Man

Javier Hernán Romero Parra

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Rational Design, Synthesis, Biological Evaluation and Structure-Activity Relationship study of novel Benzo[d]imidazoles and Benzo[b]thiophenes as agonists of the cannabinoid type 1 and 2 receptors.

Educación

  •  Químico Farmacéutico , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Organic Chemistry, Medicinal Chemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2015
  •  Diplomado en Docencia Universitaria , UNIVERSIDAD CATOLICA DEL NORTE. Chile, 2019

Experiencia Académica

  •   INVESTIGADOR Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química

    Santiago , Chile

    2009 - 2017

  •   PROFESOR INSTRUCTOR ADJUNTO Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química

    Santiago , Chile

    2014 - 2017

  •   DOCENTE Part Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Viña del Mar , Chile

    2015 - 2017

  •   Profesor Asistente Full Time

    UNIVERSIDAD CATOLICA DEL NORTE

    Facultad de Ciencias

    Antofagasta, Chile

    2018 - 2019

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santtiago, Chile

    2019 - At present

Experiencia Profesional

  •   PROFESOR INSTRUCTOR ADJUNTO Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago , Chile

    2014 - 2017

  •   DOCENTE Part Time

    UNIVERSIDAD ANDRES BELLO VIÑA DEL MAR

    Viña del Mar , Chile

    2015 - 2017

  •   DOCENTE Part Time

    Universidad Andrés Bello

    Santiago, Chile

    2015 - 2016

  •   Profesor Asistente Full Time

    UNIVERSIDAD CATOLICA DEL NORTE

    Antofagasta, Chile

    2018 - 2019

  •   Profesor Asistente Full Time

    Universidad de Chile

    Santiago, Chile

    2019 - At present


 

Article (26)

Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (<i>Drimys winteri</i> J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits

Barrientos, Ruth E.; Romero-Parra, Javier; Cifuentes, Fredi; Palacios, Javier; Romero-Jola, Nestor Jaime; Paredes, Adrian; Vargas-Arana, Gabriel; Simirgiotis, Mario J.

Article ISI
FOODS  (2023)

Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[<i>d</i>]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists

Cho, Analia Young Hwa; Chung, Hery; Romero-Parra, Javier; Kumar, Poulami; Allara, Marco; Ligresti, Alessia; Gallardo-Garrido, Carlos; Pessoa-Mahana, Hernan; Faundez, Mario; Pessoa-Mahana, Carlos David

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2023)

Alkaloid Profiling, Anti-Enzymatic and Antiproliferative Activity of the Endemic Chilean Amaryllidaceae Phycella cyrtanthoides

Fernandez-Galleguillos, Carlos; Romero-Parra, Javier; Puerta, Adrian; Padron, Jose M.; Simirgiotis, Mario J.

Article ISI
METABOLITES  (2022)

Design of benzimidazoles, benzoxazoles, benzothiazoles and thiazolopyridines as leukotriene A4 hydrolase inhibitors through 3D-QSAR, docking and molecular dynamics

Lorca, Marcos; Faundez, Mario; Pessoa-Mahana, C. David; Recabarren-Gajardo, Gonzalo; Diethelm-Varela, Benjamin; Millan, Daniela; Celik, Ismail; Mellado, Marco; Araque, Ileana; Mella, Jaime; Romero-Parra, Javier

Article ISI
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY  (2022)

Phenolic Fingerprinting and Bioactivity Profiling of Extracts and Isolated Compounds from Gypothamnium pinifolium Phil.

Barrientos, Ruth E.; Ibanez, Elena; Puerta, Adrian; Padron, Jose M.; PAREDES-POBLETE, ADRIAN GUILLERMO; Cifuentes, Fredi; Romero-Parra, Javier; PALACIOS-COLLAO, JAVIER ALEJANDRO; BORQUEZ-RAMIREZ, JORGE PATRICIO; Simirgiotis, Mario J.

Article ISI SCOPUS
Antioxidants  (2022)

Phenolic Profile, Antioxidant and Enzyme Inhibition Properties of the Chilean Endemic Plant Ovidia pillopillo (Gay) Meissner (Thymelaeaceae)

Cortes, Carmen; Gonzalez-Cabrera, Diego A.; Barrientos, Ruth; Parra, Claudio; Romero-Parra, Javier; Pertino, Mariano Walter; Areche, Carlos; Sepulveda, Beatriz; Borquez, Jorge; Torres-Benitez, Alfredo; Simirgiotis, Mario J.

Article ISI
METABOLITES  (2022)

UHPLC-MS Metabolomic Fingerprinting, Antioxidant, and Enzyme Inhibition Activities of <i>Himantormia lugubris</i> from Antarctica

ARECHE-MEDINA, CARLOS ALBERTO; Romero Parra, Javier; Parra, Javier Romero; Sepulveda, Beatriz; GARCIA-BELTRAN, OLIMPO JOSE; Simirgiotis, Mario J.

Article ISI SCOPUS
Metabolites  (2022)

Analysis of Carotenoids in Haloarchaea Species from Atacama Saline Lakes by High Resolution UHPLC-Q-Orbitrap-Mass Spectrometry: Antioxidant Potential and Biological Effect on Cell Viability

Lizama, Catherine; Romero-Parra, Javier; Andrade, Daniel; Riveros, Felipe; Borquez, Jorge; Ahmed, Shakeel; Venegas-Salas, Luis; Cabalin, Carolina; Simirgiotis, Mario J.

Article ISI
ANTIOXIDANTS  (2021)

UHPLC-MS Chemical Fingerprinting and Antioxidant, Antiproliferative, and Enzyme Inhibition Potential of <i>Gaultheria pumila</i> Berries

Fernandez-Galleguillos, Carlos; Quesada-Romero, Luisa; Puerta, Adrian; Padron, Jose M.; Souza, Ernane; Romero-Parra, Javier; Simirgiotis, Mario J.

Article ISI
METABOLITES  (2021)

Chemical Fingerprinting and Biological Evaluation of the Endemic Chilean FruitGreigia sphacelata(Ruiz and Pav.) Regel (Bromeliaceae) by UHPLC-PDA-Orbitrap-Mass Spectrometry

Barrientos, Ruth E.; Ahmed, Shakeel; Cortes, Carmen; Fernandez-Galleguillos, Carlos; Romero-Parra, Javier; Simirgiotis, Mario J; Echeverria, Javier

Article ISI
MOLECULES  (2020)

Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae)

Jose Larrazabal-Fuentes, Maria; Fernandez-Galleguillos, Carlos; Palma-Ramirez, Jenifer; Romero-Parra, Javier; Sepulveda, Kevin; Galetovic, Alexandra; Gonzalez, Jorge; Paredes, Adrian; Borquez, Jorge; Simirgiotis, Mario J; Echeverria, Javier

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

DARK Classics in Chemical Neuroscience: Heroin and Desomorphine

Mella-Raipan, Jaime; Romero-Parra, Javier; Recabarren-Gajardo, Gonzalo

Article ISI
ACS Chemical Neuroscience  (2020)

Metabolomic Analysis, Fast Isolation of Phenolic Compounds, and Evaluation of Biological Activities of the Bark From Weinmannia trichosperma Cav. (Cunoniaceae)

Barrientos, Ruth; Fernandez-Galleguillos, Carlos; Pastene, Edgar; simirgiotis, mario; Romero-Parra, Javier; Ahmed, Shakeel; Echeverria, Javier

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

Passive Commuting and Higher Sedentary Time Is Associated with Vitamin D Deficiency in Adult and Older Women: Results from Chilean National Health Survey 2016-2017

Solis-Urra, Patricio; Cristi-Montero, Carlos; Romero-Parra, Javier; Pablo Zavala-Crichton, Juan; Jose Saez-Lara, Maria; Plaza-Diaz, Julio

Article ISI SCOPUS
NUTRIENTS  (2019)

Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands

Lorca; Valdes; Chung; Romero-Parra; pessoa-mahana; Mella

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2019)

Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor

Romero-Parra, Javier; Chung, Hery; Tapia, Ricardo A.; Faúndez, Mario; Morales-Verdejo, Cesar; Lorca, Marcos; Lagos, Carlos F.; Di Marzo, Vincenzo; David Pessoa-Mahana, C.; Mella, Jaime

Article ISI SCOPUS
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES  (2017)

Effect of alpha lipoic acid on leukotriene A(4) hydrolase

Torres, Mar?a Jos?; Fierro, Ang?lica; Pessoa-Mahana, C. David; Romero-Parra, Javier; Cabrera, Gonzalo; Fa?ndez, Mario

Article ISI SCOPUS
EUROPEAN JOURNAL OF PHARMACOLOGY  (2017)

NADPH oxidase activity: Spectrophotometric determination of superoxide using pyrogallol red

Cortés-Ríos J.; Torres M.J.; Campos-Bustamante M.P.; Romero-Parra J.; Letelier M.E.; Pessoa-Mahana D.; Chung H.; Faúndez M.

Article ISI SCOPUS
ANALYTICAL BIOCHEMISTRY  (2017)

Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor

Javier Romero-Parra, Jaime Mella-Raipan, Vittoria Palmieri, Marco Allarà, Maria Jose Torres, Hernán Pessoa-Mahana, Patricio Iturriaga, Rossy Escobar, Mario Faúndez, Vincenzo Di Marzo, and C. David Pessoa-Mahana

Article ISI SCOPUS
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  (2016)

A combined CoMFA and CoMSIA 3D-QSAR study of benzamide type antibacterial inhibitors of the FtsZ protein in drug-resistant Staphylococcus aureus

Andrades, J.; Campanini, J.; Vásquez D.; Silvestri, C.; Morales C. ; Romero J.; Mella, J

Article ISI
SAR AND QSAR IN ENVIRONMENTAL RESEARCH  (2015)

Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1

Espinosa-Bustos, C; Lagos, C. F.; Romero-Parra J.; Zarate A.M.; Mella-Raipan J.; Pessoa-Mahana H.; Recabarren-Gajardo G.; Iturriaga-Vasquez, P; Tapia, R.A.; Pessoa-Mahana C.D.

Article ISI SCOPUS
ARCHIV DER PHARMAZIE  (2015)

Benzo[b]thiophene dimerization: A promising experimental finding directed to the C-3 functionalization with aryl alcohols.

Javier Romero-Parra; Hernán Pessoa-Mahana and C. David Pessoa-Mahana.

Article
Blucher Proceedings  (2013)

Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands

Mella-Raipan, JA; Lagos, CF; Recabarren-Gajardo G.; Espinosa-Bustos, C; Romero-Parra J.; Pessoa-Mahana H.; Iturriaga-Vasquez, P; Pessoa-Mahana, CD

Article ISI SCOPUS
MOLECULES  (2013)

Synthesis and Docking of new (2-(2,5-dimethoxyphenyl)-1Hbenzo[ d]imidazol-1-yl)(aryl)methanone derivatives designed as novel cannabinoid CB1 receptor antagonists

Espinosa-Bustos C; Lagos C F; Romero-Parra J; Mella-Raipán J; Pessoa-Mahana H; Recabarren-Gajardo G; Pessoa-Mahana C D

Article
Blucher Proceedings  (2013)

Synthesis and docking of new benzimidazole derivates designed as novel and potent CB1 cannabinoid ligands.

Romero-Parra J; Lagos C F; Espinosa-Bustos C; Mella-Raipán J; Pessoa-Mahana; Recabarren G; Pessoa-Mahana C D

Article
Blucher Proceedings  (2013)

Synthesis, characterization, and electrochemical studies of new 5-and 6-nitro N-acyl-1H-indazoles

Recabarren-Gajardo G.; Gacitua, M; Murueva I.; Romero J.; Espinosa-Bustos, C; Mella-Raipan J.; del Valle, MA; Pessoa-Mahana, CD; Tapia, R

Article ISI SCOPUS
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY  (2011)

BookSection (1)

Genome Editing and Protein Energy Malnutrition

Sergio Moreno-Nombela, Javier Romero-Parra, Francisco Javier Ruiz-Ojeda, Patricio Solis-Urra, Aiman Tariq Baig & Julio Plaza-Diaz

BookSection
 (2023)

Proyecto (3)

Rational Design, Synthesis, Biological Evaluation and Structure Activity Relationship study of novel Benzo[d]imidazoles and Benzo[b]thiophenes as agonists of the cannabinoid type 1 and 2 receptors.

Javier Romero Parra

Proyecto
 (2019)

SÍNTESIS, EVALUACIÓN BIOLÓGICA Y ANÁLISIS DE RELACIÓN ESTRUCTURA-ACTIVIDAD DE DERIVADOS DE ÁCIDO (BENZO[B]TIOFENIL/METOXI/METILÉNAMINO)ALQUIL/BENZOIL-OICO COMO INHIBIDORES DE LA LEUCOTRIENO A4 HIDROLASA HUMANA

FONDECYT (3160402)

Proyecto
2015-2018
Inv. Responsable

SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS STUDIES OF NOVEL CB1 RECEPTOR LIGANDS.

FONDECYT (1100493)

Proyecto
2010-2014
Tesista

25
Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

8
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

6
Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Ruth Barrientos

Docente

Química y Farmacia

Universidad San Sebastián

Puerto Montt, Chile

3
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
MARIO SIMIRGIOTIS

full professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Carlos Fernández

Académico

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

2
María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Javier Echeverría

Profesor Asistente e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

2
Gonzalo Recabarren

Académico

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Daniela Millan

Academico investigador

Centro integrativo de biologia y quimica aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Luis Venegas

Bioquímico/investigador

Anatomía Patológica

Clínica Alemana de Santiago

Santiago, Chile

1
Javiera Cortés

Estudiante de Doctorado

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

1
Carlos Cristi

Docente-Investigador Jerarquizado, Escuela de Educación Física.

Pontificia Universidad Catolica de Valparaiso

Viña del Mar, Chile

1
Maria Larrazabal

Academico

Departamento Ciencias de los Alimentos y Nutricion

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

1
Carolina Cabalín

Investigadora

Pediatría

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Alexandra Galetovic

Profesora Asociada

Biomédico

Universidad de Antofagasta

ANTOFAGASTA, Chile

1
CLAUDIO PARRA

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Rossy Escobar

Profesor Académico Auxiliar

Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

1
Patricio Solis

1
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
Javier Campanini

Docente Investigador

Facultad de Medicina y Ciencia

Universidad San Sebastian

Puerto Montt, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Zavala

1
Luisa Quesada

Docente e investigadora

Nutrición y Dietética

Universidad San Sebastián

Valdivia, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Marco Mellado

Profesor / Investigador

Facultad de Medicina y Ciencias de la Salud

Universidad Central de Chile

Santiago, Chile

1
Manuel Gacitúa

Profesor asistente

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile