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Romina Victoria Sepúlveda Sepúlveda

Profesor Investigador

Universidad Andrés Bello

Santiago, Chile

Mis lineas de investigación están dedicadas a resolver problemas biológicos con estrategias computacionales. Actualmente estoy enfocada en incorporar algoritmos de visión computación y machine learning en problemas de interés local.

Bioinformática, UNIVERSIDAD ANDRES BELLO. Chile, 2018
Ingeniero en Bioinformática, UNIVERSIDAD DE TALCA. Chile, 2011

FONDECYT Postdoctorado Full Time

UNIVERSIDAD ANDRES BELLO

Ciencias Biologicas

Santiago, Chile

2020 - At present

PostDoc FONDEF ID19I10160 Full Time

UNAB

Santiago, Chile

2020 - 2020
Senior Bioinformatician Full Time

uBiome

Santiago, Chile

2018 - 2019
Tesista doctoral Full Time

Universidad Andres Bello

Santiago, Chile

2013 - 2018
PostDoc Full Time

Universidad Andres Bello

Chile

2020 - 2022

Dirección de tesis:

Licenciatura en Biología, Universidad Andrés Bello
2024 "Diseño de moléculas moduladores del canal TRPV1 con Inteligencia Artificial" Javier Roumaeu

Ingeniería en Bioinformática, Universidad Andrés Bello
2022 "Despliegue en la nube del software AgroIA implementando la infraestructura con los servicios de Amazon Web Services" Juan Pablo Calderon Soto
2022 "Caracterización de las diferencias en especificidad de transportadores de nucleotidos de azúcar URGT2 y UXT1 de Arabidopsis thaliana a traves de simulación molecular" Maricarmen Osses

Ingeniería en Biotecnología Universidad Andrés Bello
2022 “Análisis y elaboración de un modelo in silico para 2 proteasas romboides (AtRBL10 Y AtRBL13) de Arabidopsis thaliana para el estudio de la relación entre secuencia y función”, Luis Cifuentes Ahumada.


Insights into Early Steps of Decanoic Acid Self-Assemblies under Prebiotic Temperatures Using Molecular Dynamics Simulations Sepulveda, Romina V.; Sbarbaro, Christopher; Opazo, Ma Cecilia; Duarte, Yorley; Gonzalez-Nilo, Fernando; Aguayo, Daniel Article ISI MEMBRANES (2023)
The Emergence of New Catalytic Abilities in an Endoxylanase from Family GH10 by Removing an Intrinsically Disordered Region Gil-Duran, Carlos; Sepulveda, Romina, V; Rojas, Maximiliano; Castro-Fernandez, Victor; Guixe, Victoria; Vaca, Inmaculada; Levican, Gloria; Gonzalez-Nilo, Fernando D.; Ravanal, Maria-Cristina; Chavez, Renato Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
A method for characterizing the thermal stability and antimicrobial binding to Lipopolysaccharides of Gram-negative isogenic mutant strains Navarro, Belen; Alarcon, Mackarenna; Osees, Maricarmen; Gomez-Alvear, Felipe; Sepulveda, Romina, V; Huerta, Jaime; Cecilia Opazo, Maria; Aguayo, Daniel Article ISI METHODSX (2021)
A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids Steinberg, Ximena; Galpin, Jason; Nasir, Gibran; Sepulveda, Romina, V; Ladron de Guevara, Ernesto; Gonzalez-Nilo, Fernando; Islas, Leon D.; Ahern, Christopher A.; Brauchi, Sebastian E. Article ISI HELIYON (2020)
Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin Duarte, Yorley; Caceres, Javier; Sepulveda, Romina V.; Arriagada, Diego; Olivares, Pedro; Diaz-Franulic, Ignacio; Stehberg, Jimmy; Gonzalez-Nilo, Fernando Article ISI FRONTIERS IN PHARMACOLOGY (2020)
The molecular nature of the 17 beta-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel beta 1 subunit Granados S.T.; Castillo K.; Bravo-Moraga F.; SepÃºlveda R.V.; Carrasquel-Ursulaez W.; Rojas M.; Carmona E.; Lorenzo-Ceballos Y.; GonzÃ¡lez-Nilo F.; GonzÃ¡lez C.; Latorre R.; Torres Y.P. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Heterologous expression, purification and characterization of three novel esterases secreted by the lignocellulolytic fungus Penicillium purpurogenum when grown on sugar beet pulp Oleas, G; Callegari, E.; Sepúlveda R.V., and Eyzaguirre J. Article CARBOHYDRATE RESEARCH (2017)
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase Rubat, Sebastián; Varas, Ignacio; Sepúlveda, Romina; Almonacid, Daniel; González-Nilo, Fernando; Agosin, Eduardo Article ISI FEMS YEAST RESEARCH (2017)
MOLECULAR DETERMINANTS OF BK CHANNEL FUNCTIONAL DIVERSITY AND FUNCTIONING Latorre, Ramon; Castillo, Karen; Carrasquel-Ursulaez, Willy; Sepulveda, Romina V.; Gonzalez-Nilo, Fernando; González, Carlos; Alvarez, Osvaldo Article ISI SCOPUS PHYSIOLOGICAL REVIEWS (2017)
Structural determinants of 5 ',6 '-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel Berna-Erro, Alejandro; Izquierdo-Serra, Mercè; Sepúlveda, Romina V.; Rubio-Moscardo, Fanny; Doñate-Macián, Pau; Serra, Selma A.; Carrillo-Garcia, Julia; Perálvarez-Marín, Alex; González-Nilo, Fernando; Fernández-Fernández, José M.; Valverde, Miguel A. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
beta 1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel Castillo J.P.; Sánchez-Rodríguez J.E.; Hyde H.C.; Zaelzer C.A.; Aguayo, D; Sepúlveda R.V.; Luk L.Y.P.; Kent S.B.H.; Gonzalez-Nilo, F. D.; Bezanilla, F; Latorre R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1 Diaz-Franulic, I.; Caceres-Molina, J.; Sepulveda, R. V.; Gonzalez-Nilo, F.; Latorre, R. Article ISI SCOPUS Molecular Pharmacology (2016)
Effects of the Accessory Subunit gamma 1 on the External Architecture of BK Channel Carrasquel-Ursulaez, Willy; Castillo, Juan P.; Lorenzo, Yenisleidy; Sepulveda, Romina; Aguayo, Daniel; Bezanilla, Francisco; Gonzalez-Nilo, Fernando D.; Latorre, Ramon Article ISI BIOPHYSICAL JOURNAL (2015)
Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel Carrasquel-Ursulaez, W; Contreras G.F.; Sepúlveda R.V.; Aguayo, D; Gonzalez-Nilo, F; González C; Latorre R. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2015)
Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels Garcia-Elias, A; Berna-Erro, A; Rubio-Moscardo, F; Pardo-Pastor, C; Mrkonjic, S; Sepulveda, RV; Vicente R.; Gonzalez-Nilo, F; Valverde, MA Article ISI SCOPUS Structure (2015)
Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P-2) Binding to Transient Receptor Potential V1 (TRPV1) Channels Poblete, H.; Oyarzun, I; Olivero P.; Comer, J.; Zúñiga M; Sepúlveda R.V.; Baez-Nieto, D; Leon, C.G; Gonzalez-Nilo, F; Latorre R. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels Diaz-Franulic, I; Sepulveda, RV; Navarro-Quezada, N; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Journal of General Physiology (2015)
Substitutions at F380 in S6 by Small Hydrophobic Amino Acids Makes the Opening Transition in BK Channels Rate Limiting Carrasquel-Ursulaez, Willy; Contreras, Gustavo F.; Sepulveda, Romina; Aguayo, Daniel; Gonzalez-Nilo, Fernando D.; Gonzalez, Carlos; Latorre, Ramon Article ISI BIOPHYSICAL JOURNAL (2014)
Turning a Small into Large Conductance K-Channel - How Far Can We Go? Diaz-Franulic, Ignacio; Navarro, Nieves; Gonzalez-Nilo, Fernando; Sepulveda, Romina V.; Naranjo, David Article ISI BIOPHYSICAL JOURNAL (2014)
K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance Moscoso, C.; Vergara-Jaque, A; Marquez-Miranda, V; Sepúlveda R.V.; Valencia I.; Diaz-Franulic, I; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Biophysical Journal (2012)


Thermal Diffusion Pathways of TRPV1 Gonzalez-Nilo, FD; Diaz-Franulic, I; Sepulveda, RV; Gomez-Becerra, FA; Mino-Galazi, G; Latorre, R Abstract ISI BIOPHYSICAL JOURNAL (2018)
17 beta-Estradiol Binds and Modulates BK Channel through its beta 1 Auxiliary Subunit Granados, ST; Bravo, F; Sepulveda, R; Gonzalez-Nilo, D; González, J; Latorre, R; Torres, Y Abstract ISI BIOPHYSICAL JOURNAL (2016)
Structural Characterization of Ligand-Specific Interactions in TRPV1 Channel: Gating Mechanism by Capsaicin and Capsazepine Gonzalez-Nilo, FD; Caceres-Molina, J; Bravo-Moraga, F; Sepulveda, R; Diaz-Franulic, I Abstract ISI BIOPHYSICAL JOURNAL (2016)
Rational discovery of new capsaicin analogues as TRPV1 activators Caceres J.; sepulveda, r; Navas C.; Latorre R.; Gonzalez-Nilo, F Abstract ISI BMC BIOINFORMATICS (2015)