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Patricio Alejandro Castro Maldonado

profesor asistente

UNIVERSIDAD Concepcion

concepcion, Chile

Líneas de Investigación


Neurofisiologia; Neurofarmacologia; Biologia Celular y Molecular

Educación

  •  Licenciatura Bioquimica, UNIVERSIDAD DE CONCEPCION. Chile, 2003
  •  Doctor en Ciencias Biologicas, mencion Biologia Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2012
  •  Bioquimico, UNIVERSIDAD DE CONCEPCION. Chile, 2005

Experiencia Académica

  •   PostDoc Full Time

    UC Davis

    sacramento, Estados Unidos

    2012 - 2014

Experiencia Profesional

  •   Colaborador Docente - Procesos Biologicos III (Medicina)

    Universidad Católica del Norte

    Chile

    2012 - 2012

  •   Alumno Ayudante de Departamento Fisiologia

    Universidad de Concepción

    Chile

    2006 - 2008

  •   Colaborador Docente - Talentos UdeC (Dr L Aguayo & Dr J Roa)

    Universidad de Concepción

    Chile

    2004 - 2009

  •   Colaborador Docente - Postgraduate Course FRONTIERS IN BRAIN DISEASES (Dr. Aguayo)

    Universidad de Concepción

    Chile

    2009 - 2009

  •   Colaborador Docente - Tecnicas Basicas de Laboratorio

    Universidad de Concepción

    Chile

    2009 - 2012

  •   Tesis Doctorado - Projecto NIH U01 (AA017875-01)

    Univ de Concepción -NIH - Univ Pittsburgh

    Chile

    2009 - 2012

  •   Postdoctorado

    UC Davis

    Estados Unidos

    2012 - 2014

  •   Estadia Investigacion (Dr. Gregg Homanics)

    University of Pittsburgh

    Estados Unidos

    2009 - 2009

  •   Estadia Investigacion (Dr. David Lovinger)

    NIH

    Estados Unidos

    2009 - 2009

  •   Estadia Investigacion (Dr. David Lovinger)

    NIH

    Estados Unidos

    2010 - 2010

  •   Encargado - Brain awareness week

    Univ Concepcion - Biblioteca Municipal

    Chile

    2011 - 2011

  •   Tesis Pregrado - Projecto Fondecyt (1020475)

    Univ de Concepción

    Chile

    2004 - 2005

  •   Tesis Doctorado - Projecto NIH R01 (AA15150-01)

    Univ de Concepción

    Chile

    2005 - 2006

  •   Colaborador - Proyecto Fundacion Andes (NºC14060/77) (Dr C Opazo)

    Univ de Concepción

    Chile

    2005 - 2006

  •   colaborador docente Farmacologia/Fisiopatologia para Kinesiologia

    universidad santo tomas

    Chile

    2016 - At present

  •   colaborador Docente Psiquiatria (Neuro-desarrollo)

    universidad catolica del norte

    Chile

    2016 - At present

  •   miembro comite etico cientifico UCN-COQ

    universidad catolica del norte

    Chile

    2016 - At present


 

Article (27)

The Ω-3 fatty acid docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer

Ortega, Lorena; Lobos-González, Lorena; Reyna-Jeldes, Mauricio; Cerda, Daniela; De la Fuente-Ortega, Erwin; Castro, Patricio; Bernal, Giuliano; CODDOU, Claudio

Article
European Journal of Pharmacology  (2021)

Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects

Benavides-Rivas, Camila; Tovar, Lina Mariana; Zúñiga, Nicolás; Pinto-Borguero, Ingrid; Retamal, Claudio; Yévenes, Gonzalo E.; Moraga-Cid, Gustavo; Fuentealba, Jorge; Guzmán, Leonardo; CODDOU, Claudio; Bascuñán-Godoy, Luisa; Castro, Patricio A.

Article
FRONTIERS IN PHARMACOLOGY  (2020)

Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

Panes, Jessica D.; Godoy, Pamela A.; Silva-Grecchi, Tiare; Celis, Maria T.; Ramirez-Molina, Oscar; Gavilan, Javiera; Munoz-Montecino, Carola; Castro, Patricio A.; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Guzman, Leonardo; Salisbury, Jeffrey L.; Trushina, Eugenia; Fuentealba, Jorge

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

Modulation of glycine receptor single-channel conductance by intracellular phosphorylation

Moraga-Cid G.; San Martín V.P.; Lara C.O.; Muñoz B.; Marileo A.M.; Sazo A.; Muñoz-Montesino C.; Fuentealba, J; Castro P.A.; Guzmán L.; Burgos C.F.; Zeilhofer H.U.; Aguayo, L. G.; Corringer P.-J.; Yévenes G.E.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2020)

Seed characterization and early Nitrogen metabolism performance of seedlings from Altiplano and Coastal ecotypes of Quinoa

Katherine Pinto-Irish; Teodoro Coba de la Pena; Enrique Ostria-Gallardo; Cristian Ibanez; Vilbett Briones; Alexander Vergara; Rodrigo Alvarez; Catalina Castro; Carolina Sanhueza; Patricio Castro; Luisa Bascunan-Godoy

Article
BMC PLANT BIOLOGY  (2020)

Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers

Vasquez, Pilar A.; San Martin, Loreto; Argel, Yenifer; Riquelme, Camila; Torres, Josefa; Vidal, Felipe; Cayuman, Francisca; Castro, Patricio; Fuentealba, Jorge; Moraga-Cid, Gustavo; Yevenes, Gonzalo; Jin, Chunyang; Jimenez, Veronica A.; Guzman, Leonardo

Article ISI
JOURNAL OF CHEMICAL INFORMATION AND MODELING  (2020)

17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors

Gavilan, Javiera; Mennickent, Daniela; Ramirez-Molina, Oscar; Trivino, Sergio; Perez, Claudia; Silva-Grecchi, Tiare; Godoy, Pamela A.; Becerra, Jose; Aguayo, Luis G; Moraga-Cid, Gustavo; San Martin, Victoria; Yevenes, Gonzalo E.; Castro, Patricio A.; Guzman, Leonardo; Fuentealba, Jorge

Article ISI SCOPUS
JOURNAL OF ALZHEIMERS DISEASE  (2019)

Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors

Jose Hevia, Maria; Castro, Patricio; Pinto, Katherine; Reyna-Jeldes, Mauricio; Rodriguez-Tirado, Felipe; Robles-Planells, Claudia; Ramirez-Rivera, Sebastian; Andres Madariaga, Juan; Gutierrez, Felipe; Lopez, Javier; Barra, Marcelo; De la Fuente-Ortega, Erwin; Bernal, Giuliano; CODDOU, Claudio

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function

San Martin, Victoria P.; Burgos, Carlos F.; Marileo, Ana M.; Lara, Cesar O.; Sazo, Anggelo; Fuentealba, Jorge; Guzman, Leonardo; Castro, Patricio A.; Aguayo, Luis G; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

Lara, Cesar O.; Burgos, Carlos F.; Silva-Grecchi, Tiare; Munoz-Montesino, Carola; Aguayo, Luis G; Fuentealba, Jorge; Castro, Patricio A.; Guzman, Jose L.; Corringer, Pierre-Jean; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo

Article ISI SCOPUS
ACS Chemical Neuroscience  (2019)

NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects.

Sequerra, Eduardo B; Goyal, Raman; Castro, Patricio A; Levin, Jacqueline B; Borodinsky, Laura N

Article
The Journal of neuroscience => the official journal of the Society for Neuroscience  (2018)

Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel

Rokic, MB; Castro, P; Leiva-Salcedo, E; Tomic M., Stojilkovic; SS, Coddou

Article
International Journal of Molecular Sciences  (2018)

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Coddou, C; Sandoval, R; Castro, P; Lazcano, P; Hevia, M; Rokik, M; Hall, B; Terse, A; Gonzalez-Billault, C; Kulkarni, AB; Stojilkovic, SS; Utreras, E

Article ISI SCOPUS
Pain  (2017)

Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?

