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Marcela Katherine Sjoberg Herrera

Assistant professor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Epigenetic mechanisms regulating gene expression; Dynamics of DNA methylation in the immune system; Non-coding RNAs; Interplay between metabolic sensors and regulators of genome function; Mapping immune cell diversity using across Latin America

Educación

  •  Doctor en Biología Celular, Molecular y Neurociencias , UNIVERSIDAD DE CHILE. Chile, 2006
  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2002

Experiencia Académica

  •   Assistant professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Ciencias Biológicas

    Santiago, Chile

    2016 - At present

Experiencia Profesional

  •   Ayudante curso Biología Celular

    Universidad de Chile

    Chile

    1997 - 1998

  •   Asistente de investigación proyecto Fondecyt 1970276

    Universidad Católica de Chile

    Chile

    1999 - 1999

  •   Estadía de investigación

    René Descartes University

    Francia

    2003 - 2003

  •   Estadía de investigación

    Case Western Reserve University

    Estados Unidos

    2005 - 2005

  •   Estudiante de Doctorado

    Universidad de Chile

    Chile

    2001 - 2006

  •   Postdoctorado - Career development fellow

    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE

    Reino Unido

    2006 - 2010

  •   Research Associate

    University of Cambridge

    Reino Unido

    2012 - 2016

  •   Postdoctoral Scientist

    Wellcome Trust Sanger Institute

    Reino Unido

    2012 - 2016

Formación de Capital Humano


Autor(es):Rojas, Pamela
Título: "Characterization of the effects induced by ADAR1 over long non-coding RNAs A-to-I editing and expression levels in breast cancer",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Doctorado/PhD, 2020

Autor(es):Rivera, Carlos
Título: "Unveiling non canonical roles for RCOR1 and RCOR2 transcriptional co-repressors",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Doctorado/PhD, 2020

Autor(es):Ballesteros, Rocío
Título: "La metilcitosina dioxigenasa Tet1: Factores de transcripción que regulan su expresión, isoformas y localización subcelular",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Magíster/Master/DEA, 2022

Autor(es):Villalobos, Daniela
Título: "Investigating TET proteins partners that control hydroxymetylated genes in the adaptive immune system",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Licenciatura/Bachillerato/Bachelor, 2020

Autor(es):Reinoso, María Javiera
Título: "Examining the binding of Tet1 and histone H3K4 trimethylation enzymes and their association to 5hmc marked genes in naïve CD4+ T cells",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Licenciatura/Bachillerato/Bachelor, 2020

Autor(es):Hernández, Macarena
Título: "Estudio de la asociación de proteínas lectoras de DNA metilado a genes hidroximetilados en linfocitos T CD4+ naïve",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Magíster/Master/DEA, 2019


Premios y Distinciones

  •   Beca Doctorado

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2002

    Beca CONICYT para financiar estudios de Doctorado en Chile

  •   Beca Doctorado

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2001

    Beca Instituto Milenio CBB P99-031-F para financiar estudios de doctorado en Chile

  •   Postdoctoral Fellowship

    MEDICAL RESEARCH COUNCIL

    Reino Unido, 2006

    MRC Career development fellowship of postdoctoral researcher


 

Article (15)

Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin
Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis
Needs for a Curricular Change in Primary and Secondary Education From the One Health Perspective: A Pilot Study on Pneumonia in Schools
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis
Identification, Characterization, and Heritability of Murine Metastable Epialleles: Implications for Non-genetic Inheritance
Simulation-based benchmarking of isoform quantification in single-cell RNA-seq
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci
The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation
The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts
E180splice Mutation in the Growth Hormone Receptor Gene in a Chilean Family with Growth Hormone Insensitivity: A Probable Common Mediterranean Ancestor
Novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells
Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization
Study of GH sensitivity in Chilean patients with idiopathic short stature

Abstract (1)

OPA1 GTPase and GE Domain-Specific Mutations Differentially Alter Mitochondrial Fusion Dynamics and Calcium Homeostasis

Proyecto (2)

Project Jaguar: mapping immune cell diversity across Latin America
DNA hydroxymethylation in the T cell lineage: examining the role of the DNA hydroxylase Tet1 and hydroxymethylation in bookmarking key genes for function and development

Review (1)

Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease
19
Marcela Sjoberg

Assistant professor

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Ricardo Maccioni

DIRECTOR

RESEARCH AND DEVELOPMENT

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

2
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

2
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

1
Daniela Figueroa

Presidenta

Fundación Educación y Ciencia

Santiago, Chile

1
Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

1
María Andrés

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile