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Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

Neuropharmacology - Cell biology - Molecular Biology - Signal transduction

Biochemist, Universidad de Concepcion. Chile, 2002
Neuroscience/Molecular Biology, Universidad de Concepcion. Chile, 2007
Doctor en ciencias biológicas, UNIVERSIDAD DE CONCEPCION. Chile, 2007

Assistant Professor Full Time

UNIVERSIDAD DE CONCEPCION

Faculty of Biological Sciences

Concepcion, Chile

2013 - 2018
Postdoctoral Fellow Full Time

UNIVERSITY OF ZURICH

Zurich, Suiza

2008 - 2013
Associate Professor Full Time

UNIVERSIDAD DE CONCEPCION

Faculty of Biological Sciences

Chile

2019 - At present

Associate professor Full Time

Universidad de Concepcion

Concepcion, Chile

2018 - At present

1. Participation in regular undergraduate courses of General Physiology (Univ. of Concepcion): Medicine, Nutrition, Dentistry, Pharmacy, Bioengineering, Biomedical Engineering, Biochemistry, Nursery, Psychology, Kinesiology, among others.
2. Participation in regular postgraduate courses (Univ. of Concepcion): Master in Neurobiology Program (Advanced Neuroscience),Master Program on Human physiology (Advanced Physiology I and II), PhD program on Cell and molecular biology (Cell biology).
3. Head of the Master of Neurobiology Program (Univ. of Concepcion)
4. Human resources formation as thesis supervisor:
4.1 Undergraduate thesis projects: 4 completed,
4.2 Master thesis projects: 6 completed, 2 ongoing
4.3 PhD thesis projects: 3 ongoing

1. Participation on the National Program “1000 Scientists,1000 Classrooms” of the National Week of Science and Technology
• How we feel pain? Jorge Alessandri Rodríguez C-88 School, San Fabián de Alico, Provincia de Ñuble, VIII región. 2014
• How we feel pain? Teresa de los Andes School, Bulnes, Provincia de Ñuble, VIII región. 2014
• Marihuana within our body? Monseñor Alfredo Silva Santiago Special School, Concepción, VIII región. 2014
• Marihuana within our body? Municipal Schhol of Nacimiento, Provincia de Ñuble, VIII región. 2015
• Marihuana within our body? Aurora de Chile Sur School, Chiguayante, VIII región. 2015
• Marihuana within our body? Liceo Industrial de Concepción, VIII región. 11 de Octubre 2017
• Marihuana within our body? Liceo El Arrayan, San Pedro de la Paz, VIII región. 17 de Octubre 2017
• How we feel pain?Colegio Santa Bernardita, Talcahuano, VIII Región, 19 de Octubre de 2017
2. Radio Interview on “Voices of Science” program, in Universidad de Concepción Radio. 2015.
3. Interview in "El Mercurio" newspaper. Article “New testings of novel analgesics for chronic pain”. August 2, 2016. Link: http://impresa.elmercurio.com/Pages/NewsDetail.aspx?dt=2016-08-02&dtB=02-08-2016%200:00:00&PaginaId=10&bodyid=1
4. Interview in "Concepción Newspaper". Artícle “Pharmacology testing to improve the quality of life”August 16, 2016. Link: http://www.diarioconcepcion.cl/2016/08/21/#13/z
5. “Brain Awareness week” March 2018, 2019. talk: How we feel pain? Activity organized by DANA foundation and SFN. Concepcion, Chile.

Best Undergraduate Thesis

Foundation of Cell Biology and the Chilean Society for Cell Biology

Chile, 2002

Awarded the Best Undergraduate and Master Thesis performed in Chile by the Foundation of Cell Biology and the Chilean Society for Cell Biology, 2002.
Best PhD Thesis

Foundation of Cell Biology and the Chilean Society for Cell Biology

Chile, 2007

Awarded the Best Doctoral Thesis of the year by the Foundation of Cell Biology and the Chilean Society for Cell Biology, 2007.
“Chile Bicentennial Award”

Chilean Ministry of Education and Bicentennial Committee

Chile, 2007

Awarded the “Chile Bicentennial Award” as the Best Chilean PhD thesis of the year (on all the fields of Basic Science) by the Chilean Ministry of Education and Bicentennial Committee, 2007.
Best Poster Presentation

UNIVERSITY OF ZURICH

Suiza, 2011

Awarded the Best poster in the “Zurich Pharmacology & Toxicology Day " by the University of Zurich, 2011
Elly Lilly Chapter Travel Award

Society of Neuroscience

Estados Unidos, 2005

Support for Assistance to SFN 2005, given by the Society for Neuroscience, USA.


Molecular Pharmacology of Gelsemium Alkaloids on Inhibitory Receptors Marileo Ana M.; Lara Cesar O.; Sazo Anggelo; Contreras Omayra V.; González Gabriel; Castro Patricio A.; Aguayo Luis G.; Moraga-Cid Gustavo; Fuentealba Jorge; Burgos Carlos F.; Yévenes Gonzalo E. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Elephant Black Garlic's Beneficial Properties for Hippocampal Neuronal Network, Chemical Characterization and Biological Evaluation Gavilan, Javiera; Mardones, Claudia; Oyarce, Gabriela; Trivino, Sergio; Espinoza-Rubilar, Nicole; Ramirez-Molina, Oscar; Perez, Claudia; Becerra, Jose; Varas, Patricio; Duran-Arcos, Robinson; Munoz-Montesino, Carola; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Fuentealba, Jorge Article ISI FOODS (2023)
Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine. Marileo Ana M.; Gavilán Javiera; San Martín Victoria P.;, Lara Cesar O.; Sazo Anggelo; Muñoz-Montesino Carola, Castro Patricio A.; Burgos Carlos F.; Leiva-Salcedo Elias; Aguayo Luis G.; Moraga-Cid Gustavo; Fuentealba Jorge; Yévenes Gonzalo E. Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2023)
TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease Panes-Fernandeza, Jessica; Godoy, Pamela A.; Gavilan, Javiera; Ramirez-Molina, Oscar; Burgos, Carlos Felipe; Marileo, Ana; Flores-Nunez, Oscar; Castro, Patricio A.; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Munoz-Montesino, Carola; Fuentealba, Jorge Article ISI BIOMEDICINE & PHARMACOTHERAPY (2023)
Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation Tovar Lina M.; Burgos Carlos F.; Yévenes Gonzalo E.; Moraga-Cid Gustavo; Fuentealba Jorge; Coddou Claudio; Bascunan-Godoy Luisa; Catrupay Claudio; Torres Angel; Castro Patricio A. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets Castro Patricio A.; Pinto-Borguero Ingrid; Yévenes Gonzalo E., Moraga-Cid Gustavo, Fuentealba Jorge. Article ISI FRONTIERS IN PHARMACOLOGY (2022)
Glycine Receptor Subtypes and Their Roles in Nociception and Chronic Pain. San Martín Victoria P.; Sazo Anggelo; Utreras Elias; Moraga-Cid Gustavo; Yévenes Gonzalo E. Article FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)
Roles of the Unsaturated Fatty Acid Docosahexaenoic Acid in the Central Nervous System: Molecular and Cellular Insights Petermann, Ana B.; Reyna-Jeldes, Mauricio; Ortega, Lorena; Coddou, Claudio; Yevenes, Gonzalo E. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Contribution of GlyR alpha 3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens San Martin, Loreto S.; Armijo-Weingart, Lorena; Araya, Anibal; Yevenes, Gonzalo E.; Harvey, Robert J.; Aguayo, Luis G. Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)
Glycine Receptors in Spinal Nociceptive Control—An Update Zeilhofer Hanns U., Werynska, Karolina, Gingras, Jacinthe, Yévenes, Gonzalo E. Article ISI BIOMOLECULES (2021)
Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors Muñoz Braulio; Mariqueo Trinidad; Murath Pablo; Peters Christian; Yevenes Gonzalo E.; Moraga-Cid Gustavo; Peoples Robert W.; Aguayo Luis G. Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)
Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects Benavides-Rivas, Camila; Tovar, Lina Mariana; Zuniga, Nicolas; Pinto-Borguero, Ingrid; Retamal, Claudio; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo; Fuentealba, Jorge; Guzman, Leonardo; CODDOU, Claudio; Bascunan-Godoy, Luisa; Castro, Patricio A. Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model Panes, Jessica D.; Godoy, Pamela A.; Silva-Grecchi, Tiare; Celis, Maria T.; Ramirez-Molina, Oscar; Gavilan, Javiera; Munoz-Montecino, Carola; Castro, Patricio A.; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Guzman, Leonardo; Salisbury, Jeffrey L.; Trushina, Eugenia; Fuentealba, Jorge Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Editorial: Celebrating 40 Years of the Chilean Society of Pharmacology Yevenes, Gonzalo E.; Bravo, Javier A.; Diaz-Araya, Guillermo; Sotomayor-Zarate, Ramon; Fiedler, Jenny L.; Reyes-Parada, Miguel; Fuentealba, Jorge Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Inhibition of the Glycine Receptor alpha 3 Function by Colchicine Munoz-Montesino, Carola; Burgos, Carlos F.; Lara, Cesar O.; Riquelme, Camila R.; Flaig, David; San Martin, Victoria P.; Aguayo, Luis G.; Fuentealba, Jorge; Castro, Patricio A.; Guzman, Leonardo; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation Moraga-Cid G.; San MartÃn V.P.; Lara C.O.; MuÃ±oz B.; Marileo A.M.; Sazo A.; MuÃ±oz-Montesino C.; Fuentealba, J; Castro P.A.; GuzmÃ¡n L.; Burgos C.F.; Zeilhofer H.U.; Aguayo, L. G.; Corringer P.-J.; YÃ©venes G.E. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation. Moraga-Cid G, San Martín VP, Lara CO, Muñoz B, Marileo AM, Sazo A, Muñoz-Montesino C, Fuentealba J, Castro PA, Guzmán L, Burgos CF, Zeilhofer HU, Aguayo LG, Corringer PJ, Yévenes GE. Article ISI SCOPUS SCIENTIFIC REPORTS (2020)
Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers Vasquez, Pilar A.; San Martin, Loreto; Argel, Yenifer; Riquelme, Camila; Torres, Josefa; Vidal, Felipe; Cayuman, Francisca; Castro, Patricio; Fuentealba, Jorge; Moraga-Cid, Gustavo; Yevenes, Gonzalo; Jin, Chunyang; Jimenez, Veronica A.; Guzman, Leonardo Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors Gavilan, Javiera; Mennickent, Daniela; Ramirez-Molina, Oscar; Trivino, Sergio; Perez, Claudia; Silva-Grecchi, Tiare; Godoy, Pamela A.; Becerra, Jose; Aguayo, Luis G; Moraga-Cid, Gustavo; San Martin, Victoria; Yevenes, Gonzalo E.; Castro, Patricio A.; Guzman, Leonardo; Fuentealba, Jorge Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2019)
Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function San Martin, Victoria P.; Burgos, Carlos F.; Marileo, Ana M.; Lara, Cesar O.; Sazo, Anggelo; Fuentealba, Jorge; Guzman, Leonardo; Castro, Patricio A.; Aguayo, Luis G; Moraga-Cid, Gustavo; Yevenes, Gonzalo E. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Inhibitory Actions of Tropeines on the alpha3 Glycine Receptor Function. San Martín VP, Burgos CF, Marileo AM, Lara CO, Sazo A, Fuentealba J, Guzmán L, Castro PA, Aguayo LG, Moraga-Cid G, Yévenes GE. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors Lara, Cesar O.; Burgos, Carlos F.; Silva-Grecchi, Tiare; Munoz-Montesino, Carola; Aguayo, Luis G; Fuentealba, Jorge; Castro, Patricio A.; Guzman, Jose L.; Corringer, Pierre-Jean; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo Article ISI SCOPUS ACS Chemical Neuroscience (2019)
Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers Diaz, Carola; Benitez, Carolina; Vidal, Felipe; Barraza, Luis F.; Jiménez, Verónica A.; Guzman, Leonardo; Fuentealba, Jorge; Yevenes, Gonzalo E.; Alderete, Joel B Article ISI SCOPUS NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)
P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease Saez-Orellana, F; Fuentes-Fuentes, MC; Godoy, PA; Silva-Grecchi, T; Panes, JD; Guzman, L; Yevenes, GE; Gavilan, J; Egan, TM; Aguayo, LG; Fuentealba, J Article ISI SCOPUS NEUROPHARMACOLOGY (2018)
Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens Munoz, B; Yevenes, GE; Forstera, B; Lovinger, DM; Aguayo, LG Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization Vidal, Felipe; Vasquez, Pilar; Cayuman, Francisca R.; Diaz, Carola; Fuentealba, Jorge; Aguayo, Luis G; Yevenes, Gonzalo E.; Alderete, Joel; Guzman, Leonardo Article ISI SCOPUS NANOMATERIALS (2018)
Functional modulation of glycine receptors by the alkaloid gelsemine Lara C.O.; Murath P.; Muñoz B.; Marileo A.M.; Martín L.S.; San Martín V.P.; Burgos, C. F.; Mariqueo, T. A.; Aguayo, L. G.; Fuentealba, J; Godoy, P; Guzman, L; Yévenes G.E. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2016)
Functional modulation of glycine receptors by the alkaloid gelsemine. Lara CO, Murath P, Muñoz B, Marileo AM, Martín LS, San Martín VP, Burgos CF, Mariqueo TA, Aguayo LG, Fuentealba J, Godoy P, Guzman L, Yévenes GE. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2016)
Functional modulation of glycine receptors by the alkaloid gelsemine. Lara CO, Murath P, Muñoz B, Marileo AM, Martín LS, San Martín VP, Burgos CF, Mariqueo TA, Aguayo LG, Fuentealba J, Godoy P, Guzman L, Yévenes GE Article BRITISH JOURNAL OF PHARMACOLOGY (2016)
