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Sergio Alejandro Onate Betancour

Associate Professor

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

Cancer Biology, Nuclear Receptor Coregulators, Molecular Endocrinology. Mechanism by which coregulators for nuclear receptors alter gene expression in a cell/tissue compartment-specific manner in progression to recurrence and metastasis

Experimental Pathology, University of Colorado Health sciences Center. Estados Unidos, 1993
Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1986

Associate Professor Full Time

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2013 - At present
Associate Professor Full Time

UNIVERSIDAD DE CONCEPCION

Biological Sciences

CONCEPCION, Chile

2008 - 2013
ASSISTANT PROFESSOR Full Time

ROSWELL PARK CANCER INSTITUTE

BUFFALO, Estados Unidos

2004 - 2008
ASSISTANT PROFESSOR ADJUNCT Other

STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY

BUFFALO, NY, Estados Unidos

2004 - 2008
ASSISTANT PROFESSOR Full Time

UNIVERSITY OF PITTSBURGH

PITTSBURGH, PA, Chile

1998 - 2004
INSTRUCTOR Full Time

BAYLOR COLLEGE OF MEDICINE

HOUSTON, TX, Chile

1996 - 1998

Associate Professor Full Time

University of Concepcion

Chile

2008 - 2013
Assistant Professor Full Time

Roswell Park Cancer Institute

Buffalo, Estados Unidos

2004 - 2008
Assistant Professor Full Time

University of pittsburgh

Pittsburgh, Chile

1998 - 2004
Instructor Full Time

Baylor College of Medicine

Houston, Chile

1995 - 1998
POSTDOCTORAL FELLOW Full Time

BAYLOR COLLEGE OF MEDICINE

HOUSTON, TX, Estados Unidos

1993 - 1995
DOCTORAL TRAINING, EXPERIMENTAL PATHOLOGY Other

UNIVERSITY OF COLORADO HEALTH SCIENCES CENTER

DENVER, Chile

1988 - 1993

Student Supervisions.
Graduate Students. -Marjet Heitzer. -Marie Acquilano. -David Yeates. -Spephania Urso. -Rosalba Escamilla. -Patricia cano. -Victor M. Garcia.
Graduate Student Committees.
Lecture Title
“Nuclear/cytosol trafficking” “Mechanisms of Hormone Action” “Cell Biol. of Diseases States” “Specific Topics on gene Expression”
-Michelle Clinton. -Alvin Munk. -Stephanie Carson. -Julie E. Lehman. -Elizabeth Baine. -Candace Roman
1999. Current: Medical School. New York Inst. of Tech.
2000-2002. 2001. 1999. 2000-2001. 2002.
Current: Medical School, U. of Pittsburgh. Current: School of Pharmacy, U. of Pittsburgh Current: Research Technician, UCSF. Current: Undergraduate, U. of Pittsburgh
2002-present. 2001.
2002.
2002. 1999-2002, 2000-2003, 2003-present.
U. of Pitt.
U. of Pitt.
U. of Pitt.
U. of Pitt.
UPN, Mexico.
UPN, Mexico.
U. of Guadalajara, Mexico.
Frank Delfino, Ph.D. Graduate Committee (University of Pittsburgh). Kelly Sutter. Preliminary Exam committee (University of Pittsburgh). Rosalba Escamilla. Ph.D. Student Advisor
Patricia Cano. Ph.D. Student Advisor
Marjet Heitzer, Ph.D. Student Advisor
Un

PATENTS
Steroid Receptor Coactivators, Baylor College of Medicine, Houston, TX.


Lectin-Like Oxidized LDL Receptor-1 Is an Enhancer of Tumor Angiogenesis in Human Prostate Cancer Cells González-Chavarría, Iván; Cerro, Rita P.; Parra, Natalie P.; Sandoval, Felipe A.; Zuñiga, Felipe A.; Omazábal, Valeska A.; Lamperti, Liliana I.; Jiménez, Silvana P.; Fernandez, Edelmira A.; Gutiérrez, Nicolas A.; Rodríguez, Federico S.; Oñate, Sergio A.; Sánchez Oliberto; Vera, Juan C.; Toledo, Jorge R.; Pizzo, Salvatore V. Article ISI PLOS ONE (2014)
Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression Godoy, A. S.; Sotomayor, P. C.; Villagrán M.; Yacoub R.; Montecinos, V. P.; McNerney E.M.; Moser M.; Foster B.A.; Onate S.A. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2012)
Biochemical characterization of nuclear receptors for vitamin D-3 and glucocorticoids in prostate stroma cell microenvironment Hidalgo, AA; Montecinos, VP; Paredes, R.; Godoy, AS; McNerney, EM; Tovar, H; Pantoja D.; Johnson C.; Trump D.; Onate, SA Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
Prx1 Enhances Androgen Receptor Function in Prostate Cancer Cells by Increasing Receptor Affinity to Dihydrotestosterone Chhipa, RR; Lee, KS; Oñate S.; Wu, Y; Ip, C Article ISI SCOPUS MOLECULAR CANCER RESEARCH (2009)
1 alpha,25-dihydroxy vitamin D-3-Enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1 alpha,25-dihydroxy vitamin D-3 Receptor-SRC-1 coactivator complex Carvallo L; Henriquez, B; Paredes, R.; Olate, J; Oñate S.; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
1?,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1?,25-dihydroxy vitamin D 3 receptor-SRC-1 coactivator complex Carvallo L; Henriquez, B; Paredes, R.; Olate, J; Montecino, M.; Oñate S.; van Wijnen A.J.; Lian J.B.; Stein G.S.; Stein J.L. Article JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2 Godoy A.; Ormazabal, V; Moraga-Cid, G; Zuniga, FA; Sotomayor P.; Barra V; Vásquez O.; Montecinos, V.; Mardones L.; Guzmán C; Villagrán M.; Aguayo, LG; Onate, SA; Reyes, AM; Carcamo, JG; Rivas, CI; Vera, JC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Phosphorylation at serine 208 of the 1 alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators Arriagada, G; Paredes, R.; Olate, J; van Wijnen A.; Lian, JB; Stein, GS; Stein, JL; Oñate S.; Montecino, M. Article ISI SCOPUS JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
Phosphorylation at serine 208 of the 1?,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators Arriagada, G; Paredes, R.; Olate, J; Montecino, M.; van Wijnen A.; Lian J.B.; Stein G.S.; Oñate S.; Stein J.L. Article JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
The 1 alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene Carvallo L; Henriquez, B; Olate, J; van Wijnen, AJ; Lian, JB; Stein, GS; Oñate S.; Stein, JL; Montecino, M. Article ISI SCOPUS JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
The 1?,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene Carvallo L; Henriquez, B; Olate, J; Montecino, M.; van Wijnen A.J.; Lian J.B.; Stein G.S.; Stein J.L.; Oñate S. Article JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione Montecinos, V.; Guzman P.; Barra V; Villagrán M.; Munoz-Montesino, C; Sotomayor, K; Escobar, E; Godoy A.; Mardones L.; Sotomayor P.; Guzmán C; Vásquez O.; Gallardo V.; van Zundert, B; Bono, MR.; Onate, SA; Bustamante, M; Carcamo, JG; Rivas, CI; Vera, JC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing Garcia, MD; Millán C; Balmaceda-Aguilera, C; Castro, T.; Pastor P; Montecinos, H.; Reinicke K; Zuniga, F; Vera, JC; Onate, SA; Nualart, F. Article ISI JOURNAL OF NEUROCHEMISTRY (2003)
The 1 alpha,25-dihydroxyvitamin D-3-enchancement of the OC gene is dependent upon binding of bone-specific transcription factor Runx2 to gene promoter Paredes, R.; Arriagada, G; Cruzat F.; Villagra, A; Zaidi, K; Olate, J; van Wijnen A.; Lian J.; Stein, J; Onate, SA; Montecino MA Article MOLECULAR BIOLOGY OF THE CELL


Glucokinase is expressed in mouse hypothalamic tanycytes, an enzyme involved in glucose sensing García MA; Millán C; Pastor P; Escamilla, R; Oñate S.; Nualart, F. Abstract JOURNAL OF NEUROCHEMISTRY (2003)


Bone Stroma induces AR basal transcriptional activity in prostate cancer cells Villagrán M.; Mardones L.; Rivas, CI; Vera, JC; Onate, SA; Onate, SA ConferencePaper 15th International Conference on Electronics, Communications and Computers, Proceedings (2009)


Altered androgen receptor-dependent transcriptional activity in tumoral prostatic cells in the presence of bone stromal cells Villagrán M.; Mardones L.; Soliz, C; Rivas, C; Vera, JC; Oñate S.; Vera, JC ConferencePoster 15th International Conference on Electronics, Communications and Computers, Proceedings (2008)

Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

Oliberto Sanchez

Associate Professor

Pharmacology

University of Concepción

Concepción, Chile

PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Alejandro Hidalgo

Associate Professor

Escuela de Química y Farmacia

Universidad Andres Bello

Santiago, Chile

Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

IVAN GONZALEZ

Profesor Asistente

Fisiopatología

Universidad De Concepcion

Concepción, Chile

Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Natalie Parra

Colaborador Académico

Farmacología

Universidad de Concepción

Concepción, Chile

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

Sergio Alejandro Onate Betancour

Líneas de Investigación

Educación

Experimental Pathology, University of Colorado Health sciences Center. Estados Unidos, 1993

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1986

Experiencia Académica

Associate Professor Full Time

Associate Professor Full Time

ASSISTANT PROFESSOR Full Time

ASSISTANT PROFESSOR ADJUNCT Other

ASSISTANT PROFESSOR Full Time

INSTRUCTOR Full Time

Experiencia Profesional

Associate Professor Full Time

Assistant Professor Full Time

Assistant Professor Full Time

Instructor Full Time

POSTDOCTORAL FELLOW Full Time

DOCTORAL TRAINING, EXPERIMENTAL PATHOLOGY Other

Formación de Capital Humano

Difusión y Transferencia

Article (14)

Abstract (1)

ConferencePaper (1)

ConferencePoster (1)