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Paula Camila Sotomayor Fahrenkrog

Investigador

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Investigación de resistencias a drogas anti-cancerígenas. Estudio del microambiente y vasculatura tumoral. Marcadores diagnósticos y pronósticos en cáncer.

Educación

  •  Licenciado en Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2004
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2005
  •  PhD Ciencias Biológicas, STATE UNIVERSITY OF NEY YORK AT BUFFALO. Estados Unidos, 2013

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Santiago, Chile

    2014 - 2018

  •   Investigador Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2018 - At present

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad Andrés Bello

    SANTIAGO, Chile

    2014 - 2018

  •   Investigador Full Time

    Pontificia Universidad Católica de Chile

    SANTIAGO, Chile

    2018 - At present


 

Article (25)

Anti-Inflammatory Chilean Endemic Plants

Otero, Carolina; Klagges, Carolina; Morales, Bernardo; Sotomayor, Paula; Escobar, Jorge; Fuentes, Juan A; Moreno, Adrian A; Llancalahuen, Felipe M; Arratia-Perez, Ramiro; Gordillo-Fuenzalida, Felipe; Herrera, Michelle; Martínez, Jose L; Rodríguez-Díaz, Ma

Article
PHARMACEUTICS  (2023)

Active Surveillance in Prostate Cancer: Current and Potentially Emerging Biomarkers for Patient Selection Criteria

Sotomayor, Paula C. C.; Aguilar, Juan C. C.; Mujica, Karen; Zuniga, Alvaro; Godoy, Alejandro S. S.; Smith, Gary J. J.; Mohler, James L. L.; Vitagliano, Gonzalo; San Francisco, Ignacio F. F.

Article ISI
UROLOGIA INTERNATIONALIS  (2022)

The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells

Torres-Estay, Veronica; Mastri, Michalis; Rosario, Spencer; Fuenzalida, Patricia; Echeverria, Carolina E.; Flores, Emilia; Watts, Anica; Cerda-Infante, Javier; Montecinos, Viviana P.; Sotomayor, Paula C.; Amigo, Julio; Escudero, Carlos; Nualart, Francisco; Ebos, John M. L.; Smiraglia, Dominic J.; Godoy, Alejandro S.

Article ISI
CANCERS  (2022)

Dietary Fructose Promotes Prostate Cancer Growth

Carreno, Daniela, V; Corro, Nestor B.; Cerda-Infante, Javier F.; Echeverria, Carolina E.; Asencio-Barria, Catalina A.; Torres-Estay, Veronica A.; Mayorga-Weber, Gonzalo A.; Rojas, Pablo A.; Veliz, Loreto P.; Cisternas, Pedro A.; Montecinos, Viviana P.; San Francisco, Ignacio F.; Varas-Godoy, Manuel A.; Sotomayor, Paula C.; Castro, Maite A.; Nualart, Francisco J.; Inestrosa, Nibaldo C.; Godoy, Alejandro S.

Article ISI
CANCER RESEARCH  (2021)

Intranasal delivery of interferon-beta-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy

Gonzalez, Luis F.; Acuna, Eric; Arellano, Gabriel; Morales, Paola; Sotomayor, Paula; Oyarzun-Ampuero, Felipe; Naves, Rodrigo

Article ISI
JOURNAL OF CONTROLLED RELEASE  (2021)

Fructose and prostate cancer: toward an integrated view of cancer cell metabolism

Carreno, Daniela; Corro, Nestor; Torres-Estay, Veronica; Veliz, Loreto P.; Jaimovich, Rodrigo; Cisternas, Pedro; San Francisco, Ignacio F.; Sotomayor, Paula C.; Tanasova, Marina; Inestrosa, Nibaldo C.; Godoy, Alejandro S.

Article ISI SCOPUS
PROSTATE CANCER AND PROSTATIC DISEASES  (2019)

Androgens modulate male-derived endothelial cell homeostasis using androgen receptor-dependent and receptor-independent mechanisms

Torres-Estay, Verónica; Carreño, Daniela V.; Fuenzalida, Patricia; Watts, Anica; San Francisco, Ignacio F.; Montecinos, Viviana P.; Sotomayor, Paula C.; Ebos, John; Smith, Gary J.; Godoy, Alejandro S.

Article ISI SCOPUS
ANGIOGENESIS  (2017)

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells

Pinto, Mauricio; SOTOMAYOR, PAULA; Carrasco-Avino, Gonzalo; Corvalan, Alejandro; Owen, Gareth

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2016)

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma

Ramakrishnan, Swathi; Ku, ShengYu; Ciamporcero, Eric; Miles, Kiersten Marie; Attwood, Kris; Chintala, Sreenivasulu; Shen, Li; Ellis, Leigh; SOTOMAYOR, PAULA; Swetzig, Wendy; Huang, Ray; Conroy, Dylan; Orillion, Ashley; Das, Gokul; Pili, Roberto

Article ISI SCOPUS
BMC CANCER  (2016)

Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic Modifications

Adelaiye, R.; Ciamporcero, E.; Miles, K. M.; Sotomayor, P.; Bard, J.; Tsompana, M.; Conroy, D.; Shen, L.; Ramakrishnan, S.; Ku, S.-Y.; Orillion, A.; Prey, J.; Fetterly, G.; Buck, M.; Chintala, S.; Bjarnason, G. A.; Pili, R.

Article
Molecular Cancer Therapeutics  (2015)

Dll4 Blockade Potentiates the Anti-Tumor Effects of VEGF Inhibition in Renal Cell Carcinoma Patient-Derived Xenografts

Miles, Kiersten Marie; Seshadri, Mukund; Ciamporcero, Eric; Adelaiye, Remi; Gillard, Bryan; SOTOMAYOR, PAULA; Attwood, Kristopher; Shen, Li; Conroy, Dylan; Kuhnert, Frank; Lalani, Alshad S.; Thurston, Gavin; Pili, Roberto; Kyprianou, Natasha

Article
PLOS ONE  (2014)

Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression

Godoy, A. S.; Sotomayor, P. C.; Villagrán M.; Yacoub R.; Montecinos, V. P.; McNerney E.M.; Moser M.; Foster B.A.; Onate S.A.

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2012)

Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue

Reinicke K; Sotomayor P.; Cisterna, P; Delgado C.; Nualart, F.; Godoy A.

Article ISI SCOPUS
Journal of Cellular Biochemistry  (2012)

Characterization of iNOS+ Neutrophil-like ring cell in tumor-bearing mice

Virtuoso, Lauren P; Harden, Jamie L; SOTOMAYOR, PAULA; Sigurdson, Wade J; Yoshimura, Fuminobu; Egilmez, Nejat K; Minev, Boris; Kilinc, Mehmet O

Article
JOURNAL OF TRANSLATIONAL MEDICINE  (2012)

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

Shen, Li; Ciesielski, Michael; Ramakrishnan, Swathi; Miles, Kiersten M.; Ellis, Leigh; SOTOMAYOR, PAULA; Shrikant, Protul; Fenstermaker, Robert; Pili, Roberto; Ling, Ming Tat

Article
PLOS ONE  (2012)

Vascular Disruption in Combination with mTOR Inhibition in Renal Cell Carcinoma

Ellis, L.; Shah, P.; Hammers, H.; Lehet, K.; Sotomayor, P.; Azabdaftari, G.; Seshadri, M.; Pili, R.

Article
Molecular Cancer Therapeutics  (2012)

Androgen deprivation induces rapid involution and recovery of human prostate vasculature

Godoy A.; Montecinos, V. P.; Gray, D. R.; Sotomayor P.; Yau, J. M.; Vethanayagam, R. R.; Singh, S; Mohler, J. L.; Smith, G. J.

Article ISI
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM  (2011)

Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

Pettazzoni, Piergiorgio; Pizzimenti, Stefania; Toaldo, Cristina; SOTOMAYOR, PAULA; Tagliavacca, Luigina; Liu, Song; Wang, Dan; Minelli, Rosalba; Ellis, Leigh; Atadja, Peter; Ciamporcero, Eric; Dianzani, Mario Umberto; Barrera, Giuseppina; Pili, Roberto

Article
Free Radical Biology and Medicine  (2011)

TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells

Safina, A.; Sotomayor, P.; Limoge, M.; Morrison, C.; Bakin, A. V.

Article
Molecular Cancer Research  (2011)

Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12

Akakura, Shin; Nochajski, Peter; Gao, Lingqiu; SOTOMAYOR, PAULA; Matsui, Sei-ichi; Gelman, Irwin H.

Article
Cell Cycle  (2010)

ABCG2-mediated DyeCycle Violet efflux defined side population in benign and malignant prostate

Mathew, Grinu; Timm, Earl A.; Sotomayor, Paula; Godoy, Alejandro; Montecinos, Viviana P.; Smith, Gary J.; Huss, Wendy J.

Article
CELL CYCLE  (2009)

Oct4A is expressed by a subpopulation of prostate neuroendocrine cells

SOTOMAYOR, PAULA; Godoy, Alejandro; Smith, Gary J.; Huss, Wendy J.

Article
The Prostate  (2009)

Androgen Receptor Is Causally Involved in the Homeostasis of the Human Prostate Endothelial Cell

Godoy, Alejandro; Watts, Anica; Sotomayor, Paula; Montecinos, Viviana P.; Huss, Wendy J.; Oñate, Sergio A.; Smith, Gary J.

Article
ENDOCRINOLOGY  (2008)

Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2

Godoy A.; Ormazabal, V; Moraga-Cid, G; Zuniga, FA; Sotomayor P.; Barra V; Vásquez O.; Montecinos, V.; Mardones L.; Guzmán C; Villagrán M.; Aguayo, LG; Onate, SA; Reyes, AM; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione

Montecinos, V.; Guzman P.; Barra V; Villagrán M.; Munoz-Montesino, C; Sotomayor, K; Escobar, E; Godoy A.; Mardones L.; Sotomayor P.; Guzmán C; Vásquez O.; Gallardo V.; van Zundert, B; Bono, MR.; Onate, SA; Bustamante, M; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Proyecto (6)

Vigilancia activa en cáncer de próstata: efectividad de la firma de cuatro arns largos no codificant es como marcador tisular de pronóstico tumoral

Sotomayor, Paula

Proyecto
 (2019)

The extracellular matrix promotes the process of vasculogenic mimicry and thus delivers an advantage to ovarian cancer progression

Owen , Gareth

Proyecto
 (2018)

Paracrine Effect of the Endothelium on Prostate Cancer Cells and Its Role During Tumor Progression

FONDECYT (224119)

Proyecto
2016-2018
Coinvestigador(a)

Nano-Carbosome=> Development of a nanoparticle loaded with Carboplatin and Proteasome Inhibitor against resistance and recurrence in ovarian cancer.

Proyectos Núcleos UNAB

Proyecto
2014-2017
Coinvestigador(a)

Role of Pericytes and Tumor Epithelial Cells in the Acquisition of Resistance to Antiangiogenic Therapy

FONDECYT (11140255)

Proyecto
2014-2018
Inv. Principal

Plataforma de estudios preclínicos de xenotransplantes de tejidos metastáticos humanos para la evaluación de sensibilidad a drogas anticancerígenas.

FONDEF (CA12i10333)

Proyecto
2012-2015
Investigador(a)

Review (3)

Biological role of fructose in the male reproductive system: Potential implications for prostate cancer

Echeverria, Carolina E.; Oyarzun, Vanessa I.; Lopez-Cortes, Andres; Cancino, Jorge; Sotomayor, Paula C.; Goncalves, Marcus D.; Godoy, Alejandro S.

Review ISI
PROSTATE  (2023)

Exercise and prostate cancer: From basic science to clinical applications

Campos, C; Sotomayor, P; Jerez, D; Gonzalez, J; Schmidt, CB; Schmidt K.; Banzer, W; Godoy, AS

Review ISI SCOPUS
PROSTATE  (2018)

Androgen receptor in human endothelial cells

Torres-Estay, V; Carreno, DV; Francisco, IFS; Sotomayor P.; Godoy, AS; Smith, GJ

Review ISI SCOPUS
Journal of Endocrinology  (2015)

30
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

12
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

8
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

4
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

3
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

2
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

1
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

1
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
CAROLINA DELGADO

Encargado de proyectos de desarrollo de Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Felipe Oyarzún

Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Christian Campos

Decano

Universidad Andrés Bello

santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Néstor Corro

1
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile