Man

Carola Andrea Muñoz Montesino

Profesor Asistente

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Líneas de Investigación


Oxidative stress and neurodegeneration: the role of antioxidants management inside affected cells PrP Sequence modifications and consequences in function and pathology Biology of Prion Diseases Bioethics in dementia

Educación

  •  DOCTORADO EN CIENCIAS BIOLOGICAS AREA BIOLOGIA CELULAR Y MOLECULAR, UNIVERSIDAD DE CONCEPCION. Chile, 2009
  •  BIOLOGO, UNIVERSIDAD DE CONCEPCION. Chile, 2002
  •  Bioética, UNIVERSIDAD DE CHILE. Chile

Experiencia Académica

  •   COLABORADOR DOCENTE Part Time

    UNIVERSIDAD DE CONCEPCION

    CIENCIAS BIOLOGICAS

    CONCEPCION, Chile

    2008 - 2010

Experiencia Profesional

  •   Colaborador Docente Fisiopatología

    Universidad de Concepcion

    Chile

    2008 - 2009

  •   Docente tiempo parcial Microscopía

    Universidad San Sebastian

    Chile

    2006 - 2009

  •   Docente tiempo parcial Biología Celular

    Universidad Nacional Andres Bello

    Chile

    2009 - 2009

  •   Profesor Invitado Magister Fisiología

    Universidad de Concepcion

    Chile

    2016 - 2016

  •   Investigador Postdoctoral Full Time

    Instituto Pasteur

    Paris, Francia

    2011 - 2012

  •   Investigador Postdoctoral Full Time

    Instituto Nacional de la Investigación Agronomica (INRA Jouy en Josas)

    Jouy en Josas, Francia

    2012 - 2016

  •   Director Científico Part Time

    Fundacion de Enfermedades Neurodegenerativas

    Chile

    2016 - 2020

  •   Profesor Asistente Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2018 - At present


 

Article (21)

Elephant Black Garlic's Beneficial Properties for Hippocampal Neuronal Network, Chemical Characterization and Biological Evaluation

Gavilan, Javiera; Mardones, Claudia; Oyarce, Gabriela; Trivino, Sergio; Espinoza-Rubilar, Nicole; Ramirez-Molina, Oscar; Perez, Claudia; Becerra, Jose; Varas, Patricio; Duran-Arcos, Robinson; Munoz-Montesino, Carola; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Fuentealba, Jorge

Article ISI
FOODS  (2023)

Modulation of GABA<sub>A</sub> receptors and of GABAergic synapses by the natural alkaloid gelsemine

Marileo, Ana M.; Gavilan, Javiera; San Martin, Victoria P.; Lara, Cesar O.; Sazo, Anggelo; Munoz-Montesino, Carola; Castro, Patricio A.; Burgos, Carlos F.; Leiva-Salcedo, Elias; Aguayo, Luis G.; Moraga-Cid, Gustavo; Fuentealba, Jorge; Yevenes, Gonzalo E.

Article ISI
FRONTIERS IN MOLECULAR NEUROSCIENCE  (2023)

TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease

Panes-Fernandeza, Jessica; Godoy, Pamela A.; Gavilan, Javiera; Ramirez-Molina, Oscar; Burgos, Carlos Felipe; Marileo, Ana; Flores-Nunez, Oscar; Castro, Patricio A.; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Munoz-Montesino, Carola; Fuentealba, Jorge

Article ISI
BIOMEDICINE & PHARMACOTHERAPY  (2023)

Transport of Vitamin C in Cancer

Munoz-Montesino, Carola; Pena, Eduardo; Roa, Francisco J.; Sotomayor, Kirsty; Escobar, Elizabeth; RIVAS, Coralia I.

Article ISI
ANTIOXIDANTS & REDOX SIGNALING  (2021)

A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP

Carola Muñoz-Montesino, Djabir Larkem, Clément Barbereau, Angélique Igel-Egalon, Sandrine Truchet, Eric Jacquet, Naïma Nhiri, Mohammed Moudjou, Christina Sizun, Human Rezaei, Vincent Béringue, and Michel Dron.

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (2020)

Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

Panes, Jessica D.; Godoy, Pamela A.; Silva-Grecchi, Tiare; Celis, Maria T.; Ramirez-Molina, Oscar; Gavilan, Javiera; Munoz-Montecino, Carola; Castro, Patricio A.; Moraga-Cid, Gustavo; Yevenes, Gonzalo E.; Guzman, Leonardo; Salisbury, Jeffrey L.; Trushina, Eugenia; Fuentealba, Jorge

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

Inhibition of the Glycine Receptor alpha 3 Function by Colchicine

Munoz-Montesino, Carola; Burgos, Carlos F.; Lara, Cesar O.; Riquelme, Camila R.; Flaig, David; San Martin, Victoria P.; Aguayo, Luis G.; Fuentealba, Jorge; Castro, Patricio A.; Guzman, Leonardo; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

Inhibition of the glycine receptor alpha 3 function by colchicine.

Munoz-Montesino C, Carlos F. Burgos, Camila R Riquelme Vidal, David Flaig, Victoria P San Martin, Luis Gerardo Aguayo, Jorge Fuentealba, Patricio A Castro, Jose L Guzmán, Gonzalo E Yevenes* and Gustavo Moraga-Cid*

Article WOS, ISI, SCOPUS
FRONTIERS IN PHARMACOLOGY  (2020)

Modulation of glycine receptor single-channel conductance by intracellular phosphorylation

Moraga-Cid G.; San Martín V.P.; Lara C.O.; Muñoz B.; Marileo A.M.; Sazo A.; Muñoz-Montesino C.; Fuentealba, J; Castro P.A.; Guzmán L.; Burgos C.F.; Zeilhofer H.U.; Aguayo, L. G.; Corringer P.-J.; Yévenes G.E.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2020)

Data on SVCT2 transporter expression and localization in cancer cell lines and tissues

Roa, Francisco J.; Pena, Eduardo; Inostroza, Eveling; Sotomayor, Kirsty; Gonzalez, Mauricio; Gutierrez-Castro, Francisco A.; Maurin, Michelle; Sweet, Karen; Labrousse, Claire; Gatica, Marcell; Aylwin, Carlos E.; Mendoza, Pamela; Maldonado, Mafalda; Delgado, Carolina; Madariaga, Jaime; Panes, Jessica; Silva-Grecchi, Tiare; CONCHA, Ilona I.; Moraga-Cid, Gustavo; Reyes, Alejandro M.; Munoz-Montesino, Carola; Carlos Vera, Juan; RIVAS, Coralia I.

Article WOS-ESCI SCOPUS
Data in Brief  (2019)

Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer

Peña E, Roa FJ, Inostroza E, Sotomayor K, González M, Gutierrez-Castro FA, Maurin M, Sweet K, Labrousse C, Gatica M, Aylwin CF, Mendoza P, Maldonado M, Delgado C, Madariaga J, Panes J, Grecchi-Silva T, Concha II, Moraga-Cid G, Reyes AM, Muñoz-Montesino C,

Article ISI SCOPUS
FREE RADICAL BIOLOGY AND MEDICINE  (2019)

Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer.

Peña, Eduardo; Roa, Francisco J; Inostroza, Evelyn; Sotomayor, Kirsty; González, Mauricio; Gutierrez-Castro Francisco A; Maurin, Michelle; Sweet, Karen; Labrousse, Claire; Gatica, Marcell; Aylwin, Carlos F; Mendoza, Pamela; Maldonado, Mafalda;; Delgado, Carolina; Madariaga, Jaime; Panes, Jessica; Silva-Grecchi, Tiare; Concha Ilona I; Moraga-Cid, Gustavo; Reyes, Alejandro M; Muñoz-Montesino, Carola; Vera, Juan Carlos; Rivas, Coralia I.

Article WOS, ISI, SCOPUS
FREE RADICAL BIOLOGY AND MEDICINE  (2019)

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors.

Lara, Cesar O; Burgos, Carlos F; Silva-Grecchi, Tiare; Muñoz-Montesino, Carola; Aguayo, Luis G; Fuentealba, Jorge; Castro, Patricio A; Guzmán, Jose L; Corringer, Pierre-Jean; Yévenes, Gonzalo E; Moraga-Cid, Gustavo

Article
ACS chemical neuroscience  (2019)

A stretch of residues within the protease-resistant core is not necessary for prion structure and infectivity

Munoz-Montesino, Carola; Sizun, Christina; Moudjou, Mohammed; Herzog, Laetitia; Reine, Fabienne; Igel-Egalon, Angelique; Barbereau, Clement; Chapuis, Jerome; Ciric, Danica; Laude, Hubert; Beringue, Vincent; Rezaei, Human; Dron, Michel

Article ISI
PRION  (2017)

Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy

Maldonado, Mafalda; Inostroza, Eveling; Peña, Eduardo; Moncada, Natacha; Mardones, Lorena; Medina, José Luis; Muñoz, Alejandra; Gatica, Marcell; Villagrán, Marcelo; Escobar, Elizabeth; Mendoza, Pamela; Roa, Francisco J.; González, Mauricio; Guzmán, Paula; Gutiérrez-Castro, Francisco A.; Sweet, Karen; Muñoz-Montesino, Carola; Vera, Juan Carlos; Rivas, Coralia I.

Article
Free Radical Biology and Medicine  (2017)

Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy

Maldonado, Mafalda; Inostroza, Eveling; Peña, Eduardo; Moncada, Natacha; Mardones, Lorena; Medina, José Luis; Muñoz, Alejandra; Gatica, Marcell; Villagrán, Marcelo; Escobar, Elizabeth; Mendoza, Pamela; Roa, Francisco J.; González, Mauricio; Guzmán, Paula; Gutiérrez-Castro, Francisco A.; Sweet, Karen; Muñoz-Montesino, Carola; Vera, Juan Carlos; Rivas, Coralia I.

Article ISI SCOPUS
FREE RADICAL BIOLOGY AND MEDICINE  (2017)

Generating Bona Fide Mammalian Prions with Internal Deletions

Munoz-Montesino, Carola; Sizun, Christina; Moudjou, Mohammed; Herzog, Laetitia; Reine, Fabienne; Chapuis, Jerome; Ciric, Danica; Igel-Egalon, Angelique; Laude, Hubert; Beringue, Vincent; Rezaei, Human; Dron, Michel

Article ISI
JOURNAL OF VIROLOGY  (2016)

Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2.

Muñoz-Montesino, Carola; Roa, Francisco J; Peña, Eduardo; González, Mauricio; Sotomayor, Kirsty; Inostroza, Eveling; Muñoz, Carolina A; González, Iván; Maldonado, Mafalda; Soliz, Carlos; Reyes, Alejandro M; Vera, Juan Carlos; Rivas, Coralia I

Article
Free radical biology & medicine  (2014)

Mammalian prions Tolerance to sequence changes-how far?

Salamat, Muhammad Khalid; Munoz-Montesino, Carola; Moudjou, Mohammed; Rezaei, Human; Laude, Hubert; Beringue, Vincent; Dron, Michel

Article ISI
PRION  (2013)

Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione

Montecinos, V.; Guzman P.; Barra V; Villagrán M.; Munoz-Montesino, C; Sotomayor, K; Escobar, E; Godoy A.; Mardones L.; Sotomayor P.; Guzmán C; Vásquez O.; Gallardo V.; van Zundert, B; Bono, MR.; Onate, SA; Bustamante, M; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4(+) and CD8(+) T cells

Munoz-Montesino, C; Andrews E.; Rivers, R; Gonzalez-Smith, A; Moraga-Cid, G; Folch H.; Cespedes, S; Onate, AA

Article ISI SCOPUS
INFECTION AND IMMUNITY  (2004)

Abstract (1)

Vitamin C metabolism in human cancer cells

Rivas, CI; Munoz, C; Quilodran, J; Barra V; Vera, JC; Sotomayor, K

Abstract ISI
FREE RADICAL RESEARCH  (2006)

ConferencePoster (1)

SVCT2 expression in a model of Alzheimer’s disease.

Torres-Fuentes, Carla; Morel-Soto, Camila; Caceres, Tamara; RIVAS, Coralia I.; Muñoz-Montesino, Carola

ConferencePoster
 (2023)

Proyecto (5)

Señas de mi Tierra

Valentina Muñoz

Proyecto
 (2020)

Abeta assemblies propagation and cell damage in Alzheimer disease

Ecos-CONICYT 2017 (C16S01)

Proyecto
2017-2019
Investigador(a)

« Molecular mechanisms of structural information transfer during prion replication ».

Proyecto French Fondation pour la Recherche Médicale (DEQ20150331689))

Proyecto
2013-2014
Postdoctorado

Biología Celular y Molecular de Prion

PFCHA (no tiene)

Proyecto
2011-2013
Postdoctorado

“Protecting the food chain from prions=> shaping European priorities through basic and applied research ».

Financiado por 7th FWP (Seventh Framework Programme) (PRIORITY 222887)

Proyecto
2011-2012
Postdoctorado

Review (2)

PrP(c) as a Transducer of Physiological and Pathological Signals

Panes, Jessica D.; Saavedra, Paulina; Pineda, Benjamin; Escobar, Kathleen; Cuevas, Magdalena E.; Moraga-Cid, Gustavo; Fuentealba, Jorge; RIVAS, Coralia I.; Rezaei, Human; Munoz-Montesino, Carola

Review ISI
FRONTIERS IN MOLECULAR NEUROSCIENCE  (2021)

Therapeutic Use of Vitamin C in Cancer: Physiological Considerations

Roa F.J.; Peña E.; Gatica M.; Escobar-Acuña K.; Saavedra P.; Maldonado M.; Cuevas M.E.; Moraga-Cid G.; Rivas C.I.; Muñoz-Montesino C.

Review ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2020)

23
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

6
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

6
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

5
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

5
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

4
Marcell Gatica

Profesora asistente

Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

4
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

4
MAFALDA MALDONADO

PROFESOR ASOCIADO

Fisopatología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

4
JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

3
mauricio gonzalez

phd

fisiopatologia

universidad de concepción

concepcion, Chile

3
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

3
Oscar Ramírez

PhD Candidate

Fisiología

Universidad de Concepción

Concepción, Chile

2
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

2
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

2
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

2
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

2
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

2
Hugo Folch

Professor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Pamela Godoy

Colaboradora académica

Fisiología

Universidad de Concepción

Concepcion, Chile

1
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

1
Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

1
Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Francisco Roa

Profesor Asistente

Fisiopatología, Facultad de Ciencias Biológicas

Universidad de Concepción

Concepción, Chile

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

1
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
CAROLINA DELGADO

Encargado de proyectos de desarrollo de Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile