Man

Rodrigo Antonio Naves Pichuante

Associate Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


NeuroImmunology and Immune response in Tuberculosis

Educación

  •  Cell and molecular biology, UNIVERSIDAD DE CHILE. Chile, 2000
  •  Sciences with mention in Biology, UNIVERSIDAD DE CHILE. Chile, 1992

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2014 - 2018

  •   Associate professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2018 - At present

Experiencia Profesional

  •   Associate professor Full Time

    Universidad de Chile

    Santiago, Chile

    2018 - At present

  •   Research stay Other

    Institut Pasteur

    Paris, Francia

    1998 - 1998

  •   Postdoctoral Fellow Other

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2000 - 2002

  •   Postdoctoral Fellow Other

    University of Alabama

    Birmingham, Estados Unidos

    2009 - 2010

  •   Assistant professor Full Time

    Universidad de Chile

    Santiago, Chile

    2014 - 2018

Formación de Capital Humano


Participation in Postgraduate Mentoring:
1. Period: 2016-2018.
Postdoctoral Mentor.
Student: Dr. Luis González.
2. Period: 2015-2017.
Postdoctoral Mentor.
Student: Dr. Juan Tichauer.
3. Period: 2017.
Postgraduate Research Unit Mentor, Program in Immunology.
Student: Dr. Gabriela Romero.
Escuela de Medicina. Universidad de Chile.
4. Period: 2015.
Postgraduate Research Unit Mentor, Program in Immunology.
Student: Dr. Francisco Sosa.
Escuela de Medicina. Universidad de Chile.
5. Period: 2014 (I semester).
Mentor Research Unit, Doctoral in Biomedical Sciences.
Student: Mr. Gabriel Arellano Lorca, First year student.
Facultad de Medicina de la Universidad de Chile.

Participation in Undergraduate Mentoring:
6. Period: 2016.
Research Unit Mentor, Career Medical Technology.
Student: Ms. Nicole Oliva Aravena.
Course of Medical Technology “Tecnologías Moleculares aplicadas al diagnóstico”. Escuela de Medicina. Universidad de Chile.
7. Period: 2015.
Mentor of Student Assistant, Career of Medicine.
Student: Mr. Javier Moreno.
Escuela de Medicina. Universidad de Chile.
8. Period: 2013 March -June.
Research Unit Mentor, Career in Biochemistry.
Student: Ms. Macarena Cielo.
Universidad San Sebastián.
9. Period: 2013 December- January.
Professional Practice to qualify for the Degree in Plant Biotechnology Engineering.
Student: Mr. Felipe Ruiz.
Universidad de Concepción.
10. Period: July-December 2012.
Research Unit Mentor, Career in Biochemistry.
Student: Mr. Emiliano Molina.
Universidad de Chile.
11. Period: March 2006
Research Unit Mentor, Medical Career.
Students: Lorna Villagrán, Pablo Díaz, Camilo Iñiguez
Clínica Alemana - Universidad del Desarrollo
12. Period: 2005 March
Research Unit Mentor, Medical Career.
Student: Ms. Francisca León.
Clínica Alemana - Universidad del Desarrollo
13. Period: 2004 March
Research Unit Mentor, Medical Career.
Student: Mrs. María Fernanda Rozas.
Clínica Alemana - Universidad del Desarrollo

Master and Doctoral thesis director.
1. Period: 2014 - 2017.
PhD Thesis Mentor in Biomedical Sciences.
Student: Mr. Gabriel Arellano Lorca.
Escuela de Medicina. Universidad de Chile.

Thesis director.
1. Period: 2014 - 2017.
PhD thesis Mentor.
Student: Mr. Gabriel Arellano Lorca.
Thesis for the Degree of Doctor of Biomedical Sciences.
Escuela de Medicina. Universidad de Chile.
2. Period: 2014 - 2017.
Undergraduate Thesis Mentor.
Student: Mr. Cristian Castillo Bravo.
Thesis for the Bachelor's Degree in Biotechnology
Universidad Iberoamericana de Ciencias y Tecnología.
He graduated in January 2017.
3. Period: 2011 - 2012.
Undergraduate Thesis Mentor.
Student: Mr. Fabián Vergara Morales
Thesis for the degree of Biochemistry (USACH).
Escuela de Medicina. Pontificia Universidad Católica de Chile.
He graduated in July 2012.
4. Period: 2011 - 2012.
Undergraduate Thesis Mentor.
Student: Mr. Gabriel Arellano Lorca.
Thesis for the degree of Biochemistry (USACH).
Escuela de Medicina. Pontificia Universidad Católica de Chile.
He graduated in July 2012.

Member of thesis committees.
1. 2018
Ms. Carla Álvarez Rivas.
Doctoral thesis. Doctoral Program in Biomedical Sciences.
First chair commission
Facultad de Medicina. Universidad de Chile.
2. 2017
Mr. Ignacio Montorfano Navarro.
Doctoral thesis. Doctoral Program in Biomedical Sciences.
Facultad de Medicina. Universidad de Chile.
3. 2017
Miss Elizabeth Rivas Yáñez.
Doctoral thesis. Doctoral Program in Biomedical Sciences.
Facultad de Medicina. Universidad de Chile.
4. 2016
Miss Elianet Fonseca Pérez.
Master's thesis. Master's Program in Immunology.
First chair commission
Facultad de Medicina. Universidad de Chile.
5. 2016
Mr. Felipe Gálvez Jirón.
Master's thesis. Master's Program in Immunology.
Facultad de Medicina. Universidad de Chile.
6. 2015
Miss Paulina García González.
Doctoral thesis. Doctoral Program in Biomedical Sciences.
Facultad de Medicina. Universidad de Chile.
7. 2014
Ms. María Josefina Siña Barriga.
Defense thesis project. Master in Immunology
Facultad de Medicina. Universidad de Chile.
8. 2013
Mr. Mauricio Olivares Morales.
Doctoral thesis. Doctoral Program in Biomedical Sciences.
Facultad de Medicina. Universidad de Chile.

Undergraduate Teaching at Universidad de Chile from 2014 - present.
1. Course "Inmunología".
Third year students of Nutrición y Dietética
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Professor in charge of the course of "Inmunología".
2. Annual Course "Unidad de Investigación I y II".
Second year students of Medicine.
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Mentor
3. Course "Inmunología".
Second year students of Tecnología Médica.
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Teaching lectures, seminars and clinical cases
4. Course "Inmunología".
Second year students of Obstetricia y Puericultura.
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Teaching lectures, seminars and clinical cases
5. Course "Respuesta Inmune el Ser Humano".
Second year students of Enfermería.
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars
6. Course "Inmunología".
Third year students of Kinesiología.
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars
7. Course "Inmunología".
Second year students of Medicine.
Escuela de Medicina de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars

Postgraduate teaching at Universidad de Chile from 2014 - present.
1. Postgraduate Course "Introducción a la Inmunología"
Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédica de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars
2. Postgraduate Course "Nuevos conceptos en enfermedades neurodegenerativas: mecanismos y terapias".
Programa de Biología Celular y Molecular Instituto de Ciencias Biomédica de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars
3. Postgraduate Course "Inmunología Celular y Molecular"
Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédica de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars
4. Postgraduate Bibliographic Seminar "Rol de mal plegamiento de proteínas en enfermedades neurodegenerativas: mecanismos y terapias".
Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédica de la Facultad de Medicina de la Universidad de Chile.
Teaching theory classes and seminars


Difusión y Transferencia


Participation in Extension Activities in Courses:
1. Member Organizing Committee. III SYMPOSIUM ON IMMUNE REGULATION: FROM BASIC SCIENCE TO NOVEL IMMUNOTHERAPEUTIC STRATEGIES.
Santiago, October 25. 2016
2. Member Organizing Committee. IMMUNOLOGY WEEK.
Santiago, October 21-28. 2016
3. Director. INTERNATIONAL SYMPOSIUM: ADVANCING IN NEUROIMMUNOLOGY AND MULTIPLE SCLEROSIS (ANIMUS) Symposium
Fondecyt - VID University of Chile
Santiago, October 24, 2016
4. Coordinator. SIMPOSIO NEUROINMUNOLOGÍA.
LVIII Reunión Anual de la Sociedad de Biología de Chile.
Puerto Varas, November 23 - 25, 2015
5. Exhibitor SIMPOSIO NEUROINMUNOLOGÍA.
Facultad de Medicina de la Universidad de Chile.
Santiago, April 11, 2013
6. Exhibitor. INTERNATIONAL SYMPOSIUM CANCER AND INFLAMMATION :FROM ADHERENS JUNCTIONS TO DISEASE.
Universidad Austral de Chile.
Valdivia, January 16 - 17, 2013
7. Exhibito. JORNADA NEUROINMUNOLOGIA EN LA MEDICINA DEL FUTURO.
Universidad San Sebastián.
Santiago, December 27,. 2012
Topic "Mecanismos inmunopatogénicos de la esclerosis múltiple y de la búsqueda e innovación de las nuevas terapias inmunomoduladoras, que pueden servir para llevar un mejo tratamiento de los pacientes y superar todos los problemas".
8. Speaker. PROGRAMA EXPLORA DE CONICYT with the talk ""Inmunología y enfermedades autoinmunes"
Schools in Santiago: Liceo Salesianos de Macul y Merryland from Puente Alto.
Santiago, 2012
9. Director. SIMPOSIO INTERNACIONAL: "ESCLEROSIS MÚLTIPLE: INTEGRANDO LA INVESTIGACIÓN BIOMÉDICA Y LA PRÁCTICA CLÍNICA".
Escuela de Medicina de la Pontificia Universidad de Chile.
Santiago, June 25 - 26, 2012

Media participation.
Year 2019:
1. Interviewed in newspaper Las Ultimas Noticias about the development of a nanoformulation to treat multiple sclerosis. April 06, 2019
2. Interviewed on Channel 24 horas of TVN about the development of a nanoformulation to treat multiple sclerosis. April 11, 2019.
3. Interviewed by EMOL TV about the development of a nanoformulation to treat the multiple sclerosis. April 16, 2019.
4. Interviewed by Canal MEGA about nanotechnology and its application to medicine. April 17, 2019.
5. Interviewed by ICBM journalist about the development of a nanoformulation for treat multiple sclerosis April 3, 2019.
6. Interviewed by journalist from the Faculty of Medicine, Universidad de Chile, about the development of a nanoformulation to treat multiple sclerosis. March 27, 2019.
7. Interview by Prensa U Chile, about the development of a nanoformulation to treat multiple sclerosis April 9, 2019
Year 2017:
1. Interview disseminated by the website of the Faculty of Medicine, Universidad de Chile about the research to be developed in the FONDEF-IDEA project.
Year 2016:
1. Consulted by the newspaper El Mercurio, Section of Science and Technology to comment about the contribution of the ANIMUS International Symposium 2016. October 24, 2016.
2. Consulted by the newspaper El Mercurio, Section of Science and Technology, to comment about the dissemination of a research article in Neuro-Immunology: "Sistemas inmune y nervioso: “La Neuroinmunología tendría la clave para curar vario males." August 19 of 2016.
3. Interview disseminated by the website of the Faculty of Medicine, Universidad de Chile, about the International Symposium ANIMUS 2016.
Year 2014:
1. Consulted by the newspaper El Mercurio, Science and Technology Section to comment about the dissemination of a research article in Neuroimmunology. " August 14, 2014.
2. Participation in the chapter entitled "Esclerosis Múltiple: enemigo puertas adentro" of the scientific program "Vida Conciencia", Neuroscience season, transmitted by the Canal CNN Chile.
Year 2012:
1. Interviewed by the newspaper El Mercurio, Science and Technology Section about “El tratamiento de la esclerosis múltiple avanza lento, pero seguro" July 02, 2012.
Year 2010:
1. Interviewed by the newspaper El Mercurio, Science and Technology Section about my research participation describing a scientific finding in Multiple Sclerosis". April 10, 2010.

Extension to the Society:
1. Exhibition "Inmunología y enfermedades autoinmunes" in two schools in Santiago: Liceo Salesianos de Macul and Merryland de Puente Alto. Explora Program from CONICYT. Santiago, 2012.

Requested Conferences:
1. Date: April 8 - 12, 2018.
Invitation received to deliver a conference on Neuroinflammation.
2018 Biomedical and Life Sciences Meeting (BLS Victoria). Victory. Canada.
2. Date: December 15, 2017
Conference "El mito del privilegio inmunológico del cerebro".
I Curso de NeuroInmunología en Pediatría. Santiago. Chile.
3. Date: November 18, 2016
Conference "Actividad dual de interferón-gamma en neuroinflamación autoinmune "
XXXIV Congreso Nacional de Sociedad de Psiquiatría y Neurología de la Infancia y
Adolescencia (SOPNIA). Puerto Varas. Chile.
4. Date: November 17, 2016
Conference "Identificando biomarcadores de progresión de enfermedad y respuesta a tratamiento en esclerosis múltiple".
XXXIV Congreso Nacional de Sociedad de Psiquiatría y Neurología de la Infancia y Adolescencia (SOPNIA). Puerto Varas. Chile.
5. Date: October 24, 2016
Conference "Dual role of interferon-gamma in experimental and human multiple sclerosis. "
ANIMUS (Advancing in Neuroimmunology and Multiple Sclerosis) International Symposium 2016. Santiago, Chile.
6. Date: November 23 - 25, 2015
Conference "Funciones opuestas de Interferón-gamma en diferentes fases de la encefalomielitis aguda experimental y esclerosis múltiple".
National Symposium on "Neuroimmunology". XIII Reunión Anual de la Sociedad Chilena de Inmunología. Puerto Varas. Chile.
7. Date: April 2013
Guest speaker
Symposium on Neuroimmunology. "Immunopathogenesis and Immunotherapy of Multiple Sclerosis. "Faculty of Medicine, University of Chile, Santiago, Chile.
8. Date: January 16, 2013
Guest speaker
International Symposium "Cancer and Inflammation: from adherens junctions to disease".
Facultad de Medicina. Universidad Austral de Chile. Valdivia, Chile.
9. Date: November 2012
Conference "Immunopathogenesis and development of therapies in Multiple Sclerosis".
Symposium "Neuroinmunología en la Medicina del Futuro" organized by Universidad San Sebastián. Santiago, Chile.
10. Date: October 2012
Conference "nmunopatogénesis de la Esclerosis Múltiple y desarrollo de nuevas terapias inmunomoduladoras."
Research seminars organized by Dirección de Investigación, Escuela de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile.
11. Date: June 25-26, 2012
Conference "Interferon-gamma in MS: an immunological duality".
International Symposium: "Multiple Sclerosis: integrating scientific research biomedical and clinical practice. "Santiago, Chile.
12. Date: May 2012
Conference "Interferón-gamma en Esclerosis Múltiple: una dualidad inmunológica".
Programa de Inmunología. Instituto de Ciencias Biomédicas. Escuela de Medicina. Universidad de Chile.
13. Date: December 2011
Conference "Inmunopatogénesis de la Esclerosis Múltiple".
Post-graduate course "Inmunología Celular y Molecular”, Escuela de Medicina, Universidad de Chile.
14. Date: October 2011
Lecture "Balance de citoquinas Th1 y Th17 en pacientes con diferentes formas clínicas de Esclerosis Múltiple. "
Departamento Kinesiología. Escuela de Medicina. Pontificia Universidad Católica de Chile.
15. Date: April 2011
Conference "Nuevas terapias y marcadores biológicos para el tratamiento de la Esclerosis Múltiple".
Núcleo Milenio de Biología Regenerativa. Facultad de Ciencias Biológicas. Pontificia Universidad Católica de Chile. Santiago, Chile
16. Date: June 3, 2010
Conference "Biomarcadores para el diagnóstico y tratamiento diferencial de la esclerosis múltiple".
Departamento de Biología Celular. Pontificia Universidad Católica de Chile. Santiago. Chile
17. Date: May 2010
Conference "Función individual y cooperativa de interferones tipo I y II en Neuroinflamación Autoinmune. "
Departamento de Biología Celular. Pontificia Universidad Católica de Chile. Santiago. Chile
18. Date: June 3, 2010
Conference "Biomarcadores para el diagnóstico y tratamiento diferencial de la Esclerosis Múltiple".
Depto. Biología Celular y Molecular. Facultad de Ciencias Biológicas. Pontificia Universidad Católica de Chile. Santiago, Chile.
19. Date: April 2010
Conference "Marcadores Biológicos para un diagnóstico y tratamiento diferencial de la Esclerosis Múltiple".
Departamento de Neurología. Escuela de Medicina. Pontificia Universidad Católica de Chile. Santiago, Chile


Premios y Distinciones

  •   MECESUP Scholarship

    MECESUP

    Chile, 2011

    The scholarship allow me to hold the position of Assistant Professor in the School of Medicine at the University.

  •   Postdoctoral scholarship

    Confirmar institución

    Chile, 2010

    The scholarship allowed me to perform Postgraduate studies abroad in the Division of Clinical Immunlogy and Rheumatology at the University of Alabama at Birmingham.

  •   Chile CONICYT Bicentennial Scholarship

    CONICYT

    Chile, 2009

    The scholarship allowed me to perform Postgraduate studies abroad.

  •   Postdoctoral scholarship

    Instituto Milenio para la Investigación Fundamental y Aplicada (MIFAB)

    Chile, 2000

    The scholarship allowed me to perform national Postgraduate studies.

  •   CONICYT Scholarship

    CONICYT

    Chile, 1993

    The scholarship allowed me to perform a PhD in Sciences in Chile.

  •   Academic assistance scholarship

    Confirmar Institución

    Chile, 1990

    Used in the Department of Biology. Faculty of Sciences, University of Chile

  •   Research units of medical students, Thematic in Immune Response

    Congreso de las Unidades de Investigación

    Chile, 2017

    First place in the Research units of medical students, Thematic in Immune Response. The research was presented at the XXV Congreso de las Unidades de Investigación, with the work entitled "Bajas dosis de IFN-gamma in vitro inducen un fenotipo M2 en microglia de ratones en fase crónica con encefalomielitis autoinmune experimental".

  •   Research in Neurology

    Congreso Anual Chileno de Neurología, Psiquiatría y Neurocirugía

    Chile, 2012

    First place in Research in Neurology at LXVII Congreso Anual Chileno de Neurología, Psiquiatría y Neurocirugía with the work entitled "El balance Th1/Th17 predice discapacidad y respuesta a tratamiento en pacientes con esclerosis múltiple recurrente-remitente".

  •   Travel Award

    Federation of Clinical Immunology Societies

    Estados Unidos, 2010

    The Travel Award allowed me to attend the 10th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) in Boston, United States. This scholarship, consisting of US $ 750, was awarded through open competition in relation to merits of the postulants and quality of the submitted works. The abstract sent was also selected for oral presentation. The presentation was titled: “Distinctive and cooperative role of type I and type II interferons in the pathogenesis of Th1 and Th17 cells in autoinmune neuroinflammation”.

  •   Research Award

    The Office of Postdoctoral Education and the UAB

    Chile, 2010

    Every year, the University of Alabama at Birmingham Postdoctoral Office organizes scientific activities where all postdoctoral students of the University present their results. The event is organized in several sessions according to different thematic areas. The presentation title "Distinctive and cooperative role of type I and type II interferons in the pathogenesis of Th1 and Th17 cells in autoimmune neuroinflammation" won the second place in its respective thematic area session.

  •   Sanofi-Aventis “Dr. Antonio Reginato 2004”

    XXV Congreso Anual de Reumatología

    Chile, 2004

    The work titled “Expresión de BAFF en fibroblastos sinoviales de pacientes con artritis reumatoidea”, received an honorable mention


 

Article (15)

Unraveling the Role of MicroRNAs in Mycobacterium tuberculosis Infection and Disease: Advances and Pitfalls
Diagnostic performance of GM-CSF and IL-2 in response to long-term specific-antigen cell stimulation in patients with active and latent tuberculosis infection
Glucocorticoids Impair Phagocytosis and Inflammatory Response Against Crohns Disease-Associated Adherent-Invasive Escherichia coli
Tuberculosis and impaired IL-23–dependent IFN- immunity in humans homozygous for a common TYK2 missense variant
Association of vitamin D deficiency, season of the year, and latent tuberculosis infection among household contacts
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis
Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes
Transgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responses
The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Lithium Controls Central Nervous System Autoimmunity through Modulation of IFN-? Signaling
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
Dexamethasone inhibits BAFF expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis
BAFF: A regulatory cytokine of B lymphocytes involved in autoimmunity and lymphoid cancer
Lymphoid B cells induce NF-kappa B activation in high endothelial cells from human tonsils
MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator

Abstract (4)

Comparison of Health-Related Quality of Life in Chilean Patients with Systemic Lupus Erythematosus, Rheumatoid Arthritis and Systemic Sclerosis
Dual activity of interferon gamma in experimental autoimmune encephalomyelitis
IFN-gamma signaling intrinsically regulates expansion of effector encephalitogenic Th1 cells in experimental autoimmune encephalomyelitis (EAE)
IFN-gamma signaling-dependent response to lithium, an inhibitor of GSK3, in the treatment of experimental autoimmune encephalomyelitis (EAE)

BookSection (2)

Citoquinas
Ontogenia y diferenciación de células B y T

ConferencePaper (5)

ANDROGRAPHOLIDE SUPPRESSES CHRONIC AND RELAPSING-REMITTING EXPERIMENTAL AUTOINMUNE ENCEPHALOMYELITIS
DIFFERENTIAL EFFECT OF LITHIUM IN EAE: OPPOSITE RESPONSE IN TH1 VERSUS TH17 DISEASE
DISTINCTIVE AND COOPERATIVE ROLE OF TYPE I AND TYPE II INTERFERONS IN THE PATHOGENESIS OF TH1 AND TH17 CELLS IN AUTOIMMUNE NEUROINFLAMMATION
OPPOSING AND DISEASE STAGE SPECIFIC ACTIVITY OF INTERFERON GAMMA IN EAE MODULATED BY TYPE I INTERFERON SIGNALS
CIITA EXPRESSION ON A MUTANT CELL LINE

ConferencePoster (45)

Interferon-gamma-induced tolerogenic profile in a microglia subset in experimental autoimmune encephalomyelitis
THERAPEUTIC INTERFERON (IFN)-GAMMA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IS DEPENDENT ON REGULATORY T CELLS INDUCTION BY CD11B+ CELLS
THE ROLE OF INTERFERON (IFN)-GAMMA IN THE REGULATION OF T REGULATORY LYMPHOCYTES IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
TOLEROGENIC ACTIVITY OF IFN-g ON MACROPHAGES/MICROGLIA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
TOLEROGENIC ACTIVITY OF INETERFERON-GAMMA ON MACROPHAGES/MICROGLIA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
TREGULATION OF THE RESPONSE OF T REGULATORY LYMPHOCYTES BY INTERFERON-GAMMA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
HYPOVITAMINOSIS D IS HIGHLY PREVALENT AMONG TUBERCULOSIS HOUSEHOLD CONTACTS AND FURTHER ACCENTUATED AMONG MIGRANT POPULATION
INCREASED SERUM IL-21 IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH VITAMIN D DEFICIENCY
PROTECTIVE ROLE OF INTERFERON-GAMMA DURING THE CHRONIC PHASE OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
VITAMIN D DEFICIENCY AND LATENT TUBERCULOSIS INFECTION RISK AMONG TUBERCULOSIS HOUSEHOLD CONTACTS
A SUBSET OF TUBERCULOSIS HOUSEHOLD CONTACTS SHOW AN INFLAMMATORY STATUS THAT IS INDEPENDENT OF INTERFERON-GAMMA RELEASE ASSAY RESULT AND THAT MAY REFLECT RECENTLY ACQUIRED INFECTION
ANDROGRAPHOLIDE AMELIORATES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
ASOCIACIÓN ENTRE NIVELES BASALES DE VITAMINA D Y CITOQUINAS INFLAMATORIAS/REGULADORAS EN PACIENTES CON ESCLEROSIS MÚLTIPLE
INTERFERÓN-GAMMA INDUCE INMUNOSUPRESIÓN DURANTE LA FASE CRÓNICA DE LA ENCEFALOMIELITIS AUTOINMUNE EXPERIMENTAL
PACIENTES CON LUPUS ERITEMATOSO SISTÉMICO DEFICIENTES DE VITAMINA D PRESENTAN MAYORES NIVELES SÉRICOS DE IL-21
ANDROGRAPHOLIDE AMELIORATES CHRONIC EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY INHIBITING PROLIFERATION OF ENCEPHALITOGENIC T CD4+ CELLS
CARACTERÍSTICAS CLÍNICAS Y DEMOGRÁFICAS DE CASOS NUEVOS DE TUBERCULOSIS PULMONAR Y SUS CONTACTOS INTRADOMICIALIARIOS EN EL SERVICIO DE SALUD METROPOLITANO CENTRAL
CONTACTOS CON INFECCIÓN TUBERCULOSA LATENTE DIFIEREN SIGNIFICATIVAMENTE EN SU PERFIL DE CITOQUINAS TH1, TH2 Y TH17 DE CONTACTOS NO INFECTADOS Y DE ENFERMOS CON TUBERCULOSIS ACTIVA
LA PROPORCIÓN ENTRE CITOQUINAS TH1/TH17 DEFINE DIFERENTES SUBTIPOS CLÍNICOS DE ESCLEROSIS MÚLTIPLE
PERFIL DE CITOQUINAS TH1, TH2 Y TH17 DIFIERE SIGNIFICATIVAMENTE ENTRE CONTACTOS INTRADOMICILIARIOS CON INFECCIÓN TUBERCULOSA LATENTE, CONTACTOS NO INFECTADOS Y ENFERMOS CON TUBERCULOSIS PULMONAR ACTIVA
TH1/TH17 IMBALANCE IN CLINICAL SUBTYPES OF MULTIPLE SCLEROSIS: ASSOCIATION WITH DISABILITY AND UNRESPONSIVENESS TO IFN-???? THERAPY IN RELAPSINGREMITTING DISEASE
DESEQUILIBRIO DE LINFOCITOS TH1, TH17 Y T REGULADORES EN PACIENTES CON DIFERENTES FORMAS CLÍNICAS DE ESCLEROSIS MÚLTIPLE
DUAL ROLE OF INTERFERON-GAMMA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MODULATED BY TYPE I INTERFERONS SIGNALS
EL BALANCE TH1/TH17 PREDICE DISCAPACIDAD Y RESPUESTA A TRATAMIENTO EN PACIENTES CON ESCLEROSIS MÚLTIPLE RECURRENTE-REMITENTE
BALANCE DE CITOQUINAS TH1 Y TH17 EN PACIENTES CON DIFERENTES FORMAS CLÍNICAS DE ESCLEROSIS MÚLTIPLE
CARACTERIZACIÓN DE PACIENTES CONTROLADOS EN EL PROGRAMA DE ESCLEROSIS MÚLTIPLE (EM) DE LA PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
THERAPEUTIC EFFECT OF LITHIUM IN EAE: EFFECTS ON DENDRITIC CELLS AND ENCEPHALITOGENIC ACTIVITY OF T CELLS
DISTINCTIVE AND CO-OPERATIVE ROLE OF TYPE 1 AND TYPE 2 INTERFERONS IN THE IMMUNOPATHOGENESIS OF TH1 AND TH2 CELLS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
THE THERAPEUTIC EFFECT OF LITHIUM, AN INHIBITOR OF GSK3, IN EAE IS DEPENDENT ON INTERFERON GAMMA SIGNALING
REGULACION DE LA EXPRESION DE BAFF MEDIADA POR LA ACTIVACION DE PPAR/NF-KB EN FIBROBLASTOS SINOVIALES DE PACIENTES CON ARTRITIS REUMATOIDE
ANALYSIS OF THE MEMORY T CELL RESPONSE TO ANDES HANTAVIRUS IN CHILEAN PATIENTS
ANALYSIS OF THE MEMORY T CELLS RESPONSE IN CHILEAN PATIENTS WITH PAST ANDES HANTAVIRUS INFECTION
DEXAMETASONA INHIBE LA EXPRESION DE BAFF EN FIBROBLASTOS SINOVIALES DE PACIENTES CON ARTRITIS REUMATOIDE
EXPRESION DE BAFF Y EL RECEPTOR BAFF-R EN TUMORES SOLIDOS HUMANOS
ANALISIS DE LA RESPUESTA INMUNE DE MEMORIA ESPECIFICA POR HANTAVIRUS ANDES EN PACIENTES CHILENO
ANALISIS DE LA RESPUESTA INMUNE DE MEMORIA ESPECIFICA POR HANTAVIRUS ANDES EN PACIENTES CHILENOS
CONSTITUTIVE AND IFN-GAMMA-INDUCED EXPRESSION OF BAFF, A B CELL ACTIVATING CYTOKINE, AND ITS RECEPTOR, BAFF-R, BY NON-LYMPHOID TUMOR CELL LINES
EXPRESION DE BAFF EN FIBROBLASTOS SINOVIALES DE PACIENTES CON ARTRITIS REUMATOIDEA
REGULACION DE LA EXPRESION DE BAFF EN CELULAS TUMORALES DE ORIGEN NO-MIELOIDE
LOS LINFOCITOS INDUCEN ACTIVACION DEL FACTOR TRANSCRIPCIONAL NF-KB/REL EN CELULAS ENDOTELIALES DE AMIGDALAS
EXPRESION DEL MRNA DE CIITA EN DOS LINEAS CELULARES DEFICIENTES EN LA EXPRESION DE LAS MOLECULAS MHC DE CLASE II
ANÁLISIS MOLECULAR DE LA EXPRESIÓN DE LAS MOLÉCULAS MHC DE CLASE II POR INTERFERÓN GAMMA
MOLECULAR ANALYSIS OF THE EXPRESSION OF THE MHC CLASS II MOLECULES BY INTERFERON GAMMA
REGULACION DE LA EXPRESION DE MOLECULAS MHC-II POR INTERFERON GAMMA
RELOJ DEL DESARROLLO ANTES DE LA IMPLANTACIÓN

Patent (2)

Biomarcadores para predecir respuesta a un tratamiento inmunomodulares en pacientes con enfermedad inflamatoria
Nanoparticle of chitosan and cyclodextrin containing encapsulated interferon and pharmaceutical compositions that contain it

Proyecto (34)

Fondecyt Regular=> Interferon-gamma-induced regulatory T cell response is dependent on PD-1/PD-L1 pathway in experimental autoimmune encephalomyelitis and multiple sclerosis
INTERFERON-GAMMA-INDUCED REGULATORY T CELL RESPONSE IS DEPENDENT ON PD-1/PD-L1 PATHWAY IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS
DETERMINANTS FOR TUBERCULOSIS INFECTION ACQUISITION IN CONTACTS: EXPLORING THE ROLE OF NASOPHARYNGEAL MUCOSAL ENVIRONMENT
Determinants for tuberculosis infection acquisition in contacts=> exploring the role of nasopharyngeal mucosal environment
NANOINMUNOTERAPIA PARA ESCLEROSIS MULTIPLE: NUEVA ESTRATEGIA TERAPÉUTICA PARA LA ENTREGA DIRECTA DE INMUNOMODULADORES EN EL SISTEMA NERVIOSO CENTRAL
Animus (Advancing in NeuroImmunology and Multiple Sclerosis) Symposium 2016
ANIMUS: ADVANCING IN NEUROIMMUNOLOGY AND MULTIPLE SCLEROSIS
Nanoinmunoterapia para esclerosis multiple=> nueva estrategia terapéutica para la entrega directa de inmunomoduladores en el sistema nervioso central
NEUROINMUNOLOGÍA Y ESCLEROSIS MÚLTIPLE: INTEGRANDO INVESTIGACIÓN BÁSICA Y CLÍNICA
ACTIVIDAD TOLEROGÉNICA DE INTERFERÓN-GAMMA SOBRE LA MICROGLIA EN UN MODELO EXPERIMENTAL DE NEUROINFLAMACIÓN AUTOINMUNE
Actividad tolerogénica de interferón-gamma sobre la microglia en un modelo experimental de neuroinflamación autoinmune
CITÓMETRO DE FLUJO MULTIPARAMÉTRICO
Citómetro de flujo multiparamétrico
DESARROLLO DE UNA DROGA BOTÁNICA EN BASE A ANDROGRAFÓLIDO PARA LAS FORMAS PROGRESIVAS DE ESCLEROSIS MÚLTIPLE
Desarrollo de una droga en base a Andrografólido para las formas progresivas de Esclerosis Múltiple
IMMUNOMODULATORY AND THERAPEUTICAL ACTIVITY OF ANDROGRAPHOLIDE IN EXPERIMENTAL MODELS OF MULTIPLE SCLEROSIS
Interferon-gamma induced activation of a regulatory T cell subset specialized in the suppression of experimental autoimmune encephalomyelitis and multiple sclerosis
INTERFERON-GAMMA-INDUCED ACTIVATION OF A REGULATORY T CELL SUBSET SPECIALIZED IN THE SUPPRESSION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS
Vitamin D Modulation of Toll-like Receptor Expression in B cells of Systemic Lupus Erythematosus Patients
VITAMIN D MODULATION OF TOLL-LIKE RECEPTOR EXPRESSION IN B CELLS OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
ASSOCIATION BETWEEN MYCOBACTERIUM TUBERCULOSIS STRAIN AND SPECIFIC TH1, TH2 AND TH17 HUMAN 14 IMMUNE RESPONSE: A WAY TO IDENTIFY BIOMARKERS THAT ARE BETTER PREDICTORS OF THE RISK OF TUBERCULOSIS INFECTION
Fondecyt Regular => "Association between Mycobacterium tuberculosis strain and specific Th1, Th2 and Th17 human immune response=> a way to identify biomarkers that are better predictors of the risk of tuberculosis infection"
ESCLEROSIS MÚLTIPLE: INTEGRANDO LA INVESTIGACIÓN CIENTÍFICA Y LA PRÁCTICA CLÍNICA
Proyecto Apoyo a la organización de reuniones científicas 2012. Simposio Internacional=> "Esclerosis Múltiple=> integrando la investigación científica y la práctica clínica".
TH1 AND TH17 BALANCE IN DIFFERENT CLINICAL FORMS OF MULTIPLE SCLEROSIS: A NEW OPPORTUNITY TO EVALUATE AN IMMUNOMODULATORY THERAPY BASED IN INTERFERON-GAMMA
Fondecyt Regular => "INTERFERON-GAMMA THERAPY FOR PROGRESSIVE CLINICAL FORMS OF MULTIPLE SCLEROSIS"
INTERFERON-GAMMA THERAPY FOR PROGRESSIVE CLINICAL FORMS OF MULTIPLE SCLEROSIS
ROLE OF BAFF AND ITS RECEPTOR BAFF-R IN THE SURVIVAL OF HUMAN TUMOR CELLS
REGULATION OF BAFF EXPRESSION: AN ACTIVATOR FACTOR OF B LYMPHOCYTES
INDUCCION DE LAS MOLECULAS DE HISTOCOMPATIBILIDAD DE CLASE II POR LA ADHESION LINFOCITARIA
Proyecto Término de Tesis Doctoral=> "REGULACION DE LA EXPRESION DE LOS ANTIGENOS DE HISTOCOMPATIBILIDAD DE CLASE -II ( MHC-II) POR INTERFERON GAMA"
REGULACION DE LA EXPRESION DE LOS ANTIGENOS DE HISTOCOMPATIBILIDAD DE CLASE -11 (MHC-11) POR INTERFERON GAMA.
Proyecto de Tesis Doctoral=> "UTILIZACION DE HIBRIDOS SOMATICOS EN EL ESTUDIO DE LA EXPRESIONE DE LAS MOLECULAS DE HISTOCOMPATIBILIDAD DE CLASE II REGULADAS POR INTERFERON GAMA"
UTILIZACION DE HIBRIDOS SOMATICOS EN EL ESTUDIO DE LA EXPRESIONE DE LAS MOLECULAS DE HISTOCOMPATIBILIDAD DE CLASE II REGULADAS POR INTERFERON GAMA

Review (4)

Immune response modulation by vitamin D: role in systemic lupus erythematosus
Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation
Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
BAFF: A regulatory cytokine of B lymphocytes involved in autoimmunity and lymphoid cancer
96
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

6
LILIAN REYES

Director de Escuela de Bioquímica

Universidad San Sebastián

Santiago, Chile

3
CLAUDIA CARCAMO

Profesor Asociado

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

3
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

2
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

2
María Balcells

Associate Professor

Department of Infectious Diseases of the Adult

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Francesca Zegna Ratá

Docente

Salud

Universidad de Los Lagos

Osorno, Chile

1
Luis González

postdoctorante

Universidad de Chile

santiago, Chile

1
Nayaret Chamorro

Investigadora

Centro de Biologia Integrativa

Biome Therapeutics/Universidad Mayor

Santiago, Chile

1
KATIA ABARCA

Profesor Titular

Pediatría

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

1
Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Cristián Labarca

Médico reumatólogo

Medicina Interna

clinica alemana de santiago

Santiago., Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Daniela Parada

Asistente de investigación

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

1
Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
Juan Tichauer

Bioquímico

Medicina intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cinthya Ruiz-Tagle

Research Assistant

Department of Infectious Disease

Pontificia Universidad Católica de Chile

Santiago, Chile