Benjamin Förstera, Patricio A Castro, Gustavo Moraga-Cid, Luis G Aguayo

Article
FRONTIERS IN CELLULAR NEUROSCIENCE  (2016)

Evidence for alpha-Helices in the Large Intracellular Domain Mediating Modulation of the alpha 1-Glycine Receptor by Ethanol and G beta gamma

Burgos, C. F.; Castro P.A.; Mariqueo T; Bunster, M; Guzman, L; Aguayo, L. G.

Article ISI SCOPUS
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS  (2015)

Spatiotemporal integration of developmental cues in neural development.

Borodinsky LN, Belgacem YH, Swapna I, Visina O, Balashova OA, Sequerra EB, Tu MK, Levin JB, Spencer KA, Castro PA, Hamilton AM, Shim S.

Article
Dev Neurobiol. .  (2015)

Altered Sedative Effects of Ethanol in Mice with alpha 1 Glycine Receptor Subunits that are Insensitive to G beta gamma Modulation

Aguayo, LG; Castro P. ; Mariqueo T; Muñoz B.; Xiong W.; Zhang, L; Lovinger, DM; Homanics, GE

Article ISI SCOPUS
NEUROPSYCHOPHARMACOLOGY  (2014)

Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons.

Castro PA, Ramirez A, Sepúlveda FJ, Peters C, Fierro H, Waldron J, Luza S, Fuentealba J, Muñoz FJ, De Ferrari GV, Bush AI, Aguayo LG, Opazo CM.

Article
Front Aging Neurosci.  (2014)

Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine=> modulation of synaptic activity in hippocampal neurons.

Castro, Patricio A; Ramirez, Alejandra; Sepúlveda, Fernando J; Peters, Christian; Fierro, Humberto; Waldron, Javier; Luza, Sandra; Fuentealba, Jorge; Muñoz, Francisco J; De Ferrari, Giancarlo V; Bush, Ashley I; Aguayo, Luis G; Opazo, Carlos M

Article
Frontiers in aging neuroscience  (2014)

The Basic Property of Lys385 Is Important for Potentiation of the Human alpha 1 Glycine Receptor by Ethanol

Castro P.A.; Figueroa, M; Yévenes G.E.; San Martin, L. S.; Aguayo, L. G.

Article ISI SCOPUS
Journal of Pharmacology and Experimental Therapeutics  (2012)

Abstracts-Posters



Article
Alcoholism: Clinical and Experimental Research  (2011)

Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons

Larrucea, C; Castro P. ; Sepulveda, FJ; Wandersleben G.; Roa, J; Aguayo, LG

Article ISI SCOPUS
BRAIN RESEARCH  (2008)

Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons.

Carrasco MA, Castro PA, Sepulveda FJ, Cuevas M, Tapia JC, Izaurieta P, van Zundert B, Aguayo LG.

Article
J Neurochem  (2007)

Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons

Carrasco MA; Castro P. ; Sepulveda, FJ; Tapia, JC; Gatica K.; Davis, MI; Aguayo, LG

Article ISI SCOPUS
NEUROSCIENCE  (2007)

Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons

van Zundert, B; Castro P. ; Aguayo, LG

Article ISI SCOPUS
BRAIN RESEARCH  (2005)

The presence of glia stimulates the appearance of glycinergic synaptic transmission in spinal cord neurons

Cuevas ME; Carrasco MA; Fuentes, YY; Castro P. ; Nualart, F.; Roa, J; Aguayo, LG

Article ISI SCOPUS
MOLECULAR AND CELLULAR NEUROSCIENCE  (2005)

Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?

Benjamin Förstera, Patricio A. Castro, Gustavo Moraga-Cid and Luis G. Aguayo

Article
Frontiers in Cellular Neuroscience  (0)

BookSection (1)

Zn 2+ -protein interactions in normal brain physiology and neuropathology.

Opazo, Carlos; Castro, Patricio; Waldron, J; Parodi, Jorge; Fuentealaba, Jorge; Aguayo, Luis; Bernhardi, RV; Inestrosa, NC

BookSection
 (2008)

Proyecto (8)

ROLE OF GLUTAMATE SIGNALING ON NORMAL AND PATHOLOGICAL NEURAL TUBE CLOSURE. IMPLICATIONS FOR THE USE OF ANTIEPILEPTIC DRUGS DURING PREGNANCY.

FONDECYT (11160562)

Proyecto
2016-2019
Inv. Responsable

Role of purinergic signaling on the pathophysiology of gastric cancer

FONDECYT (1161490)

Proyecto
2016-2020
Investigador(a)

ROLE OF ACYLPEPTIDE HYDROLASE IN SYNAPTIC FUNCTION DURING THE ONTOGENY OF SPRAGUE-DAWLEY RATS. INVOLVEMENT OF ENDOGENOUS BETA-AMYLOID PEPTIDE LEVELS AND a7 NICOTINIC RECEPTORS IN THIS MECHANISM

FONDECYT (1140856)

Proyecto
2014-2018
Investigador(a)

THE USE OF XENOPUS LAEVIS AS AN ANIMAL MODEL SYSTEM ON THE STUDY OF SPINAL CORD DEVELOPMENT

PFCHA (74130069)

Proyecto
2012-2014
Postdoctorado

Determinantes Moleculares del dominio citoplasmático de los receptores de glicina y GABA(A) que participan en la modulación por G-betagama y Etanol

PFCHA (AT-2408012)

Proyecto
2008-2009
Tesista

G protein modulation of glycine receptor function and ethanol action

NIH (UO1 AA017875)

Proyecto
2008-2012
Tesista

Potenciación del receptor de glicina por etanol

NIH (AA15150-01)

Proyecto
2006-2007
Tesista

ESTUDIO DE SINAPTOGENESIS EN NEURONAS ESPINALES IN VITRO. EFECTOS DEL BLOQUEO DE LA ACTIVIDAD ELECTRICA Y SINAPTICA SOBRE PLASTICIDAD HOMEOSTATICA

FONDECYT (1020475)

Proyecto
2002-2006
Tesista

Review (1)

Potentiation of Gamma Aminobutyric Acid Receptors (GABA(A)R) by Ethanol How Are Inhibitory Receptors Affected?

Förstera B.; Castro P.A.; Moraga-Cid G.; Aguayo, L. G.

Review ISI SCOPUS
FRONTIERS IN CELLULAR NEUROSCIENCE  (2016)

22
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

7
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

7
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

6
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

4
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

4
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

3
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

2
Oscar Ramírez

PhD Candidate

Fisiología

Universidad de Concepción

Concepción, Chile

2
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Pamela Godoy

Colaboradora académica

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

2
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

2
Loreto San Martín

2
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

2
SEBASTIAN RAMIREZ

Estudiante de Postgrado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

2
Trinidad Mariqueo

Profesor Conferenciante

Escuela de Medicina

Universidad de Talca

Talca, Chile

2
Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

1
Maria Hevia

Prosefora

Ciencias Biomedicas

Universidad Cátolica del Norte

Coquimbo, Chile

1
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Erwin de la Fuente

PROFESOR ASOCIADO

CIENCIAS BIOMÉDICAS

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

1
Magdalena Cuevas

Profesor Asistente

Departamento de Fisiología

Universidad de Concepción

Concepción, Chile

1
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mauricio Reyna

Asistente de Investigación

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Juan Tapia

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

1
Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

1
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

1
Pablo Lazcano

Asistente de Investigacion

CIIB

Universidad de Los Andes

Santiago, Chile

1
Marta Cecilia Bunster

DIRECTORA

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

1
Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

1
Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile