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Carlos Areche Medina

ASSOCIATE PROFESSOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


PRODUCTOS NATURALES; Fungal secondary metabolism; Biotechnology of Natural Products y sus aplicaciones biologicas; Biotransformaciones; Natural Product Chemistry; Pharmacological activity; Medicinal Chemistry; protein NMR.

Educación

  •  Natural Product Chemistry, UNIVERSIDAD DE TALCA. Chile, 2007
  •  Organic chemistry, universidad Nacional de Ingenieria. Peru, 2003
  •  Quimico Farmaceutico, UIGV. Chile, 1999

Experiencia Académica

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE CHILE

    CIENCIAS

    Santiago, Chile

    2009 - At present

Experiencia Profesional

  •   pharmacist Full Time

    Public Heath Institute

    Lima, Peru

    1999 - 2003

Formación de Capital Humano


UNDERGRADUATE STUDENTS

1.- Diego Alonso Vilches Retamal. Purificación de Meroditerpenoides policíclicos del alga parda Stypopodium Flabelliforme. Grado académico de Licenciado en Química. Universidad de Chile. 2009.

2.- Teresa Parra. Síntesis y actividad biológica de diterpenos de Baccharis tola. Grado académico de Químico industrial. UTEM. 2012.

3.- Solange Nuñez. Sintésis del flavonoide pinocembrina. Grado académico de Licenciado en Química. Universidad de Chile. 2012.

4.- Camila Barahona. Sintésis de flavanonas. Grado académico de Licenciado en Química. Universidad de Chile. 2012.

5.- Pamela Labbe. Biotransformacion del meroditerpeno acetato de stypotriol. Químico Industrial UTEM 2013.

6.- Francisco Salgado. Biotransformacion del diterpeno ácido mulin-11,13-dien-20-oico mediante hongos filamentosos. Grado académico de Licenciado en Química. Universidad de Chile. 2013.

7.- Felipe Valdevenito. Estudio Químico de Beilschmiedia miersii “belloto” en curso. Grado académico de Licenciado en Química. Universidad de Chile.

8.- Sebastian Cifuentes. Pruebas de eficiencia de nuevos antioxidantes mediante dpph: extraidos a partir de vegetales endémicos. En curso. Químico Industrial UTEM.

POSTGRADUATE STUDENTS

Qco. Carlos Lima. Estudiante de Doctorado en Ciencias Químicas. UNIDAD EN CURSO

Qco. Francisco Salgado. Estudiante de Maestria en Ciencias Químicas. EN CURSO


Premios y Distinciones

  •   ESTANCIA POSTDOCTORAL

    CSIC, IPNA

    España, 2010

    ESTANCIA POSTDOCTORAL EN EL LAB. DE PRODUCTOS MARINOS DEL PROFESOR JOSE DARIAS. IPNA, CSIC, TENERIFE, ESPAÑA.

  •   COIMBRA FELLOWSHIP

    IRB, BARCELONA, ESPAÑA

    Chile, 2012

    ESTANCIA POSTDOCTORAL EN EL LABORATORIO DE RESONANCIA MAGNETICA NUCLEAR DE PROTEINAS BAJO LA DIRECCION DEL PROFESOR MARIA JOSE MACIAS, IRB, BARCELONA, ESPAÑA.


 

Article (67)

A sustainable application for the extraction of lichen metabolites from Usnea cornuta: nontargeted metabolomics and antioxidant activity
Antioxidant activity and enzymatic of lichen substances: A study based on cyclic voltammetry and theoretical
Phenolic Profile, Antioxidant and Enzyme Inhibition Properties of the Chilean Endemic Plant Ovidia pillopillo (Gay) Meissner (Thymelaeaceae)
Activity of Semi-Synthetic Mulinanes against MDR, Pre-XDR, and XDR Strains of Mycobacterium tuberculosis
Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies
Dammarane triterpenes targeting alpha-synuclein: biological activity and evaluation of binding sites by molecular docking
Green ultrasound-assisted extraction of lichen substances from Hypotrachyna cirrhata. Ethyl lactate, a better extracting agent than methanol toxic organic solvent?
In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main Protease
Structure-antioxidant activity relationships in boldine and glaucine: a DFT study
Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 protease
Are Ionic Liquids Better Extracting Agents Than Toxic Volatile Organic Solvents? A Combination of Ionic Liquids, Microwave and LC/MS/MS, Applied to the Lichen Stereocaulon glareosum
Corryocactus brevistylus (K. Schum. ex Vaupel) Britton Rose (Cactaceae): Antioxidant, Gastroprotective Effects, and Metabolomic Profiling by Ultrahigh-Pressure Liquid Chromatography and Electrospray High Resolution Orbitrap Tandem Mass Spectrometry
Isolation, Gastroprotective Effects and Untargeted Metabolomics Analysis of Lycium Minutifolium J. Remy (Solanaceae)
The crystal structure of 1-carboxy-2-(1H-indol-3-yl)-N,N,N-trimethylethan-1-ammonium chloride, C14H19N2O2Cl
Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine-Cysteine Interaction.
Biological activity and chemical characterization of Pouteria lucuma seeds=> A possible use of an agricultural waste.
Mulinane and Azorellane Diterpenoid Biomarkers by GC-MS from a Representative Apiaceae (Umbelliferae) Species of the Andes.
Mulinum crassifolium Phil; Two New Mulinanes, Gastroprotective Activity and Metabolomic Analysis by UHPLC-Orbitrap Mass Spectrometry
Phytochemical Profiling of (Cactaceae) Growing in Greenhouse Conditions Using Ultra-High-Performance Liquid Chromatography�Tandem Mass Spectrometry.
Characterization and Salt Response in Recurrent Halotolerant Exiguobacterium sp SH31 Isolated From Sediments of Salar de Huasco, Chilean Altiplano
Continental and Antarctic Lichens=> isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor.
Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert
Secondary Metabolite Profiling of Species of the Genus Usnea by UHPLC-ESI-OT-MS-MS
UHPLC-ESI-ORBITRAP-MS analysis of the native Mapuche medicinal plant palo negro (Leptocarpha rivularis DC. - Asteraceae) and evaluation of its antioxidant and cholinesterase inhibitory properties
Metabolomic Analysis of the Lichen Everniopsis trulla Using Ultra High Performance Liquid Chromatography-Quadrupole-Orbitrap Mass Spectrometry (UHPLC-Q-OT-MS)
Metabolomic Analysis of Two Parmotrema Lichens=> P-robustum (Degel.) Hale and P-andinum (Mull. Arg.) Hale Using UHPLC-ESI-OT-MS-MS
Metabolomic Analysis of Two Parmotrema Lichens=> P-robustum (Degel.) Hale and P-andinum (Mull. Arg.) Hale Using UHPLC-ESI-OT-MS-MS
Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to beta sheet in tau protein linked to Alzheimer's disease
UHPLC high resolution orbitrap metabolomic fingerprinting of the unique species Ophryosporus triangularis Meyen from the Atacama Desert, Northern Chile
Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC-Q/Orbitrap/MS/MS)
Gastroprotective activity of synthetic coumarins: Role of endogenous prostaglandins, nitric oxide, non-protein sulfhydryls and vanilloid receptors
Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a β-cyclodextrin complex with microbial and chemical transformations
Phenolic compounds in chilean mistletoe (quintral, Tristerix tetrandus) analyzed by UHPLC-Q/Orbitrap/MS/MS and its antioxidant properties
Secondary Metabolites in Ramalina terebrata Detected by UHPLC/ESI/MS/MS and Identification of Parietin as Tau Protein Inhibitor
3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp Fungus
Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS
Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls
Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium flabelliforme and Its Gastroprotective Effect in Mouse Model
A new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Peru
An unusual mulinane diterpenoid from the Chilean plant Azorella trifurcata (Gaertn) Pers
Anthocyanin Characterization, Total Phenolic Quantification and Antioxidant Features of Some Chilean Edible Berry Extracts
Concise and Straightforward Asymmetric Synthesis of a Cyclic Natural Hydroxy-Amino Acid
Coumarins isolated from Esenbeckia alata (Rutaceae)
HPLC-PDA-MS Profiles of Phenolic Compounds and Antioxidant Activity of Fruits From Three Citrus Species Consumed in Northern Chile.
HPLC-UV-MS Profiles of Phenolic Compounds and Antioxidant Activity of Fruits from Three Citrus Species Consumed in Northern Chile
Further mulinane diterpenoids from Azorella compacta
LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
Variations in the chemical profile and biological activities of licorice (Glycyrrhiza glabra L.), as influenced by harvest times
Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms
ABSOLUTE CONFIGURATION OF THE MERODITERPENOIDS TAONDIOL AND EPITAONDIOL DIACETATES BY VIBRATIONAL CIRCULAR DICHROISM
Biological Activity of Isoflavonoids from Azorella madreporica
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrina fusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrinafusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS
Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines
Biotransformation of Stypotriol triacetate by Aspergillus niger
Gastroprotective Activity of Epitaondiol and Sargaol
ABSOLUTE CONFIGURATION OF SARGAOL ACETATE USING DFT CALCULATIONS AND VIBRATIONAL CIRCULAR DICHROISM
Diterpenoids from Azorella madreporica and Their Antibacterial Activity
Stereostructure Reassignment and Absolute Configuration of Isoepitaondiol, a Meroditerpenoid from Stypopodium flabelliforme
An unusual halogenated meroditerpenoid from Stypopodium flabelliforme: Studies by NMR spectroscopic and computational methods
Gastroprotective effect and cytotoxicity of abietane diterpenes from the Chilean Lamiaceae Sphacele chamaedryoides (Balbis) Briq.
TRITERPENOIDS FROM Azorella trifurcata (Gaertn.) Pers AND THEIR EFFECT AGAINST THE ENZYME ACETYLCHOLINESTERASE
VCD Determination of the Absolute Configuration of Stypotriol
Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells
Gastroprotective activity of ferruginol in mice and rats: effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls
Microbial transformation of the diterpene mulin-11,13-dien-20-oic acid by Mucor plumbeus
Gastroprotective and cytotoxic effect of semisynthetic ferruginol derivatives

Proyecto (5)

Depsides, despsidones and anthraquinones from Chilean lichens=> Isolation, molecular simulation and biological activity as tau-reducing agents.
Polyphenols isolated from antarctic Lichens as inhibitors of tau aggregation
Terrestrial and marine organism as source of gastroprotective drugs
azorella compacta como fuente de metabolitos activos
Natural or Hemisynthetic products of Pharmacological agrochemical and forestry interest and its possible biotechnological development
78
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

18
Juana Rovirosa

Professor Ad. Honorem

Ciencias

Facultad de Ciencias y Recursos Naturales

Punta Arenas, Chile

17
MARIO SIMIRGIOTIS

full professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

12
AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

6
Cristina Quispe

ACADEMICO

FACULTAD DE CIENCIAS DE LA SALUD

UNIVERSIDAD ARTURO PRAT

IQUIQUE, Chile

5
Jorge Borquez

Académico

Química

Universidad de Antofagasta

Antofagasta, Chile

5
osvaldo yañez

Académico Investigador

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

5
Inmaculada Vaca

Associate Professor

Chemistry Department

UNIVERSIDAD DE CHILE

Santiago, Chile

5
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

4
Marcelo Muñoz

Profesor Auxiliar

Instituto de Ciencias Químicas

Universidad Austral de Chile

Valdivia, Chile

3
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

3
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

3
Beatriz Sepúlveda

Profesor adjunto

UNIVERSIDAD ANDRES BELLO

2
Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

2
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

2
Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

2
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

2
Manuel Osorio

Docente

Medicina

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

2
Reinaldo Vargas

Académico

Departamento de Biología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

2
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

2
Francisco Melo

FULL PROFESSOR

FISICA

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

2
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

1
Felipe Aguilar

Académico

UNIVERSIDAD DE AYSEN

Coyhaique, Chile

1
Bárbara Fuentes

Acádemcia, Investigadora, Jefe de Carrera

Departamento de Ingeniería Química

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
FRANCISCO REMONSELLEZ

Professor

Ingenieria Química

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Coral Pardo

Investigador postdoctoral

Universidad Católica del Norte

antofagasta, Chile

1
Javier Echeverría

Profesor Asistente e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

1
Renato Chavez

Full Professor

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

1
Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

1
Luisa Quesada

Docente e investigadora

Nutrición y Dietética

Universidad San Sebastián

Valdivia, Chile

1
Juan Castro

Post-Doctorante

Universidad Católica del Norte

Antofagasta, Chile

1
Pablo Aguilar

Academico

Departamento de Biotecnologia

Universidad de Antofagasta

Antofagasta, Chile

1
Edison Osorio

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
CLAUDIO PARRA

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Jessica Bravo

Profesor asociado, investigador jornada

UNIVERSIDAD DIEGO PORTALES

santiago, Chile

1
Rogelio Hernández

Jefe de la unidad Patología Experimental

DEPARTAMENTO DE PATOLOGÍA

INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICICIÓN SALVADOR ZUBIRAN

Ciudad México, México

1
silvana moris

Investigadora

vicerrectoria de investigacion y postgrado

Universidad Católica del Maule

Talca, Chile

1
Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Marlene Henríquez

Gestora de Transferencia Tecnológica

Dirección de Gestión Tecnológica

Universidad de Santiago de Chile

Santiago, Santiago Metropolitan, Chile, Chile