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CAROLINA VALCK CALDERÓN

ASSISTANT PROFESSOR

UNIVERSIDAD DE CHILE

Santiago, Chile

INMUNOGENETICA E INMUNOQUIMICA DEL SISTEMA DEL SISTEMA DEL COMPLEMENTO; CALRETICULINA, ANGIOGENESIS, TUMORES; Enfermedad de Chagas; Sistema del Complemento; Parasitologia; Cancer; Inmuno-parasitologia de la Enfermedad de Chagas; Angiogenesis Tumoral

PhD BIOMEDICAL SCIENCES, UNIVERSIDAD DE CHILE. Chile, 2010
BIOCHEMIST, UNIVERSIDAD DE CHILE. Chile, 2002

ASSISTANT PROFESSOR Full Time

UNIVERSIDAD DE CHILE

MEDICINE

SANTIAGO, Chile

2011 - At present

LABORATORY TECHNICIAN Full Time

FONDECYT PROJECT 1010930

SANTIAGO, Chile

2001 - 2005
CO-INVESTIGATOR Full Time

FONDECYT PROJECT 1050133

SANTIAGO, Chile

2005 - 2009
CO-INVESTIGATOR Other

FONDECYT PROJECT 1095095

SANTIAGO, Chile

2009 - 2013
CO-INVESTIGATOR Other

PIA - ACT 112

SANTIAGO, Chile

2009 - 2012
CO-INVESTIGATOR Other

PIA - C11S02

SANTIAGO, Chile

2012 - 2014
CO-INVESTIGATOR Other

FONDECYT PROJECT 1130099

SANTIAGO, Chile

2013 - At present
PRINCIPAL INVESTIGATOR Full Time

FONDECYT PROJECT 11110519

SANTIAGO, Chile

2011 - At present

NOT APPLICABLE

AWARD FOR FIRST PLACE IN SCIENTIFIC WORK

SOCIEDAD CHILENA DE PARASITOLOGIA

Chile

FIRST PLACE IN XIII JORNADAS ANUALES DE PARASITOLOGÍA


In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis Sosoniuk-Roche, Eduardo.; Cruz, Pamela.; Maldonado, Ismael.; Duaso, Leonora.; Pesce, Bárbara.; Michalak, Marek.; Valck, Carolina.; Ferreira, Arturo. Article ISI/SCOPUS Corresponding Author: Valck, C MOLECULAR IMMUNOLOGY (2020)
Structural bases that underline Trypanosoma cruzi calreticulin proinfective, antiangiogenic and antitumor properties Peña Álvarez, Jaime; Teneb, Jaime; Maldonado, Ismael; Weinberger, Katherine; Rosas, Carlos; Lemus, David; Valck, Carolina.; Olivera-Nappa, Álvaro; Asenjo, Juan A.; Ferreira, Arturo Article ISI SCOPUS IMMUNOBIOLOGY (2020)
The interactions of parasite calreticulin with initial complement components: Consequences in immunity and virulence Ramirez-Toloza, Galia.; Aguilar-Guzmán, Lorena.; Valck, Carolina.; Ferreira, Viviana P.; Ferreira, Arturo. Article Manuscript ID: 556854 Edited by: Heribert Stoiber FRONTIERS IN IMMUNOLOGY (2020)
Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis. Ramírez-Toloza, G.; Sosoniuk-Roche, Eduardo.; Valck, Carolina.; Aguilar-Guzmán, Lorena.; Ferreira, Viviana P.; Ferreira, Arturo. Article ISI/SCOPUS TRENDS IN PARASITOLOGY (2020)
Exogenous Calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal host cells Sosoniuk-Roche, E; Vallejos, G; Aguilar-Guzmán, L; Pizarro-Bäuerle, J; Weinberger, K; Rosas, C; Valck, C; Michalak, M; Ferreira, A Article IMMUNOBIOLOGY (2017)
Exogenous Calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal host cells. Sosoniuk-Roche, Eduardo.; Vallejos, Gerardo.; Aguilar-Guzmán, Lorena.; Pizarro-Bäuerle, Javier.; Weinberger, Katherine.; Rosas, Carlos.; Valck, Carolina.; Michalak, Marek.; Ferreira, Arturo. Article ISI/SCOPUS Corresponding Author: Valck, Carolina IMMUNOBIOLOGY (2017)
Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies. Pizarro-Bauerle, Javier; Maldonado, Ismael; Sosoniuk-Roche, Eduardo; Vallejos, Gerardo; López, Mercedes N.; Salazar-Onfray, Flavio; Aguilar-Guzmán, Lorena; Valck, Carolina; Ferreira, Arturo; Becker, María Inés Article Frontiers in Immunology (2017)
Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does Not Increase Susceptibility to Trypanosoma cruzi Infection Ribeiro, C.H.; Lynch N.J.; Stover C.M.; Ali Y.M.; Valck C.; Noya-Leal F.; Schwaeble W.J.; Ferreira A. Article ISI SCOPUS AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2015)
Is it all That Bad When Living with an Intracellular Protozoan? The Role of Trypanosoma cruzi Calreticulin in Angiogenesis and Tumor Growth. Ramírez-Toloza, Galia.; Aguilar-Guzmán, Lorena.; Valck, Carolina.; Abello, Paula; Ferreira, Arturo Article ISI/SCOPUS FRONTIERS IN ONCOLOGY (2015)
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin Sosoniuk, E; Vallejos, G; Kenawy, H; Gaboriaud, C; Thielens, N; Fujita, T; Schwaeble, W; Ferreira, A; Valck, C Article MOLECULAR IMMUNOLOGY (2014)
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin. Sosoniuk, Eduardo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira, Arturo; Valck, Carolina Article Molecular immunology (2014)
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with LFicolin. Sosoniuk, Eduardo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira, Arturo; Valck, Carolina Article http://dx.doi.org/10.1016/j.molimm.2014.03.014 MOLECULAR IMMUNOLOGY (2014)
Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages González, A.; Valck, C.; Sánchez, G.; Härtel, S.; Mansilla, J.; Ramírez, G.; Fernández, M.; Arias, J.; Galanti, N.; Ferreira, A. Article Accepted for publication American Journal of Tropical Medicine & Hygiene (2014)
The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta Ferreira A.; Castillo C.; Duaso, J.; Maldonado I.; Valck C.; Rosas, C; Aguilar, L; Ramirez G.; Galanti N.; Kemmerling U. Article JOURNAL OF IMMUNOLOGY (2013)
Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity Ramirez G.; Valck C.; Molina, MC; Ribeiro, CH; López N.; Sánchez G; Ferreira, VP; Billetta, R; Aguilar, L; Maldonado I.; Cattan, P; Schwaeble, W; Ferreira A. Article ISI SCOPUS Immunobiology (2011)
Antiangiogenic and Antitumor Effects of Trypanosoma cruzi Calreticulin Lopez, NC; Valck C.; Ramirez G.; Rodríguez, M.; Ribeiro, C; Orellana J.; Maldonado I.; Albini, A; ANACONA, D; Lemus D.; Aguilar, L; Schwaeble, W; Ferreira A. Article ISI SCOPUS PLOS NEGLECTED TROPICAL DISEASES (2010)
Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens Toledo, V.; Ramirez G.; Valck C.; López N.; Ribeiro, CH; Maldonado I.; Aguilar, L; Lemus D.; Ferreira A. Article ISI SCIELO SCOPUS Biological Research (2010)
Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin Valck C.; Ramirez G.; López N.; Ribeiro, CH; Maldonado I.; Sánchez G; Ferreira, VP; Schwaeble, W; Ferreira A. Article ISI SCOPUS Molecular Immunology (2010)
Trypanosoma cruzi calreticulin: a possible role in Chagas' disease autoimmunity. Ribeiro, Carolina Hager; López, Nandy C; Ramírez, Galia A; Valck, Carolina E; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero, Sergio; Gingras, Alexandre R; Schwaeble, Wilhelm; Ferreira, Arturo Article Molecular immunology (2009)
Trypanosoma cruzi calreticulin=> A possible role in Chagas' disease autoimmunity Ribeiro, CH; Lopez, NC; Ramirez, GA; Valck, CE; Molina MC, Aguilar L; Rodríguez, M.; Maldonado I, Martínez R.; González C, Troncoso R.; Lavandero S., Gingras; AR, Schwaeble; W, Ferreira A. Article Molecular Immunology (2009)
An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis Molina M.C.; Ferreira V.; Valck C.; Aguilar L.; Orellana J.; Rojas A.; Ramirez G.; Billetta R.; Schwaeble W.; Lemus D.; Ferreira A. Article ISI SCOPUS MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2005)
F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement Aguilar, L; Ramirez G.; Valck C.; Molina, MC; Rojas A.; Schwaeble, W; Ferreira, V; Ferreira A. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2005)
The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi Ferreira, V; Valck C.; Sánchez G; Gingras, A; Tzima, S; Molina, MC; Simó R.; Schwaeble, W; Ferreira A. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2004)
PARASITE CALRETICULIN: POSSIBLE ROLES IN THE PARASITE/HOST INTERFACE Valck, Carolina.; Rojas, Alvaro; Molina, maria; Ferreira, Luis; Ferreira, Viviana Article Inmunologia (2002)


Exogenous calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal hosts cells Roche, ES; Vallejos, G; Guzman, LA; Bauerle, JP; Weinberger, K; Rosas, C; Valck, C; Michalak, M; Ferreira, A Abstract ISI EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
Trypanosoma cruzi calreticulin (TcCRT) modulates infection in human placental chorionic villi explants Castillo C.; Duaso, J.; Maldonado I.; Valck C.; Ferreira A.; Kemmerling U. Abstract PLACENTA (2013)
C1 interaction with Trypanosoma cruzi calreticulin mediates ex vivo infection of human placenta Castillo C.; Duaso, J.; Maldonado I.; Ramirez G.; Valck C.; Kemmerling U.; Ferreira A. Abstract ISI IMMUNOBIOLOGY (2012)
Trypanosoma cruzi calreticulin inhibits the classical pathway of complement activation in Gallus gallus Abello P; Maldonado I.; Ramirez G.; Hidalgo H.; Ferreira A.; Valck C. Abstract ISI IMMUNOBIOLOGY (2012)
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin Ferreira A.; Ramirez G.; Sánchez G; Ribeiro, CH; López N.; Maldonado I.; Fujita T.; Schwaeble, W; Valck C. Abstract ISI MOLECULAR IMMUNOLOGY (2010)
Trypanosoma cruzi calreticulin, a virulence factor that binds C1/C1q on the parasite surface Ramirez G.; Valck C.; Molina, MC; Ribeiro, CH; López N.; Sánchez G; Maldonado I.; Ferreira, VP; Schwaeble, W; Ferreira A. Abstract ISI MOLECULAR IMMUNOLOGY (2010)


TRYPANOSOMA CRUZI CALRETICULIN, BY VIRTUE OF ITS ANTI-ANGIOGENIC PROPERTIES, INHIBITS TUMOR GROWTH IN EXPERIMENTAL MODELS FONDECYT (1130099) Proyecto 2013-2017 Coinvestigador(a)
Visión molecular sobre cómo los parásitos evaden la inmunidad del hospedero=> caracterización estructural y funcional de las interacciones entre colágenos defensivos solubles y Calreticulina de Trypanosoma cruzi PIA (C11S02) Proyecto 2012-2014 Coinvestigador(a)
SOME MOLECULAR BASIS OF THE DIFFERENTIAL BEHAVIOR OF THE AVIAN AND THE HUMAN COMPLEMENT SYSTEMS, IN THE CONTEXT OF TRYPANOSOMA CRUZI AGGRESSION FONDECYT (11110519) Proyecto 2011-2014 Inv. Responsable
"Trypanosoma cruzi Calreticulin=> Interplay with the Complement System and Angiogenesis" FONDECYT (1095095) Proyecto 2009-2013 Coinvestigador(a)
Advanced Center for Training and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplastic Aggressions PIA (ACT-112,) Proyecto 2009-2012 Coinvestigador(a)
Trypanosoma cruzi Calreticulin=> Interplay with the Complement System and Angiogenesis FONDECYT (1095095) Proyecto 2009-2013 Coinvestigador(a)
CALRETICULINA DE TRYPANOSOMA CRUZI EN LA RELACION HOSPEDERO / PARASITO=> ROLES EN EL SISTEMA DE COMPLEMENTO, AUTOINMUNIDAD Y ANGIOGENESIS FONDECYT (1050133) Proyecto 2005-2009 Investigador(a)
ROL DE CALRETICULINA DE TRYPANOSOMA CRUZI EN LA MODULACION DE INTERACCIONES HUESPED/PARASITO FONDECYT (1010930) Proyecto 2001-2005 Personal técnico y/o de apoyo


Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis RamÃrez-Toloza G.; Sosoniuk-Roche E.; Valck C.; Aguilar-GuzmÃ¡n L.; Ferreira V.P.; Ferreira A. Review ISI SCOPUS TRENDS IN PARASITOLOGY (2020)
Is it all that bad when living with an intracellular protozoan?The role of Trypanosoma cruzi calreticulin in angiogenesis and tumor growth Ramirez-Toloza, G; Aguilar-Guzman, L; Valck C.; Abello P; Ferreira A. Review ISI FRONTIERS IN ONCOLOGY (2015)
Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth Ramirez G.; Valck C.; Aguilar, L; Kemmerling U.; Lopez-Munoz, R; Cabrera G.; Morello A.; Ferreira J.; Maya J.D.; Galanti N.; Ferreira A. Review ISI SCOPUS Molecular Immunology (2012)
Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay Ramirez G.; Valck C.; Ferreira, VP; López N.; Ferreira A. Review ISI SCOPUS Trends in Parasitology (2011)
Role of calreticulin from parasites in its interaction with vertebrate hosts Ferreira, V; Molina, MC; Valck C.; Rojas A.; Aguilar, L; Ramirez G.; Schwaeble, W; Ferreira A. Review ISI SCOPUS MOLECULAR IMMUNOLOGY (2004)