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MARIANO WALTER PERTINO

Profesor conferenciante

UNIVERSIDAD DE TALCA, INSTITUTO DE QUÍMICA DE RECURSOS NATURALES

TALCA, Chile

Biological activity of naturally occurring and synthetic compounds; Action mechanisms of bioactive compounds in human cell cultures; Cytotoxicity and antiproliferative activity in human cell cultures; Natural Products Chemistry; Biological activity of Â naturally occurring compounds and semisynthetic derivatives; Ethnopharmacology; Structure-activity relationships in bioactive compounds; Semisynthesis; Natural products

DOCTOR EN CIENCIAS, UNIVERSIDAD DE TALCA. Chile, 2006
LICENCIADO EN QUÍMICA, UNIVERSIDAD NACIONAL DEL SUR. Argentina, 2002

Profesor conferenciante Full Time

Universidad de Talca

Instituto de Química de Recursos Naturales

Talca, Chile

2011 - At present

Profesor conferenciante Full Time

Universidad de Talca

Talca, Chile

2011 - At present


Isolation, Gastroprotective Effects and Untargeted Metabolomics Analysis of Lycium Minutifolium J. Remy (Solanaceae) Rodriguez, Stephanie; Pertino, Mariano Walter; Arcos, Chantal; Reichert, Luana; Echeverria, Javier; simirgiotis, mario; Borquez, Jorge; Cornejo, Alberto; Areche, Carlos; Sepulveda, Beatriz Article FOODS (2020)
Synthesis and Cytotoxic Analysis of Novel Myrtenyl Grafted Pseudo-Peptides Revealed Potential Candidates for Anticancer Therapy Concepción, Odette; Belmar, Julio; F. de la Torre, Alexander; M. Muñiz, Francisco; Pertino, Mariano W.; Alarcón, Barbara; Ormazabal, Valeska; Nova-Lamperti, Estefania; Zúñiga, Felipe A.; Jiménez, Claudio A. Article MOLECULES (2020)
Synthesis, trypanocidal and anti-Leishmania activity of new triazole-lapachol and norlapachol hybrids Mariano Walter Pertino; Alexander F. de la Torre; Guillermo Schmeda-Hirschmann; Celeste Vega; Miriam Rolón; Cathia Coronel; Antonieta Rojas de Arias; Pilar Carranza-Rosales; Karla Leal López; Ezequiel Viveros Valdez Article BIOORGANIC CHEMISTRY (2020)
Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs=> In vitro and in silico studies Theoduloz, Cristina; Alzate-Morales, Jans; Jiménez-Aspee, Felipe; Isla, Maria Inés; Alberto, María Rosa; Pertino, Mariano Walter; Schmeda-Hirschmann, Guillermo Article CHEMICAL BIOLOGY AND DRUG DESIGN (2019)
An efficient cyclization of lapachol to new benzo[h]chromene hybrid compounds=> a stepwise vs. one-pot esterification-click (CuAAC) study Alexander F. de la Torre,* Akbar Ali; b Bernhard Westermann, Guillermo Schmeda-Hirschmannd and Mariano Walter Pertino* Article NEW JOURNAL OF CHEMISTRY (2018)
Synthesis, Antiviral and Cytotoxic Activity of Novel Terpenyl Hybrid Molecules Prepared by Click Chemistry Pertino, Mariano Walter; Petrera, Erina; Alché, Laura Edith; Schmeda-Hirschmann, Guillermo Article MOLECULES (2018)
Antiprotozoal Activity of Triazole Derivatives of Dehydroabietic Acid and Oleanolic Acid Pertino M.W., Vega C.; Rolón M., Coronel C.; De Arias A.R., Schmeda-Hirschmann G. Article MOLECULES (2017)
Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway Bueno, C; Michelini, F; Pertino, M; Gómez C; Schmeda-Hirschmann, G; Alche, LE Article ISI SCOPUS Medical Microbiology and Immunology (2015)
Synthesis, antiproliferative and antifungal activities of 1,2,3-triazole-substituted carnosic Acid and carnosol derivatives. Pertino, Mariano Walter; Theoduloz, Cristina; Butassi, Estefania; Zacchino, Susana; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2015)
Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs. Theoduloz, Cristina; Delporte, Carla; Valenzuela-Barra, Gabriela; Silva, Ximena; Cádiz, Solange; Bustamante, Fernanda; Pertino, Mariano Walter; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2015)
Gastroprotective Mechanisms of Action of Semisynthetic Carnosic Acid Derivatives in Human Cells Theoduloz, C; Pertino M.W.; Schmeda-Hirschmann, G Article ISI MOLECULES (2014)
Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid. Pertino, Mariano Walter; Verdugo, Valery; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2014)
1,2,3-triazole-substituted oleanolic Acid derivatives: synthesis and antiproliferative activity. Pertino, Mariano Walter; Lopez, Cecilia; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2013)
Dimeric labdane diterpenes: synthesis and antiproliferative effects. Pertino, Mariano Walter; Theoduloz, Cristina; Bastías, Marco; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2013)
Diterpenylquinone hybrids: synthesis and assessment of gastroprotective mechanisms of action in human cells. Theoduloz, Cristina; Bravo, Ivanna; Pertino, Mariano Walter; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2013)
Absolute Configuration and H-1 NMR Characterization of Rosmaridiphenol Diacetate Muñoz M.A.; Perez-Hernandez, N; Pertino M.W.; Schmeda-Hirschmann, G; Joseph-Nathan, P Article ISI SCOPUS Journal of Natural Products (2012)
New Gastroprotective Labdeneamides from (4S, 9R, 10R) Methyl 18-carboxy-labda-8,13(E)-diene-15-oate Olate V.R.; Pertino M.W.; Theoduloz, C; Yesilada, E; Monsalve, F; Gonzalez P.; Droguett, D.; Richomme P.; Hadi A.H.A.; Schmeda-Hirschmann, G Article ISI SCOPUS Planta Medica (2012)
Potential Gastroprotective Effect of Novel Cyperenoic Acid/Quinone Derivatives in Human Cell Cultures Theoduloz, C; Carrion I.; Pertino, M; Valenzuela, D; Schmeda-Hirschmann, G Article ISI SCOPUS Planta Medica (2012)
Gastroprotective Effect and Cytotoxicity of Carnosic Acid Derivatives Theoduloz, C; Pertino, M; Rodriguez JA.; Schmeda-Hirschmann, G Article ISI SCOPUS Planta Medica (2011)
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives. Pertino, Mariano Walter; Theoduloz, Cristina; Palenzuela, Jose Antonio; Afonso, Maria del Mar; Yesilada, Erdem; Monsalve, Francisco; González, Paulo; Droguett, Daniel; Schmeda-Hirschmann, Guillermo Article Molecules (Basel, Switzerland) (2011)
Gastroprotective effect of carnosic acid gamma-lactone derivatives. Pertino, Mariano Walter; Theoduloz, Cristina; Rodríguez, Jaime A; Yáñez, Tania; Lazo, Viviana; Schmeda-Hirschmann, Guillermo Article Journal of natural products (2010)
Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides. Schmeda-Hirschmann, Guillermo; Pertino, Mariano Walter; Rodriguez, Jaime A; Monsalve, Francisco; Droguett, Daniel; Theoduloz, Cristina Article Molecules (Basel, Switzerland) (2010)
The corrected structure of rosmaridiphenol, a bioactive diterpene from Rosmarinus officinalis. Pertino, Mariano Walter; Schmeda-Hirschmann, Guillermo Article Planta medica (2010)
Antiproliferative Activity of the Diterpenes Jatrophone and Jatropholone and Their Derivatives Theoduloz, C; Rodriguez JA.; Pertino, M; Schmeda-Hirschmann, G Article ISI SCOPUS PLANTA MEDICA (2009)
A new antifungal and antiprotozoal depside from the Andean lichen Protousnea poeppigii Schmeda-Hirschmann, G; Tapia, A; Lima B.; Pertino, M; Sortino, M; Zacchino, S; De Arias, AR; Feresin, GE Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2008)
Biotransformation of jatrophone by Aspergillus niger ATCC 16404 Pertino, M; Schmeda-Hirschmann, G; Santos, LS; Rodriguez JA.; Theoduloz, C Article ISI SCOPUS ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES (2007)
Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives Pertino, M; Schmeda-Hirschmann, G; Rodriguez JA.; Theoduloz, C Article ISI SCOPUS PLANTA MEDICA (2007)
Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug yagua rova" (Jatropha isabelli)" Pertino, M; Schmeda-Hirschmann, G; Rodriguez JA.; Theoduloz, C Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2007)
Gastroprotective activity and cytotoxic effect of cyperenoic acid derivatives Pertino, M; Rodriguez JA.; Theoduloz, C; Razmilic I.; Schmeda-Hirschmann, G Article ISI SCOPUS JOURNAL OF PHARMACY AND PHARMACOLOGY (2006)


DISEÑO, SÍNTESIS Y EVALUACIÓN ANTI-CANCERÍGENA DE NUEVOS HÍBRIDOS DERIVADOS DEL MONOTERPENO MIRTENAL (MIR). FONDECYT (3170012) Proyecto 2017-2020 Inv. Patrocinante
SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL NAPHTHOQUINONE-TRIAZOLE DERIVATIVES PREPARED BY CLICK CHEMISTRY FONDECYT (1161092) Proyecto 2016-2019 Inv. Responsable
NOVEL HYBRID TERPENE-NAPHTHOQUINONE GASTROPROTECTIVE COMPOUNDS=> SYNTHESIS AND ASSESSMENT OF ACTION MECHANISMS USING HUMAN CELL CULTURE MODELS. FONDECYT (1110054) Proyecto 2011-2015 Coinvestigador(a)
SYNTHESIS OF CYTOTOXIC TERPENES=> A CLICK CHEMISTRY APPROACH FONDECYT (11100046) Proyecto 2010-2013 Inv. Responsable