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain Acu?a, Mario A.; Y?venes, Gonzalo E.; Ralvenius, William T.; Benke, Dietmar; Di Lio, Alessandra; Lara, Cesar O.; Mu?oz, Braulio; Burgos, Carlos F.; Moraga-Cid, Gustavo; Corringer, Pierre-Jean; Zeilhofer, Hanns Ulrich Article ISI SCOPUS JOURNAL OF CLINICAL INVESTIGATION (2016)
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, Zeilhofer HU. Article JOURNAL OF CLINICAL INVESTIGATION (2016)
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, Zeilhofer HU. Article ISI SCOPUS JOURNAL OF CLINICAL INVESTIGATION (2016)
Reversal of Ethanol-induced Intoxication by a Novel Modulator of G beta gamma Protein Potentiation of the Glycine Receptor San Martin, Loreto; Cerda, Fabian; Jin, Chunyang; Jimenez, Veronica; Yevenes, Gonzalo E.; Hernandez, Tania; Nova, Daniela; Fuentealba, Jorge; Aguayo, Luis G.; Guzman, Leonardo Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Reversal of Ethanol-Induced Intoxication by a Novel Modulator of Gbetagamma Potentiation of Glycine Receptor. San Martin L, Cerda F, Jin C, Jimenez V, Yevenes GE, Hernandez T, Nova D, Fuentealba J, Aguayo LG, Guzman L. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission Ghosh, Himanish; Auguadri, Luca; Battaglia, Sereina; Simone Thirouin, Zahra; Zemoura, Khaled; Messner, Simon; Acu?a, Mario A.; Wildner, Hendrik; Y?venes, Gonzalo E.; Dieter, Andrea; Kawasaki, Hiroshi; O. Hottiger, Michael; Zeilhofer, Hanns Ulrich; Fritschy, Jean-Marc; Tyagarajan, Shiva K. Article ISI SCOPUS NATURE COMMUNICATIONS (2016)
Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors Burgos, C. F.; Yevenes, G. E.; Aguayo, L. G. Article ISI SCOPUS Molecular Pharmacology (2016)
Structure and pharmacological modulation of inhibitory glycine receptors. Burgos CF, Yevenes GE, Aguayo LG. Article MOLECULAR PHARMACOLOGY (2016)
Control of Ethanol Sensitivity of the Glycine Receptor alpha 3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain Sanchez A.; Yévenes G.E.; Martín L.S.; Burgos, C. F.; Moraga-Cid, G; Harvey R.J.; Aguayo, L. G. Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Control of ethanol sensitivity of the glycine receptor Î±3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domains. Sánchez A, Yévenes GE, San Martin L, Burgos CF, Moraga-Cid G, Harvey RJ, Aguayo LG. Article JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Article NEUROPSYCHOPHARMACOLOGY (2014)
Antihyperalgesia by alpha 2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites Paul, Jolly; Yevenes, Gonzalo E.; Benke, Dietmar; Di Lio, Alessandra; Ralvenius, William T.; Witschi, Robert; Scheurer, Louis; Cook, James M.; Rudolph, Uwe; Fritschy, Jean-Marc; Zeilhofer, Hanns Ulrich Article ISI NEUROPSYCHOPHARMACOLOGY (2014)
Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Article ISI NEUROPSYCHOPHARMACOLOGY (2014)
Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface γ-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHO Maier PJ, Zemoura K, Acuña MA, Yévenes GE, Zeilhofer HU, Benke D. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface γ-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHOP). Maier PJ, Zemoura K, Acuña MA, Yévenes GE, Zeilhofer HU, Benke D. Article ISI The Journal of Biological Chemistry (2014)
Endoplasmic reticulum-associated degradation controls cell surface expression of Î³-aminobutyric acid, type B receptors. Zemoura K, Schenkel M, Acuña MA, Yévenes GE, Zeilhofer HU, Benke D. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. Zemoura K, Schenkel M, Acuña MA, Yévenes GE, Zeilhofer HU, Benke D. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control. Zeilhofer HU, Benke D, Yevenes GE. Article ISI Annual Review of Pharmacology and Toxicology (2012)
Chronic pain states: pharmacologicalstrategies to restore diminished inhibitory spinal pain control. Zeilhofer HU, Benke D, Yevenes GE Article Annual Review of Pharmacology and Toxicology (2012)
Fast synaptic inhibition in spinal sensory processing and pain control. Zeilhofer HU, Wildner H, Yévenes GE. Article ISI PHYSIOLOGICAL REVIEWS (2012)
Fast synaptic inhibition in spinal sensory processing and pain control. Zeilhofer HU, Wildner H, Yévenes GE. Article PHYSIOLOGICAL REVIEWS (2012)
The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol. Castro PA, Figueroa M, Yevenes GE, San Martin LS, Aguayo LG. Article JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
The Basic Property of Lys385 Is Important for Potentiation of the Human alpha 1 Glycine Receptor by Ethanol Castro P.A.; Figueroa, M; Yévenes G.E.; San Martin, L. S.; Aguayo, L. G. Article ISI SCOPUS Journal of Pharmacology and Experimental Therapeutics (2012)
A Single Phenylalanine Residue in the Main Intracellular Loop of alpha 1 gamma-Aminobutyric Acid Type A and Glycine Receptors Influences Their Sensitivity to Propofol Moraga-Cid G, Yevenes GE, Schmalzing G, Peoples RW, Aguayo LG Article ANESTHESIOLOGY (2011)
A Single Phenylalanine Residue in the Main Intracellular Loop of alpha 1 gamma-Aminobutyric Acid Type A and Glycine Receptors Influences Their Sensitivity to Propofol Moraga-Cid, G; Yevenes, GE; Schmalzing, G; Peoples, RW; Aguayo, LG Article ISI SCOPUS Anesthesiology (2011)
Activated G protein α s subunits increase the ethanol sensitivity of human glycine receptors. Yévenes GE, Moraga-Cid G, Romo X, Aguayo LG. Article JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Activated G Protein alpha(s) Subunits Increase the Ethanol Sensitivity of Human Glycine Receptors Yevenes, GE; Moraga-Cid, G; Romo, X.; Aguayo, LG Article ISI SCOPUS Journal of Pharmacology and Experimental Therapeutics (2011)
Allosteric modulation of glycine receptors Yevenes GE, Zeilhofer HU Article BRITISH JOURNAL OF PHARMACOLOGY (2011)
Allosteric modulation of glycine receptors. Yevenes GE, Zeilhofer HU Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2011)
Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. Yevenes GE, Zeilhofer HU Article ISI PLOS ONE (2011)
Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. Yévenes GE, Zeilhofer HU. Article PLoS One (2011)
Potentiation and inhibition of glycine receptors by tutin Fuentealba, J; Muñoz B.; Yevenes, G; Moraga-Cid, G; Guzman, L; Aguayo, L. G.; Pérez, C.; Rigo J.M. Article ISI SCOPUS Neuropharmacology (2011)
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin. Tyagarajan SK, Ghosh H, Yévenes GE, Nikonenko I, Ebeling C, Schwerdel C, Sidler C, Zeilhofer HU, Gerrits B, Muller D, Fritschy JM. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin. Tyagarajan SK, Ghosh H, Yévenes GE, Nikonenko I, Ebeling C, Schwerdel C, Sidler C, Zeilhofer HU, Gerrits B, Muller D, Fritschy JM. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective G beta gamma Modulation Yevenes, GE; Moraga-Cid, G; Avila, A; Guzman, L; Figueroa, M; Peoples, RW; Aguayo, LG Article ISI SCOPUS Journal of Biological Chemistry (2010)
Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation. Yevenes GE, Moraga-Cid G, Avila A, Guzmán L, Figueroa M, Peoples RW, Aguayo LG. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding. Guzman, Leonardo; Moraga-Cid, Gustavo; Avila, Ariel; Figueroa, Maximiliano; Yevenes, Gonzalo E; Fuentealba, Jorge; Aguayo, Luis G Article The Journal of pharmacology and experimental therapeutics (2009)
A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Peoples, Robert W; Schmalzing, Günther; Aguayo, Luis G Article Proceedings of the National Academy of Sciences of the United States of America (2008)
Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors. Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Guzmán, Leonardo; Haeger, Svenja; Oliveira, Laerte; Olate, Juan; Schmalzing, Günther; Aguayo, Luis G Article The Journal of biological chemistry (2006)
Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Yevenes, Gonzalo E; Peoples, Robert W; Tapia, Juan C; Parodi, Jorge; Soto, Ximena; Olate, Juan; Aguayo, Luis G Article Nature Neuroscience (2003)
GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? Aguayo, Luis G; Peoples, Robert W; Yeh, Hermes H; Yevenes, Gonzalo E Article Current topics in medicinal chemistry (2002)
Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons. van Zundert, Brigitte; Alvarez, Francisco J; Yevenes, Gonzalo E; Cárcamo, Juan G; Vera, Juan Carlos; Aguayo, Luis G Article Journal of neurophysiology (2002)


