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Felipe Salech

Academic

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Líneas de Investigación


Aging Biology, Neuroscience, Delirium Falls Older Adults Osteosarcopenia Sarcopenia

Educación

  •  PhD Medical Sciences, UNIVERSIDAD DE CHILE. Chile, 2015
  •  MD, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Internal Medicine, UNIVERSIDAD DE CHILE. Chile, 2014
  •  Geriatric Medicine, UNIVERSIDAD DE CHILE. Chile, 2017

Experiencia Académica

  •   Assistant Professor Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Chile

    2016 - At present

  •   Program Director Geriatric Medicine Fellowship Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Chile

    2021 - At present

Experiencia Profesional

  •   Principal Investigator Part Time

    Centro de Investigación Clínica Avanzada / Facultad de Medicina Universidad de Chile

    Chile

    2016 - At present

  •   Geriatrician Part Time

    Clinica Las Condes

    Santiago, Chile

    2018 - At present

  •   Director - Falls and Fracture Clinic Part Time

    Hospital Clinici Universidad de Chile

    Chile

    2019 - At present

  •   Associate Researcher Part Time

    FONDAP Centro de Gerociencia, Salud Mental y Metabolismo, GERO

    Santiago, Chile

    2020 - At present

Formación de Capital Humano


Program Director, Geriatric Medicine Fellowship, Faculty of Medicine, University of Chile

Completed Thesis:

Msc in Gerontological Physical Therapy, Universidad Mayor, Chile, Ignacio Galleguillos, Physical Therapist

Msc in Gerontological Physical Therapy Universidad Mayor, Chile, Alejandro Quevedo, Physical Therapist

Ongoing Thesis:

Msc in Neuroscience University of Chile, student Nicole Jara Occupational Therapist.


Difusión y Transferencia


1) Santiago Summer School in Aging, Universidad de Chile, January 2018, Santiago de Chile. Course Director

2) International Workshop “Transferring innovative solutions to assist elderly people", AgeWell - Universidad de Chile, Santiago de Chile, August 2018, Member of the organizing committee.

3) Santiago Summer School in Aging, January 2017, Universidad de Chile, Santiago de Chile. Organized committee member

4) Santiago Summer School in Aging, January 2016, Universidad de Chile, Santiago de Chile. Organizing committee member

5) 2014- ongoing: Member of the Transdisciplinary Network on Aging, Universidad de Chile, co-author of the group's framework document.


Premios y Distinciones

  •   Best Presentation, oral presentation

    XV Congreso Chileno de Geriatría

    Chile, 2011

    Klotho, una proteina asociada al envejecimiento inhibe la expresión de neuroD1, un gen relevante para la neurogénesis hipocampal del adulto. Salech F, Gonzalez M, Michea L, Behrens MI, Couve A. oral presentation at: - XV Congreso Chileno de Geriatría, 2011, Santiago de Chile.

  •   second place, oral presentation

    XV Congreso Chileno de Geriatría

    Chile, 2015

    Calidad Metodológica de las Revisiones Sistemáticas en Geriatría Indexadas en Pubmed. Salech F, Bravo M, Pino F, Herrera A, Fasce G, Rada G oral presentation at: - XIX Congreso Chileno de Geriatría, 2015, Santiago de Chile.

  •   second place, oral presentation

    XV Congreso Chileno de Geriatría

    Chile, 2013

    Revisiones Sistemáticas en Geriatría Indexadas en Pubmed. Salech F, Bravo M, Pino F, Herrera A, Fasce G, Rada G Oral presentation at: - XVII Congreso Chileno de Geriatría, 2013, Santiago de Chile.


 

Article (24)

A software to prevent delirium in hospitalised older adults: development and feasibility assessment

Alvarez, Evelyn A.; Garrido, Maricel; Ponce, Daniela P.; Pizarro, Gaspar; Cordova, Andres A.; Vera, Felipe; Ruiz, Rocio; Fernandez, Raul; Velasquez, Juan D.; Tobar, Eduardo; Salech, Felipe

Article ISI SCOPUS
AGE AND AGEING  (2020)

Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non-pharmacological delirium prevention program

Garrido, Maricel A.; Alvarez, Evelyn A.; Ponce, Daniela P.; Salech, Felipe; Tobar, Daniel I.; Tobar, Eduardo A.

Article ISI
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY  (2020)

Correspondence: Fall Prevention in Community-Dwelling Older Adults

Kirk, Ben; Salech, Felipe; Duque, Gustavo

Article ISI
The New England Journal of Medicine  (2020)

Inverse Relationship Between Alzheimer's Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases

Rogers, Nicole K.; Romero, Cesar; SanMartin, Carol D.; Ponce, Daniela P.; Salech, Felipe; Lopez, Mercedes N.; Gleisner, Alejandra; Tempio, Fabian; Behrens, Maria I.

Article ISI SCOPUS
JOURNAL OF ALZHEIMERS DISEASE  (2020)

Mobile ECMO in COVID-19 patient: case report

Daniela, Martinez; Felipe, Salech; Van Nicolette, Sint Jan; Tomas, Regueira; Eli, Villalabeitia; Jorge, Rufs; Christian, Fajardo; Roberto, Castillo; Jose, Iniguez; Luisa, Duran; Rodrigo, Diaz

Article ISI
JOURNAL OF ARTIFICIAL ORGANS  (2020)

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease

Salech, Felipe; Ponce, Daniela P.; Paula-Lima, Andrea C.; SanMartin, Carol D.; Behrens, Maria I.

Article ISI
FRONTIERS IN AGING NEUROSCIENCE  (2020)

Osteosarcopenia Predicts Falls, Fractures, and Mortality in Chilean Community-Dwelling Older Adults

Felipe Salech, Carlos Marquez, Lydia Lera, Bárbara Angel, Rodrigo Saguez, Cecilia Albala

Article ISI, SCOPUS
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION  (2020)

Una visión transdisciplinaria del envejecimiento

Salech, Felipe; Thumala, Daniela; Arnold, Marcelo; Arenas, Ángela; Pizzi, Marcela; Hodgson, Nancy; Gajardo, Jean; Kose, Satoshi; Meriño, Jaqueline; Riveros, Pablo

Article Latindex
Revista Médica Clínica Las Condes  (2020)

Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimers Disease

Behrens, Maria I.; Rogers, Nicole K.; Salech, Felipe; Henriquez, Mauricio; SanMartin, Carol D.; Ponce, Daniela P.

Article ISI SCOPUS
FRONTIERS IN NEUROSCIENCE  (2018)

Vitamin D Increases A beta 140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

SanMartin, CD; Henriquez, M; Chacon, C; Ponce, DP; Salech, F; Rogers, NK; Behrens, MI

Article ISI SCOPUS
CURRENT ALZHEIMER RESEARCH  (2018)

Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus

Salech, Felipe; Varela-Nallar, Lorena; Arredondo, Sebastián B; Bustamante, Daniel B; Andaur, Gabriela A; Cisneros, Rodrigo; Ponce, Daniela P; Ayala, Patricia; Inestrosa, Nibaldo C; Valdés, José L; I. Behrens, María; Couve, Andrés

Article
J Gerontol A Biol Sci Med Sci.  (2017)

PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

Salech, F; Ponce, DP; SanMartin, CD; Rogers, NK; Chacon, C; Henriquez, M; Behrens, MI

Article ISI SCOPUS
FRONTIERS IN AGING NEUROSCIENCE  (2017)

Tumor-induced osteomalacia: experience from a South American academic center

Gonzalez G. ; Baudrand R.; Sepulveda, MF; Vucetich N; Guarda, FJ; Villanueva P.; Contreras O.; Villa, A; Salech, F; Toro, L.; Michea, L.; Florenzano, P

Article ISI
Osteoporos Int  (2017)

Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

San Martín, Carol D; Henriquez, Mauricio; Chacon, Carlos; Ponce, Daniela P; Salech, Felipe; Rogers, Nicole; Behrens, María Isabel

Article
Current alzheimer Research  (2017)

EPIDEMIOLOGY OF DRUG USE IN THE ELDERLY

Salech, F; Palma D.; GARRIDO, P.

Article Latindex
Revista Médica Clínica Las Condes (http://doi.org/10.1016/j.rmclc.2016.09.011)  (2016)

Frizzled-1 receptor regulates adult hippocampal neurogenesis

Mardones M.D.; Andaur G.A.; Varas-Godoy, M; Henriquez J.F.; Salech, F; Behrens, M. I.; couve, a; Inestrosa, N. C.; Varela-Nallar L.

Article ISI SCOPUS
MOLECULAR BRAIN  (2016)

Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity

Ponce, DP; Salech, F; San Martin, CD; Silva M.; Xiong, C.; Roe, CM; Henríquez M; Quest, AF; Behrens, MI

Article ISI SCOPUS
CURRENT ALZHEIMER RESEARCH  (2014)

Cambios fisiológicos asociados al envejecimiento

Salech, F; Michea, L.; Jara R.

Article Latindex
Revista Médica Clínica Las Condes (10.1016/S0716-8640(12)70269-9)  (2012)

Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer

Behrens, M. I.; Silva M.; Salech, F; Ponce D.P.; Merino D.; Sinning, M; Xiong, C.; Roe C.M.; Quest, A.F.G.

Article ISI SCOPUS
Journals of Gerontology - Series A Biological Sciences and Medical Sciences  (2012)

Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress

Behrens, MI; Silva M.; Schmied, A.; Salech, F; Manzur, H.; Rebolledo R.; Bull, R; Torres V.; Henríquez M; Quest, AFG

Article ISI SCOPUS
Journals of Gerontology - Series A Biological Sciences and Medical Sciences  (2011)

Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: A case report with a long term follow-up

Salech, F; Valderrama S; Nervi, B; Rodriguez, JC; Oksenberg D.; Koch, A; Smok, G; Duarte, I; Perez-Ayuso, RM; Jarufe, N; Martinez, J.; Soza A.; Arrese M.; Riquelme A.

Article ISI SCOPUS
Annals of Hepatology  (2011)

Estudios que evalúan un test diagnóstico: interpretando sus resultados

Salech, Felipe; Mery, Victoria; Larrondo, Francisco; Rada, Gabriel

Article SCIELO
REVISTA MEDICA DE CHILE  (2008)

Studies about diagnostic tests: interpreting the results

Salech, F; Mery V.; Larrondo, F; Rada, G

Article ISI
REVISTA MEDICA DE CHILE  (2008)

Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis - A meta-analysis

Riquelme A.; Calvo M.; Salech, F; Valderrama S; Pattillo, A; Arellano M.; Arrese M.; Soza A.; Viviani, P; Letelier, LM

Article ISI
JOURNAL OF CLINICAL GASTROENTEROLOGY  (2006)

Abstract (1)

Effect of poly(ADP-ribose) polymerase-1 (PARP-1) inhibition on metabolic insults occurring at birth: promises and limitations

Morales P.; Salech, F; Katunar, M; Canovas, J.; Klawitter, V; Bustamante D, D; Kukuljan M.; Antonelli M.; couve, a; Herrera-Marschitz, M

Abstract ISI
AMINO ACIDS  (2007)

BookSection (4)

Biología del Envejecimiento y Gerosciencia

Salech, Felipe

BookSection
 (2021)

Common Biological Mechanisms in Alzheimer’s Disease and Cancer

Behrens, MI; Ponce, DP; Roe M; Salech, F

BookSection
 (2014)

Hipernatremia

Romero, Carlos; Salech, Felipe; Segovia, Eriko

BookSection
 (2012)

Hiponatremia

Romero C.; Salech, Felipe; Segovia, Eriko

BookSection
 (2012)

ConferencePoster (2)

A software to prevent delirium in hospitalized older adults

Alvarez Evelyn, Garrido Maricel, Ponce de la Vega Daniela, Pizarro Gaspar, Cordova Andres, Vera Felipe, Ruiz Rocío, Fernandez Raul, Velazquez J, Tobar Eduardo, Salech Felipe.

ConferencePoster
 (2018)

THE ROLE OF KLOTHO IN THE REGULATION OF ADULT HIPPOCAMPAL NEUROGENESIS

Salech, F; Varela-Nallar L.; Arredondo S.; Bustamante D.; Ponce, DP; Inestrosa NI; Behrens, MI; couve, a

ConferencePoster
 (2015)

Proyecto (10)

Herramienta multimodal no invasiva para el diagnóstico diferencial entre depresión y enfermedad de alzheimer inicial

Paula Lima A.C.

