Man

Francisca Soledad Sepúlveda Guevara

PhD(c)

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Vesículas extracelulares secretadas por adipocitos asociados a cáncer Terapia antisentido para cáncer Desarrollo modelos pre clínicos

Educación

  •  Biotecnología, Universidad Andrés Bello. Chile, 2018
  •  Ingeniero en Biotecnología, Universidad Andrés Bello. Chile, 2016
  •  Ciencia e Innovación en Medicina, Universidad del Desarrollo. Chile, 2022
  •  Ciencia e Innovación en Medicina, Universidad del Desarrollo. Chile

Experiencia Profesional

  •   Asistente de Investigación Full Time

    Andes Biotechnologies

    Santiago, Chile

    2017 - 2019

  •   Asistente de Investigación Full Time

    Merken Biotech SpA

    Santiago, Chile

    2019 - 2021

  •   Monitor Científico Other

    BioClass

    Santiago, Chile

    2018 - 2019

  •   PhD (c) Other

    Universidad del Desarrollo

    Chile

    2021 - At present

Formación de Capital Humano


Entrenamiento de tesistas en manejo de animales inmunosuprimidos


Difusión y Transferencia


Presentación en congresos nacionales de la especialidad



 

Article (5)

Knockdown of Antisense Noncoding Mitochondrial RNA Reduces Tumorigenicity of Patient-Derived Clear Cell Renal Carcinoma Cells in an Orthotopic Xenograft Mouse Model
Caveolin-1-dependent tenascin C inclusion in extracellular vesicles is required to promote breast cancer cell malignancy
Increase in ADAR1p110 activates the canonical Wnt signaling pathway associated with aggressive phenotype in triple negative breast cancer cells
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia
Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors

BookSection (1)

Chapter 6: Non-Coding Mitochondrial RNAs (ncmtRNAs) in Gynecological and Urinary Malignancies: Universal Targets for Development of an Efficient Therapy?

ConferencePoster (14)

Aptamers as a potential therapeutic tool for blocking Epithelial-Mesenchymal transition in triple negative breast cancer model
Aptámeros bloquean capacidades tumorogénicas promovidas por vesículas extracelulalres de cáncer de mama
Functionalized gold nanoparticles blocking Lactadherin present in extracellular vesicles secreted by triple negative breast cancer cells diminished the migratory capacity in receptor cells
Searching for radioresistance-promotor miRNAs in breast cancer
Blocking Lactadherin present in triple positive breast cancer BT474 cells exosomes with functionalized gold nanoparticles decrease EMT in breast epithelial cells MCF10A
Antisense therapy against non-coding mitochondrial RNAs as potent therapy for prostate cancer
The antisense long non-coding mitocondrial RNA (AS-NCMTRNA) interference with ANDES- 1537 AS a novel treatment for renal carcinoma
Caveolin-1 containing extracelular vesicles promote malignant ascites formation in vitro an in vivo model of peritoneal carcinomatosis
Evaluation in vivo of the efficacy of an antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer
Evaluation of antisense therapy in PDX models of advanced cervical cancer: Mitochondrial noncoding RNAs as target
Primer modelo murino de lesiones preneoplásicas de la vesícula biliar asociado a litiasis inducida por dieta
Development and characterization of the first lithiasis-associated gallbladder cancer model in mice
Evaluation of the efficacy of antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer
Exosomes released upon knockdown of the Antisense non-coding mitochondrial RNAs modulate tumorigenic properties of the human breast cancer cell line MDA-MB-231

Review (1)

EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment
21
Francisca Sepúlveda

PhD(c)

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Vincenzo Borgna

Investigador

Inmuno-Oncología

FUNDACION CIENCIA VIDA

Santiago, Chile

1
JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Nicolás Saavedra

Profesor Asociado

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Maximiliano Bendek

ninguno

ninguna

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricia García

Profesor Asistente

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Carolina Bizama

Assistant professor

Department of Pathology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Claudio Villota

Profesor/investigador Asociado

Facultad de Salud

Universidad Bernardo O'Higgins

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile