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Rodrigo Andrés Herrera Molina

Group Leader (staff member)

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1) Synaptic mechanisms of learning and memory and amnesia and linked to calcium homeostasis and neuronal signalling 2) Novel bio-nanomaterials for neuronal recording in vitro and in vivo 3) Novel biopeptides for treating inflammation and amnesia

Biomedical Science / Neurobiology, UNIVERSIDAD DE CHILE. Chile, 2010
Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004
EMBO Laboratory Leadership, EMBO Solutions GmbH. Alemania, 2019
Advanced training course for gene technology, BioMed Concept GmbH. Alemania, 2018

Lecturer for Neuroscience PhD students Other

Universidad de los Andes

Santiago, Chile

2014 - At present
Lecturer for Neuroscience MSc and PhD students Other

Universidad Bernardo O’Higgins

Santiago, Chile

2018 - At present
Lecturer for Neuroscience MSc students Other

Otto von Guericke University

Magdeburg, Alemania

2014 - At present

PhD Student Full Time

Universidad de Chile

Santiago, Chile

2006 - 2010
Postdoctoral Researcher Full Time

Leibniz Institute for Neurobiology

Magdeburg, Alemania

2012 - 2016
Lecturer for Neuroscience PhD students Other

Universidad de los Andes

Santiago, Chile

2014 - At present
Invited Guest Scientist Other

Universidad Bernardo O’Higgins

Santiago, Chile

2017 - At present
Co-Group Leader Full Time

Leibniz Institute for Neurobiology

Magdeburg, Alemania

2017 - 2017
Group Leader (staff member) Full Time

Leibniz Institute for Neurobiology

Magdeburg, Alemania

2018 - At present
Group Leader Full Time

Leibniz Institute for Neurobiology

Magdeburg, Alemania

2019 - At present
Associated Reasearcher Part Time

Universidad Bernardo O'Higgins

Santiago, Chile

2020 - At present

Supervision of students (MSc, MD, and PhD):
2021 – Currently Liang Yi, M.D. Master student
2020 – Currently Harini Srinivasan, MSc thesis
2017 – Currently Ayse Malci, PhD thesis
2016 – Currently Xiao Lin, PhD thesis

Former students supervised (last 5 years only):
2018 Benedikt Auer MSc and Lennart Junge, M.D.
2017 Sampath Vemula, PhD
2016 Ting Jiao, MSc and Abaya Prakash, MSc

Hugo Junkers Award 2020

State of Saxony-Anhalt, Germany

Alemania, 2020

Category: “Most innovative approaches in basic research” (3er place)
Hugo Junkers Award 2016

State of Saxony-Anhalt, Germany

Alemania, 2016

Category: “Most innovative approaches in basic research” (2nd place)
Young Investigator Colloquia Award

International Society for Neurochemistry

Canada, 2019

Young Investigators Colloquia: Signalling, development and disease: “Neuroplastins are essential for synapse formation and memory: Is the Neuroplastin-PMCA-dependent Ca2+ regulation a mechanism for these functions?”


Neuroplastin expression is essential for hearing and hair cell PMCA expression Lin X; Brunk MGK; Yuanxiang P; Curran AW; Zhang E; Stöber F; Goldschmidt J; Gundelfinger ED; Vollmer M; Happel MFK; Herrera-Molina, R Article BRAIN STRUCTURE AND FUNCTION (2021)
Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation Garcia, Francisca; Lobos, Pedro; Ponce, Alejandra; Cataldo, Karla; Meza, Daniela; Farias, Patricio; Estay, Carolina; Oyarzun-Ampuero, Felipe; Herrera-Molina, Rodrigo; Paula-Lima, Andrea; Ardiles, Alvaro O.; Hidalgo, Cecilia; Adasme, Tatiana; Munoz, Pablo Article ISI Marine Drugs (2020)
Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity Luarte, Alejandro; Henzi, Roberto; Fernandez, Anllely; Gaete, Diego; Cisternas, Pablo; Pizarro, Matias; Batiz, Luis Federico; Villalobos, Isabel; Masalleras, Matias; Vergara, Rodrigo; Varas-Godoy, Manuel; Abarzua-Catalan, Lorena; Herrera-Molina, Rodrigo; Lafourcade, Carlos; Wyneken, Ursula Article ISI CELLS (2020)
Electrochemical Roughening and Carbon Nanotube Coating of Tetrodes for Chronic Single-Unit Recording Xia Z; Arias-Gil G; Deckert M; Vollmer M; Curran A; Herrera-Molina, R; Brosch M; Krug K; Schmidt, B.; Ohl FW; Lippert MT Article Preprint Article bioRxiv (2020)
The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development Vemula, Sampath Kumar; Malci, Ayse; Junge, Lennart; Lehmann, Anne-Christin; Rama, Ramya; Hradsky, Johannes; Matute, Ricardo A.; Weber, Andre; Prigge, Matthias; Naumann, Michael; Kreutz, Michael R.; Seidenbecher, Constanze I.; Gundelfinger, Eckart D.; Herrera-Molina, Rodrigo Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity? Ilic, Katarina; Auer, Benedikt; Mlinac-Jerkovic, Kristina; Herrera-Molina, Rodrigo Article ISI SCOPUS FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)
Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition Lang D.; Schott, BH; van Ham, M; Morton, L; Kulikovskaja, L; Herrera-Molina, R; Pielot, R; Klawonn, F; Montag, D; Jansch, L; Gundelfinger ED; Smalla, KH; Dunay, IR Article ISI SCOPUS JOURNAL OF NEUROINFLAMMATION (2018)
Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration Lagos-Cabre, R; Brenet, M.; Diaz, J; Perez, RD; Perez, LA; Herrera-Molina, R; Quest, AFG; Leyton, L Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K Bruna, Barbara; Lobos, Pedro; Herrera-Molina, Rodrigo; Hidalgo, Cecilia; Paula-Lima, Andrea; Adasme ,Tatiana Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation Thomas, Ulrich; Naumann, Michael; Korthals, Mark; Seidenbecher, Constanze; Smalla, Karl-Heinz; Zuschratter, Werner; Herrera-Molina, Rodrigo; Tedford, Kerry; Lehmann, Anne-Christin; Gundelfinger, Eckart D.; Langnaese, Kristina; Montag, Dirk; Handschuh, Juliane; Fischer, Klaus-Dieter; Kahne, Thilo; Mamula, Dejan Article ISI SCIENTIFIC REPORTS (2017)
alpha(V)beta(3) Integrin regulates astrocyte reactivity Lagos-Cabré R.; Alvarez A.; Kong M.; Burgos-Bravo F.; Cárdenas A.; Rojas-Mancilla E.; Pérez-Nuñez R.; Herrera-Molina R.; Rojas F.; Schneider P.; Herrera-Marschitz M.; Quest A.F.G.; van Zundert B.; Leyton L. Article ISI SCOPUS JOURNAL OF NEUROINFLAMMATION (2017)
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway Maldonado, H.; Calderon, C.; Burgos-Bravo, F.; Kobler, O.; Zuschratter, W.; Ramirez, O.; H?rtel, S.; Schneider, P.; Quest, A.F.G.; Herrera-Molina, R.; Leyton, L. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation Bhattacharya, Soumee; Herrera-Molina, Rodrigo; Sabanov, Victor; Ahmed, Tariq; Iscru, Emilia; Stoeber, Franziska; Richter, Karin; Fischer, Klaus-Dieter; Angenstein, Frank; Goldschmidt, Juergen; Beesley, Philip W.; Balschun, Detlef; Smalla, Karl-Heinz; Gundelfinger, Eckart D.; Montag, Dirk Article ISI BIOLOGICAL PSYCHIATRY (2017)
Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration Montag, Dirk; Milosevic, Natasa Jovanov; Herrera-Molina, Rodrigo; Simic, Goran; Ilic, Katarina; Smalla, Karl-Heinz; Vemula, Sampath Kumar; Goldschmidt, Juergen; Mlinac-Jerkovic, Kristina; Bognar, Svjetlana Kalanj; Sandoval, Mauricio; Stoeber, Franziska Article ISI SCIENTIFIC REPORTS (2017)
Structure of Excitatory Synapses and GABAA Receptor Localization at Inhibitory Synapses Are Regulated by Neuroplastin-65 Herrera-Molina, R; Sarto-Jackson, I; Montenegro-Venegas, C; Heine M.; Smalla, KH; Seidenbecher, CI; Beesley, PW; Gundelfinger ED; Montag, D Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment Sandoval M.; Luarte, A; Herrera-Molina, R; Varas-Godoy, M; Santibañez M.; Rubio, FJ; Smit, AB; Gundelfinger ED; Li, KW; Smalla, KH; Wyneken, U Article ISI SCOPUS Brain Research (2013)
Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of alpha v beta(3) integrin and syndecan-4 Kong M.; Muñoz, N.; Valdivia, A; Alvarez A.; Herrera-Molina, R; Cardenas, A; Schneider, P.; Burridge, K; Quest, AFG; Leyton, L Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2013)
Astrocytic alpha(V)beta(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1 Herrera-Molina, R; Frischknecht R.; Maldonado, H.; Seidenbecher C.I.; Gundelfinger E.D.; hetz C.; de la Luz Aylwin M.; Schneider, P.; Quest, A.F.G.; Leyton, L Article ISI SCOPUS PLOS ONE (2012)
Modulation of interferon-gamma-induced glial cell activation by transforming growth factor beta 1: A role for STAT1 and MAPK pathways Herrera-Molina, R; Flores, B; Orellana J.A.; von Bernhardi R. Article ISI SCOPUS Journal of Neurochemistry (2012)
The Cell Adhesion Molecule Neuroplastin-65 Is a Novel Interaction Partner of gamma-Aminobutyric Acid Type A Receptors Sarto-Jackson, Isabella; Milenkovic, Ivan; Smalla, Karl-Heinz; Gundelfinger, Eckart D.; Kaehne, Thilo; Herrera-Molina, Rodrigo; Thomas, Sabine; Kiebler, Michael A.; Sieghart, Werner Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation Henríquez M; Herrera-Molina, R; Valdivia, A; Alvarez A.; Kong M.; Muñoz, N.; Eisner V.; Jaimovich E.; Schneider, P.; Quest, AFG; Leyton, L Article ISI SCOPUS Journal of Cell Science (2011)
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v beta 3 integrin that activates PKC alpha and RhoA Avalos, AM; Valdivia, AD; Muñoz, N.; Herrera-Molina, R; Tapia, JC; Lavandero S.; Chiong M.; Burridge, K; Schneider, P.; Quest, AFG; Leyton, L Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2009)
REDUCTION OF beta-AMYLOID-INDUCED NEUROTOXICITY ON HIPPOCAMPAL CELL CULTURES BY MODERATE ACIDOSIS IS MEDIATED BY TRANSFORMING GROWTH FACTOR beta Martin, RUS; Herrera-Molina, R; Olavarria, L.; Ramirez G.; von Bernhardi R. Article ISI SCOPUS NEUROSCIENCE (2009)
Direct Thy-1/alpha(V)beta(3) integrin interaction mediates neuron to astrocyte communication Hermosilla T.; Muñoz D; Herrera-Molina, R; Valdivia, A; Muñoz, N.; Nham, SU; Schneider, P.; Burridge, K; Quest, AFG; Leyton, L Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
Pro- and anti-inflammatory cytokines regulate the ERK pathway: Implication of the timing for the activation of microglial cells Saud, K; Herrera-Molina, R; von Bernhardi R. Article ISI NEUROTOXICITY RESEARCH (2005)
Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture Herrera-Molina, R; von Bernhardi R. Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2005)


