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Juan Cristóbal Maass Oñate

Asistan Professor

universidad de chile

Santiago, Chile

Inner ear regeneration and development Hearing loss genetics and genomics Otolaryngology Otology and Neuro-otology Sudden deafness Artificial Intelligence-aided diagnosis

Doctor en Ciencias Medicas mencion en otorrinolaringologia, Universidad de Chile. Chile, 2010
Medico cirujano, Universidad de Chile. Chile, 2001
Otorrinolaringologia, Universidad de Chile. Chile, 2005

Assistant Professor Part Time

Universidad de Chile

Medicina

Santiago, Chile

2013 - At present
Assistant Professor Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2005 - At present
Postdoctoral associate Full Time

BAYLOR COLLEGE OF MEDICINE

Houston, Estados Unidos

2010 - 2012

Assistant Professor Part Time

University of Chile

Santiago, Chile

2005 - At present
Otolaryngologist Part Time

Clinica Alemana-Universidad del Desarrollo

Santiago, Chile

2008 - At present
Otolaryngologist Part Time

Hospital Clínico Universidad de Chile

Santiago, Chile

2005 - At present

Undergraduate education
Tesis seminar: Validación de la expresión espacio-temporal de genes del oído interno en ratón postnatal y su posible uso con fin terapéutico, Silvia Cantelllano 2014
Graduate Education
MD PhD Tesis: Disminución de la expresión génica de Notch1 como aproximaciòn para la regeneración de células ciliadas y eventual tratamiento para la hipoacusia. Francisca Leon 2019

Mejor trabajo cientifico congreso

SOCIEDAD CHILENA DE OTORRINOLARINGOLOGIA

Chile, 2018

Best Podium presentation at the LXXV Otolaryngology, Head and Neck Chilean Congress. Santa Cruz, Chile.
Mejor trabajo cientifico congreso

SOCIEDAD CHILENA DE OTORRINOLARINGOLOGIA

Chile, 2010

Best Podium presentation at the LVII Otolaryngology, Head and Neck Chilean Congress. Valdivia, Chile


Computer-aided diagnosis of external and middle ear conditions: A machine learning approach Viscaino, Michelle; Maass, Juan C.; Delano, Paul H.; Torrente, Mariela; Stott, Carlos; Auat Cheein, Fernando Article SCOPUS PLOS ONE (2020)
Preventing presbycusis in mice with enhanced medial olivocochlear feedback Boero, Luis E.; Castagna, Valeria C.; Terreros, Gonzalo; Moglie, Marcelo J.; Silva, Sebastian; Maass, Juan C.; Fuchs, Paul A.; Delano, Paul H.; Belen Elgoyhen, Ana; Eugenia Gomez-Casati, Maria Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis Delano, Paul H.; Belkhiria, Chama; Vergara, Rodrigo C.; Martinez, Melissa; Leiva, Alexis; Andrade, Maricarmen; Marcenaro, Bruno; Torrente, Mariela; Maass, Juan C.; Delgado, Carolina Article ISI PLOS ONE (2020)
p27(Kip1) down-regulation as achieved by two clinically feasible means did not induce proliferation of supporting cells in the rat neonatal cochlea in vivo Silva, SA; Maass JC Article ISI SCOPUS HEARING RESEARCH (2019)
SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex Saud K.; Cánovas J.; Lopez C.I.; Berndt F.A.; López E.; Maass J.C.; Barriga A.; Kukuljan M. Article ISI SCOPUS INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2017)
Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing Maass, JC; Gu, RD; Cai, TT; Wan, YW; Cantellano, SC; Asprer, JST; Zhang, HY; Jen, HI; Edlund, RK; Liu, ZD; Groves, AK Article ISI SCOPUS PLOS ONE (2016)
Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea Maass JC; Gu, RD; Basch, ML; Waldhaus, J; Lopez, EM; Xia, AP; Oghalai, JS; Heller S.; Groves, AK Article ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a Canovas, J.; Berndt, FA; Sepulveda, H; Aguilar R.; Veloso FA; Montecino, M.; Oliva, C; Maass JC; Sierralta, J; Kukuljan M. Article ISI SCOPUS Journal of Neuroscience (2015)
SÍNTOMAS LARÍNGEOS Y LARINGITIS POSTERIOR: ¿SIEMPRE ES SECUNDARIO A REFLUJO GASTROESOFÁGICO? Italo Braghetto M.; Francisco Venturelli M.; Alberto Rodr; Beatriz Brunetto M; Juan Maass O; Ana Henr Article ISI SCIELO REVISTA CHILENA DE CIRUGIA (2014)
Analysis of FGF-Dependent and FGF-Independent Pathways in Otic Placode Induction Yang, L; O'Neill, P; Martin K.; Maass JC; Vassilev, V; Ladher, R; Groves, AK Article ISI SCOPUS PLOS ONE (2013)
p27Kip1 Knockdown Induces Proliferation in the Organ of Corti in Culture after Efficient shRNA Lentiviral Transduction Maass JC; Berndt, FA; Canovas, J.; Kukuljan M. Article ISI SCOPUS JARO - Journal of the Association for Research in Otolaryngology (2013)
CoREST represses the heat shock response mediated by HSF1 Gomez, AV; Galleguillos D; Maass JC; Battaglioli, E; Kukuljan M.; Andres, ME Article ISI SCOPUS MOLECULAR CELL (2008)
Estudio morfológico del oído medio e interno de la Chinchilla laniger Carrasco M, Loreto; Maass O, J. Cristóbal; Dentone S, Luis; Miranda G, Gonzalo; Kukuljan P, Manuel Article ISI SCIELO REVISTA DE OTORRINOLARINGOLOGIA Y CIRUGIA DE CABEZA Y CUELLO (2008)
Efecto del factor de crecimiento endotelio vascular (VEGF) sobre perforaciones timpánicas en ratas Long-Evans Zúñiga P, Jorge; Maass O, Juan Cristóbal; Amagada A, Christian Article ISI SCIELO REVISTA DE OTORRINOLARINGOLOGIA Y CIRUGIA DE CABEZA Y CUELLO (2007)


Hair Cell Regeneration Maass, Juan C.; Goycolea Marco BookSection (2012)


IDENTIFYING MUTATIONS THAT CAUSE CONGENITAL DEAFNESS IN CHILE Helmuth Sanchez; Cortese, Elvira M.; Agustin Martinez; Juan Cristobal Maass; Moya Fuentes, Pablo Proyecto (2018)
Efferent neural dynamics from auditory cortex to the cochlear receptor during selective attention paradigms in tinnitus patients and chinchillas Delano, P. H.; Maass O, Juan Cristóbal Proyecto (2016)
EFFERENT NEURAL DYNAMICS FROM AUDITORY CORTEX TO THE COCHLEAR RECEPTOR DURING SELECTIVE ATTENTION PARADIGMS IN TINNITUS PATIENTS AND CHINCHILLAS FONDECYT (1161155) Proyecto 2016-2020 Coinvestigador(a)
International network for Auditory and Cognition Center (Chile-Argentina) Delano, P. H.; Maass JC; Elgoyhen A.B. Proyecto (2016)
From presbycusis to dementia: a basic and clinical approach Paul Delano; Maass J.C. Proyecto (2014)
“Otobanco=> Banco de muestras de DNA de pacientes con enfermedades otorrinolaringológicas infrecuentes u origen genético” SOCIEDAD CHILENA DE OTORRINOLARINGOLOGIA SOCHIORL (SOCHIORL 2013) Proyecto 2014-2015 Inv. Principal
“Predisposición genética en la respuesta a cortico-esteroides y su asociación con el resultado auditivo final en pacientes con hipoacusia súbita” CLINICA ALEMANA DE SANTIAGO (CAS 2013) Proyecto 2014-2015 Inv. Principal
Supporting cell next generation gene expression profile in the purse of an inducible and sequential proliferation-transdifferentiation approach for a more efficient and stable cochlear regenerative response in vivo FONDECYT (11130247) Proyecto 2013-2017 Inv. Principal
Supporting cell next generation gene expression profile in the pursuit of an inducible and sequencial proliferation-transdifferentiation approach for a more efficient and stable cochlear regenerative esponse in vivo Juan C Maass Proyecto (2013)
Treating combat hearing loss with Atoh1 Gene Therapy United States of America Department of Defense (DOD) (W81XWH-10-2-116) Proyecto 2011-2013 Investigador(a)
Interferencia en la expression de genes en el oído interno como herramienta molecular para regenerar células ciliadas (apoyo tesis doctoral) PFCHA (AT24071080) Proyecto 2007-2009 Inv. Principal
Molecular interference as tool for Inner Ear Regeneration Maass O, Juan Cristóbal Proyecto (2007)
Interferencia en la expression de genes en el oido interno como herramienta molecular para regenerar células ciliadas Sociedad chilena de otorrinolaringologia, medicina y cirugía de cabeza y cuello (concurso anual SOCHIROL 2006) Proyecto 2006-2007 Inv. Principal
Identification of mutations causing genetic deafness in Chile Sanchez, Helmuth; Maass O, Juan Cristóbal; Martinez, Agustin; Cortese, Elvira M.; Moya, Pablo Proyecto (0)


Terapia génica como herramienta molecular para regenerar células ciliadas Maass O, Juan Cristóbal; Carrasco M, Loreto; Dentone S, Luis; Kukuljan P, Manuel Review ISI SCIELO REVISTA DE OTORRINOLARINGOLOGIA Y CIRUGIA DE CABEZA Y CUELLO (2009)