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Monica Alejandra Carrasco Pastenes

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

Regulations between Neurons and its surrounding in both health and disease. With focus on understanding ALS Disease Mechanisms using human IPSC patient-derived motor neurons.

Biología Molecular y Celular, UNIVERSIDAD DE CONCEPCION. Chile, 2005
Lic. en Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 1999
Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2001

Profesor Asociado Full Time

UNIVERSIDAD DE TALCA

Talca, Chile

2015 - At present

Postdoctoral

Harvard University

Estados Unidos

2006 - 2009
Research Associate

Columbia University

Estados Unidos

2010 - 2015

2022-Ongoing
Cotutora Tesista Doctoral: Matias Osorio
Programa en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca.

2020-2022
Cotutora: Tesista Magister: Alumno Felipe Franco
Programa de Magister en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca

2020-2022
Cotutora: Tesista Magister: Alumna Solange Besoain
Programa de Magister en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca

2015-2020.
Tutora Tesista Doctoral: Alumna Daniela Caceres
Programa en Ciencias BioMedicas
Departamento de Ciencias BioMedicas
Universidad de Talca, Talca.

Best talks at IPS 2017: Pluripotent Stem Cells and Gene Editing Symposium: From Bench Success Clinical Promises.

UNIVERSIDAD DE LOS ANDES

Chile, 2017

Best talks at IPS 2017: Pluripotent Stem Cells and Gene Editing Symposium: From Bench Success Clinical Promises. Organized by the Universidad de los Andes and Universidad del Desarrollo (Chile) in collaboration with the University of Cambridge (UK) Event Date: March 30-31, 2017 Event Time: 9:00-18:00 CLST
Milton-Safenowitz Post Doctoral Fellowship for ALS Research

ALSA

Estados Unidos, 2006

We have taken a multifaceted approach to the study of ALS disease mechanisms. We use mouse models of ALS to study the interactions between motor neurons (the cells of the nervous system that control movement) and glia, (the cells that support and surround neurons in the spinal cord). With the advent of the new stem cell technologies, we have also initiated studies aimed at exploring the interactions between neurons and glia in human ALS.


Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model. Valdebenito-Maturana B.; Arancibia E.; Riadi G.; Tapia JC.; Carrasco M. Article WOS, PubMed, GoogleScholar, Scopus PLOS ONE (2021)
Spatially Resolved Expression of Transposable Elements in Disease and Somatic Tissue with SpatialTE Valdebenito-Maturana B.; Guatimosim C; Carrasco MA; Tapia JC. Article indexed within Scopus, SCIE (Web of Science), PubMed, PMC, MEDLINE, Embase, CAPlus / SciFinder, and other databases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Coarse-Grained Parameters for Divalent Cations within the SIRAH Force Field Klein, Florencia; Caceres, Daniela; Carrasco, Monica A.; Carlos Tapia, Juan; Caballero, Julio; Alzate-Morales, Jans; Pantano, Sergio Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Altered lactate metabolism in Huntingtons disease is dependent on GLUT3 expression Solís-Maldonado, Macarena; Miró, María Paz; Acuña, Aníbal I.; Covarrubias-Pinto, Adriana; Loaiza, Anitsi; Mayorga, Gonzalo; Beltrán, Felipe A.; Cepeda, Carlos; Levine, Michael S.; CONCHA, Ilona I.; Bátiz, Luis Federico; Carrasco, Mónica A.; Castro, Maite A. Article ISI SCOPUS CNS NEUROSCIENCE & THERAPEUTICS (2018)
Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species He, J; Zhou R.; Wu, Z; Carrasco M.A.; Kurshan P.T.; Farley J.E.; Simon D.J.; Wang, G; Han, B; Hao J.; Heller E.; Freeman M.R.; Shen K.; Maniatis T.; Tessier-Lavigne M.; Zhuang, X Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells Nishimura, AL; Shum, C; Scotter, EL; Abdelgany, A; Sardone, V; Wright J.; Lee, YB; Chen, HJ; Bilican, B; Carrasco M.; Maniatis T.; Chandran, S; Rogelj, B; Gallo, JM; Shaw, CE Article ISI PLOS ONE (2014)
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells Nishimura AL; Shum C; Scotter EL; Abdelgany A; Sardone V; Wright J; Lee YB; Chen HJ; Bilican B; Carrasco M; Maniatis T; Chandran S3; Rogelj B; Gallo JM; Shaw CE. Article Plos One (2014)
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP. Article Neuron (2014)
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H Article J Neuroscience (2013)
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, Shaw CE, Finkbeiner S, Chandran S Article Proc Natl Acad Sci U S A (2013)
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells" Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Article Sci Transl Med (2013)
Intricate interplay between astrocytes and motor neurons in ALS Phatnani HP, Guarnieri P, Friedman BA, Carrasco MA, Muratet M, O'Keeffe S, Nwakeze C, Pauli-Behn F, Newberry KM, Meadows SK, Tapia JC, Myers RM, Maniatis T Article Proc Natl Acad Sci U S A (2013)
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, Gygi SP, Shneider NA, Maniatis T, Reed R Article Cell Rep (2012)
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S Article Proc Natl Acad Sci U S A (2012)
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability Bilican, B; Serio, A; Barmada, SJ; Nishimura, AL; Sullivan, GJ; Carrasco M.; Phatnani, HP; Puddifoot, CA; Story, D; Fletcher J.; Park, IH; Friedman, BA; Daley, GQ; Wyllie, DJA; Hardingham, GE; Wilmut, I; Finkbeiner, S; Maniatis T.; Shaw, CE; Chandran, S Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC Article Proc Natl Acad Sci U S A (2009)
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons. Carrasco MA, Castro PA, Sepulveda FJ, Cuevas M, Tapia JC, Izaurieta P, van Zundert B, Aguayo LG. Article J Neurochem. (2007)
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K *co-first Article Nat Neurosci (2007)
Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons. Carrasco MA, Castro P, Sepulveda FJ, Tapia JC, Gatica K, Davis MI, Aguayo LG. Article Neuroscience (2007)
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing Makeyev EV, Zhang J, Carrasco MA, Maniatis T. Article Mol Cell. (2007)
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues Godoy A, Ulloa V, Rodríguez F, Reinicke K, Yañez AJ, García Mde L, Medina RA, Carrasco M, Barberis S, Castro T, Martínez F, Koch X, Vera JC, Poblete MT, Figueroa CD, Peruzzo B, Pérez F, Nualart F. Article J Cell Physiol. (2006)
Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall Silva-Alvarez C, Carrasco M, Balmaceda-Aguilera C, Pastor P, García Mde L, Reinicke K, Aguayo L, Molina B, Cifuentes M, Medina R, Nualart F Article Neurochem Res. (2005)
The presence of glia stimulates the appearance of glycinergic synaptic transmission in spinal cord neurons Cuevas ME, Carrasco MA, Fuentes Y, Castro P, Nualart F, Roa J, Aguayo LG. Article Mol Cell Neurosci. (2005)
Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier. Garcia MA, Carrasco M, Godoy A, Reinicke K, Montecinos VP, Aguayo LG, Tapia JC, Vera JC, Nualart F Article J Cell Biochem (2001)


Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain Lara C.O.; Burgos C.F.; Moraga-Cid G.; Carrasco M.A.; YÃ©venes G.E. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2020)