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Carlos David Pessoa Mahana

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Desarrollo de Moduladores Sintéticos Benzimidazólicos del Sistema Endocannabinoide. Química Medicinal de Cannabinoides. Síntesis de heterociclos bioactivos. Sistema Serotoninérgico.

Organic Synthesis, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

PROFESOR TITULAR Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

FACULTAD DE QUÍMICA Y DE FARMACIA

SANTIAGO, Chile

1994 - At present

PROFESOR TITULAR Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1994 - At present

A la fecha he doctorado a:
Dr.Jaime Mella
Profesor Adjunto
Laboratorio de Química Medicinal y Orgánica
Instituto de Química y Bioquímica
Facultad de Ciencias
Universidad de Valparaíso

Dr.Javier Romero
Profesor Asistente
Departamento de Química Orgánica y Físicoquímica
Facultad de Ciencias Químicas y Farmacéuticas
Universidad de Chile

Dr. Christian Espinosa
Profesor Asistente
Departamento de Farmacia
Facultad de Química y de Farmacia
Pontificia Universidad Católica de Chile

Por dar su examen final durante junio 2020 está Rossy Escobar, Directora de la Carrera de Química y Farmacia de la Universidad Autónoma, sede Talca.
A la vez he dirigido numerosas tesis de licenciatura desde 1998 a la fecha.
Desde el punto de vista de clases presenciales, he dictado el curso de postgrado de Fármaco-Química para la carrera de Química y Farmacia desde 1994 a la fecha. Además dicto un curso optativo en nuestro programa de Doctorado en Química, llamado "Química Medicinal".

He participado en diversos eventos de difusión que incluyen: congreso nacional de estudiantes de Química y farmacia, Workshop de Química, charlas.


