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Gustavo Alonso Moraga Cid

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

Estructura y Funcion de Canales ionicos activados por ligando; Farmacologia de Canales Ionicos

Ciencias Biologicas area Biologia Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2009
Biologo Marino, UNIVERSIDAD DE CONCEPCION. Chile, 2002

Assistant Professor Full Time

UNIVERSIDAD DE CONCEPCION

Faculty of Biological Sciences

Chile

2016 - At present

Postdoctoral Fellow

National Center of Scientific Research (CNRS)

Francia

2015 - At present
Postdoctoral Fellow

Institut Pasteur

Francia

2010 - 2015
Instructor

University Andres Bello

Chile

2009 - 2009
Instructor

University Santo Tomas

Chile

2007 - 2009


Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects Benavides-Rivas, Camila; Tovar, Lina Mariana; Zuniga, Nicolas; Pinto-Borguero, Ingrid; Retamal, Claudio; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo; Fuentealba, Jorge; Guzman, Leonardo; CODDOU, Claudio; Bascunan-Godoy, Luisa; Castro, Patricio A. Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model Panes, Jessica D.; Godoy, Pamela A.; Silva-Grecchi, Tiare; Celis, Maria T.; Ramirez-Molina, Oscar; Gavilan, Javiera; Munoz-Montecino, Carola; Castro, Patricio A.; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Guzman, Leonardo; Salisbury, Jeffrey L.; Trushina, Eugenia; Fuentealba, Jorge Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Inhibition of the Glycine Receptor alpha 3 Function by Colchicine Munoz-Montesino, Carola; Burgos, Carlos F.; Lara, Cesar O.; Riquelme, Camila R.; Flaig, David; San Martin, Victoria P.; Aguayo, Luis G.; Fuentealba, Jorge; Castro, Patricio A.; Guzman, Leonardo; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers Vásquez, Pilar A.; San Martín, Loreto; Argel, Yenifer; Riquelme, Camila; Torres, Josefa; Vidal, Felipe; Cayuman, Francisca; Castro, Patricio; Fuentealba, Jorge; Moraga-Cid, Gustavo; Yevenes, Gonzalo; Jin, Chunyang; Jiménez, Verónica A.; Guzmán, Leonardo Article Journal of Chemical Information and Modeling (2020)
Data on SVCT2 transporter expression and localization in cancer cell lines and tissues Roa, Francisco J.; Pena, Eduardo; Inostroza, Eveling; Sotomayor, Kirsty; Gonzalez, Mauricio; Gutierrez-Castro, Francisco A.; Maurin, Michelle; Sweet, Karen; Labrousse, Claire; Gatica, Marcell; Aylwin, Carlos E.; Mendoza, Pamela; Maldonado, Mafalda; Delgado, Carolina; Madariaga, Jaime; Panes, Jessica; Silva-Grecchi, Tiare; CONCHA, Ilona I.; Moraga-Cid, Gustavo; Reyes, Alejandro M.; Munoz-Montesino, Carola; Carlos Vera, Juan; RIVAS, Coralia I. Article WOS-ESCI SCOPUS Data in Brief (2019)
Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer. Peña E, Roa FJ; Inostroza E, Sotomayor K; González M, Gutierrez-Castro FA; Maurin M, Sweet K; Labrousse C, Gatica M; Aylwin CF, Mendoza P; Maldonado M, Delgado C; Madariaga J, Panes J; Silva-Grecchi T, Concha II; Moraga-Cid G, Reyes AM Article ADVANCES IN FREE RADICAL BIOLOGY AND MEDICINE (2019)
Inhibitory actions of tropeines on the alpha3 glycine receptor function San Martin VP, Burgos CF; Marileo AM, Lara CO; Fuentealba J, Guzmán L; Castro PA, Aguayo LG; Moraga-Cid G, Yévenes GE. Article FRONTIERS IN PHARMACOLOGY (2019)
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors. Lara CO, Burgos CF; Silva-Grecchi T, Muñoz-Montesino C; Aguayo LG, Fuentealba J; Castro PA, Guzmán JL; Corringer PJ, Yévenes GE Article ACS CHEMICAL NEUROSCIENCE (2019)
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. Acuña, Mario A; Yévenes, Gonzalo E; Ralvenius, William T; Benke, Dietmar; Di Lio, Alessandra; Lara, Cesar O; Muñoz, Braulio; Burgos, Carlos F; Moraga-Cid, Gustavo; Corringer, Pierre-Jean; Zeilhofer, Hanns Ulrich Article The Journal of clinical investigation (2016)
Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected? Förstera, Benjamin; Castro, Patricio A; Moraga-Cid, Gustavo; Aguayo, Luis G Article Frontiers in cellular neuroscience (2016)
Allosteric and hyperekplexic mutant phenotypes investigated on an Î±1 glycine receptor transmembrane structure. Moraga-Cid, Gustavo; Sauguet, Ludovic; Huon, Christèle; Malherbe, Laurie; Girard-Blanc, Christine; Petres, Stéphane; Murail, Samuel; Taly, Antoine; Baaden, Marc; Delarue, Marc; Corringer, Pierre-Jean Article Proceedings of the National Academy of Sciences of the United States of America (2015)
Intermediate closed state for glycine receptor function revealed by cysteine cross-linking. Prevost, Marie S; Moraga-Cid, Gustavo; Van Renterghem, Catherine; Edelstein, Stuart J; Changeux, Jean-Pierre; Corringer, Pierre-Jean Article Proceedings of the National Academy of Sciences of the United States of America (2013)
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. Sauguet, Ludovic; Poitevin, Frédéric; Murail, Samuel; Van Renterghem, Catherine; Moraga-Cid, Gustavo; Malherbe, Laurie; Thompson, Andrew W; Koehl, Patrice; Corringer, Pierre-Jean; Baaden, Marc; Delarue, Marc Article The EMBO journal (2013)
A Single phenylalanine residue in the main intracellular loop of Î±1 Î³-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol. Moraga-Cid, Gustavo; Yevenes, Gonzalo E; Schmalzing, Günther; Peoples, Robert W; Aguayo, Luis G Article Anesthesiology (2011)
Activated G protein Î± s subunits increase the ethanol sensitivity of human glycine receptors. Yévenes, Gonzalo E; Moraga-Cid, Gustavo; Romo, Ximena; Aguayo, Luis G Article The Journal of pharmacology and experimental therapeutics (2011)
Allosteric modulation of retinal GABA receptors by ascorbic acid. Calero, Cecilia I; Vickers, Evan; Moraga Cid, Gustavo; Aguayo, Luis G; von Gersdorff, Henrique; Calvo, Daniel J Article The Journal of neuroscience : the official journal of the Society for Neuroscience (2011)
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. Duret, Guillaume; Van Renterghem, Catherine; Weng, Yun; Prevost, Marie; Moraga-Cid, Gustavo; Huon, Christèle; Sonner, James M; Corringer, Pierre-Jean Article Proceedings of the National Academy of Sciences of the United States of America (2011)
Potentiation and inhibition of glycine receptors by tutin Fuentealba, J; Munoz B.; Yevenes, G; Moraga-Cid G.; Guzman L.; Aguayo L.G.; Perez, C; Rigo J.M. Article NEUROPHARMACOLOGY (2011)
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. Avila, Miguel E; Sepúlveda, Fernando J; Burgos, Carlos F; Moraga-Cid, Gustavo; Parodi, Jorge; Moon, Randall T; Aguayo, Luis G; Opazo, Carlos; De Ferrari, Giancarlo V Article The Journal of biological chemistry (2010)
Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective G beta gamma Modulation Yevenes, GE; Moraga-Cid G.; Avila A.; Guzman L.; Figueroa M.; Peoples, RW; Aguayo, LG Article JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with GB gamma Binding Guzman L.; Moraga-Cid G.; Avila A.; Figueroa M.; Yevenes, GE; Fuentealba, J; Aguayo, LG Article JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Peoples, Robert W; Schmalzing, Günther; Aguayo, Luis G Article Proceedings of the National Academy of Sciences of the United States of America (2008)
Effects of pulp and paper mill discharges on caged rainbow trout (Oncorhynchus mykiss): Biomarker responses along a pollution gradient in the Biobio River, Chile Orrego, R; Burgos, A; Moraga-Cid G.; Inzunza, B; Gonzalez, M; Valenzuela, A; Barra, R; Gavilan, JE Article ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2006)
Molecular determinants for G protein beta gamma modulation of ionotropic glycine receptors Yevenes, GE; Moraga-Cid G.; Guzman L.; Haeger, S; Oliveira, L; Olate, J; Schmalzing, G; Aguayo, LG Article JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
An RNA vaccine based on recombinant semliki forest virus particles expressing the Cu,Zn superoxide dismutase protein of Brucella abortus induces protective immunity in BALB/c mice Onate, AA; Donoso, G; Moraga-Cid G.; Folch H.; Cespedes, S; Andrews, E Article INFECTION AND IMMUNITY (2005)
Reproductive, physiological, and biochemical responses in juvenile female rainbow trout (Oncorhynchus mykiss) exposed to sediment from pulp and paper mill industrial discharge areas Orrego, R; Moraga-Cid G.; Gonzalez, M; Barra, R; Valenzuela, A; Burgos, A; Gavilan, JE Article ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2005)
Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4(+) and CD8(+) T cells Munoz-Montesino, C; Andrews, E; Rivers, R; Gonzalez-Smith, A; Moraga-Cid G.; Folch H.; Cespedes, S; Onate, AA Article INFECTION AND IMMUNITY (2004)


Targeting glycine receptors for the treatment of chronic pain, hyperekplexia and anxiety=> development of novel modulators based on recent structural and pharmacological insights FONDECYT (1170252) Proyecto 2018-2021 Coinvestigador(a)
DISEÑO Y MEJORAMIENTO DE MODULADORES ALOSTÉRICOS CON ACTIVIDAD INSECTICIDA BASADO EN LA ESTRUCTURA CRISTALOGRÁFICA DEL RECEPTOR DE GABA RDL FONDECYT (3170108) Proyecto 2017-2020 Inv. Patrocinante
Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors. FONDECYT (1160851) Proyecto 2016-2018 Inv. Principal
Holographic Dissection of Neuronal Circuits National Agency of the Research (ANR). France (ANR-12-BSV5-0011) Proyecto 2013-2016 Postdoctorado
Molecular pharmacology of ethanol action on pentameric channel receptors based on their 3D structures=> an electrophysiological study Foundation for the Medical Research (FRM). France (SPF20120523888) Proyecto 2012-2014 Inv. Responsable
Structural characterization of the open and closed state of the an ionic channel from the cys loop family National Research Agency (ANR) France (ANR-10-BLAN-1534) Proyecto 2011-2014 Postdoctorado
“Modulation of glycine receptor by ethanol” NIAAA, USA (NIH R01 AA15150) Proyecto 2004-2008 Tesista


Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain Lara C.O.; Burgos C.F.; Moraga-Cid G.; Carrasco M.A.; YÃ©venes G.E. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2020)
Therapeutic Use of Vitamin C in Cancer: Physiological Considerations Roa F.J.; PeÃ±a E.; Gatica M.; Escobar-AcuÃ±a K.; Saavedra P.; Maldonado M.; Cuevas M.E.; Moraga-Cid G.; Rivas C.I.; MuÃ±oz-Montesino C. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2020)