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Natalia Isabel Diaz Valdivia

Postdoctoral Fellow

Universidad de Barcelona

Barcelona , España

Biochemistry /Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007
Biochemistry / Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2010
Biochemistry / Bioquímica , UNIVERSIDAD DE CHILE. Chile, 2016

Undergraduate Thesis Student / Tesista de Pregrado Full Time

Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

Santiago, Chile

2008 - 2010
Research Assistant / Asistente de Laboratorio Full Time

Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

Santiago, Chile

2010 - 2011
Graduate Student, PhD Thesis / Tesista de Doctorado Full Time

Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile.

Santiago, Chile

2011 - 2016
Postdoctoral Fellow / Investigador Postdoctoral Full Time

Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile.

Santiago, Chile

2016 - 2018
Postdoctoral Fellow / Investigador Postdoctoral Full Time

Universidad de Barcelona

Barcelona , España

2018 - At present
International PhD Student Fellow Full Time

Linus Pauling Institute, Oregon State University.

Corvallis, Oregon , Estados Unidos

2014 - 2015

Best Poster Prize

Biochemical Journal and Advanced Center for Chronic Diseases (ACCDiS)

Chile, 2016

Best Poster Prize presented in the ACCDiS Cancer Spring Symposium 2016, 7-9 September 2016, Olmué, Chile given by the Biochemical Journal.


Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells Ortiz, Rina; Leyton, Lisette Article CiteScore 4.42; Impact Factor 4.825 Biochemical Pharmacology (2020)
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis DÃaz-Valdivia N.I.; Burgos-Ravanal R.A.; Torres, VA Article ISI SCOPUS ONCOGENE (2020)
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells MartÃnez-Meza S.; Sandoval-BÃ³rquez A.; Huilcaman, R.; Ocaranza, MP Article ISI SCOPUS CANCERS (2019)
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress Rothermel, BA; Hill, JA Article ISI CELL DEATH AND DIFFERENTIATION (2019)
Stromal Markers of Activated Tumor Associated Fibroblasts Predict Poor Survival and Are Associated With Necrosis in Non-Small Cell Lung Cancer Carrasco, JL; Millares, L; Luis, IC; Fernandez-Porras, FJ; Martinez-romero, A; De Cos, JS; Seijo, L; Pajares JM; Reguart, N; Barreiro, E Article CiteScore: 4.52 Impact Factor: 4.599 5-Year Impact Factor: 4.443 Source Normalized Impact per Paper (SNIP): 1.276 SCImago Journal Rank (SJR): 1.905 LUNG CANCER (2019)
Biomimetic Quantum dot labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis in vivo. Victor M. Diaz-Garcia , Simon Guerrero ; Natalia Díaz-Valdivia , Lorena Lobos-Gonzalez; Johanna Catalan , Marcelo Kogan ; Jose Manuel Perez-Donoso, Andrew F.G Quest Article International Journal of Nanomedicine (2018)
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress Ortiz-Sandoval, Carolina; Rodríguez, Andrea E.; Tahbaz, Nasser; Rothermel, Beverly A; Hill, Joseph A.; Cifuentes, Mariana; Simmen, Thomas; Quest, Andrew, F. G. Article SCOPUS Cell Death and Differentiation (2018)
Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer America Campos , Carlos Salomon ; Rocio Bustos , Jorge Diaz ; Samuel Martinez , Constanza Reyes ; Natalia Diaz-Valdivia , Manuel Varas-Godoy ; Lorena Lobos-Gonzalez, Andrew F.G Quest Article Nanomedicine (2018)
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. Natalia Díaz-Valdivia , Claudia Calderon ; Jorge Diaz , Lorena Lobos-Gonzalez; Hugo Sepulveda , Rina Ortiz ; Samuel Martinez, Veronica Silva ; Horacio Maldonado, Patricio Silva ; Sergio Wehinger , Veronica Burzio ; Vicente A. Torres , Martin Montecino; Lisette Leyton , Andrew F.G Quest Article Oncotarget (2017)
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses Moreau, HD Article ISI SCOPUS Frontiers in immunology (2017)
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses. Cesar Oyarce , Sebastian Cruz-Gomez; Felipe Gálvez-Cancino , Pablo Vargas ; Helene Moreau, Natalia Díaz-Valdivia ; Jorge Díaz , Flavio Salazar-Onfray; Rodrigo Pacheco, Ana Maria Lennon-Dumenil; Andrew F.G Quest, Alvaro Lladser Article Frontiers in Immunology (2017)
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. Rina Ortiz , Jorge Diaz; Natalia Diaz , Lorena Lobos-Gonzalez; Areli Cardenas , Pamela Contreras ; Maria Ines Diaz , Ellen Otte; Justin Cooper-White , Vicente A. Torres ; Lisette Leyton , Andrew F.G Quest Article Oncotarget (2016)
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation Silva, P; Soto, N; Diaz, J; Mendoza, P; Diaz, N; Quest, AFG Article ISI SCOPUS Biochemical and Biophysical Research Communications (2015)
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation. Patricio Silva , Nicolas Soto; Jorge Díaz , Pablo Mendoza ; Natalia Díaz , Andrew F. G. Quest Article Biochemical and Biophysical Research Communications (2015)
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells Natalia Díaz-Valdivia , Denisse Bravo ; Hernan Huerta , Soledad Henriquez ; Fernando Gabler , Margarita Vega; Carmen Romero , Claudia Calderon ; Gareth I. Owen , Lisette Leyton Article BMC Cancer (2015)
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells Diaz-Valdivia, N.; Bravo, D; Huerta, H; Henriquez, S; Gabler, F; Vega, M; Romero, C; Calderon, C; Owen, GI; Leyton, L; et al. Article ISI SCOPUS BMC Cancer (2015)
CAVEOLIN-1 IN CELL MIGRATION AND METASTASIS Sergio Nuñez, Rina J. Ortiz; Natalia Díaz, Jorge Díaz ; Lorena Lobos-Gonzalez, Andrew F. G. Quest Article Current Molecular Medicine (2014)
Molecular insights to a novel Caveolin-1-Rab5-Rac-1 signaling pathway important for metastatic cancer cell migration and invasion Jorge Díaz, Natalia Diaz ; Lisette Leyton , Vicente A. Torres Article Cancer Cell & Microenvironment (2014)
Rab5 is required in metastatic cancer cells for Caveolin-1- enhanced Rac1 activation, migration and invasion Jorge Díaz, Natalia Díaz; Lisette Leyton, Dwayne Stupack; Andrew F. G. Quest, Vicente A. Torres Article Journal of Cell Science (2014)
Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion Diaz, J; Mendoza, P; Ortiz, R; Diaz, N; Leyton, L; Stupack, D. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2014)
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription. Jaime G. Fernandez , David Lemus ; Natalia Díaz , Mathew Wright ; Lisette Leyton , Julio C. Tapia Article Journal Molecular Cancer (2014)
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription Valenzuela,M.; Calderon, C; Urzua, U; Munroe D.; Rosas, C; Lemus D.; Diaz, N; Wright, MC; Leyton, L; Quest, AFG Article ISI SCOPUS MOLECULAR CANCER (2014)
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells Lorena Lobos-Gonzalez, Lorena Aguilar; Jorge Díaz , Natalia Díaz ; Hery Urra, Vicente A Torres ; Veronica Silva , Christopher Fitzpatrick; Alvaro Lladser, Keith S. Hoek; Lisette Leyton , Andrew F. G. Quest Article Pigment Cell Melanoma Research (2013)
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells Lobos-González, L; Aguilar, L; Diaz, J; Diaz, N; Urra, H; Silva, V; Fitzpatrick, C; Lladser, A; Hoek KS; Leyton, L; et al. Article ISI SCOPUS Pigment Cell and Melanoma Research (2013)
Helicobacter pylori-Induced Loss of Survivin and Gastric Cell Viability Is Attributable to Secreted Bacterial Gamma-Glutamyl Transpeptidase Activity Valenzuela,M.; Bravo, D; Canales, J; Sanhueza, C; Diaz, N; Almarza O.; Toledo, H; Quest, AFG Article ISI SCOPUS JOURNAL OF INFECTIOUS DISEASES (2013)
Helicobacter pylori–Induced Loss of Survivin and Gastric Cell Viability Is Attributable to Secreted Bacterial Gamma-Glutamyl Transpeptidase Activity Manuel Valenzuela, Denisse Bravo; Jimena Canales, Carlos Sanhueza; Natalia Diaz, Oscar Almarza; Hector Toledo, Andrew F. G. Quest Article Journal of Infectious Diseases (2013)
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells Urra, H; Torres, VA; Lobos, L; Diaz, N; Härtel, S; Leyton, L Article ISI SCOPUS PLOS ONE (2012)
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells Hery Urra, Vicente A. Torres; Rina J. Ortiz, Lorena Lobos; Marıa I. Dıaz, Natalia Diaz; Steffen Hartel, Lisette Leyton Article Plos One (2012)


Sub-cytotoxic doses of anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells Abstract ISI FEBS JOURNAL (2017)
Anti-neoplastic drugs at sub lethal doses augment caveolin-1 expression and caveolin-1 dependent migration and invasion of cancer cells. Diaz, N; Calderon, C; Diaz, J; Maldonado, H; Castillo, J; Ortiz, R; Leyton, L; Quest, A. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
E-cadherin is a molecular switch for Caveolin-1 function in melanoma cells that synergizes in tumor suppression and blocks Caveolin-1-enhanced metastasis Aguilar, L; Diaz, J; Diaz, N; Urra, H; Lladser, A; Hoek, K; Leyton, L; Quest, A. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)


Phosphatases and exosomes in caveolin-1-mediated metastasis. FONDECYT (1170925) Proyecto 2017-2020 Investigador(a)
Centro de Estudios Avanzados de Enfermedades Crónicas (ACCDIS) FONDAP (15130011) Proyecto 2014-2018 Tesista
The Thy-1 receptors alphavbeta3 integrin and Syndecan-4 on astrocytes control mitochondrial location as well as ATP release and thereby contribute to the neurotoxic effects of reactive astrocytes FONDECYT (1150744) Proyecto 2014-2018 Tesista
caveolin-1 dependent migration of metastasis of cancer cells requires Tyr14 phosphorylation sequestration of p85a and activation Rab5-Rac1 pathway which are inhibited by the expression of E-cadherin FONDECYT (1130250) Proyecto 2013-2017 Tesista
CENTER FOR ADVANCED STUDIES OF CRONIC DISEASES FONDAP (15130011) Proyecto 2013-2018 Tesista
Pro-Inflammatory Stimuli Increase Alphavbeta3 Integrin Expression In Astrocytes, Which Upon Engagement Of Neuronal Thy-1 Triggers Bidirectional-Signaling Events Required For Astrocyte Migration And Axonal Retraction. FONDECYT (1110149) Proyecto 2011-2013 Tesista
Supression of tumor growth by caveolin-1 involved inhibition of unfolded protein response FONDECYT (1090071) Proyecto 2009-2013 Tesista
CENTRO DE ESTUDIOS MOLECULARES DE LA CELULA (CEMC) FONDAP (1501006) Proyecto 2001-2012 Tesista

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

Denisse Bravo

Profesora Titular

Odontología

Universidad Andrés Bello

Santiago, Chile

Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

Lisette Leyton

Full Professor

Núcleo Interdisciplinario Biología y Genética

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Soledad Henriquez

Profesor Asistente

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

LORENA AGUILAR

Assistant Professor

Animal Pathology

Faculty of Veterinary Medicine and Livestock Sciences, University of Chile

Santiago, Chile

Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

Flavio Salazar

Profesor Titular

Oncología Básico Clínica

Universidad de Chile

SANTIAGO, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

oscar almarza

Universidad Mayor

Santiago, Chile

Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

Hery Urra

Staff scientist

INSTITUTO DE NEUROCIENCIA BIOMEDICA (BNI)

Santiago, Chile

Manuel Valenzuela

Académico Investigador

VRA

Universidad Central de Chile

santiago, Chile

Rina Ortiz

Académica Asociada

Universidad Vina del Mar

Viña del Mar, Chile

Alejandra Sandoval

Associate Professor

Faculty of Sciences

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

María Díaz

Part time Professor

Ciencias Quimicas y Biologicas

Universidad Bernado O´higgins

Santiago , Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Maria Ocaranza

Full Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

CARLOS ROSAS

Profesor Asociado

Universidad San Sebastián

Valdivia, Chile

Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

Camila López

Eugenia Diaz

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Cesar Oyarce Diaz

Posdtoc

MMB

UMCG

Groningen, Holanda

Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

Renato Burgos

Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

Ricardo Huilcamán

Investigador

Universidad de Chile

Santiago, Chile

Natalia Isabel Diaz Valdivia

Líneas de Investigación

Educación

Biochemistry /Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007

Biochemistry / Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2010

Biochemistry / Bioquímica , UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Profesional

Undergraduate Thesis Student / Tesista de Pregrado Full Time

Research Assistant / Asistente de Laboratorio Full Time

Graduate Student, PhD Thesis / Tesista de Doctorado Full Time

Postdoctoral Fellow / Investigador Postdoctoral Full Time

Postdoctoral Fellow / Investigador Postdoctoral Full Time

International PhD Student Fellow Full Time

Premios y Distinciones

Best Poster Prize

Article (28)

Abstract (3)

Proyecto (8)

Phosphatases and exosomes in caveolin-1-mediated metastasis.

Centro de Estudios Avanzados de Enfermedades Crónicas (ACCDIS)

The Thy-1 receptors alphavbeta3 integrin and Syndecan-4 on astrocytes control mitochondrial location as well as ATP release and thereby contribute to the neurotoxic effects of reactive astrocytes

caveolin-1 dependent migration of metastasis of cancer cells requires Tyr14 phosphorylation sequestration of p85a and activation Rab5-Rac1 pathway which are inhibited by the expression of E-cadherin

CENTER FOR ADVANCED STUDIES OF CRONIC DISEASES

Pro-Inflammatory Stimuli Increase Alphavbeta3 Integrin Expression In Astrocytes, Which Upon Engagement Of Neuronal Thy-1 Triggers Bidirectional-Signaling Events Required For Astrocyte Migration And Axonal Retraction. &#65279;

Supression of tumor growth by caveolin-1 involved inhibition of unfolded protein response

CENTRO DE ESTUDIOS MOLECULARES DE LA CELULA (CEMC)

Pro-Inflammatory Stimuli Increase Alphavbeta3 Integrin Expression In Astrocytes, Which Upon Engagement Of Neuronal Thy-1 Triggers Bidirectional-Signaling Events Required For Astrocyte Migration And Axonal Retraction.