1. Role of the Neurovascular Niche and Blood-Derived Elements in CNS Myelin Regeneration and Brain Rejuvenation. 2. Development of Mesenchymal Stem Cell Therapy for Multiple Sclerosis. 3. Development of Naturopathic Therapies for Brain Rejuvenation.

Mentoring for Undergraduate Students

• 2023 – Present: Supervision of Diploma thesis, UACh, Valdivia Chile. Thesis author: Kataly Qvanstrom.
• 2018 – Present: Supervision of Diploma thesis, UACh, Valdivia Chile. Thesis author: Matias Hernández.
• 2018 – 2022: Supervision of Diploma thesis, UACh, Valdivia Chile. Thesis author: Cristóbal Espinoza.
• 2018 – 2021: Supervision of 2 Diploma thesis, UACh, Valdivia Chile. Thesis author: Carolina Reyes, and Carlos Krugmann.
• 2018 – 2021: Supervision of Diploma thesis, UACh, Valdivia Chile. Thesis author: Carlos Valenzuela Krugmann.
• 2017 – 2018: Co-supervision of Thesis in Medicine, PMU, Salzburg, Austria. Thesis author: Laura Ratcliffe.
• 2016 – 2017: Co-supervision of Bachelor, UACh, Valdivia, Chile. Thesis author: Gonzalo Mayorga.
• 2008 – 2013: Supervision of Thesis in Medicine, Department of Neurology, Uni. Regensburg. Thesis author: Anna Grigorakakis. Publication: Frontiers in Neuroscience 2019; 13: 1242.
• 2010 – 2011: Supervision of Thesis in Medicine, PMU, Salzburg, Austria. Thesis author: Roman Wodnar. Publication: Glia 2019; 67(8):1510-1525.
• 2008 – 2011: Supervision of Thesis in Medicine, Department of Neurology, Uni. Regensburg. Thesis author: Franz Dechant. Publication: Stem Cells and Development; 21(11):1838-51.
• 2007 – 2008: Supervision of Thesis in Medicine, Department of Neurology, Uni. Regensburg. Thesis author: Christophe Huber. Publication: Cellular Physiology and Biochemistry; 28(5):793-804.
• 2007 – 2009: Supervision of Diploma thesis, Department of Neurology, Uni. Regensburg. Thesis author: Carolin Steffenhagen. Publication: Stem Cell Reviews; 7(4):815-835.

Mentoring for Postgraduate Students

• 2023 – Present: Supervision of Master student, University of Helsinki, Finland. Thesis author: Pyry-Pekka Puustinen.
• 2023 – Present: Supervision of PhD student, University of Helsinki, Finland. Thesis author: Carlos Valenzuela Krugmann.
• 2023 – Present: Supervision of PhD student, University of Helsinki, Finland. Thesis author: Carolina Reyes.
• 2017 – Present: Supervision of PhD student, UACh, Valdivia Chile. Thesis author: Bryan Hinrichsen.
• 2018 – 2021: Supervision of PhD student, UACh, Valdivia Chile. Thesis author: Amber Philp. Manuscript: eLife: Reviewed Reprint.
• 2011 – 2016: Supervision of PhD thesis, Uni. Salzburg, Salzburg, Austria. Thesis author: Simona Lange. Publication: Cell Reports; 20(8):1755-1764.
• 2011 – 2014: Supervision of Master thesis, Uni. Salzburg, Salzburg, Austria. Thesis author: Martina Feichtner. Publication: Experimental Neurology; 269:75-89.
• 2010 – 2013: Supervision of PhD thesis, Uni. Salzburg, Salzburg, Austria. Thesis author: Carolin Steffenhagen. Publication: Stem Cells and Development 2012; 21(11):1838-51.

Undergraduate Thesis Reviewer

• October 2023: Evaluation Committee Member for Catalina Mujica. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.
• May 2023: Evaluation Committee Member for Angélica Ríos. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.
• October 2021: Evaluation Committee Member for Carolina Paredes. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.
• September 2021: Evaluation Committee Member for Carolina Reyes. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.
• March 2021: Evaluation Committee Member for Carlos Krugmann. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.
• April 2018: Evaluation Committee Member for Alexis Morales. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.
• September 2018: Evaluation Committee Member for Martin Held. Undergraduate examination for Pharmacy, UACh, Valdivia, Chile.
• December 2017: Evaluation Committee Member for Gonzalo Mayorga. Undergraduate examination for Biochemistry, UACh, Valdivia, Chile.

Postgraduate Thesis Reviewer

• January 2023 – Present: Evaluation Committee Member for Stefany Órdenes. PhD Program in Neurosciences, Universidad de Valparaíso, Valparaíso, Chile.
• January 2022 – Present: Evaluation Committee Member for Coram Guevara. PhD Program in Biomedical Sciences, Universidad Autónoma de Chile, Santiago, Chile.
• December 2020 – Present: Evaluation Committee Member for Daniela Urrutia. PhD program in Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Santiago, Chile.
• April 2017 – Present: Evaluation Committee Member for Eduardo Papic. PhD Program in Cellular and Molecular Biology, UACh, Valdivia, Chile.
• December 2018 – April 2020: Evaluation Committee Member for Robinson Arce. PhD Program in Cellular and Molecular Biology, UACh, Valdivia, Chile.
• October 2018: Reviewer for the PhD Thesis entitled:” “Diabetic Retinopathy: Pericyte fate and the interrelation of vascular and neuronal degeneration”. Presented by Daniela Brucker at Naturwissenschaftliche Fakultät, Uni. Salzburg, Austria.
• June 2017: External Member of the Evaluation Committee for the PhD Thesis entitled: "Papel del Óxido Nítrico en la Regulación de la Respuesta a Hipoxia y la Función Mitocondrial en Células Madre" Presented by Estefanía Caballano Infantes at the International PhD Program of the Universidad Pablo de Olavide, Seville, Spain.
• July – August 2015: Reviewer for the PhD Thesis entitled: “Plastizität von gefässbildenden Endtothelzellen in vivo und in vitro”. Presented by Sebastian Töpfer at Naturwissenschaftliche Fakultät, Uni. Salzburg, Austria.

Supervision of Research Staff

• 2020 – Present: Supervision of Maria Elena Silva, PhD. Scientist at Fondecyt Project N° 1201706, entitled: From Blood to Myelin - Exploring Mechanisms for Platelets Contribution to CNS Remyelination.
• 2020 – Present: Supervision of Josselyne Mansilla, Bs. Research Assistant at Fondecyt Project N° 1201706, entitled: From Blood to Myelin - Exploring Mechanisms for Platelets Contribution to CNS
Remyelination.
• 2016 – 2020: Supervision of Maria Elena Silva, PhD. Scientist at Fondecyt Project N° 1161787, entitled: The Neurovascular Niche in Regeneration: Mechanisms for CNS Pericytes Contribution to
Remyelination.
• 2020 – Present: Supervision of Josselyne Mansilla, Bs. Research Assistant at Fondecyt Project N° 1161787, entitled: The Neurovascular Niche in Regeneration: Mechanisms for CNS Pericytes
Contribution to Remyelination.
• 2016 – 2018: Supervision of Diego Halabi, PhD. Postdoctoral Fellow at FONDEF-IDeA Project N° ID17AM0043, entitled: The Fountain of Youth: Development of an Anti-oxidant, Anti-inflammatory and
Neuroregenerative Supplement Derived from Hops for Brain Rejuvenation.
• 2012 – 2016: Co-Supervision of Barbara Klein, PhD. Postdoctoral Fellow at EU Collaborative Project N° HEALTH-F2-2011-27885, entitled: Imaging of Neuroinflammation in Neurodegenerative Diseases
(INMiND).

Invited Speaker in Academic Institutions

University of Helsinki (2022), University of Rostock, Germany (2022), Universidad Austral de Chile, Chile (several times); Paracelsus Medical University Salzburg, Austria (several times); Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Spain (2019); Centro de Estudios, CECs (2018); Universidad de Chile, Chile (2018); Universidad Autónoma de Chile, Chile (2018); Institut d'Imagerie Biomédicale (I2BM), Paris, France (2018); Universidad de Magallanes, Punta Arenas, Chile (2017, 2015); Universidad de Los Andes, Chile (2021, 2017); Universidad de Valparaíso, CINV-Max Planck, Chile (2015); University Hospital Erlangen, Germany (2014); Linköping University, Sweden (2014); Universidad Católica de Chile, Chile (2014); University of Reading, UK (2014); University of Cambridge, UK (2013); Cabimer, Sevilla, Spain (2006).

Invited Plenary Lecturer in Scientific Meetings

21st International Symposium on Signal Transduction at the Blood-Brain Barriers, Arad, Romania (2018).
VI Neuroscience Update Conference Hospital Israelita Albert Einstein and Cleveland Clinic, Sao Paolo, Brazil (2015).

Invited Speaker in Scientific Meetings

XIX Annual Meeting, Chilean Society for Neuroscience, La Serena, Chile (2023); IV Annual Meeting of the Chilean Association of Immunology (ASOCHIN), Pirque, Santiago, Chile (2022); III Annual Meeting of the Chilean Association of Immunology (ASOCHIN), Web based, Santiago, Chile (2020); 3rd International Symposium Cancer and Inflammation: From Cell Biology to Therapy, Valdivia, Chile (2018); XXXI Chilean Society for Cell Biology Annual Meeting, Puerto Varas, Chile (2017); V Jornadas PIEI-ES, Universidad de Talca, Talca, Chile (2017); XXI Congreso de Geriatría y Gerontología de Chile, Centro Parque, Santiago, Chile (2017); XIII European Meeting on Glial Cells in Health and Disease, Edinburgh, UK (2017); XXX Annual Meeting, Hotel Patagónico, Puerto Varas, Chile (2016); Austrian Cluster for Tissue Regeneration, Annual Meeting, Salzburg, Austria (2016); International Workshop Prometeo-Generalitat Valenciana “Jornada en Epigenética y Biomedicina”, Elche, Spain (2016); 14th Austrian Neuroscience Association (ANA) Meeting, Salzburg, Austria (2015), GlowBrain Final Conference, School of Medicine, University of Zagreb, Croacia (2015); 2nd International Annual Conference of the German Stem Cell Network (GSCN), Heidelberg, Germany (2014); Symposium Neuro-Urology, Salzburg, Austria (2012); Annual Meeting of Austrian Association of Molecular Life Sciences and Biotechnology (ÖGMBT), Salzburg, Austria (2011); Annual Meeting “Molecular pathway in health and disease of the nervous system”, Homburg, Germany (2008); Network Meeting of the Alexander von Humboldt Foundation, Marburg, Germany (2008); Society for Neuroscience (SFN), San Diego, CA, USA (2007); XIX Annual Meeting of the Chilean Society for Cell Biology, Pucón, Chile (2005).

Chair and Organized of Scientific Symposia Meetings

Brain Aging and Glial Cells – When Neuroinflammation Shapes Brain Function Symposium. Chaired and Organized at XVII Annual Meeting of the Chilean Society for Neuroscience, Web-based, Chile (2021).
ReBrain – Coupling Circulation to CNS International Conference. Chaired and Organized at Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile (2020).
CISNe - ReBrain Symposium: New Insights in Brain Ageing and Rejuvenation. Chaired and Organized at the XXXI Chilean Society for Cell Biology Annual Meeting, Puerto Varas, Chile (2017).

Major Scientific and Academic Conferences

FENS (2008, 2010, 2012, 2018), EuroGlia (2013, 2015, 2017, 2019, 2021, 2023), SFN (2006, 2008), ISSCR (2009, 2011, 2015), ANA Meeting (2009, 2011, 2013, 2015), SBCCH (2017), ASOCHIN (2020).

Innovations

2013 Bauer HC, Tempfer H., Rivera F.J., Gehwolf R., Aigner L., Pluripotent Tendon and Ligament Perivascular Cells. Publication Number: WO/2013/011131. Published at the European Patent Office. January 24th 2013.
2012 Aigner L., Oberbauer E., Couillard-Despres S., Rivera F.J., Riepl H., Urmann C., Biendl M. Chromane-like cyclic Prenylflavonoids for the Medical Intervention in Neurological Disorders. Publication Number: WO/2012/172090. Published at the European Patent Office. December 20th 2012.

Other Scientific Merits

Reviewer for Scientific Journals and Funding Agencies

2009 – Present: Reviewer for Scientific Journals: Acta Neuropathologica, Biological Research, BMC Neuroscience, Brain Research, Cells Tissues Organs, Experimental Neurology, Frontiers in Bioengineering and Biotechnology, Frontiers in Cell and Developmental Biology, Frontiers in Cellular Neuroscience, Frontiers in Neuroscience, Future Medicine, Gene, Glia, International Journal of Developmental Neuroscience, Islets, Journal of Neuroimmunology, Journal of Neuropathology and Experimental Neurology, Journal of Neuroscience, Journal of Neuroscience Methods, Journal of Tissue Engineering and Regenerative Medicine, Molecular and Cellular Neuroscience, Neurochemistry International, Neuroscience Letters, Plos One, Regenerative Medicine, Stem Cells, Stem Cell and Development, Stem Cells International, Stem Cell Research and Therapy, Tissue Engineering and Regenerative Medicine, The American Journal of Pathology.

2011 – Present: Reviewer for Funding Agencies: 1. National Agency for Research Founding ANID, (Agencia Nacional de Investigación y Desarrollo), Chile. 2. CONICYT (Comisión Nacional de Investigación Científica y Tecnológica), Chile. 3. King’s Health Partners R&D Challenge Fund, Kings College London, UK. 4. MRC (Medical Research Council), UK. 5. ANR (Agence Nationale de la Recherche), France. 6. MS Research Australia, Australia. 7. National Science Centre, PRELUDIUM Funding, Poland
2022 – 2023: Director of Biomedical Board, ANID, Chile.
2019 – 2023: Member of Biomedical Board, ANID, Chile.

