Man

Maria Margarita Vega Blanco

Academico Profesora Titular

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Líneas de Investigación


Regulation of female reproduction function: Cellular and molecular regulatory mechanisms of normal and pathological ovarian and endometrial function; Regulation of endometrial homeostasis and function in tissues obtained from patients with polycystic ovary syndrome

Educación

  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1972

Experiencia Académica

  •   Academico - Profesora Titular Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1972 - At present

Experiencia Profesional

  •   Academico - Profesora Titular Full Time

    Universidad de Chile - Facultad de Medicina

    Santiago, Chile

    1972 - At present


 

Article (63)

Metformin improves ovarian insulin signaling alterations caused by fetal programming
Effect of TNF-alpha on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome
Metformin prevents Nerve Growth Factor-dependent proliferative and pro-angiogenic effects in epithelial ovarian cancer cells and endothelial cellsc
Effect of estradiol on the expression of angiogenic factors in epithelial ovarian cancer
Molecular Mechanisms of Androstenediol in the Regulation of the Proliferative Process of Human Endometrial Cells
The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer cells
Altered steroid metabolism and insulin signaling in PCOS endometria: Impact in tissue function
Altered steroid metabolism and insulin signaling in PCOS endometria: Impact in tissue function.
Hyperandrogenism decreases GRP78 protein level and glucose uptake in human endometrial stromal cells
Levels of regulatory proteins associated with cell proliferation in endometria from untreated patients having PCOS with and without endometrial hyperplasia.
Levels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasia
Pro-inflammatory environment and role of TNF-a in endometrial function of obese women having Polycystic Ovarian Syndrome
Role of dihydrotestosterone (DHT) on TGF-β1 signaling pathway in epithelial ovarian cancer cells.
Role of dihydrotestosterone (DHT) on TGF-beta 1 signaling pathway in epithelial ovarian cancer cells
Endometria from Obese PCOS Women with Hyperinsulinemia Exhibit Altered Adiponectin Signaling
Endometria from Obese PCOS women with hyperinsulinemia exhibit altered adiponectin signaling.
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells.
Expression of steroid sulfated transporters and 3 beta-HSD activity in endometrium of women having polycystic ovary syndrome
Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome.
Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells
Levels of regulatory proteins associated with cell proliferation in endometria from untreated patients having PCOS with and without endometrial hyperplasia.
Role of dihydrotestosterone (DHT) on TGF-beta1 signaling pathway in epithelial ovarian cancer cells.
The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ovary syndrome
The role of androst-5-ene-3β,17β-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ovary syndrome.
Decreased Phosphorylation of Y(14)Caveolin-1 in Endometrial Tissue of Polycystic Ovary Syndrome Patients may be Related with an Insulin Resistant State in this Tissue
Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients
Testosterone Modulates the Expression of Molecules Linked to Insulin Action and Glucose Uptake in Endometrial Cells
Nerve Growth Factor Induces the Expression of Chaperone Protein Calreticulin in Human Epithelial Ovarian Cells
Nerve Growth Factor Stimulates Cellular Proliferation of Human Epithelial Ovarian Cancer
Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)
Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer
Changes in the Expression of Insulin Signaling Pathway Molecules in Endometria from Polycystic Ovary Syndrome Women with or without Hyperinsulinemia
Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women
Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome
The conversion of dehydroepiandrosterone into androst-5-ene-3 beta,17 beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome
Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome
Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway
Activities of steroid metabolic enzymes in secretory endometria from untreated women with Polycystic Ovary Syndrome
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia
Deregulation of tissue homeostasis in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia
Sex hormone-binding globulin expression in the endometria of women with polycystic ovary syndrome
Androgen and estrogen receptors and co-regulators levels in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia
Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome
Expression of molecules associated with tissue homeostasis in secretory endometria from untreated women with polycystic ovary syndrome
Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion
Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-betaI and bax genes
Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo-ovulatory women treated with clorniphene citrate
Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients
Differential in vitro actions of nitric oxide on human endometrial cell survival
Interleukin-1 beta up-regulates nitrite production: effects on ovarian function
P(450)Arom and estrogenic microenvironment of eutopic endometria in endometriosis
Potential action of androstenedione on the proliferation and apoptosis of stromal endometrial cells
Expression of steroid receptors and proteins related to apoptosis in endometria of women with polycystic ovary syndrome
Control of human luteal steroidogenesis
Molecular regulation of progesterone secretion by the human corpus luteum throughout the menstrual cycle
Regulation of steroid synthesis and apoptosis by insulin-like growth factor I and insulin-like growth factor binding protein 3 in human corpus luteum during the midluteal phase
Role of nitric oxide and bcl-2 family genes in the regulation of human endometrial apoptosis
Effect of nitric oxide on the expression of insulin-like growth factors and insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum
Effect of nitrix oxide on the expression of insulin-like growth factors and insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum
Expression of steroidogenic acute regulatory protein in the human corpus luteum throughout the luteal phase
Endocrine and paracrine-autocrine regulation of the human corpus luteum during the mid-luteal phase
Nitric oxide induces apoptosis in the human corpus luteum in vitro