Csk-Binding-Protein mediates Thy-1 signaling and neurite retraction caused by astrocyte alpha v beta 3 integrin in neuronal cultures. Maldonado, H.; Leyton, L; Quest, A; Herrera-Molina, R Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
POSSIBLE ROLE FOR THY-1/ALPHAVBETA3 INTEGRIN: INHIBITION OF NEURITE OUTGROWTH BY CELL-CELL CONTACT BETWEEN NEURONS AND ASTROCYTES Herrera-Molina, R; Quest, AF; Leyton, L Abstract ISI JOURNAL OF NEUROCHEMISTRY (2009)


Electrode device, electrophysiological recording system and computer program Takagaki K; Lippert M; Zifeng X; Herrera-Molina, R Patent Patent Pending. See related Preprint at https://www.biorxiv.org/content/10.1101/738245v2.full


"NeuroReact" Croatian Science Fundation (HRZZ-IP-2016-06-8636) Proyecto 2018-2021 Coinvestigador(a)
Präsynaptische Funktionen von Neuroplastin - Implikationen für Endo- und Exocytose und den Exocyst-Komplex (Neuroplastin goes presynaptic - implications for endo-/exocytosis and the exocyst complex) BMDF _ Germany ("PrePLASTic") Proyecto 2017-2020 Investigador(a)
THY-1/AVB3 INTEGRIN INTERACTION ACTIVATES BIDIRECTIONAL SIGNALING PATHWAYS INVOLVING PKCA AND RHO GTPASES IN BOTH ASTROCYTES AND NEURONS FONDECYT (1070699) Proyecto 2007-2011 Tesista
"SIGNALING MECHANISMS TRIGGERED BY THE INTERACTION BETWEEN THY-1 AND AvB3 INTEGRIN=> AN ESSENTIAL STEP TOWARDS UNRAVELING THY-1 FUNCTION IN NEURONS AND ASTROCYTES". FONDECYT (1040390) Proyecto 2004-2007 Tesista
SENESCENCIA E INFLAMACION=> FACTORES DESENCADENANTES O MODULADORES DE LA NEURODEGENERACION? UNA PROPOSICION EXPERIMENTAL PARA EVALUAR SU RELEVANCIA EN LA PATOGENIA DE LA ENFERMEDAD DE ALZHEIMER. FONDECYT (1040831) Proyecto 2004-2008 Personal técnico y/o de apoyo
LA GLIA EN LA ENFERMEDAD DE ALZHEIMER=> SU PARTICIPACION EN EL PROCESAMIENTO DEL APP Y SUS DERIVADOS FONDECYT (1010146) Proyecto 2001-2004 Tesista


The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function Beesley, PW; Herrera-Molina, R; Smalla, KH; Seidenbecher, C Review ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2014)
Thy-1-Interacting Molecules and Cellular Signaling in Cis and Trans Herrera-Molina, R; Valdivia, A; Kong M.; Alvarez A.; Cardenas, A; Quest, AFG; Leyton, L Review ISI SCOPUS International Review of Cell and Molecular Biology (2013)

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

ARELI CÁRDENAS

Académica e Investigadora

Universidad Bernardo O'Higgins

Santiago, Chile

Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Pedro Lobos

Posdoctoral Research

Universidad de Chile

Santiago, Chile

Alejandro Luarte

Profesor Investigador

Neurociencias

Universidad de Los Andes

santiago, Chile

Felipe Oyarzún

Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

Leonardo Pérez

Investigador docente

Universidad de Chile

Santiago, Chile

Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Raúl Lagos

Research associate

Department of Pharmacology

University of Cambridge

Cambridge, Reino Unido

Katherine Saud

Lab Manager

Terapia Celular

Bioscell S.A.

Santiago, Chile

Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Rodrigo Vergara

Investigador

Psicología

Universidad San Sebastián

Valdivia, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

Ricardo Matute

Academic Faculty

Departamento de Química

Universidad Técnica Federico Santa María

Valparaíso, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Omar Ramírez

Postdoc

UNIVERSITAT HEIDELBERG

Heidelberg, Alemania

Matías Pizarro

research assistant

Psicología

Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez.

Santiago, Chile

Rodrigo Andrés Herrera Molina

Líneas de Investigación

Educación

Biomedical Science / Neurobiology, UNIVERSIDAD DE CHILE. Chile, 2010

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004

EMBO Laboratory Leadership, EMBO Solutions GmbH. Alemania, 2019

Advanced training course for gene technology, BioMed Concept GmbH. Alemania, 2018

Experiencia Académica

Lecturer for Neuroscience PhD students Other

Lecturer for Neuroscience MSc and PhD students Other

Lecturer for Neuroscience MSc students Other

Experiencia Profesional

PhD Student Full Time

Postdoctoral Researcher Full Time

Lecturer for Neuroscience PhD students Other

Invited Guest Scientist Other

Co-Group Leader Full Time

Group Leader (staff member) Full Time

Group Leader Full Time

Associated Reasearcher Part Time

Formación de Capital Humano

Premios y Distinciones

Hugo Junkers Award 2020

Hugo Junkers Award 2016

Young Investigator Colloquia Award

Article (26)

Abstract (2)

Patent (1)

Proyecto (6)

"NeuroReact"

Präsynaptische Funktionen von Neuroplastin - Implikationen für Endo- und Exocytose und den Exocyst-Komplex (Neuroplastin goes presynaptic - implications for endo-/exocytosis and the exocyst complex)

THY-1/AVB3 INTEGRIN INTERACTION ACTIVATES BIDIRECTIONAL SIGNALING PATHWAYS INVOLVING PKCA AND RHO GTPASES IN BOTH ASTROCYTES AND NEURONS

"SIGNALING MECHANISMS TRIGGERED BY THE INTERACTION BETWEEN THY-1 AND AvB3 INTEGRIN=> AN ESSENTIAL STEP TOWARDS UNRAVELING THY-1 FUNCTION IN NEURONS AND ASTROCYTES".

SENESCENCIA E INFLAMACION=> FACTORES DESENCADENANTES O MODULADORES DE LA NEURODEGENERACION? UNA PROPOSICION EXPERIMENTAL PARA EVALUAR SU RELEVANCIA EN LA PATOGENIA DE LA ENFERMEDAD DE ALZHEIMER.

LA GLIA EN LA ENFERMEDAD DE ALZHEIMER=> SU PARTICIPACION EN EL PROCESAMIENTO DEL APP Y SUS DERIVADOS

Review (2)