Man

YORLEY ANDREA DUARTE AYALA

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


Síntesis Orgánica, Drug Discovery, Química Médica, Simulación Molecular.

Educación

  •  Química de Alimentos, Universidad Pedagógica y Tecnológica de Colombia. Colombia, 2005
  •  Magister en Ciencias Químicas, Universidad Nacional de Colombia. Chile, 2009
  •  Doctora en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2015

Experiencia Académica

  •   Auxiliar Docente. Especialización en Ciencia y Tecnología de Alimentos. Part Time

    Universidad Nacional de Colombia

    de Ciencias

    Bogotá D.C., Colombia

    2008 - 2009

  •   Docente Tiempo Completo Ocasional; Química I y II, Química inorgánica y Orgánica. Full Time

    Universidad del Atlántico

    de Ciencias Químicas

    Barranquilla, Colombia

    2010 - 2010

  •   Docente, laboratorios Química general-Organica Other

    UNIVERSIDAD DE TALCA

    Talca, Chile

    2012 - 2013

  •   Profesora asociada Full Time

    UNIVERSIDAD ANDRES BELLO

    Ciencias de la Vida

    Santiago, Chile

    2020 - At present

  •   Investigadora Full Time

    UNIVERSIDAD ANDRES BELLO

    Ciencias de la Vida

    Santiago, Chile

    2015 - 2020

Experiencia Profesional

  •   Analista Químico Full Time

    Ivonne Bernier Laboratorio

    Bogotá D. C. , Colombia

    2006 - 2007

  •   Estudiante Investigadora Full Time

    Universidad de Talca

    Talca, Chile

    2011 - 2012

Formación de Capital Humano


Tesis Co-dirigidas

“Si?ntesis y estudio de actividad biolo?gica de heterociclos nitrogenados ana?logos de quinolinas”.
Michelle Campos. 2014. Tecnologi?a Me?dica-Universidad de Talca.

“Si?ntesis de hibridos cumarino-quinolini?cos como inhibidoresselectivos de colinesterasas”.
Raphael Latorre. 2014. Tecnologi?a Me?dica-Universidad de Talca.

“Si?ntesis de hi?bridos cumarino-quinolinas como potenciales agentes antioxidantes”.
Oliver Orellana. 2015. Tecnologi?a Me?dica-Universidad de Talca.


Difusión y Transferencia


CONGRESOS

II Encuentro Regional de Semilleros de Investigacio?n. Presentacio?n de la Ponencia del tema de trabajo de grado. UPTC, Duitama, Boyaca? Septiembre 22 al 24 de 2004.

VII Encuentro Nacional de Semilleros de Investigacio?n. Red Colombiana de Semilleros de Investigacio?n REDCOLSI y Universidad de San Buenaventura. Presentacio?n de la Ponencia de Trabajo de grado. Cartagena de Indias. Octubre 14-17 de 2004.

III Congreso latinoamericano de Estudiantes de Ciencia y Tecnologi?a de Alimentos, II Congreso Nacional ACECTA. Cartagena de Indias, Mayo 25 al 28 de 2005.

XXIX Congreso Latinoamericano de Qui?mica. Comportamiento del benzotriazol como grupo saliente en las reacciones de sustitucio?n nucleofi?lica de N,N-bis(1H- benzotriazoL-1-il-metil)-1,2-diaminobenceno con fenoles. Cartagena, Colombia 2010, 27.

XXIX Jornadas Chilenas de Qui?mica. SI?NTESIS DE DERIVADOS AZO?LICOS A PARTIR DE CETONAS ?,?---INSATURADAS Y BINUCLEOFILOS VIA REACCIO?N DE ADICIO?N 1,4 DE MICHAEL. Panima?vida, Chile 2011, QO 196.

XIX Jornadas Chilenas de Qui?mica. SINTESIS DE TETRAHIDROQUINOLINAS Y SU ACTIVIDAD BIOLOGICA. Panima?vida, Chile 2011, QO 198.

XVIII SINAQO. SINTESIS DE TETRAHIDROQUINOLINAS Y SU ACTIVIDAD BIOLOGICA. Villa Carlos Paz, Argentina 2011, QO 73.

XIX SINAQO. Synthesis of bistetrahydroquinolines as AchE inhibitor by double Diels- Alder reactions. Mar del Plata, Argentina 2013.

III SEQT Summer School. NITROGEN HETEROCYCLES AS POTENTIAL AGENTS ANTI- ALZHEIMER, Madrid, Espan?a, 2013. 53.

XIX SINAQO. DISEN?O, SI?NTESIS Y ESTUDIO FARMACOLO?GICO DE DIFERENTES AMIDAS DERIVADAS DE CUMARINAS COMO INHIBIDORES DE AChE Y BuChE. Mar del Plata Argentina, 2013. 83.

Workshop in Modern Approaches in Drug Discovery for Neglected Infectious diseases. Instituto Pasteur de Montevideo, Montevideo, Uruguay. Curso. 3-18/Nov- 2014.

16th. BMOS. Experimental and Theoretical Study of phenanthroline- tetrahydroquinolines by Povarov Reaction. Bu?zios, Brazil, 2015. 100, 170.



