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Horacio Javier Maldonado Lorca

Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2015
Proteinas recombinantes , UNIVERSIDAD DE CHILE. Chile, 2009
Bioquimico, UNIVERSIDAD DE CHILE. Chile, 2008

Posdoctoral Reseach Associate Full Time

UNIVERSITY OF LIVERPOOL

Liverpool, Reino Unido

2016 - 2019
Posdoctoral Reseach Associate Full Time

UNIVERSITY OF LIVERPOOL

Liverpool, Reino Unido

2021 - 2024


A trafficking regulatory subnetwork governs α<sub>V</sub>β<sub>6</sub> integrin-HER2 cross-talk to control breast cancer invasion and drug resistance Maldonado, Horacio; Dreger, Marcel; Bedgood, Lara D.; Kyriakou, Theano; Wolanska, Katarzyna I.; Rigby, Megan E.; Marotta, Valeria E.; Webster, Justine M.; Wang, Jun; Rusilowicz-Jones, Emma V.; et al. Article ISI SCIENCE ADVANCES (2024)
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function Maldonado, Horacio; Savage, Bryan D.; Barker, Harlan R.; May, Ulrike; Vahatupa, Maria; Badiani, Rahul K.; Wolanska, Katarzyna I.; Turner, Craig M. L.; Pemmari, Toini; Ketomaki, Tuomo; et al. Article ISI NATURE COMMUNICATIONS (2023)
Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells Valdivia, Alejandra; Brenet, Marianne; Maldonado, Horacio; Kong, Milene; Burridge, Keith; Schneider, Pascal; Garcia-Mata, Rafael; Leyton, Lisette Article ISI SCOPUS Cell Communication and Signaling (2020)
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway Maldonado H.; Kobler, O.; Zuschratter, W.; Schneider P. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)
Signaling Pathways Involved in Neuron-Astrocyte Adhesion and Migration CÃ¡rdenas A.; Kong M.; Álvarez, A; Maldonado H.; Leyton L. Article ISI CURRENT MOLECULAR MEDICINE (2014)
Astrocytic alpha(V)beta(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1 Herrera-Molina R.; Frischknecht R.; Maldonado H.; Hetz C.; de la Luz Aylwin M.; Schneider P.; Leyton L. Article ISI SCOPUS PLOS ONE (2012)
Inhibition of Cyclin-Dependent Kinase 5 but Not of Glycogen Synthase Kinase 3-beta Prevents Neurite Retraction and Tau Hyperphosphorylation Caused by Secretable Products of Human T-Cell Leukemia Virus Type I-Infected Lymphocytes Maldonado H.; Ramírez E; Utreras E.; Pando M.E.; Chiong M; Collados, L; Puente, J; Cartier, L; Valenzuela M.A. Article ISI SCOPUS Journal of Neuroscience Research (2011)
Comparative Study of CSF Neurofilaments in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis and Other Neurological Disorders Alberti C.; González, J; Maldonado H.; Medina F.; Barriga A.; Garcia L.; Kettlun, A; Collados, L; Puente, J; Cartier, L; et al. Article ISI SCOPUS AIDS RESEARCH AND HUMAN RETROVIRUSES (2009)
Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis associated with HTLV-I infection and in SH-SY5Y cells: An in vitro model of HTLV-I-induced disease Maldonado H.; Ortiz-Riano, E; Krause B.; Barriga A.; Medina F.; Pando, M E; Alberti C.; Kettlun A.M.; Collados, L; Garcia L.; et al. Article SCOPUS Biological Research (2008)


Exposure to the pro-inflammatory prostaglandin E2 disrupts E-cadherin/Caveolin1-mediated tumor suppression to favor Caveolin-1 enhanced migration, invasion and metastasis of melanoma cells Lobos-GonzÃ¡lez L.; Oróstica, L; Natalia, D; Rojas, VM; Campos A.; Farfán, N; Silva, V; Maldonado H.; Leyton L.; Quest A.F. Abstract ISI (2022)
Anti-neoplastic drugs at sub lethal doses augment caveolin-1 expression and caveolin-1 dependent migration and invasion of cancer cells. Diaz N.; Calderon C.; Diaz J.; Maldonado H.; Castillo J.; Ortiz R.; Leyton L.; Quest, A. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Csk-Binding-Protein mediates Thy-1 signaling and neurite retraction caused by astrocyte alpha v beta 3 integrin in neuronal cultures. Maldonado H.; Leyton L.; Quest, A.; Herrera-Molina R. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Inhibition of CDK5 but not of GSK3-? Prevents Neurite Retraction and Tau Hyperphophorylation Caused by Secretable Products of MT-2 Cells Maldonado H.; Pando M.E.; Ramírez E; Collados, L; Cartier, L; Valenzuela M.A. Abstract ISI AIDS RESEARCH AND HUMAN RETROVIRUSES (2009)
Neurite Outgrowth Delay and Retraction of PC12 Cells Cocultured with HTLV-1 infected Cells MT2 Pando M.E.; Maldonado H.; Ramírez E; Collados, L; Cartier, L; Valenzuela M.A. Abstract ISI AIDS RESEARCH AND HUMAN RETROVIRUSES (2009)


CSK-mediated signalling by integrins in cancer Maldonado, Horacio; Leyton, Lisette Review ISI SCOPUS Frontiers in Cell and Developmental Biology (2023)
Cooperative signaling between integrins and growth factor receptors in fibrosis Maldonado, Horacio; Hagood, James S. Review ISI JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

3

Eugenio Ramírez

INSTITUTO DE SALUD PÚBLICA DE CHILE

Santiago, Chile

2

ANDRES BARRIGA

Profesional

CEPEDEQ

UNIVERSIDAD DE CHILE

Santiago, Chile

1

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

5

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2

Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

4

Lisette Leyton

Full Professor

Núcleo Interdisciplinario Biología y Genética

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1

ARELI CÁRDENAS

Académica e Investigadora

Universidad Bernardo O'Higgins

Santiago, Chile

1

Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1

MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

1

Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

3

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1

Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

2

Maria Pando

Profesor asistente

Nutrición

Universidad de Chile

Santiago, Chile

2

Maria Valenzuela

Profesor TItular

Bioquimica y Biología Molecular

Universidad de Chile

Santiagao, Chile

1

Omar Ramírez

Postdoc

UNIVERSITAT HEIDELBERG

Heidelberg, Alemania

1

ALEJANDRA SAN MARTIN

Professor

Medicine

Universidad Andrés Bello

Santiago, Chile

16

Horacio Maldonado