New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists Faundez-Parraguez, Manuel; Alarcón-Miranda, Carlos; Cho, Young Hwa; Pessoa-Mahana, Hernán; Gallardo-Garrido, Carlos; Chung, Hery; Faúndez, Mario A.; Pessoa-Mahana, David Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism Gallardo-Garrido, Carlos; Cho, Young Hwa; Cortés-Rios Javiera; Vasquez, D; Pessoa-Mahana, C. David; Araya-Maturana, Ramiro; Pessoa-Mahana, Hernán; Faundez, Mario Article SCOPUS Toxicology and Applied Pharmacology (2020)
Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands Cerda-Cavieres, Christopher; Quiroz, Gabriel; Iturriaga-Vasquez, Patricio; Rodriguez-Lavado, Julio; Alarcon-Esposito, Jazmin; Saitz, Claudio; Pessoa-Mahana, Carlos D.; Chung, Hery; Araya-Maturana, Ramiro; Mella-Raipan, Jaime; Cabezas, David; Ojeda-Gomez, Claudia; Reyes-Parada, Miguel; Pessoa-Mahana, Hernan Article ISI MOLECULES (2020)
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease Rodriguez-Lavado, Julio; Gallardo-Garrido, Carlos; Mallea, Michael; Bustos, Victor; Osorio, Rodrigo; Hodar-Salazar, Martin; Chung, Hery; Araya-Maturana, Ramiro; Lorca, Marcos; David Pessoa-Mahana, C.; Mella-Raipan, Jaime; Saitz, Claudio; Jaque, Pablo; Reyes-Parada, Miguel; Iturriaga-Vasquez, Patricio; Pessoa-Mahana, Hernan Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer’s disease Rodríguez-Lavado, Julio; Gallardo-Garrido, Carlos; Mallea, Michael; Bustos,Victor; Osorio, Rodrigo; Hödar-Salazar, Martín; Chung, Hery; Araya-Maturana, Ramiro; Lorca,Marcos; Pessoa-Mahana, C. David; Mella-Raipán, Jaime; Saitz,Claudio; Jaque, Pablo; Reyes-Parada, Miguel; Iturriaga-Vásquez, Patricio; Pessoa-Mahana, Hernán * Article ISI, SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study Chung H.; Fierro A.; David Pessoa-Mahana C. Article ISI SCOPUS PLOS ONE (2019)
Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands Lorca; Valdes; Chung; Romero-Parra; pessoa-mahana; Mella Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core Mendez-Rojas, C; Quiroz, G; Faundez, M; Gallardo-Garrido, C; Pessoa-Mahana, CD; Chung, H; Gallardo-Toledo, E; Saitz-Barria, C; Araya-Maturana, R; Kogan, MJ; Zuniga-Lopez, MC; Iturriaga-Vasquez, P; Valenzuela-Gutierrez, C; Pessoa-Mahana, H Article ISI SCOPUS ARCHIV DER PHARMAZIE (2018)
2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human beta(3)-Adrenergic Activity Apablaza, Gastón; Montoya, Luisa; Morales-Verdejo, Cesar; Mellado, Marco; Cuellar, Mauricio; Lagos, Carlos; Soto-Delgado, Jorge; Chung, Hery; Pessoa-Mahana, Carlos; Mella, Jaime Article ISI SCOPUS MOLECULES (2017)
Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor Romero-Parra, Javier; Chung, Hery; Tapia, Ricardo A.; Faúndez, Mario; Morales-Verdejo, Cesar; Lorca, Marcos; Lagos, Carlos F.; Di Marzo, Vincenzo; David Pessoa-Mahana, C.; Mella, Jaime Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Effect of alpha lipoic acid on leukotriene A(4) hydrolase Torres, Mar?a Jos?; Fierro, Ang?lica; Pessoa-Mahana, C. David; Romero-Parra, Javier; Cabrera, Gonzalo; Fa?ndez, Mario Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
NADPH oxidase activity: Spectrophotometric determination of superoxide using pyrogallol red Cortés-Ríos J.; Torres M.J.; Campos-Bustamante M.P.; Romero-Parra J.; Letelier M.E.; Pessoa-Mahana D.; Chung H.; Faúndez M. Article ISI SCOPUS ANALYTICAL BIOCHEMISTRY (2017)
Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT Pessoa-Mahana, Hernán; Silva-Matus, Paul; Pessoa-Mahana, C. David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata-Torres, Gerald; Saitz-Barría, Claudio; Araya-Maturana, Ramiro; Reyes-Parada, Miguel Article ISI SCOPUS ARCHIV DER PHARMAZIE (2017)
Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation Vera, Gonzalo; Lagos, Carlos F; Almendras, Sebastián; Hebel, Dan; Flores, Francisco; Valle-Corvalán, Gissella; Pessoa-Mahana, C. David; Mella-Raipán, Jaime; Montecinos, Rodrigo; Recabarren-Gajardo, Gonzalo Article ISI SCOPUS MOLECULES (2016)
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor Javier Romero-Parra, Jaime Mella-Raipan, Vittoria Palmieri, Marco Allarà, Maria Jose Torres, Hernán Pessoa-Mahana, Patricio Iturriaga, Rossy Escobar, Mario Faúndez, Vincenzo Di Marzo, and C. David Pessoa-Mahana Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1 Espinosa-Bustos, C; Lagos, C. F.; Romero-Parra J.; Zarate A.M.; Mella-Raipan J.; Pessoa-Mahana H.; Recabarren-Gajardo G.; Iturriaga-Vasquez, P; Tapia, R.A.; Pessoa-Mahana C.D. Article ISI SCOPUS ARCHIV DER PHARMAZIE (2015)
3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors Mella-Raipán, Jaime; Hernández-Pino, Santiago; Morales-Verdejo, Cesar; Pessoa-Mahana, David Article Molecules (2014)
3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors. Jaime Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo and David Pessoa-Mahana Article MOLECULES (2014)
3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors. Mella-Raipán, Jaime; Hernández-Pino, Santiago; Morales-Verdejo, César; Pessoa-Mahana, David Article Molecules (Basel, Switzerland) (2014)
Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter Ojeda-Gómez, Claudia; Pessoa-Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa-Mahana, Carlos David; Recabarren-Gajardo, Gonzalo; Méndez-Rojas, Claudio Article Archiv der Pharmazie (2014)
Synthesis and biological screening of novel indolalkyl arenes targeting the serotonine transporter. Ojeda-Gómez, Claudia; Pessoa-Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa-Mahana, Carlos David; Recabarren-Gajardo, Gonzalo; Méndez-Rojas, Claudio Article Archiv der Pharmazie (2014)
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands Mella-Raipan, JA; Lagos CF, Recabarren-Gajardo G.; Espinosa-Bustos, C; Romero-Parra J., Pessoa-Mahana H.; Iturriaga-Vasquez, P; Pessoa-Mahana, CD Article Molecules (2013)
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor Pessoa-Mahana, H; Gonzalez-Lira, C; Fierro, A; Zapata-Torres, G; Pessoa-Mahana, CD; Ortiz-Severin, J; Iturriaga-Vasquez, P; Reyes-Parada, M; Silva-Matus, P; Saitz-Barria, C; Araya-Maturana, R Article BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor. Pessoa-Mahana, Hernán; González-Lira, Christian; Fierro, Angélica; Zapata-Torres, Gerald; Pessoa-Mahana, C David; Ortiz-Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes-Parada, Miguel; Silva-Matus, Paul; Saitz-Barría, Claudio; Araya-Maturana, Ramiro Article Bioorganic & medicinal chemistry (2013)
Biological activities and correlations tendency of electrochemical properties of some indolizino[1,2-b]quinoline derivatives. Cañete A, Armijo F , Del Valle M, Tapia R, Theoduloz C, Pessoa C, Cantuarias L , Recabarren G Article Journal Of The Chilean Chemical Society (2012)
Synthesis, 5-Hydroxytriptamine 1A Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-piperazinyl)-propyl]-1H- Indole Derivatives Hernan Pessoa-Mahana,* Catalina Ugarte Nuñez, Ramiro Araya-Maturana, Claudio Saitz Barria, Gerald Zapata-Torres ; C. David Pessoa-Mahana; Patricio Iturriaga Vasquez; Jaime Mella Raipan; Miguel Reyes Parada and Cristian Celis Barros. Article CHEMICAL & PHARMACEUTICAL BULLETIN (2012)
Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors Pessoa-Mahana, H; Recabarren-Gajardo, G; Temer, JF; Zapata-Torres, G; Pessoa-Mahana, CD; Barria, CS; Araya-Maturana, R Article MOLECULES (2012)
Evaluation of the Membrane Permeability (PAMPA and Skin) of Benzimidazoles with Potential Cannabinoid Activity and their Relation with the Biopharmaceutics Classification System (BCS) Alvarez-Figueroa, MJ; Pessoa-Mahana, CD; Palavecino-Gonzalez, ME; Mella-Raipan J.; Espinosa-Bustos, C; Lagos-Munoz, ME Article AAPS PHARMSCITECH (2011)
Interaction of 5-aminosalicylic acid with nitrous acid: formation of the diazonium derivative and nitric oxide release Lopez C, Lissi E , Hoffmann P , Mella J , Pessoa C , Speisky H , Moller M , Ferrer G , Denicola A Article CANADIAN JOURNAL OF CHEMISTRY (2011)
SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES. NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY Pessoa-Mahana, H; Cuevas, MI; PESSOA-MAHANA, D; Araya-Maturana, R; Fajardo, IA; Barria, CS Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2011)
Synthesis, characterization, and electrochemical studies of new 5-and 6-nitro N-acyl-1H-indazoles Recabarren G, Gacitua M , Murueva I , Romero J, Espinosa C, Mella J , Del Valle M, Pessoa C, Tapia R Article JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2011)
Antioxidant Capacity of Pure Compounds and Complex Mixtures Evaluated by the ORAC-Pyrogallol Red Assay in the Presence of Triton X-100 Micelles Romero, M; Rojano B.; Mella-Raipan J.; Pessoa-Mahana, CD; Lissi, E; Lopez-Alarcon, C Article MOLECULES (2010)
Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues. David Pessoa-Mahana, Andrés Núñez, Christian Espinosa, Jaime Mella-Raipán and Hernán Pessoa-Mahana Article Journal of the Brazilian Chemical Society (2010)
Microwave-assisted synthesis and regioisomeric structural elucidation of novel benzimidazo[1,2d][1,4]benzodiazepinone derivatives PESSOA-MAHANA, D; Espinosa-Bustos, C; Mella-Raipan J.; Canales-Pacheco J.; Pessoa-Mahana, H Article ARKIVOC (2009)
SCAVENGING ACTIVITY OF DICLOFENAC. INTERACTION WITH ABTS RADICAL CATION AND PEROXYL RADICALS ROJO, C; Alvarez-Figueroa, MJ; Soto, M; Canete, A; PESSOA-MAHANA, D; Lopez-Alarcon, C Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2009)
Solvent-free microwave-promoted Michael addition of aza-nucleophiles to benzo[b]thiophen-2-yl-2-propenone Hernán Pessoa-Mahana, Marcos González C., Marcelo González S., C. David Pessoa-Mahana, Ramiro Araya-Maturana, Nadia Ron H. and Claudio Saitz B Article ARKIVOC (2009)
Synthesis of conformationally restricted n-{4-[4-(4,7-dimethoxy-benzo[b]thiophene–2–carbonyl)-1-piperazinyl]phenyl}-arylcarboxamides. Potential ligands with 5-ht1a binding affinity. Hernán Pessoa-Mahana, Christian González L., Ramiro Araya- Maturana, Claudio Saitz B. Article Journal of the Chilean Chemical Society (2009)
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion Galarce, GD; Foncea, RE; Edwards, AM; Pessoa-Mahana, H; Pessoa-Mahana, CD; Ebensperger, RA Article Biol. Res. (2008)
Computational modeling study of functional microdomains in cannabinoid receptor type 1 Gonzalez, A; Duran, LS; Araya-Secchi R.; Garate, JA; Pessoa-Mahana, CD; Lagos, CF; Perez-Acle T. Article BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Docking and QSAR studies for the bisphenylbenzimidazole family of non-nucleoside inhibitors of HIV-1 reverse transcriptase Carlos F. Lagos, Julio Caballero, Fernando D. González-Nilo, C. David Pessoa-Mahana and Tomas Perez-Acle. Article Chemical Biology and Drug Design (2008)
Influence of Lipophilia and of the Vehicle Used in the Transdermal Absorption of Novel Benzimidazole Compounds with Possible Anti-HIV Activity. Figueroa, M. J.; Pessoa-Mahana, C. D.; Gonzalez-Bustamante, D. A. Article Pharmaceutical Development and Technology (2008)
Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues David Pessoa-Mahana, Andrés Núñez, Christian Espinosa, Jaime Mella-Raipán and Hernán Pessoa-Mahana Article Journal of the Brazilian Chemical Society (2008)
1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 reverse transcriptase inhibitors Vasquez, D; Lagos, CF; Mella-Raipan J.; González, L; Ebensperger R.; Alvarez-Figueroa, MJ; Saez, E; Pessoa-Mahana, H; Araya-Secchi R.; Gonzalez-Wong A.; Perez-Acle T.; Pessoa-Mahana, CD Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2007)
Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs Pessoa-Mahana, H; Acevedo, RR; Saitz, BC; Araya-Maturana, R; Pessoa-Mahana, CD Article SYNTHETIC COMMUNICATIONS (2007)
Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity Pessoa-Mahana, H; Acevedo, R.; Araya-Maturana, R; Saitz, C; Pessoa-Mahana, CD Article SYNTHETIC COMMUNICATIONS (2007)
Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones Valderrama, JA; Gonzalez, MF; PESSOA-MAHANA, D; Tapia, RA; Fillion H.; Pautet F.; Rodriguez, JA; Theoduloz, C; Schmeda-Hirschmann, G Article BIOORGANIC & MEDICINAL CHEMISTRY (2006)
A facile approach for new dibenzo [b,f][1,5] diazocinones Pessoa-Mahana, H; Aranguiz, KGM; Araya-Maturana, R; Pessoa-Mahana, CD Article SYNTHETIC COMMUNICATIONS (2005)
Role of CB1 receptorsand Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and d 9-THC Katherine A. Araya, C. David Pessoa-Mahana and Luis G. González Article European Journal of Pharmacology (2005)
Solvent-free synthesis of 6-arylbenzimidazo[1,2-c]quinazolines under microwave irradiation Pessoa-Mahana, H; Pessoa-Mahana, CD; Salazar, R; Valderrama, JA; Saez, E; Araya-Maturana, R Article SYNTHESIS-STUTTGART (2004)
Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action Pessoa-Mahana, H; Gajardo, GR; Araya-Maturana, R; Carcamo, JK; Pessoa-Mahana, CD Article SYNTHETIC COMMUNICATIONS (2004)
A Synthethic Overview of New Molecules with 5-HT1a Binding Affinities Hernán Pessoa-Mahana; Ramiro Araya-Maturana, Claudio Saitz B and C. David Pessoa- Mahana. “A Synthethic Overview of New Molecules with 5-HT1a Binding Affinities Article Minireviews in Medicinal Chemistry (2003)
Synthesis and Antiprootozoal Activity of Naphtofuranquinones and Naphtothiophenequinones containing a Fused Thiazole Ring Ricardo A.Tapia, Luz Alegria, Carlos D.Pessoa, Cristian Salas, Manuel J.Cortés, Jaime.A.Valderrama, Marie-Elisabeth Sarciron, Félix Pautet, Nadia Walchshofer, and Houda Fillion Article Bioorganic & Medicinal Chemistry (2003)
Studies on quinones. Part 36. Synthesis and trypanocidal activity of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones Pessoa-Mahana, CD; Valderrama, JA; Olmos, MG; Espinoza, OA; Pessoa-Mahana, H; de Arias, AR; Nakayama H.; Torres, S; Miret J. Article HETEROCYCLIC COMMUNICATIONS (2002)
Studies on Quinones. Part.35. “Access to Antiprotozoal Active Euryfurylquinones and Hydroquinones Jaime A. Valderrama, Julio Benites, Manuel Cortés, David Pessoa-Mahana, Eric Prina and Alain Fournet Article Tetrahedron (2002)
Studies on quinones. Part 34: The reaction of styrene with activated 1,4-benzoquinones: access to potential antiprotozoal pyranobenzoquinones Valderrama, JA; PESSOA-MAHANA, D; Tapia, RA; de Arias, AR; Nakayama H.; Torres, S; Miret J.; Ferreira, ME Article TETRAHEDRON (2001)
Regiospecific Michael Reaction of (+)-Euryfuran with activated 1,4- Benzoquinones Jaime A. Valderrama, Manuel Cortés, Marcelo Preite, David Pessoa-Mahana and Julio Benitez Article Tetrahedron Letters (2000)
Estudios sobre quinonas. Parte 29. Reacciones inusuales de quinonas con enaminas. J.A. Valderrama, M.C. Paredes y C.D. Pessoa-Mahana Article Anales de Química de la Sociedad Española de Química (1995)
Reaction of Spiroanthracenones with DDQ: a One-pot Synthesis of Benz[a]anthraquinones Jaime A. Valderrama, Carlos Pessoa-Mahana and Ricardo Tapia Article Journal of Chemical Society. Perkin Transaction. I (1994)
Comparative determination of photodegradation kinetics of quinolones M.E. Hidalgo, C. Pessoa, E. Fernández and A.M. Cárdenas Article Journal of Photochemistry and Photobiology A: Chemistry (1993)