 

Article (37)

<i>O</i>-Alkyl derivatives of ferulic and syringic acid as lipophilic antioxidants: effect of the length of the alkyl chain on the improvement of the thermo-oxidative stability of sunflower oil
Increased Absorption of Thyroxine in a Murine Model of Hypothyroidism Using Water/CO2 Nanobubbles
Rational Design and Evaluation of Photoactive Molecularly Imprinted Nanoparticles for Tetracycline Degradation Under Visible Light
The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes
The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release
Comprehensive analysis of crystal structure, spectroscopic properties, quantum chemical insights, and molecular docking studies of two pyrazolopyridine compounds: potential anticancer agents
Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies
Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases
Insights into Early Steps of Decanoic Acid Self-Assemblies under Prebiotic Temperatures Using Molecular Dynamics Simulations
Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids
Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties
Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units
Molecular modeling and structural analysis of some tetrahydroindazole and cyclopentanepyrazole derivatives as COX-2 inhibitors
Novel N-benzoylimidazolium ionic liquids derived from benzoic and hydroxybenzoic acids as therapeutic alternative against Biofilm-forming bacteria in skin and soft-tissue infections
Synthesis multicomponent based on o‐tolyl‐isocyanide; cholinesterase inhibitors and computational studies
The TGA Transcription Factors from Clade II Negatively Regulate the Salicylic Acid Accumulation in Arabidopsis
Toward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies
A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII
Anti-parasitics drugs that modulates non-selective channels formed by connexins or pannexins
Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups
Contribution of non-selective membrane channels and receptors in epilepsy
Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation
Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study
Cationic Carbosilane Dendritic Systems as Promising Anti-Amyloid Agents in Type 2 Diabetes
Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation
Novel TRPV1 channel agonists with faster and more potent analgesic properties than capsaicin
PLIDflow: an open-source workflow for the online analysis of protein-ligand docking using galaxy
Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation
Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
Experimental and Theoretical Approaches in the Study of Phenanthroline-Tetrahydroquinolines for Alzheimer's Disease
Novel Coumarin-Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease
Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold
Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents
Acción antifúngica del extracto etanólico y sus fracciones de polaridad creciente del epicarpio de lima (Citrus aurantifolia swingle)
Crystal structure of 1,3-bis(6-methoxyquinolin-2-yl) benzene, C26H20N2O2
Synthesis of Bistetrahydroquinolines as Potential Anticholinesterasic Agents by Double Diels-Alder Reactions
X-ray and Hydrogen-bonding Properties of 1-((1H-benzotriazol-1-yl)methyl)naphthalen-2-ol

ConferencePaper (2)

Nitrogen Heterocycles as Potential Antibacterial Agents
Synthesis and Study of a Selected Series of Amides with the Coumarin Scaffold for the Treatment of Alzheimer's Disease

Proyecto (13)

Developing Novel photothermal Probes: Precision Heating for Advanced Protein Analysis and Medical Innovations
Unveiling the Potential of Sulfonamide-Quinoline Derivatives: Integration of experimental and in silico combinatorial strategies for Designing and Synthesizing Selective Innexin-2 Gap Junction Inhibitors.
Escalamiento de un prototipo de fungicida volátil encapsulado y su validación en condiciones comerciales para el control de la pudrición gris en postcosecha de uva de mesa de exportación.
Desarrollo de una cobertura cutánea costo efectiva “PanexpatchTM” para el tratamiento de úlceras venosas
Desarrollo y producción de encapsulados de embriones de las algas pardas Durvillaea incurvata y Lessonia berteroana, para su aplicación en estrategias de repoblamiento en zonas intermareales
Newly piperazinone derivatives with antithrombotic and anti-inflammatory properties: environmentally-friendly synthesis, characterization, and biological evaluation
Hybrids of Tetrahydroquinolines as Multi-Target drugs: Design, Synthesis, characterization and biological activity
Innexin2 hemichannels of caligus rogercresseyi as a new target to design antiparasitic agents through in-silico structure-based drug discovery, chemical synthesis and biological assays
Diverse cell types present pannexin1-based gap junction channels with distinct regulatory, functional and pharmacological properties
Formulación y aplicación de una espuma biodegradable e inocua para la mitigación del polvo expulsado en tronaduras mineras
FageCapsuleS, bacteriófagos de Salmonella micro-encapsulados con tecnología de liberación intestino grueso y delgado
Desarrollo de potenciales Fármacos usando los Astrocitos como blanco farmacológico para el tratamiento de enfermedades psiquiátricas
SYNTHESIS OF DERIVATIVES QUINOLINE-ISOXAZOLE AS INHIBITORS POTENTIALS OF MICROORGANISMS PHYTOPATHOGENIC

Review (1)

Integration of target discovery, drug discovery and drug delivery: A review on computational strategies
49
YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

6
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

4
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

4
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

2
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

1
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Maria Holuigue

Fundadora

Fundación Cienciarte

Santiago, Chile

1
Jonathan Cisterna

Académico

Química

Universidad Católica del Norte

Antofagasta, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

1
Alejandro Regaldiz

Estudiante de doctorado

Facultad de Ciencias de la Vida

Universidad Andrés Bello

Santiago, Chile

1
Francisco Adasme

Asistente de Investigación

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

1
Francisco Castillo

Instructor Adjunto

Química Orgánica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

1
Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Natalia Valdés

Investigador

Universidad de Santiago de Chile

Santiago, Chile

1
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

1
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
FELIPE MELO

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Efrain Polo

Docente

Universidad de Talca

Talca, Chile