, homocysteine metabolism)

Tutorship of Pre-Graduate Students in the Hemostasis and Thrombosis Laboratory.
1992-2014: Pre-Graduate Students of Medical Technology (Internship), Biochemistry and Biology (Clinical Lab Courses) rotate permanently in our Laboratories. These include students of our and other Universities: Universidades Andrés Bello, Mayor, San Sebastián.
1985-2009: Tutorship of 31 Medical Students to help in teaching activities, consultative functions in the courses I directed.
1985-1996: Tutorship of 18 medical students to participate in specific areas of our research projects. Six of them are co-authors in our papers.

Tutorship of Post-Graduate Students in the Hemostasis and Thrombosis Laboratory.
1982-2014: more than 50 physicians, mainly hematologists and clinical pathologists, either during their specialty fellowships or for further training, have spent from 1 to 3 months of stay in our Laboratories for training. We receive fellows or hematologists from all along the country, and almost all the accredited Hematology Fellowship Programs are trained by us.
1982-2014: all the Hematology and Hematology-Oncology Fellows (Adults and Pediatricians) of our Institution are trained in Hemostasis and Thrombosis in our Laboratory

Thesis.
1982-2014: I have tutored or co-tutored the Pre-Graduate Thesis of 30 students of Biochemistry, Biology, Chemistry and Pharmacy, from other Faculties or Universities. The results of the Thesis of almost all of them have been presented in scientific meetings and most of them have co-authored the publications of our laboratory.
2007-2010: co-tutor of the PhD Thesis in Medical Sciences of Sebastián Cabrera,, from the University of Chile: “Transport of L-Arginina in Human Platelets. Role of platelet dysfunction in chronic renal failure".


Premios y Distinciones

  •   IV Latin-american Scientific Meeting of Medical Students

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Venezuela, 1991

    I was the tutor of the students Mariela Torrente and Ignacio Campos. First Prize in Clinical Sciences. "Tubular Necrosis and Acute Renal Failure in Rats Treated with 5-Hydroxi tryptofan .

  •   X Chilean Congress of Hematology

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1994

    Prize to the Best Scientific Work: "Inhibition of fibrinolysis corrects the bleeding time (BT) in patients with terminal renal failure. Mezzano D, Tagle R, Downey P, Thambo S, González F, Mezzano S, Barja P, Pérez M, Panes O, Rodríguez MS, Muñoz B, Pereira J.

  •   Chilean Meeting of the Societies of Hypertension, Nephrology and Transplantation

    Societies of Hypertension, Nephrology and Transplantation

    Chile, 1994

    Prize to the Best Scientific Work. Fibrinolysis inhibition corrects the bleeding time in most patients with terminal chronic renal failure" Tagle R, Downey P, González F, Pais E, Mezzano S, Thambo S, Barja P, Pérez M, Panes O, Pereira J, Mezzano D. La Serena, 1994.

  •   Faculty of Medicine Scientific Meeting of Residents and Fellows

    Faculty of Medicine, P. Catholic University of Chile

    Chile, 1995

    First Prize to the Best Abstract. "Fibrinolysis inhibition corrects the bleeding time in most patients with terminal chronic renal failure" Fellow: Rodrigo Tagle, M.D. Tutor: D. Mezzano, M.D.

  •   IX Chilean Congress of Clinical Chemistry

    Chilean Society of Clinical Chemistry

    Chile, 1995

    "Disorders of primary hemostasis can be the consequence of clotting and fibrinolysis activation in terminal chronic renal failure" O. Panes, B. Muñoz, M. Pérez, J. Pereira, D. Mezzano.

  •   Best Publication 1996

    Sociedad Médica de Santiago

    Chile, 1996

    "Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis". Thromb Haemostas 1996; 76: 312-321. Mezzano D, Tagle R, Panes O, Pérez M, Downey P, Muñoz B, Aranda E, Barja P, Thambo S, González F, Mezzano S, Pereira J.

  •   Best Professor 3rd Grade of Medicine, 1997

    School of Medicine, P. Catholic University of Chile

    Chile, 1997

    Voted by the Students of 3rd Grade of Medicine

  •   Prize Araucaria Foundation on Coronary Artery Disease

    Chilean Society of Cardiology and cardiovascular Surgery

    Chile, 1998

    “Coronary Heart Disease: asociation with C677T gene mutation of 5,10-methylen-tetrahydrofolate reductase and plasma levels of folic acid and homocysteine". Mezzano D, Guarda E, Villagrán C, Goycoolea M, Aranda E, Quiroga T, Fajuri A, Marchant E, Martínez A, Maiz A, Pereira J.

  •   Best Professor 3rd Grade Medicine 1998

    School of Medicine, P. Catholic University of Chile

    Chile, 1998

    Voted by the 3rd Grade students

  •   Prize Senior Investigator 1999

    Faculty of Medicine, P. Catholic University of Chile

    Chile, 1999

    Elected by the Faculty Council.

  •   Prize Second Best Publication XIII Congress Chilean Society of Hematology

    Chilean Society of Hematology

    Chile, 2000

    Selected by the Scientific Committee and the Society Directors.

  •   Prize Best Professor 3rd Grade of Medicine 2000

    School of Medicine, P. Catholic University of Chile

    Chile, 2000

    Voted by the 3rd Grade Students of Medicine.

  •   Prize Medical Society of Santiago 1999 to the Best Publication during 1999.

    Medical Society of Santiago

    Chile, 1999

    “Complementary Benefits of Mediterranean diet and red wine on hemostatic factors with cardiovascular risk". Mezzano D, Martínez C, Marshall G, Muñoz B, Rodríguez S, San Martín A, Pereira J, Leighton F.

  •   Prize Academy of Medicine 2000 to a Research Career

    Chilean Academy of Medicine

    Chile, 2000

    Physiology, Pathophysiology and Clinical Aspects of Primary Hemostasis", granted during the XXII Congress of the Chilean Congress of Internal Medicine.

  •   Prize Chilean Society of Clinical Chemistry to the Best Oral Presentacion.

    Chilean Society of Clinical Chemistry

    Chile, 2001

    “Prevalence of heparin-induced anti-phospholipid and anti-platelet antibodies in patients on hemodialysis”. Palomo I, Pereira J, Jara E, Alarcón M, Espinoza M, Moore R, Hernández A, Hernández E, Díaz G, Quiroga G, Rojas P, Vásquez M, Mezzano D, Arce I.

  •   Prize Best Professor 3rd Grade 2002 of Medicine

    School of Medicine, P. Catholic University of Chile

    Chile, 2002

    Voted by the 3rd Grade Students of Medicine.

  •   Prize Dr. Germán Ducach Grinberg 2003 to the Best Publication in Clinical Hematology.

    Chilean Society of Internal Medicine

    Chile, 2003

    “Mediterranean diet, but not red wine, is associated with beneficial changes on primary haemostasis”. Mezzano D, Leighton F, Strobel P, Martínez C, Marshall G, Cuevas A, Castillo O, Panes O, Muñoz B, Rozowski J, Pereira J. Eur J Clin Nutr 2003; 57: 439-446.

  •   Prize Dr. Germán Ducach Grinberg 2005 to the Best Publication in Clinical Hematology.

    Chilean Society of Internal Medicine

    Chile, 2005

    “Template bleeding time and PFA-100® have low sensitivity to screen patients with hereditary mucocutaneous haemorrhages: comparative study in 148 patients. Quiroga T, Goycoolea M, Muñoz B, Morales M, Aranda E, Panes O, Pereira J, Mezzano D. J Thromb Haemost 2004; 2: 892-8.

  •   Prize Medical Society of Santiago 2007 to the Best Scientific Work in the XXIX Congress of the Chilean Society of Internal Medicine

    Medical Society of Santiago

    Chile, 2007

    Cerebral perfusion defects associated with hemostasis activation in chronic cocain consumers". Massardo T, Jaimovich R, Pallavicini J, Quintana JC, Panes O, Hidalgo P, Mezzano D, Sáez C, Pereira J.

  •   Prize Dr. Germán Ducach Grinberg 2009 to the Best Publication in Clinical Hematology

    Chilean Society of Internal Medicine

    Chile, 2009

    “High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. Prospective study of 280 patients and 299 controls”. Quiroga T, Goycoolea M, Panes O, Aranda E, Martínez C, Belmont S, Muñoz B, Zúñiga P, Pereira J, Mezzano D. Haematologica 2007, 92:357-365.

  •   Prize Eduardo Bunster Montero 2012, Chilean Society of Hematology

    Chilean Society of Hematology

    Chile, 2012

    Prize to the Professional Career, Elected by the Directors of the Chilean Society of Hematology. Plenary Conference 2012, Congress of the Chilean Society of Hematology.

  •   Prize Germán Ducach Grinberg 2014 to the Best Publication in Clinical Hematology.

    Chilean Society of Internal Medicine

    Chile, 2014

    An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in 4 Chilean families. V. Matus, G. Valenzuela, C. G. Sáez, P. Hidalgo, M. Lagos, E. Aranda, O. Panes, J. Pereira, X. Pillois, A.T. Nurden and D. Mezzano. J Thromb Haemost 2013; 11(9):1751-9.


 

Article (94)

Abstract (13)

BookSection (16)

BookWhole (2)

ConferencePaper (1)

Letter (3)

Review (2)

4
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

41
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

51
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Ada Cuevas

Médico

Nutrición Clínica

CLINICA LAS CONDES

Santiago, Chile

149
Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

21
Valeria Matus

Associate Researcher

Hematology-Oncology

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

18
Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
MONICA ACEVEDO

Titular Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

6
Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

1
Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Dante Lindefjeld

Staff, Assistant Professor

Cardiology

Clinical Hospital of the Pontificia Universidad Católica de Chile

Santiago, Chile

1
Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

1
Andres Aizman

Assitant Professor

Internal Medicine

Pontificia Universidad Católica de Chil

Santiago, Chile

1
Guadalupe Echeverría

Manager

Center for Molecular Nutrition and Chronic Diseases

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luz Letelier

Jefe de Departemento

Medicina Interna

Pontificia Universidad Catolica de Chile, Facultad de Medicina

Santiago, Chile

1
Edgard Pais

Director Médico

Nefrodiálisis San Lucas

Santiago, Chile

3
oscar castillo

Director Escuela

Facultad de Medicina

Universidad Finis Terrae

Santiago, Chile

3
Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

1
Patricio Fuentes

Medico Neurologo

Medicina

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Ines Urquiaga

Coordinador Cientifico

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Pamela Zúñiga

Profesor Asociado

Pediatria

Pontificia Universidad Católica de Chile

Santiago , Chile

1
Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

1
MARCELA VASQUEZ

Prof. Asistente

Bioquímica Clínica e Inmunohematología

Universidad de Talca

Talca, Chile

1
ALEJANDRA SAN MARTIN

Professor

Medicine

Universidad Andrés Bello

Santiago, Chile