Identification of molecular sites associated with the modulation of the glycine receptor by the natural alkaloid gelsemine Marileo, AM, Burgos, CF, Lara., CO, San Martín, VP, Moraga-Cid, G, Yévenes, GE. ConferencePoster (2016)
Modulation of recombinant and native glycine receptors by Gelsemium genus alkaloids Lara., CO, Murath, P, Muñoz, B, Marileo, AM, San Martín, VP, Yévenes, GE. ConferencePoster (2016)
Molecular mechanisms underlying the functional inhibition of the glycine receptor alpha3 subunit by PKA-mediated phosphorylation San Martín, VP, Muñoz, B, Lara, CO, Moraga-Cid, G, Yévenes, GE. ConferencePoster (2016)
Molecular sites for the modulation of glycine receptors by the analgesic alkaloid gelsemine Marileo, AM, Burgos, CF, Lara., CO, San Martín, VP, Moraga-Cid, G, Yévenes, GE. ConferencePoster (2016)
Relevance of the S346 residue for the functional modulation of the glycine receptor alfa3 subunit by protein kinase A San Martín, VP, Muñoz, B, Lara, CO, Moraga-Cid, G, Yévenes, GE. ConferencePoster (2016)
The alkaloids Gelsemine and Koumine modify the function of native and spinal glycine receptors Lara., CO, Murath, P, Muñoz, B, Marileo, AM, San Martín, VP, Yévenes, GE. ConferencePoster (2016)
Characterization of a molecular site for the modulation of the glycine receptor alpha3 subunit by 2,6-di-tert-butylphenol Lara, CO, Burgos CF, Muñoz, B, Moraga-Cid, G, Corringer, PJ, Yevenes, GE, ConferencePoster (2015)
Conformation-specific modulation of synaptic alpha3-containing glycine receptors alleviates chronic inflammatory pain Yévenes, GE, Acuña, M, Lara, CO, Ralvenius, W, Di Lio, A, Zeilhofer, HU ConferencePoster (2015)
Effects of the alkaloid gelsemine on recombinant glycine receptors Marileo, AM, Lara, CO, Burgos CF, Yevenes, GE, ConferencePoster (2015)
Exploring the molecular mechanisms underlying the functional inhibition of the glycine receptor alpha3 subunit by PKA-mediated phosphorylation San Martin, VP. Lara, CO, Yevenes, GE, ConferencePoster (2015)
Modulation of spinal glycine receptors by the alkaloid gelsemine Murath, P, Lara, CO, Yevenes, GE, ConferencePoster (2015)
Molecular sites for the modulation of the glycine receptor alpha3 by 2,6-di-tert-butylphenol Burgos, CF, Lara, CO, Muñoz, B, Moraga-Cid, G, Corringer, PJ, Yévenes, GE ConferencePoster (2015)
Functional effects of the alkaloid gelsemine on glycine receptor subtypes Mariqueo,TA, San Martín, L, Yévenes GE ConferencePoster (2014)
Molecular sites for glycine receptor modulation by propofol analogs Lara, CO, Burgos, CF, Fuentealba, J, Yevenes, GE, ConferencePoster (2014)
Pharmacological modulation of spinal glycine receptors in chronic pain Yevenes, GE, Lara, CO, Burgos, CF, Acuña, MA, Zeilhofer HU ConferencePoster (2014)
Pharmacological modulation of spinal synaptic alpha3-containing glycine receptors in inflammatory pain Yévenes, GE, Acuña, MA, Di Lio, A, Zeilhofer HU ConferencePoster (2014)
Phospho-specific potentiation of synaptic heteromeric alpha3-glycine receptors by 2,6-di-tert-butylphenol Acuña, MA, Yévenes, GE, Di Lio, A, Zeilhofer HU. ConferencePoster (2014)


State-dependent modulation of spinal glycine receptors Yevenes, GE ConferenceProceedingWhole (2016)


Modulation of mammalian pentameric ligand-gated ion channels by cannabidiol: molecular sites and mechanisms of allosteric modulation. Yévenes, Gonzalo E. Proyecto IBRO Collaborative Research Grant (2022)
Regulation and adaptation of inhibitory synapses by neuroactive steroids Yévenes, Gonzalo E.; Specht Christian G. Proyecto (2022)
CONTRIBUTION OF GLYCINE RECEPTORS TO THE PATHOPHYSIOLOGY OF CHRONIC PAIN AND TO THE ANALGESIA INDUCED BY ALLOSTERIC MODULATORS: NOVEL INSIGHTS COMING FROM BRAIN AND MIDBRAIN STRUCTURES WITHIN THE PAIN PATHWAY. Yévenes, Gonzalo E. Proyecto (2021)
Núcleo Milenio para el Estudio del Dolor Calvo, Margarita; Yévenes, Gonzalo E. Proyecto (2020)
Targeting glycine receptors for the treatment of chronic pain, hyperekplexia and anxiety: development of novel modulators based on recent structural and pharmacological insights Yevenes, Gonzalo E.; Moraga, Gustavo Proyecto (2017)
Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors Moraga-Cid, Gustavo; Yevenes, Gonzalo E. Proyecto (2016)
Understanding ALS Disease Mechanisms using human induced pluripotent stem cells derived motor neurons (iMNs) Carrasco, Monica; Yevenes, Gonzalo E. Proyecto (2016)
“Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors” FONDECYT (1160851) Proyecto 2016-2018 Coinvestigador(a)
“Understanding ALS Disease Mechanisms using human induced pluripotent stem cells derived motor neurons (iMNs).” FONDECYT (11611014) Proyecto 2016-2018 Coinvestigador(a)
Characterization of glycine receptor molecular determinants and alcohol depressant action PCI (DPI 201400) Proyecto 2015-2017 Subdirector(a)
Characterization of Glycine Receptor Molecular Determinants and Alcohol Depressant Action Aguayo, Luis G.; Yevenes, Gonzalo E. Proyecto (2015)
MODULATION OF SPINAL GLYCINE RECEPTOR SUBTYPES AS A STRATEGY AGAINST PAIN SENSITIZATION FONDECYT (1140515) Proyecto 2014-2017 Inv. Responsable
Modulation of spinal glycine receptor subtypes as a strategy against pain sensitization Yevenes, Gonzalo E.; Guzman, Jose L. Proyecto (2014)
“Molecular Determinants for Glycine Receptor Allosteric Modulation by Cannabinoid Ligands” Forschungskredit der Universität Zürich (54320501) Proyecto 2011-2012 Inv. Principal
Molecular Determinants for Glycine Receptor Allosteric Modulation by Cannabinoid Ligands” Yevenes, Gonzalo E. Proyecto (2011)
“ Control of Spinal Pain Processing by GABAA and Strychnine-Sensitive Glycine Receptors” Schweizerischer Nationalfonds, SNF (SNF 3100A0-116064/1, SNF 31003A-131093/1) Proyecto 2008-2012 Investigador(a)
“Modulation of glycine receptor by ethanol” NIAAA, National Institute on Alcohol Abuse and Alcoholism, USA (NIH R01 AA15150) Proyecto 2004-2008 Investigador(a)
Regulación de Receptores de Glicina por Proteinas G y etanol FONDECYT (AT4040102) Proyecto 2004-2006 Inv. Responsable


Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain Lara C.O.; Burgos C.F.; Moraga-Cid G.; Carrasco M.A.; YÃ©venes G.E. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2020)
Glycine receptors and glycine transporters: targets for novel analgesics? Zeilhofer, HU; Acuna, MA; Gingras, J; Yevenes, GE Review ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

Loreto San Martín

JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Oscar Ramírez

PhD Candidate

Fisiología

Universidad de Concepción

Concepción, Chile

Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

Pamela Godoy

Colaboradora académica

Fisiología

Universidad de Concepción

Concepcion, Chile

Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Carola Díaz

Investigadora Fondecyt Postdoctoral

Departamento de Química

Universidad Andrés Bello

Talcahuano, Chile

Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

Joel Alderete

Full Professor

Universidad de Talca

Talca, Chile

Monica Carrasco

Profesor Asociado

Escuela de Medicina

UNIVERSIDAD DE TALCA

Talca, Chile

Trinidad Mariqueo

Profesor Conferenciante

Escuela de Medicina

Universidad de Talca

Talca, Chile

Tiare Silva-Grecchi

Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

Luis Barraza

ACADEMICO-INVESTIGADOR

DEPARTAMENTO DE CIENCIAS QUIMICAS

UNIVERSIDAD DE ANDRES BELLO

Concepción, Chile

Pablo Murath

PhDc y COLABORADOR ACADÉMICO

CIENCIA Y TECNOLOGÍA DE LOS ALIMENTOS

UNIVERSIDAD DE CONCEPCIÓN

Concepción , Chile

Patricio Godoy

Group leader

System sToxicology

Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund

Dortmund, Alemania

Luisa Bascuñán

Profesora asistente

Botánica

Universidad de Concepción

Concepción, Chile

Lorena Armijo

Profesor asistent

Universidad San Se

Concepción, Chile

Andrea Sanchez

Profesor Asociado

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCION

concepcion, Chile

Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Gonzalo Yévenes

Líneas de Investigación

Educación

Biochemist, Universidad de Concepcion. Chile, 2002

Neuroscience/Molecular Biology, Universidad de Concepcion. Chile, 2007

Doctor en ciencias biológicas, UNIVERSIDAD DE CONCEPCION. Chile, 2007

Experiencia Académica

Assistant Professor Full Time

Postdoctoral Fellow Full Time

Associate Professor Full Time

Experiencia Profesional

Associate professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Best Undergraduate Thesis

Best PhD Thesis

“Chile Bicentennial Award”

Best Poster Presentation

Elly Lilly Chapter Travel Award

Article (73)

ConferencePoster (17)

ConferenceProceedingWhole (1)

Proyecto (18)

“Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors”

“Understanding ALS Disease Mechanisms using human induced pluripotent stem cells derived motor neurons (iMNs).”

Characterization of glycine receptor molecular determinants and alcohol depressant action

MODULATION OF SPINAL GLYCINE RECEPTOR SUBTYPES AS A STRATEGY AGAINST PAIN SENSITIZATION

“Molecular Determinants for Glycine Receptor Allosteric Modulation by Cannabinoid Ligands”

“ Control of Spinal Pain Processing by GABAA and Strychnine-Sensitive Glycine Receptors”

“Modulation of glycine receptor by ethanol”

Regulación de Receptores de Glicina por Proteinas G y etanol

Review (2)