2.8.2 Member of Editorial Board of Scientific Journals
2018 – Present Editorial Board Member: Review Editor at “Frontiers in Cellular Neuroscience”
2017 – Present Editorial Board Member at “Journal of Nutritional Biochemistry”
2014 – Present Editorial Board Member: Associate Editor at “Frontiers in Cell and Developmental Biology”
2014 – Present Editorial Board Member: Associate Editor at “Frontiers in Genetics”

Administrative and Managements Duties

• 2021 – Present: Director of Research at Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile. Responsible of management and decision making in research duties of this academic unit.
• 2021: Board Member of Strategic Plan Design Committee (2022 – 2025) at Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile. Involved in management and decision making in teaching, research and outreach duties of this academic unit.
• 2021: Deputy Director at the Institute of Anatomy, Histology and Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile. Involved in management and decision making in teaching and research duties of this academic unit.
• 2020 – Present: Board Member of the Medical Sciences PhD Program, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile. Involved in Management and Decision Making as well as in the academic support for Students.
• 2016 – Present: Board Member (Co-director) of Center of Interdisciplinary Studies of the Nervous System (CISNe) from Universidad Austral de Chile. Involved in management and decision making in the research and outreach duties of this academic unit.
• 2014 – 2016: Deputy Director at the Institute of Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria. Involved in Management and Decision Making.

Duties in One's Field Outside the University

• Consultant for Bioenlaces enterprise since 2002

Active Role in Society and Positions of Trust

• Director of Biomedical Board: Proposals assessment for FONDECYT funding program (ANID), section Medicine G1. 2022.
• Member of Biomedical Board: Proposals assessment for FONDECYT funding program (ANID), section Medicine G1. Since 2017.

Publications, Presentations and Dissemination of Scientific Knowledge Through Other Means

• 2022. Public Presentation for Outreach. Talk: “¿Tiene Sentido Preocuparnos por el Envejecimiento en la Esclerosis Múltiple?” Presented at Dia Nacional De La Esclerosis Múltiple: La Clínica y El Laboratorio Conversan Con La Experiencia. 25th June 2022, Santiago de Chile, Chile.
• 2020. Article at University (UACh) Webpage. Link: http://medicina.uach.cl/2020/08/proyecto-investiga-para-un-futuro-desarrollo-de-tratamiento-regenerativo-para-la-esclerosis-multiple/.
• 2019. Interview at UACh radio. “Investigadores combaten la sclerosis multiple”. Link: https://diario.uach.cl/a-ciencia-cierta-investigadores-de-la-uach-combaten-la-esclerosis- multiple/.
• 2019. Highlighted as “Top Story” at Cell therapy Magazine (Link: https://www.celltherapynews.com/issue/volume-20-16-may-6/) for our publication in Glia Journal “Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination”.
• 2019. Interview at Newspapers (La Tercera, El Mostrador) “Esclerosis múltiple – El hallazgo de científicos chilenos que advierte limitaciones de terapia experimental con células madre”. La Tercera: https://www.latercera.com/que-pasa/noticia/esclerosis-multiple-el-hallazgo-de-cientificos- chilenos-que-advierte-limitaciones-de-terapia-experimental-con-celulas-madre/734284/. El Mostrador: https://www.elmostrador.cl/agenda-pais/2019/08/05/investigadores-advierten-limitaciones-de-terapia-experimental-con-celulas-madre-en-esclerosis-mutiple/.
• 2018. August. Interview for Radio Pauta, Santiago de Chile, Chile. Topic: Brain Rejuvenation.
• 2017. September. Interview for Universidad Austral de Chile Radio, Valdivia, Chile. Topic: Consequences of Aging in Our Society.
• 2015. December. Interview for Mercurio newspaper, Chile. "Anti-asthmatic drug helps rejuvenate a brain deteriorated "Published in" El Mercurio ", Chile. Link: http://www.nexchannel.cl/Nex/noticias/noticia_pescrita.php?nota=13563240.
• 2015 Preparation of a Video for the "Wings for Life World Run" with the aim of disseminating research on Neuroregeneration in the Society.
• 2014. August. Interview for the Salzburg community about the development of local science and the work of foreign scientists, organized by the "StandortAgentur Salzburg GmbH", Austria.
• Since 2009. "Lange Nacht Der Forschung" (The Long Night of Research). Dissemination of scientific research in the Paracelsus Medical University to the community of Salzburg. Co-organizer.
• 2007 – 2008: Preparation of Calendar for the City of Regensburg, Germany "Foreigners in Regensburg". Photos and opinions of the work of foreigners in the city of Regensburg.