Abstract (9)

Activation of TRKA receptor by nerve growth factor induces shedding of P75 receptor related with progression of epithelial ovarian cancer
Is DHT involved in the action of TGF-beta 1 in epithelial ovarian cancer?
ADAM17 and TRKA receptor are involved in epithelial ovarian cancer progression
Role of dihydrotestosterone (DHT) on the TGF-beta 1 receptors expression in epithelial ovarian cancer
ADAM17 Expression Is Increased in Epithelial Ovarian Carcinoma.
The Chaperone Protein Calreticulin Is Expressed in Human Ovarian Tissues
Differential molecule expression in eutopic secretory endometria from women with endometriosis
Effect of embryonic culture media (ECM) on the expression of marker molecules of endometrial function
Cell survival in endometria from polycystic ovary syndrome patients.

ConferencePaper (1)

Differential steroidogenic effect of pituitary hormones in primate corpus luteum

Proyecto (3)

Role of nerve growth on the regulation of miRNAs 23b and miRNA145 and inflammatory molecules involved in cell proliferation and tumor angiogenesis of epithelial ovarian cancer
Involvement Of Adiponectin In The Regulation Of Endometrial Metabolic Function Of Obese Women Bearing Polycystic Ovarian Syndrome And Hyperinsulinism
Contribution of trkA receptor isoforms to the cellular proliferation and angiogenesis of epithelial ovarian cancer: Potential targets for therapeutic intervention

Review (4)

Endometrium and steroids, a pathologic overview
Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer
Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature
70
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

33
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

8
Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

6
Karla Kohan

Profesional de laboratorio

Instituto de Salud Pública

Santiago, Chile

5
Germán Iñiguez

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

4
Paulina Ormazábal

Docente investigador

Facultad de Ciencias para el cuidado de la Salud

Universidad San Sebastián

Santiago, Chile

2
Marcela Julio

Profesor Adjunto

Instituto de Química

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

Valparaiso, Chile

2
Luis Leon

Head of Bioinformatics and Computational Biology

Technology

PhageLab

Santiago, Chile

2
Susana Quezada

Consultora

Banco Mundial

McLean, Estados Unidos

2
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alfonso Paredes

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Macarena Valladares

Profesor asociado

UNIVERSIDAD BERNARDO O'HIGGINS

Santiago, Chile

1
Rocío Retamales

Consultora de análisis genómicos

Freelance

Dresden, Alemania

1
Alfonso Paredes

Investigador principal

Bioquímica y Biología Molecular

University of Chile / Faculty of Chemical Sciences and Pharmacy

Santiago, Chile

1
Soledad Henriquez

Profesor Asistente

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile