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Carolina Andrea Flores Muñoz

Investigador Postdoctoral

Universidad de Valparaíso

Valparaíso, Chile

Synaptic Plasticity, Neuronal cytoskeleton, Actin cytoskeleton dynamics, Synaptopathies, Pannexins, Rho GTPases, Inflammation, Skin wound healing, Tissue Engineer.

Licenciatura en Ciencias mención Biología, UNIVERSIDAD DE VALPARAISO. Chile, 2012
Magister en Ciencias Biológicas mención Neurociencia, UNIVERSIDAD DE VALPARAISO. Chile, 2016
Doctorado en Ciencias mención Neurociencia, UNIVERSIDAD DE VALPARAISO. Chile, 2022

Profesor Asistente Laboratorio Other

UNIVERSIDAD DE VALPARAISO

Valparaíso, Chile

2018 - 2019
Visiting Researcher Full Time

LEIBNIZ INSTITUTE FOR NEUROSCIENCE

Magdeburgo, Alemania

2021 - 2022

Investigador Postdoctoral Full Time

Universidad de Valparaíso

Valparaíso, Chile

2022 - At present
Investigador Asistente Full Time

Universidad de Valparaíso

Valparaíso, Chile

2021 - 2022
Investigador Asistente Full Time

Universidad de Valparaíso

Valparaíso, Chile

2013 - 2017
Visiting Researcher Full Time

LEIBNIZ INSTITUTE FOR NEUROSCIENCE

Magdeburg, Alemania

2021 - 2022
Investigador Asistente Part Time

Universidad de Valparaíso

Valparaíso, Chile

2012 - 2013

Beca de Doctorado Nacional CONICYT

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2018

Beca nº 21190247


Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti Abbott, Ana C.; Garcia, Isaac E.; Villanelo, Felipe; Flores-Munoz, Carolina; Ceriani, Ricardo; Maripillan, Jaime; Novoa-Molina, Joel; Figueroa-Cares, Cindel; Perez-Acle, Tomas; Saez, Juan C.; Sanchez, Helmuth A.; Martinez, Agustin D. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons Flores-Munoz, Carolina; Garcia-Rojas, Francisca; Perez, Miguel A.; Santander, Odra; Mery, Elena; Ordenes, Stefany; Illanes-Gonzalez, Javiera; Lopez-Espindola, Daniela; Gonzalez-Jamett, Arlek M.; Fuenzalida, Marco; Martinez, Agustin D.; Ardiles, Alvaro O. Article ISI CELLS (2022)
Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling Flores-Munoz, Carolina; Maripillan, Jaime; Vasquez-Navarrete, Jacqueline; Novoa-Molina, Joel; Ceriani, Ricardo; Sanchez, Helmuth A.; Abbott, Ana C.; Weinstein-Oppenheimer, Caroline; Brown, Donald I.; Cardenas, Ana Maria; Garcia, Isaac E.; Martinez, Agustin D. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease Flores-Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; Lopez-Espíndola, Daniela; Durán-Aniotz, Claudia; Hetz, Claudio; Muñoz, Pablo; Gonzalez-Jamett, Arlek M.; Ardiles, Álvaro O. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2020)
The interplay between alpha 7 nicotinic acetylcholine receptors, pannexin-1 channels and P2X7 receptors elicit exocytosis in chromaffin cells Maldifassi, Maria C.; Momboisse, Fanny; Guerra, Maria J.; Vielma, Alex H.; Maripillan, Jaime; Baez-Matus, Ximena; Flores-Munoz, Carolina; Cadiz, Barbara; Schmachtenberg, Oliver; Martinez, Agustin D.; Cardenas, Ana M. Article ISI JOURNAL OF NEUROCHEMISTRY (2020)
The interplay between α7 nACh receptors, pannexin-1 channels and P2X7 receptors elicit exocytosis in chromaffin cells Maldifassi, María C.; Momboisse, Fanny; Guerra, María J.; Vielma, Alex H.; Maripillán, Jaime; Báez-Matus, Ximena; Flores-Muñoz, Carolina; Cádiz, Bárbara; Schmachtenberg, Oliver; Martínez, Agustín D.; Cárdenas, Ana M. Article JOURNAL OF NEUROCHEMISTRY (2020)
Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice Gajardo, Ivana; Salazar, Claudia S.; Lopez-Espindola, Daniela; Estay, Carolina; Flores-Munoz, Carolina; Elgueta, Claudio; Gonzalez-Jamett, Arlek M.; Martinez, Agustin D.; Munoz, Pablo; Ardiles, Alvaro O Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Connexinopathies: a structural and functional glimpse García, Isaac E.; Prado, Pavel; Pupo, Amaury; Jara, Oscar; Rojas-Gómez, Diana; Mujica, Paula; Flores-Muñoz, Carolina; González-Casanova, Jorge; Soto-Riveros, Carolina; Pinto, Bernardo I.; Retamal, Mauricio A.; González, Carlos; Martínez, Agustín D. Article ISI SCOPUS BMC CELL BIOLOGY (2016)
Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells Momboisse F.; Olivares, MJ; Baez-Matus X; Guerra MJ; Flores-Munoz, C; Sáez JC; Martínez AD; Cárdenas AM Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice Ardiles, AO, Flores C, Ahumada J, Monyer H, Cárdenas, AM, Palacios AG, Muñoz-Carvajal P, Sáez JC, Fuenzalida M, Martínez AD. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)


Mechanism of plasma membrane permeabilization induced by syndromic deafness mutations of Cx26. FONDEF (1130855) Proyecto 2017-2020 Personal técnico y/o de apoyo
A Novel Role Of Pannexin 1 Channels In The Synaptopathy Associated To The Soluble Amyloid-b Oligomers In Alzheimer´s Disease. FONDECYT (11150776) Proyecto 2015-2018 Personal técnico y/o de apoyo
Panexina 1=> un nuevo actor en los mecanismos patológicos asociados a la enfermedad de Alzheimer. PAI (79150045) Proyecto 2015-2018 Personal técnico y/o de apoyo
MECHANISM OF PLASMA MEMBRANE PERMEABILIZATION INDUCED BY SYNDROMIC DEAFNESS MUTATIONS OF CX26. FONDECYT (1130855) Proyecto 2013-2016 Personal técnico y/o de apoyo
ROL DE PANEXINA 1 EN LA FISIOLOGIA SINAPTICA. FONDECYT (3130759) Proyecto 2013-2015 Personal técnico y/o de apoyo
VOLTAGE SENSOR OF ION CHANNELS=> FROM STRUCTURE TO FUNCTION. PIA (ACT1104) Proyecto 2012-2015 Personal técnico y/o de apoyo
INICIATIVA CIENTÍFICA MILENIO=> CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA DE VALPARAÍSO Ministerio de Economía, Fomento y Turismo de Chile (ICM- P09-022-F) Proyecto 2009-2020 Personal técnico y/o de apoyo


From Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome Garcia, IE; Bosen, F; Mujica, P.; Pupo, A; Flores-Munoz, C; Jara O.; González C; Willecke K.; Martínez AD Review ISI SCOPUS JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)