Synthesis of benzimidazole-base derivatives and molecular simulation studies to explore allosteric modulation of cannabinoid receptor type 1 Carlos David Pessoa Mahana Proyecto (2023)
Study of the benzimidazole ring as a functional framework associated to orthosteric, indirect and potential allosteric cannabinoid activity. Carlos David Pessoa Mahana Proyecto (2020)
SYNTHESIS OF NOVEL INDOLE DERIVATIVES TARGETING: SEROTONERGIC (SERT INHIBITION /5-HT4 AGONIST ACTIVITY), CHOLINERGIC (ACETYLCHOLINESTERASE INHIBITION) AND BETA-AMYLOID DEPOSITION, IN THE SEARCH OF MULTIFUNCTIONAL AGENTS IN ALZHEIMER´S DISE Hernán Pessoa Mahana; Carlos David Pessoa Mahana Proyecto (2017)
Synthesis, binding mode prediction, biological evaluation and SAR analysis of benzoimidazole-based modulators of the endocannabinoid system Carlos David Pessoa Mahana Proyecto (2015)
A Synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1H-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at sert, D2, and Mao-A Receptors Hernán Pessoa Mahana; Carlos David Pessoa Mahana Proyecto (2013)
Synthesis and structure-activity relationships studies of novel CB1 receptor ligands Carlos David Pessoa Mahana Proyecto (2010)
A rational synthetic approach to 3-indolealkyl(aryl)piperazine derivatives as new hetero and homobivalent ligands with potential serotonergic activity Hernán Pessoa Mahana; Carlos David Pessoa Mahana Proyecto (2009)
Búsqueda de nuevos inhibidores no nucleosídicos de la enzima transcriptasa reversa de HIV-1: Síntesis y evaluación biológica de nuevos derivados benzoimidazólicos Carlos David Pessoa Mahana Proyecto (2005)
Estudio de síntesis de derivados 2-benzotienil- y ((4-arilpiperazinil))-azoalquil benzo[b]tiofenos y de analogos triciclícos semirigidizados de benzotieno (2,3-d) azepinas. Una propuesta sintética orientada a la búsqueda de de ligandos serotoninérgicos de mecanismo dual Hernán Pessoa Mahana; Carlos David Pessoa Mahana Proyecto (2005)

Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Ramiro Araya Maturana

Profesor Titular

Universidad de Talca

SantiaTalcago, Chile

Carlos Gallardo

Director Médico

Laboratorio Ximena Polanco

Santiago, Chile

María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Gabriel Quiroz

Maria Zúñiga

Proffesor

Química Inorgánica y Analitica

Universidad de Chile

Santiago, Chile

Rossy Escobar

Profesor Académico Auxiliar

Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

Marco Mellado

Profesor / Investigador

Facultad de Medicina y Ciencias de la Salud

Universidad Central de Chile

Santiago, Chile

Eduardo Gallardo

Tesista de doctorado

Química farmacológica y toxicológica

Universidad de Chile

Santiago, Chile

Paul Silva

Profesor

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Claudio Méndez

Investigador en Estudios Clínicos

Farmacia

Clínica Santa María

Santiago, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

CLAUDIO SAITZ

Associate Prof.

Organic and Phisycal Chemistry

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

Mario Faúndez

Profesor Asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Cesar Morales

Associate Professor

Universidad Bernardo O'Higgins

Santiago, Chile

Pablo Jaque

Profesor Asociado

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Christopher Cerda

Profesor

Universidad Bernardo O'Higgins

Santiago, Chile

Javiera Cortés

Estudiante de Doctorado

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

Carlos David Pessoa Mahana

Líneas de Investigación

Educación

Organic Synthesis, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

Experiencia Académica

PROFESOR TITULAR Full Time

Experiencia Profesional

PROFESOR TITULAR Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (59)

Proyecto (9)