Proyecto
 (2020)

Una inmunoterapia efectiva para el tratamiento de la enfermedad de Alzheimer: ensayo pre-clínico

behrens

Proyecto
 (2020)

CANCER LEAVES A TRAIT OF DIMINISHED IMMUNE TOLERANCE THAT PROTECTS FROM ALZHEIMER'S DISEASE

FONDECYT (1190958)

Proyecto
2019-2022
Coinvestigador(a)

PARP-1 inhibition: a novel target for delirium prevention

Salech, Felipe

Proyecto
 (2019)

ESTIMULACIÓN COGNITIVA GUIADA POR SOFTWARE PREVIENE EL DESARROLLO DE DELIRIUM EN EL ADULTO MAYOR HOSPITALIZADO

Eduardo Tobar; Felipe, Salech; Juan Velasquez; Daniela Ponce; evelyn alvarez; Maricel Garrido; Rocío Ruiz

Proyecto
 (2017)

Estimulación Cognitiva Guiada por Software previene el delirium en el Adulto Mayor Hospitalizado.

FONDEF (ID16AM0080)

Proyecto
2017-2019
Subdirector(a)

Prevención no farmacológica de delirium postoperatorio por equipos de terapia ocupacional en pacientes mayores de 75 años sometidos a cirugía electiva de alta complejidad

Penna Silva, Antonello; Briceño C, Alvarez E, Ponce D, Tobar E, Salech F

Proyecto
 (2017)

CELLULAR SENESCENCE AND SENESCENCE-ASSOCIATED SECRETION PHENOTYPE (SASP) INVOLVEMENT IN THE INVERSE ASSOCIATION BETWEEN ALZHEIMER DISEASE AND CANCER

FONDECYT (1151297)

Proyecto
2015-2019
Coinvestigador(a)

Cellular senescence and senescence-associated secretion phenotype (SASP) involvement in the inverse association between Alzheimer disease and cancer

Behrens Pellegrino, María Isabel; Couve A, San Martin C, Ponce D, Salech F, Henriquez M, Sinning M

Proyecto
 (2015)

INVERSE ASSOCIATION BETWEEN CANCER AND ALZHEIMER DISEASE=> IN SEARCH OF COMMON BIOLOGICAL MECHANISMS

FONDECYT (1110189)

Proyecto
2011-2015
Coinvestigador(a)

37
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

7
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

4
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

3
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Daniela Ponce

Coordinadora de investigación

Universidad de Chile

Santiago, Chile

3
Nicole Rogers

Instructora

Universidad de Chile

Santiago, Chile

3
Mónica Silva

Lab Manager

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

2
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
Eduardo Tobar

Medico Intensivista

Medicina Interna Norte

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE. 2° PISO SECTOR C UNIDAD DE PACIENTE CRÍTICO

Santiago, Chile

2
Carlos Chacon

Asistente de Investigación

Impact

Universidad de Los Andes

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Evelyn Alvarez

Académico

Universidad Central de Chile

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

2
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
gabriel rada

director

Centro Evidencia UC

Pontificia Universidad Católica de Chile

santiago, Chile

1
Hachi Manzur

Neurólogo de Adultos

Red de Salud UC Christus

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Paola Viviani

Profesor Asistente, categoría Ordinaria

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Felix Diaz

1
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

1
Mariana Sinning

Medico Staff

Neurología Psiquiatria y Oncología

Clinica Alemana Santiago

Santiago, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Nicolette van Sint Jan

Jefe técnico

Medicina Intensiva

Clinica las Condes

Chile, Chile

1
Rodrigo Díaz

Profesor Adjunto

Departamento de Anestesiología y Reanimación

Universidad de Chile

Santiago, Chile

1
Rocio Ruiz

Directora Ejecutiva

Ingenieria Civil Industrial

Universidad de Chile

Santiago, Chile

1
Juan Velásquez

Full Professor

Industrial Engineering

UNIVERSIDAD DE CHILE

Santiago, Chile

1
MARIO CALVO

Profesor Asociado

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Rolando Rebolledo

Cirujano

Servicio de Cirugía

Hospital Dr. Sótero del Río

Santiago, Chile