Man

LORENA ANDREA AGUILAR GUZMÁN

Assistant Professor

Faculty of Veterinary Medicine and Livestock Sciences, University of Chile

Santiago, Chile

Líneas de Investigación


TUMOR ANGIOGENESIS; IMMUNOGENETICS AND IMMUNOCHEMISTRY OF THE COMPLEMENT SYSTEM; IMMUNOLOGY OF INTRACELLULAR PARASITISMS; CALRETICULIN, ANGIOGENESIS, TUMORS; IMMUNO-PARASITOLOGY OF CHAGAS DISEASE; PARASITOLOGY IMMUNOLOGY; CANCER; CHAGAS DISEASE; COMP

Educación

  •  Biochemistry Doctor, UNIVERSIDAD DE CHILE. Chile, 2013
  •  Veterinary Medicine, UNIVERSIDAD DE CHILE. Chile, 2003

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Veterinary Medicine and Livestock Sciences

    Santiago, Chile

    2014 - At present

Experiencia Profesional

  •   Posdoctoral Investigator Full Time

    Immunology Program, Medicine Faculty, University of Chile

    Santiago, Chile

    2013 - 2014

  •   Professional Support Full Time

    Immunology Program, Medicine Faculty, University of Chile

    Santiago, Chile

    2003 - 2006

Formación de Capital Humano


Co-Tutor in Undergraduate Research Projects: “Experimental Trypanosoma cruzi Infección and Tumor Development”. Gastón Nally y Patricio Olivares. Medical students. Faculty of Medicine, University of Chile, Santiago-Chile. Mar-Dec 2010.

Tutor in Undergraduate Research Projects:“Determinación de la Vida Media de Calreticulina de Trypanosoma cruzi, Inoculada Endovenosamente en Ratones (Mus musculus) Portadores de Tumores Mamarios”.Camila Chandia. Biochemestry students. Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago-Chile. Nov. 2013 -January 2014.


Premios y Distinciones

  •   Regular Doctoral Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2009

    The National Doctoral Fellowship aims to financially support students of excellence to begin or continue studies to obtain the academic degree of doctor

  •   End Doctoral Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2010

    Scholarship that allows the maintenance of doctoral students to complete the writing and defense of doctoral thesis

  •   MINEDUC Undergraduate Scholarship

    MINISTERIO DE EDUCACION

    Chile, 1996

    Scholarships for High School graduates with meritorious academic performance, which funds the annual fee of the race

  •   Travel Award, X Calreticulin Workshop

    UNIVERSITY OF ALBERTA

    Canada, 2013

    They provided money support towards travel and/or accommodation costs for attendance at the workshop

  •   Doctoral Fellowship MECESUP

    MINISTERIO DE EDUCACION

    Chile, 2008

    The MECESUP Proyect UCH0606 Doctoral Fellowship aims to financially support students of excellence to begin or continue studies to obtain the academic degree of doctor


 

Article (15)

Exogenous Calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal host cells

Sosoniuk-Roche, Eduardo; Vallejos, Gerardo; Aguilar-Guzmán, Lorena; Pizarro-Bäuerlea, Javier; Weinberger, Katherine; Rosas, Carlos; Valck, Carolina; Michalak, Marek; Ferreira, Arturo

Article SCOPUS
Immunobiology  (2017)

Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies

Pizarro-Bauerle, Javier; Maldonado, Ismael; Sosoniuk-Roche, Eduardo; Vallejos, Gerardo; López, Mercedes N.; Salazar-Onfray, Flavio; Aguilar-Guzmán, Lorena; Valck, Carolina; Ferreira, Arturo; Becker, María Inés

Article ISI SCOPUS
FRONTIERS IN IMMUNOLOGY  (2017)

Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

Abello-Cáceres P, Pizarro-Bauerle J; Rosas C, Maldonado I; Aguilar-Guzmán L, González C; Ramírez G, Ferreira J

Article
BMC CANCER  (2016)

Caveolin-1 is a risk factor for post-surgery metastasis in preclinical melanoma models

Lobos-Gonzalez, Lorena; Aguilar-Guzmán, Lorena; Díaz, Natalia; Díaz, jorge; Torres, Vicente; Urra, Herry; Silva, Verónica; Quest, andrew

Article ISI
Melanoma Research  (2014)

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models

Lobos-Gonzalez, L; Aguilar-Guzman, L; Fernandez, JG; Muñoz, N.; Hossain S.; Bieneck, S; Silva, V.; Burzio V; Sviderskaya, EV; Bennett, DC; Leyton, L; Quest, AFG

Article ISI SCOPUS
MELANOMA RESEARCH  (2014)

Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy against a Murine Melanoma In Vivo.

Aguilar-Guzmán, Lorena; Lobos-González, Lorena; Rosas, Carlos; Vallejos, Gerardo; Falcón, Cristián; Sosoniuk, Eduardo; Coddou, Francisca; Leyton, Lisette; Lemus, David; Quest, Andrew F G; Ferreira, Arturo

Article
PloS one  (2014)

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells

Lobos-Gonzalez, L; Aguilar, L; Díaz, J; Díaz N; Urra, H; Torres, VA; Silva, V.; Fitzpatrick, C; Lladser, A; Hoek KS; Leyton, L; Quest, AFG

Article ISI SCOPUS
Pigment Cell and Melanoma Research  (2013)

The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta

Ferreira A.; Castillo C.; Duaso, J.; Maldonado I.; Valck C.; Rosas, C; Aguilar, L; Ramirez G.; Galanti N.; Kemmerling U.

Article
JOURNAL OF IMMUNOLOGY  (2013)

Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity

Ramirez G.; Valck C.; Molina, MC; Ribeiro, CH; López N.; Sánchez G; Ferreira, VP; Billetta, R; Aguilar, L; Maldonado I.; Cattan, P; Schwaeble, W; Ferreira A.

Article ISI SCOPUS
Immunobiology  (2011)

Antiangiogenic and Antitumor Effects of Trypanosoma cruzi Calreticulin

Lopez, NC; Valck C.; Ramirez G.; Rodríguez, M.; Ribeiro, C; Orellana J.; Maldonado I.; Albini, A; ANACONA, D; Lemus D.; Aguilar, L; Schwaeble, W; Ferreira A.

Article ISI SCOPUS
PLOS NEGLECTED TROPICAL DISEASES  (2010)

Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens

Toledo, V.; Ramirez G.; Valck C.; López N.; Ribeiro, CH; Maldonado I.; Aguilar, L; Lemus D.; Ferreira A.

Article ISI SCIELO SCOPUS
Biological Research  (2010)

Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity

Ribeiro, CH; Lopez, NC; Ramirez, GA; Valck, CE; Molina, MC; Aguilar, L; Rodríguez, M.; Maldonado I.; Martínez R.; González C; Troncoso R.; Lavandero S.; Gingras, AR; Schwaeble, W; Ferreira A.

Article ISI SCOPUS
MOLECULAR IMMUNOLOGY  (2009)

An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis

Molina M.C.; Ferreira V.; Valck C.; Aguilar L.; Orellana J.; Rojas A.; Ramirez G.; Billetta R.; Schwaeble W.; Lemus D.; Ferreira A.

Article ISI SCOPUS
MOLECULAR AND BIOCHEMICAL PARASITOLOGY  (2005)

F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement

Aguilar, L; Ramirez G.; Valck C.; Molina, MC; Rojas A.; Schwaeble, W; Ferreira, V; Ferreira A.

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2005)

F(AB’)2 ANTIBODY FRAGMENTS AGAINST TRYPANOSOMA CRUZI CALRETICULIN INHIBIT ITS INTERACTION WITH THE FIRST COMPONENT OF HUMAN COMPLEMENT

Aguilar, Lorena; Ramírez, Galia; Valck, Carolina.; Molina, maria; Rojas, Alvaro; Schwaeble, Johannes; Ferreira, Viviana

Article
BIOLOGICAL RESEARCH  (2005)

Abstract (1)

E-cadherin is a molecular switch for Caveolin-1 function in melanoma cells that synergizes in tumor suppression and blocks Caveolin-1-enhanced metastasis

Lobos-Gonzalez, L; Aguilar, L; Díaz, J; Díaz N; Urra, H; Lladser, A; Hoek, K; Leyton, L; Quest, A

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

BookSection (1)

Caveolin-1 in Melanoma Progression

Lobos-Gonzalez, Lorena; Aguilar, Lorena; Fernández, Gonzalo; Sanhueza, Carlos; Quest, andrew; Armstrong, April W.

BookSection
 (2011)

Proyecto (4)

Determination of the expression of connection 43 and the effect of overexpression on the proliferation and apoptosis of canine lymphoma lines

Universidad de Chile (UI-013/17)

Proyecto
2017-2019
Inv. Responsable

TRYPANOSOMA CRUZI CALRETICULIN, BY VIRTUEOF ITS ANTIANGIOGENIC PROPERTIES, INHIBITS TUMOR GROWTH IN EXPERIMENTAL MODELS

FONDECYT (1130099)

Proyecto
2013-2016
Coinvestigador(a)

CALRETICULINA DE TRYPANOSOMA CRUZI EN LA RELACION HOSPEDERO / PARASITO=> ROLES EN EL SISTEMA DE COMPLEMENTO, AUTOINMUNIDAD Y ANGIOGENESIS

FONDECYT (1050133)

Proyecto
2005-2008
Personal técnico y/o de apoyo

ROL DE CALRETICULINA DE TRYPANOSOMA CRUZI EN LA MODULACION DE INTERACCIONES HUESPED/PARASITO

FONDECYT (1010930)

Proyecto
2001-2004
Personal técnico y/o de apoyo

Review (4)

Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis

Ramírez-Toloza G.; Sosoniuk-Roche E.; Valck C.; Aguilar-Guzmán L.; Ferreira V.P.; Ferreira A.

Review ISI SCOPUS
TRENDS IN PARASITOLOGY  (2020)

Is it all that bad when living with an intracellular protozoan?The role of Trypanosoma cruzi calreticulin in angiogenesis and tumor growth

Ramirez-Toloza, G; Aguilar-Guzman, L; Valck C.; Abello P; Ferreira A.

Review ISI
FRONTIERS IN ONCOLOGY  (2015)

Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth

Ramirez G.; Valck C.; Aguilar, L; Kemmerling U.; Lopez-Munoz, R; Cabrera G.; Morello A.; Ferreira J.; Maya J.D.; Galanti N.; Ferreira A.

Review ISI SCOPUS
Molecular Immunology  (2012)

Role of calreticulin from parasites in its interaction with vertebrate hosts

Ferreira, V; Molina, MC; Valck C.; Rojas A.; Aguilar, L; Ramirez G.; Schwaeble, W; Ferreira A.

Review ISI SCOPUS
MOLECULAR IMMUNOLOGY  (2004)

28
LORENA AGUILAR

Assistant Professor

Animal Pathology

Faculty of Veterinary Medicine and Livestock Sciences, University of Chile

Santiago, Chile

23
GALIA RAMIREZ

PROFESOR ASISTENTE

DEPARTAMENTO DE MEDICINA PREVENTIVA ANIMAL

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

15
CAROLINA VALCK

ASSISTANT PROFESSOR

IMMUNOLOGY DISCIPLINARY PROGRAM

UNIVERSIDAD DE CHILE

Santiago, Chile

12
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

7
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

6
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

4
Ismael Maldonado

Asistente de Investigación

Inmunología

Universidad de Chile

Santiago, Chile

4
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

3
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
pedro cattan

full professor

ciencias biologicas animales

UNIVERSIDAD DE CHILE; FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

santiago, Chile

2
Hery Urra

Staff scientist

INSTITUTO DE NEUROCIENCIA BIOMEDICA (BNI)

Santiago, Chile

2
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

1
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Lopez

Profesor Asociado

Facultad de Ciencias Veterinarias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
Katherine Weinberger

Docente adjunto

Ciencias Morfologicas

Universidad San Sebastian

Santiago, Chile

1
Paula Abello

Docente Adjunto

Ciencias Biológicas

Universidad San Sebastián

Santiago, Chile

1
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

1
CARLOS ROSAS

Profesor Asistente

Ciencias Morfológicas

Universidad San Sebastián

Santiago, Chile

1
María Becker

Scientific Director, President

Research and Development

FUNDACIÓN CIENCIA Y TECNOLOGÍA PARA EL DESARROLLLO

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile