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Natalia Isabel Diaz Valdivia

Postdoctoral Fellow

Universidad de Barcelona

Barcelona , España

Biochemistry /Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007
Biochemistry / Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2010
Biochemistry / Bioquímica , UNIVERSIDAD DE CHILE. Chile, 2016

Undergraduate Thesis Student / Tesista de Pregrado Full Time

Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

Santiago, Chile

2008 - 2010
Research Assistant / Asistente de Laboratorio Full Time

Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

Santiago, Chile

2010 - 2011
Graduate Student, PhD Thesis / Tesista de Doctorado Full Time

Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile.

Santiago, Chile

2011 - 2016
Postdoctoral Fellow / Investigador Postdoctoral Full Time

Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile.

Santiago, Chile

2016 - 2018
Postdoctoral Fellow / Investigador Postdoctoral Full Time

Universidad de Barcelona

Barcelona , España

2018 - At present
International PhD Student Fellow Full Time

Linus Pauling Institute, Oregon State University.

Corvallis, Oregon , Estados Unidos

2014 - 2015

Best Poster Prize

Biochemical Journal and Advanced Center for Chronic Diseases (ACCDiS)

Chile, 2016

Best Poster Prize presented in the ACCDiS Cancer Spring Symposium 2016, 7-9 September 2016, Olmué, Chile given by the Biochemical Journal.


Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells Ortiz, Rina; Díaz, jorge; Diaz-Valdivia, Natalia; Marinez, Samuel; Simón. Layla; Contreras, Pamela; Lobos-Gonzalez, Lorena; Guerrero, Simón; Leyton, Lisette; Quest, AFG Article CiteScore 4.42; Impact Factor 4.825 BIOCHEMICAL PHARMACOLOGY (2020)
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis DÃaz-Valdivia N.I.; DÃaz J.; Contreras P.; Campos A.; Rojas-Celis V.; Burgos-Ravanal R.A.; Lobos-GonzÃ¡lez L.; Torres, V.A.; Perez V.I.; Frei B.; Leyton L.; Quest A.F.G. Article ISI SCOPUS ONCOGENE (2020)
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells MartÃnez-Meza S.; DÃaz J.; Sandoval-BÃ³rquez A.; Valenzuela-Valderrama M.; DÃaz-Valdivia N.; Rojas-Celis V.; Contreras P.; Huilcaman R.; Ocaranza M.P.; Chiong M.; Leyton L.; Lavandero S.; Quest A.F.G. Article ISI SCOPUS CANCERS (2019)
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress Bravo-Sagua, R; Parra, V; Ortiz-Sandoval, C; Navarro-Marquez, M; Rodriguez, AE; Diaz-Valdivia, N; Sanhueza, C; Lopez-Crisosto, C; Tahbaz, N; Rothermel BA; Hill, JA; Cifuentes, M; Simmen, T; Quest, AFG; Lavandero, S Article ISI CELL DEATH AND DIFFERENTIATION (2019)
Stromal Markers of Activated Tumor Associated Fibroblasts Predict Poor Survival and Are Associated With Necrosis in Non-Small Cell Lung Cancer Alcaraz J.; Carrasco, JL; Millares, L; Luis, IC; Fernandez-Porras, FJ; Martinez-romero, A; Diaz-Valdivia, N; De Cos, JS; Rami-Porta, R; Seijo, L; Ramirez, J; Pajares JM; Reguart, N; Barreiro, E; Monso, E Article CiteScore: 4.52 Impact Factor: 4.599 5-Year Impact Factor: 4.443 Source Normalized Impact per Paper (SNIP): 1.276 SCImago Journal Rank (SJR): 1.905 LUNG CANCER (2019)
Biomimetic Quantum dot labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis in vivo. Victor M. Diaz-Garcia , Simon Guerrero ; Natalia Díaz-Valdivia , Lorena Lobos-Gonzalez; Johanna Catalan , Marcelo Kogan ; Jose Manuel Perez-Donoso, Andrew F.G Quest Article International Journal of Nanomedicine (2018)
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress Bravo-Sagua, Roberto; Parra, Valentina; Ortiz-Sandoval, Carolina; Navarro-Marquez, Mario; Rodríguez, Andrea E.; Diaz-Valdivia, Natalia; Sanhueza, Carlos; Lopez-Crisosto, Camila; Tahbaz, Nasser; Rothermel, Beverly A; Hill, Joseph A; Cifuentes, Mariana; Simmen, Thomas; Quest, Andrew F G; Lavandero, Sergio Article SCOPUS Cell Death and Differentiation (2018)
Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer America Campos , Carlos Salomon ; Rocio Bustos , Jorge Diaz ; Samuel Martinez , Constanza Reyes ; Natalia Diaz-Valdivia , Manuel Varas-Godoy ; Lorena Lobos-Gonzalez, Andrew F.G Quest Article Nanomedicine (2018)
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. Natalia Díaz-Valdivia , Claudia Calderon ; Jorge Diaz , Lorena Lobos-Gonzalez; Hugo Sepulveda , Rina Ortiz ; Samuel Martinez, Veronica Silva ; Horacio Maldonado, Patricio Silva ; Sergio Wehinger , Veronica Burzio ; Vicente A. Torres , Martin Montecino; Lisette Leyton , Andrew F.G Quest Article Oncotarget (2017)
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses Oyarce, C; Cruz-Gomez, S; Galvez-Cancino, F; Vargas, P; Moreau, HD; Diaz-Valdivia, N; Diaz, J; Salazar-Onfray, FA; Pacheco, R; Lennon-Dumenil, AM; Quest, AFG; Lladser, A Article ISI SCOPUS Frontiers in immunology (2017)
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses. Cesar Oyarce , Sebastian Cruz-Gomez; Felipe Gálvez-Cancino , Pablo Vargas ; Helene Moreau, Natalia Díaz-Valdivia ; Jorge Díaz , Flavio Salazar-Onfray; Rodrigo Pacheco, Ana Maria Lennon-Dumenil; Andrew F.G Quest, Alvaro Lladser Article Frontiers in Immunology (2017)
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. Rina Ortiz , Jorge Diaz; Natalia Diaz , Lorena Lobos-Gonzalez; Areli Cardenas , Pamela Contreras ; Maria Ines Diaz , Ellen Otte; Justin Cooper-White , Vicente A. Torres ; Lisette Leyton , Andrew F.G Quest Article Oncotarget (2016)
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation. Patricio Silva , Nicolas Soto; Jorge Díaz , Pablo Mendoza ; Natalia Díaz , Andrew F. G. Quest Article Biochemical and Biophysical Research Communications (2015)
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells Natalia Díaz-Valdivia , Denisse Bravo ; Hernan Huerta , Soledad Henriquez ; Fernando Gabler , Margarita Vega; Carmen Romero , Claudia Calderon ; Gareth I. Owen , Lisette Leyton Article BMC Cancer (2015)
CAVEOLIN-1 IN CELL MIGRATION AND METASTASIS Sergio Nuñez, Rina J. Ortiz; Natalia Díaz, Jorge Díaz ; Lorena Lobos-Gonzalez, Andrew F. G. Quest Article Current Molecular Medicine (2014)
Molecular insights to a novel Caveolin-1-Rab5-Rac-1 signaling pathway important for metastatic cancer cell migration and invasion Jorge Díaz, Natalia Diaz ; Lisette Leyton , Vicente A. Torres Article Cancer Cell & Microenvironment (2014)
Rab5 is required in metastatic cancer cells for Caveolin-1- enhanced Rac1 activation, migration and invasion Jorge Díaz, Natalia Díaz; Lisette Leyton, Dwayne Stupack; Andrew F. G. Quest, Vicente A. Torres Article Journal of Cell Science (2014)
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription. Jaime G. Fernandez , David Lemus ; Natalia Díaz , Mathew Wright ; Lisette Leyton , Julio C. Tapia Article Journal Molecular Cancer (2014)
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells Lorena Lobos-Gonzalez, Lorena Aguilar; Jorge Díaz , Natalia Díaz ; Hery Urra, Vicente A Torres ; Veronica Silva , Christopher Fitzpatrick; Alvaro Lladser, Keith S. Hoek; Lisette Leyton , Andrew F. G. Quest Article Pigment Cell Melanoma Research (2013)
Helicobacter pylori–Induced Loss of Survivin and Gastric Cell Viability Is Attributable to Secreted Bacterial Gamma-Glutamyl Transpeptidase Activity Manuel Valenzuela, Denisse Bravo; Jimena Canales, Carlos Sanhueza; Natalia Diaz, Oscar Almarza; Hector Toledo, Andrew F. G. Quest Article Journal of Infectious Diseases (2013)
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells Hery Urra, Vicente A. Torres; Rina J. Ortiz, Lorena Lobos; Marıa I. Dıaz, Natalia Diaz; Steffen Hartel, Lisette Leyton Article Plos One (2012)


Sub-cytotoxic doses of anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells Diaz, N; Leyton, L; Quest, A Abstract ISI FEBS JOURNAL (2017)


Phosphatases and exosomes in caveolin-1-mediated metastasis. FONDECYT (1170925) Proyecto 2017-2020 Investigador(a)
Centro de Estudios Avanzados de Enfermedades Crónicas (ACCDIS) FONDAP (15130011) Proyecto 2014-2018 Tesista
The Thy-1 receptors alphavbeta3 integrin and Syndecan-4 on astrocytes control mitochondrial location as well as ATP release and thereby contribute to the neurotoxic effects of reactive astrocytes FONDECYT (1150744) Proyecto 2014-2018 Tesista
caveolin-1 dependent migration of metastasis of cancer cells requires Tyr14 phosphorylation sequestration of p85a and activation Rab5-Rac1 pathway which are inhibited by the expression of E-cadherin FONDECYT (1130250) Proyecto 2013-2017 Tesista
CENTER FOR ADVANCED STUDIES OF CRONIC DISEASES FONDAP (15130011) Proyecto 2013-2018 Tesista
Pro-Inflammatory Stimuli Increase Alphavbeta3 Integrin Expression In Astrocytes, Which Upon Engagement Of Neuronal Thy-1 Triggers Bidirectional-Signaling Events Required For Astrocyte Migration And Axonal Retraction. FONDECYT (1110149) Proyecto 2011-2013 Tesista
Supression of tumor growth by caveolin-1 involved inhibition of unfolded protein response FONDECYT (1090071) Proyecto 2009-2013 Tesista
CENTRO DE ESTUDIOS MOLECULARES DE LA CELULA (CEMC) FONDAP (1501006) Proyecto 2001-2012 Tesista