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Gonzalo Ignacio Cancino Lobos

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Our main research interest is to understand how the brain cortex develops. Using animal models and iPSCs, we are trying to understand how autism-associated genes and environmental factors disrupt neurogenesis, gliogenesis and neuronal migration

BS in Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
Master in Biological Sciences mention Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
PhD in Biological Sciences mention Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009

Postdoctoral Research Fellow Full Time

THE HOSPITAL FOR SICK CHILDREN

Toronto, Canada

2009 - 2016
Postdoctoral research fellow Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biologicas

Santiago, Chile

2016 - 2017
Assistant Professor Full Time

UNIVERSIDAD MAYOR

Facultad de Ciencias

Santiago, Chile

2017 - 2022
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Biological Sciences

Santiago, Chile

2022 - At present

Teaching Assistant Part Time

Pontificia Universidad Catolica de Chile

Chile

2005 - 2009
Research Assistant Full Time

Pontificia Universidad Catolica de Chile

Chile

2004 - 2005
PhD student Full Time

Pontificia Universidad Catolica de Chile

Chile

2005 - 2009
Research Associate Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2016 - 2017

IBRO Return Home Fellowship

IBRO-International Brain Research Organization

Estados Unidos, 2016

The objective of the IBRO Return Home Program is to coordinate efforts with other research organizations to improve the opportunities for productive neuroscience research within regions of the world and to provide more support to those researchers trained overseas who wish to return to their home countries.
Postdoctoral research fellowship

Heart and Stroke Foundation of Canada

Canada, 2011

The Personnel Award program of the Heart and Stroke Foundation of Canada (HSFC) provides salary support for Canada's best young researchers. These individuals are pursuing research at universities, hospitals and institutes across Canada and abroad.
SfN Chapters Graduate Student Travel Award

Society for Neuroscience

Estados Unidos, 2007

Chapter Travel Awards enable outstanding graduate students and postdoctoral trainees nominated by their local SfN chapter to attend the SfN annual meeting. The awards provide complimentary registration and a stipend to help defray travel expenses.
Becas Chile Postdoctorado en el extranjero

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2012

La Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) llama a concurso con el fin de otorgar becas a chilenos/as y extranjeros/as con permanencia definitiva en Chile, para iniciar o continuar la realización de programas postdoctorales en instituciones de excelencia en el exterior. El presente concurso busca fomentar la productividad y el futuro posicionamiento científico de investigadores/as con el grado académico de Doctor, en el ámbito académico y productivo, a través de su incorporación en prestigiosos y consolidados grupos de investigación en el extranjero, de tal forma que, a su regreso al país contribuyan a la consolidación de las universidades y centros científicos nacionales
Excellence Award

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2009

Premio otorgado por a Vicerrectoria de investigacion y doctorado de la Pontificia Universidad Catolica de Chile a la mejor tesis de doctorado


Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice Cortes, Bastian I.; Meza, Rodrigo C.; Ancaten-Gonzalez, Carlos; Ardiles, Nicolas M.; Aranguiz, Maria-Ignacia; Tomita, Hideaki; Kaplan, David R.; Cornejo, Francisca; Nunez-Parra, Alexia; Moya, Pablo R.; Chavez, Andres E.; Cancino, Gonzalo I. Article ISI BIOLOGICAL RESEARCH (2024)
Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex Cornejo, Francisca; Franchini, Nayhara; Cortes, Bastian I.; Elgueta, Daniela; Cancino, Gonzalo I. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024)
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice Chandia-Cristi, America; Gutierrez, Daniela A.; Dulcey, Andres E.; Lara, Marcelo; Vargas, Lina; Lin, Yi-Han; Jimenez-Muñoz, Pablo; Larenas, Gabriela; Xu, Xin; Wang, Amy; Owens, Ashley; Dextras, Christopher; Chen, YuChi; Pinto, Claudio; Marín, Tamara; Almarza-Salazar, Hugo; Acevedo, Keryma; Cancino, Gonzalo I.; Hu, Xin; Rojas, Patricio; Ferrer, Marc; Southhall, Noel; Henderson, Mark J.; Zanlungo, Silvana; Marugan, Juan; Alvarez, Alejandra R. Article CELL REPORTS (2024)
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration Martinez, Alexis; Lamaizon, Cristian M.; Valls, Cristian; Llambi, Fabien; Leal, Nancy; Fitzgerald, Patrick; Guy, Cliff; Kaminski, Marcin M.; Inestrosa, Nibaldo C.; Van Zundert, Brigitte; Cancino, Gonzalo I.; Dulcey, Andres E.; Zanlungo, Silvana; Marugan, Juan J.; Hetz, Claudio; Green, Douglas R.; Alvarez, Alejandra R. Article ISI ANTIOXIDANTS (2023)
c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease Leon, R; Gutierrez, D; Pinto, C; Morales, C; De la Fuente, C; Riquelme, C; Cortes, B; Gonzalez-Martin, A; Chamorro, D; Espinosa, N; Fuentealba, P; Cancino, GI; Zanlungo, S; Dulcey, A; Marugan, J.; Alvarez, A Article FRONTIERS IN AGING NEUROSCIENCE (2023)
Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring Elgueta, Daniela; Murgas, Paola; Riquelme, Erick; Yang, Guang; Cancino, Gonzalo I. Article ISI FRONTIERS IN IMMUNOLOGY (2022)
The c-Abl/p73 pathway induces neurodegeneration in a Parkinson?s disease model Marin, Tamara; Valls, Cristian; Jerez, Carolina; Huerta, Tomas; Elgueta, Daniela; Vidal, Rene L.; Alvarez, Alejandra R.; Cancino, Gonzalo I. Article ISI IBRO NEUROSCIENCE REPORTS (2022)
LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain Cornejo, Francisca; Cortes, Bastian I.; Findlay, Greg M.; Cancino, Gonzalo I. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis Tomita, Hideaki; Cornejo, Francisca; Aranda-Pino, Begona; Woodard, Cameron L.; Rioseco, Constanza C.; Neel, Benjamin G.; Alvarez, Alejandra R.; Kaplan, David R.; Miller, Freda D.; Cancino, Gonzalo I Article ISI SCOPUS CELL REPORTS (2020)
MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content Balboa, Elisa; Castro, Juan; Pinochet, Mar?a-Jos?; Cancino, Gonzalo I.; Mat?as, Nuria; Jos? S?ez, Pablo; Mart?nez, Alexis; ?lvarez, Alejandra R.; Garcia-Ruiz, Carmen; Fernandez-Checa, Jos? C.; Zanlungo, Silvana Article ISI SCOPUS REDOX BIOLOGY (2017)
A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring Yang, Guang; Cancino, Gonzalo I; Zahr, Siraj K.; Guskjolen, Axel; Voronova, Anastassia; Gallagher, Denis; Frankland, Paul W.; Kaplan, David R.; Miller, Freda D. Article ISI CELL REPORTS (2016)
Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks Yuzwa, Scott A.; Yang, Guang; Borrett, Michael J.; Clarke, Geoff; Cancino, Gonzalo I; Zahr, Siraj K.; Zandstra, Peter W.; Kaplan, David R.; Miller, Freda D. Article ISI NEURON (2016)
The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner Gouveia, Ayden; Hsu, Karolynn; Niibori, Yosuke; Seegobin, Matthew; Cancino, Gonzalo I; He, Ling; Wondisford, Fredric E.; Bennett, Steffany; Lagace, Diane; Frankland, Paul W.; Wang, Jing Article ISI STEM CELL REPORTS (2016)
Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice Acuña M.; Gonzalez-Hodar, L; Amigo, L; Castro J.; Morales, MG; Cancino, GI; Groen, AK; Young J.; Miquel, JF; Zanlungo S. Article ISI SCOPUS JOURNAL OF HEPATOLOGY (2016)
Ankrd11 Is a Chromatin Regulator Involved in Autism that Is Essential for Neural Development Gallagher, Denis; Voronova, Anastassia; Zander, Mark A.; Cancino, Gonzalo I; Bramall, Alexa; Krause, Matthew P.; Abad, Clemer; Tekin, Mustafa; Neilsen, Paul M.; Callen, David F.; Scherer, Stephen W.; Keller, Gordon M.; Kaplan, David R.; Walz, Katherina; Miller, Freda D. Article ISI DEVELOPMENTAL CELL (2015)
Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response Gómez, Andrea V.; Córdova, Gonzalo; Munita, Roberto; Parada, Guillermo E.; Barrios, Álvaro P.; Cancino, Gonzalo I; Alvarez, Alejandra R.; Andrés, María E.; Sherman, Michael Article ISI SCOPUS PLOS ONE (2015)
Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system Cancino, Gonzalo I; Fatt, Michael P.; Miller, Freda D.; Kaplan, David R. Article ISI CELL CYCLE (2015)
Neurog1 and Neurog2 Control Two Waves of Neuronal Differentiation in the Piriform Cortex Dixit, R; Wilkinson, G.; Cancino, GI; Shaker, T; Adnani, L; Li S.; Dennis, D; Kurrasch, D; Chan, JA; Olson, EC; Kaplan, DR; Zimmer, C; Schuurmans, C Article ISI JOURNAL OF NEUROSCIENCE (2014)
p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells Fatt, MP; Cancino, GI; Miller, FD; Kaplan, DR Article ISI CELL DEATH AND DIFFERENTIATION (2014)
The Snail Transcription Factor Regulates the Numbers of Neural Precursor Cells and Newborn Neurons throughout Mammalian Life Zander, Mark A.; Cancino, Gonzalo I; Gridley, Thomas; Kaplan, David R.; Miller, Freda D. Article ISI PLOS ONE (2014)
p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior Cancino, GI; Yiu, AP; Fatt, MP; Dugani, CB; Flores, ER; Frankland, PW; Josselyn, SA; Miller, FD; Kaplan, DR Article ISI JOURNAL OF NEUROSCIENCE (2013)
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease Cancino, GI; Miller, FD; Kaplan, DR Article ISI NEUROBIOLOGY OF AGING (2013)
Transient Maternal IL-6 Mediates Long-Lasting Changes in Neural Stem Cell Pools by Deregulating an Endogenous Self-Renewal Pathway Gallagher, D; Norman, AA; Woodard, CL; Yang, G; Gauthier-Fisher, A; Fujitani, M; Vessey, JP; Cancino, GI; Sachewsky, N; Woltjen, K; Fatt, MP; Morshead, CM; Kaplan, DR; Miller, FD Article ISI CELL STEM CELL (2013)
Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation Wang J.; Gallagher, D; DeVito, LM; Cancino, GI; Tsui, D; He, L.; Keller, GM; Frankland, PW; Kaplan, DR; Miller, FD Article ISI CELL STEM CELL (2012)
c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice Cancino, GI; de Arce KP; Castro, PU; Toledo EM; von Bernhardi R.; Alvarez, AR Article ISI SCOPUS Neurobiology of Aging (2011)
Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease Klein, A.; Mosqueira, M; Martinez, G; Robledo, F; Gonzalez, M.; Caballero, B; Cancino, GI; Alvarez, AR; hetz C.; Zanlungo S. Article ISI SCOPUS NEURODEGENERATIVE DISEASES (2011)
TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors Fujitani, M; Cancino, GI; Dugani, CB; Weaver, ICG; Gauthier-Fisher, A; Paquin, A; Mak, TW; Wojtowicz, MJ; Miller, FD; Kaplan, DR Article ISI CURRENT BIOLOGY (2010)
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease Alvarez, AR; Klein, A.; Castro J.; Cancino, GI; Amigo, J; Mosqueira, M; Vargas LM; Yevenes, LF; Bronfman, FC; Zanlungo S. Article ISI SCOPUS FASEB JOURNAL (2008)
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits Cancino, GI; Toledo EM; Leal, NR; Hernández DE; Yevenes, LF; Inestrosa, NC; Alvarez, AR Article ISI SCOPUS BRAIN (2008)


Alzheimer's beta-amyloid deposits induce the c-Abl/p73 signaling in AD models. Cancino, GI; Alvarez, AR ConferencePaper ISI NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009 (2009)
Amyloid-beta-peptide activates the neuronal c-Abl tyrosine kinase/p73 signaling pathway Alvarez A.; Leal, N; Cancino G.; Castro P. ; Kosik, KS ConferencePaper ISI New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005 (2005)


ABL1 plays a key role in the synergy between beta-amyloid and tau signaling promoting the impairment of synaptic and neuronal functions in Alzheimer's disease Alvarez, Alejandra Beatriz; Cancino, Gonzalo I.; Zanlungo, Silvana Proyecto (2024)
Red Internacional para el Estudio de la Disfunción Lisosomal en Enfermedades Neurodegenerativas Zanlungo, Silvana; Cancino, Gonzalo I.; Alvarez, Alejandra Beatriz; Krause, Bernardo J. Proyecto (2023)
Red internacional para estudiar enfermedades del sistema nervioso utilizando células madre, organoides y asembloides cerebrales Cancino, GI; Cornejo, FA Proyecto (2022)
The antagonistic functions of PTPRD and ABL1 during the development of the embryonic cortex and its implications in neurodevelopmental disorders Cancino, Gonzalo I.; Cornejo, Francisca; Alvarez, Alejandra Beatriz; Manque, Patricio Proyecto (2021)
ABL kinases at the crossroads of healthy synaptic remodeling and synaptic dysfunction in in vitro excitotoxiciy and in vivo temporal lobe Epilepsy. Alvarez Rojas, Alejandra Beatriz; Cancino, Gonzalo I Proyecto (2020)
Maternal Multiple Sclerosis effect on offspring neural development in the murine model of experimental autoimmune encephalomyelitis Elgueta, Daniela; Cancino, Gonzalo I Proyecto (2020)
El gen asociado al autismo PTPRD regula la expresión de genes asociados a proliferación y diferenciación de precursores neurales Universidad Mayor (FDP I-2019068) Proyecto 2019-2019 Inv. Responsable
La neurogénesis adulta hipocampal se encuentra disminuida en ratones nulos para el gen receptor tirosina fosfatasa delta PTPRD asociado al trastorno del espectro autista Universidad Mayor (FDP I-2019069) Proyecto 2019-2019 Inv. Responsable
Modelling human brain disorders using iPSCs and brain organoids PCI (180113) Proyecto 2019-2019 Inv. Responsable
The role of the ASD-associated gene PTPRD in gliogenesis during cortical brain development FONDECYT (3190517) Proyecto 2019-2022 Inv. Patrocinante
The role of the ASD-associated gene PTPRD in gliogenesis during cortical brain development Cornejo, Francisca; Cancino, Gonzalo Proyecto (2019)
Comprendiendo las funciones de la tirosina fosfatasa PTPRD en la neurogénesis adulta, sinapsis, y sus implicancias en la etiología del autismo Universidad Mayor (N/A) Proyecto 2018-2019 Inv. Patrocinante
Modelling human brain disorders using iPSCs and brain organoids Cancino Lobos, Gonzalo Ignacio; Calegaro, Melissa; Valdivia, Leonardo Proyecto (2018)
The impact of the tyrosine phosphatase Ptprd in neural stem cell biology and its contribution to autism spectrum disorder etiology FONDECYT (1161374) Proyecto 2016-2020 Inv. Responsable
The impact of the tyrosine phosphatase Ptprd on neural stem cell biology and its contribution to autism spectrum disorder etiology Cancino Lobos, Gonzalo Ignacio; Alvarez, Alejandra Proyecto (2016)
AUTISM-ASSOCIATED GENETIC AND ENVIRONMENTAL FACTORS IMPACTING BRAIN DEVELOPMENT IBRO (n/a) Proyecto 2015-2015 Inv. Principal
p63-mediated adult neural stem cell maintenance in ischemic repair Heart and Stroke Foundation of Canada (N/A) Proyecto 2011-2013 Inv. Principal