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Darwin Elias Leiva Salcedo

Assistant professor

Universidad de Santiago de Chile

Santiago, Chile

Synaptic integration and neuronal excitability in cortical circuits

Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2009
Medical Technologist, UNIVERSIDAD DE CHILE. Chile, 2002

Postdoc Full Time

NATIONAL INSTITUTE OF HEALTH

National Institute of Child Health and development

Bethesda, Estados Unidos

2009 - 2014
Assistant professor Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Chemistry and Biology

Santiago, Chile

2014 - At present

Lecturer Part Time

Universidad Mayor

Santiago, Chile

2007 - 2009

2016 Thesis supervisor Ms. Tania Villalon, Biochemist, title “Participación de componentes de la vía secretora en la enfermedad de Niemann-Pick tipo C”, University of Santiago
2016 Thesis supervisor Mr. Hector Valenzuela, Biochemist, Title “La interacción funcional entre el canal trpm4 (transient receptor potential melastatin-4) y el canal hcn1 (hyperpolarization-activated cyclic nucleotide-gated channel 1) regula el aumento del calcio intracelular inducido por glutamato en neuronas corticales”, University of Santiago
2016 Supervisor of Dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico, Ms. Pilar Candia “Implementación de un método de detección e identificación de los ácidos nucleicos del virus de la necrosis pancreatica infecciosa mediante electroforesis”, University of Santiago
2017 Supervisor of dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Ignacio Lopez, ”Método analítico de Pre- transferencia Pemetrexed 25 mg/mL concentrado para solución para infusión de Analytica LAB a Synthon Chile Ltda”, University of Santiago
2017 Supervisor of dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Camilo Osorio. ”Técnicas microbiológicas para cuantificación de coliformes totales, fecales y escherichia coli en aguas residuales y potables”, University of Santiago
2018 Supervisor of Dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Gustavo Bustamante, “Validación de actividad bactericida de los antisépticos y desinfectantes químicos, por método de dilución neutralización según la Norma Española UNE 1040:2006”, University of Santiago
2018 Supervisor of Dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Luis Riquelme, “Verificación de la aptitud del método de recuento microbiano y microorganismos específicos acorde a usp 40 aplicado al producto aluminio hidróxido suspensíon 6%”, University of Santiago

NICHD Mentors of the Year category postdoc

NATIONAL INSTITUTE OF HEALTH

Estados Unidos, 2014

The NICHD Mentor of the Year Award is an opportunity to recognize individuals whose mentoring has made a difference in someone’s life at NIH. The two mentoring award categories are fellows and investigators. Nominations were invited from all trainee groups in NICHD, and each nominator had to write a statement, on which the selection committee based their decisions. The selection committee included NICHD clinical and postdoctoral fellows, and postbac fellows.


EB1-and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion Blanco, Constanza; Morales, Danna; Mogollones, Ignacio; Vergara-Jaque, Ariela; Vargas, Carla; Alvarez, Alhejandra; Riquelme, Denise; Leiva-Salcedo, Elias; Gonzalez, Wendy; Morales, Diego; Maureira, Diego; Aldunate, Ismael; Caceres, Monica; Varela, Diego; Cerda, Oscar Article ISI SCOPUS FASEB JOURNAL (2019)
Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma Robles-Planells, Claudia; Michelson, Sofia A.; Mena, Javier; Escrig, Daniela; Rojas, Juan L.; Sanchez-Guerrero, Giselle; Hernandez, Ronny; Barrera-Avalos, Carlos; Rojo, Leonel E; Sauma, Daniela; Kalergis, Alexis M.; Imarai, Monica; Fernandez, Ricardo; Robles, Carolina A.; Leiva-Salcedo, Elias; Santander, Rocio; Escobar, Alejandro; Acuna-Castillo, Claudio Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel. Rokic, Milos B; Castro, Patricio; Leiva-Salcedo, Elias; Tomic, Melanija; Stojilkovic, Stanko S; Coddou, Claudio Article International journal of molecular sciences (2018)
Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3 Riquelme, D; Silva, I; Philp, AM; Huidobro-Toro, JP; Cerda, O; Trimmer, JS; Leiva-Salcedo, E Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro Morales, Jonathan; Barrera-Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles-Planells, Claudia; López, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez-San Martín, Marcelo; Riquelme, Denise; Escobar, Alejandro; Fernández, Ricardo; Imarai, Mónica; Sauma, Daniela; Rojo, Leonel E.; Leiva-Salcedo, Elias; Acuña-Castillo, Claudio Article ISI SCOPUS Frontiers in immunology (2017)
Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders Yan, L; Shamir, A; Skirzewski, M; Leiva-Salcedo, E; Kwon, O B; Karavanova, I; Paredes, D; Malkesman, O; Bailey, K R; Vullhorst, D; Crawley, J N; Buonanno, A Article Molecular Psychiatry (2017)
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death Leiva-Salcedo, E; Riquelme, D; Cerda, O; Stutzin, A Article ISI SCOPUS Channels (2017)
Calcium signaling properties of a thyrotroph cell line, mouse T?T1 cells Tomi, M.; Bargi-Souza P.; Leiva-Salcedo, E; Nunes M.T.; Stojilkovic, S. S. Article SCOPUS Cell Calcium (2015)
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4 Cerda O.; Cáceres M.; Park, KS; Leiva-Salcedo, E; Romero A.; Varela D.; Trimmer, JS; Stutzin A. Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility Cáceres M.; Ortiz, L; Recabarren, T; Romero A.; Colombo, A; Leiva-Salcedo, E; Varela D.; Rivas J.; Silva I.; Morales, D; Campusano, C; Almarza O.; Simon F.; Toledo, H; Park, KS; Trimmer, JS; Cerda O. Article ISI SCOPUS PLOS ONE (2015)
Neuregulin Directly Decreases Voltage-Gated Sodium Current in Hippocampal ErbB4-Expressing Interneurons Janssen, M. J.; Leiva-Salcedo, E.; Buonanno, A. Article WOS:000309506600023 JOURNAL OF NEUROSCIENCE (2012)
The Importance of the NRG-1/ErbB4 Pathway for Synaptic Plasticity and Behaviors Associated with Psychiatric Disorders Shamir, A.; Kwon, O.-B.; Karavanova, I.; Vullhorst, D.; Leiva-Salcedo, E.; Janssen, M. J.; Buonanno, A. Article WOS:000300938100007 JOURNAL OF NEUROSCIENCE (2012)
Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor Leiva-Salcedo, E; Coddou, C.; Rodríguez FE; Penna, A; López, X; Neira, T; Fernandez, R.; Imarai M.; Rios M.; Escobar, J; Montoya, M; Huidobro-Toro, JP; Escobar A.; Acuna-Castillo, C Article ISI SCOPUS Mediators of Inflammation (2011)
Hydrogen Peroxide Removes TRPM4 Current Desensitization Conferring Increased Vulnerability to Necrotic Cell Death Simon F.; Leiva-Salcedo, E; Armisen, R; Riveros A.; Cerda O.; Varela D.; Eguiguren, AL; Olivero P.; Stutzin A. Article ISI SCOPUS Journal of Biological Chemistry (2010)
P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells Varela D.; Penna, A; Simon F.; Eguiguren, AL; Leiva-Salcedo, E; Cerda O.; Sala F.; Stutzin A. Article ISI SCOPUS Journal of Biological Chemistry (2010)
Activation of Cl(-) channels by human chorionic gonadotropin in luteinized granulosa cells of the human ovary modulates progesterone biosynthesis Olivero P.; Leiva-Salcedo, E; Devoto L.; Stutzin A. Article ISI SCOPUS ENDOCRINOLOGY (2008)
Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide Gomez, CR; Acuna-Castillo, C; Pérez, C.; Leiva-Salcedo, E; Riquelme, DM; Ordenes, G; Oshima K.; Aravena, M; Perez, VI; Nishimura S.; Sabaj V; Walter, R.; Sierra, F Article ISI SCOPUS JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2008)
Activation of H2O2-induced VSOR CI(-)currents in HTC cells require phospholipase C gamma 1 phosphorylation and Ca2+ mobilisation Varela D.; Simon F.; Olivero P.; Armisen, R; Leiva-Salcedo, E; Jorgensen, F; Sala F.; Stutzin A. Article ISI SCOPUS CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
T-kininogen induces endothelial cell proliferation Pérez V; Leiva-Salcedo, E; Acuna-Castillo, C; Aravena, M; Gómez C; Sabaj V; Colombo, A; Nishimura S.; Pérez, C.; Walter, R.; Sierra, F Article ISI SCOPUS MECHANISMS OF AGEING AND DEVELOPMENT (2006)
T-kininogen: A biomarker of aging in fisher 344 rats with possible implications for the immune response Acuna-Castillo, C; Leiva-Salcedo, E; Gomez, CR; Pérez V; Li, M; Torres C.; Walter, R.; Murasko, DM; Sierra, F Article ISI SCOPUS JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2006)
T-kininogen can either induce or inhibit proliferation in Balb/c 3T3 fibroblasts, depending on the route of administration Aravena, M; Pérez, C.; Acuna-Castillo, C; Gómez C; Leiva-Salcedo, E; Nishimura S.; Sabaj V; Walter, R.; Sierra, F Article ISI SCOPUS MECHANISMS OF AGEING AND DEVELOPMENT (2005)
T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation Acuna-Castillo, C; Aravena, M; Leiva-Salcedo, E; Pérez V; Gómez C; Sabaj V; Nishimura S.; Pérez, C.; Colombo, A; Walter, R.; Sierra, F Article ISI SCOPUS MECHANISMS OF AGEING AND DEVELOPMENT (2005)
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells Leiva-Salcedo, E; Pérez V; Acuna-Castillo, C; Walter, R.; Sierra, F Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2002)


TRPM4 channels regulate migration and invasiveness of melanoma cells. Morales, D; Canales, J; Morgan, A; Blanco, C; Saldias, M; Silva, I; Rivas, J; Riquelme, D; Leiva-Salcedo, E; Caceres, M; Cerda, O Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2016)
TRPM4 channels are required for biomechanical remodeling during wound healing Ortiz, L; Recabarren, T; Colombo, A; Leiva-Salcedo, E; Romero A.; Rivas J.; Silva I.; Flores, G; Alvarez A.; Cáceres M.; Cerda O. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
The Ca2+ activated non-selective cationic channel TRPM4 enhances cellular migration and contractility by modulating the focal adhesions dynamics Cáceres M.; Park, KS; Romero A.; Recabarren, T; Almarza O.; Leiva-Salcedo, E; Trimmer, JS; Cerda O. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
Protons and calcium modulate the open probability of a non selective cation channel in epithelial cells Leiva-Salcedo, E; Varela D.; Simon F.; Stutzin A. Abstract ISI PLACENTA (2006)
Critical role of histidines 120, 213, 245 and 319 for the potentiation of the P2X(2) receptor by copper or zinc Huidobro-Toro, JP; Lorca, R; Bull, P; Bravo, L; Arredondo, C; Gonzalez, J; Leiva E. Abstract ISI FUNDAMENTAL CLINICAL PHARMACOLOGY (2004)


Cholinergic modulation of dendritic excitability and synaptic integration in medial prefrontal cortex layer 2/3 through CAN and H channels Elias Leiva-Salcedo Proyecto (2018)
Fortalecimiento de la docencia en Bioquímica Clínica, Genética y postgrado de la Facultad de Qca y Biologia Elias Leiva-Salcedo Proyecto (2014)
Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the mechanisms of chronic pain Luis Constandil; Elias Leiva-Salcedo Proyecto (2014)
ROLE OF TRPM4 CHANNEL IN THE REGULATION OF FIRING PATTERNS AND EXCITABILITY OF THE PREFRONTAL CORTEX NEURONS Elias Leiva-Salcedo Proyecto (2014)


Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins Stojilkovic, SS; Leiva-Salcedo, E; Rokic, MB; Coddou, C. Review ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2014)

Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Claudio Perez

Investigador PhD Fondef

Producción Animal

Universidad de Chile

Santiago, Chile

Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

Cesar Gomez

Responsible for coordinating research projects between the Department and companies, universities and research institutions.

Department of Mining and Materials Engineering, Mineral Processing Group

McGill University

Montreal, Quebec, Canada

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

Juan García-Huidobro

Profesor Titular

Biologia

Universidad de Santiago de Chile

Santiago de Chile, Chile

Sofía Michelson

Dra (c) Biotecnología

Biología

Universidad de Santiago de Chile

Santiago, Chile

Camilo Campusano

Doctorante

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Universidad de Santiago de Chile

Estación Central, Chile

Marcelo Cortez

Académico

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Rocio Santander

Encargada de Laboratorio, Equipos de UHPLC-MS y GC-MS/MS

Departamento de Ciencias del Ambiente, Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

Ariela Vergara

Associate Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

Juan Pablo Garcia Huidobro

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Tatiana Recabarren

Research assistant FONDECYT regular 1211931

Universidad San Sebastián

Concepción, Chile

Darwin Elias Leiva Salcedo

Líneas de Investigación

Educación

Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2009

Medical Technologist, UNIVERSIDAD DE CHILE. Chile, 2002

Experiencia Académica

Postdoc Full Time

Assistant professor Full Time

Experiencia Profesional

Lecturer Part Time

Formación de Capital Humano

Premios y Distinciones

NICHD Mentors of the Year category postdoc

Article (23)

Abstract (5)

Proyecto (4)

Review (1)