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Luis Andrés Cea Pisani

Profesor programa teaching

Universidad Autónoma de Chile

Santiago, Chile

músculo estriado; hemicanales formados por conexinas; miopatías; distrofias musculares

Doctor en Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2015 - At present
Docente Part Time

UNIVERSIDAD AUTONOMA DE CHILE

Ciencias de la Salud

Chile

2018 - At present

Docente Part Time

Universidad Autónoma de Chile

Santiago, Chile

2018 - At present
Profesor Asistente Full Time

Universidad de Chile

Santiago, Chile

2015 - At present


Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation Cisterna, Bruno A.; Vargas, Aníbal A.; Puebla, Carlos; Fernández, Paola; Escamilla, Rosalba; Lagos, Carlos F; Matus, María F.; Vilos, Cristian; Cea, Luis A.; Barnafi, Esteban; Gaete, Hugo; Escobar, Daniel F.; Cardozo, Christopher P.; Sáez, Juan C. Article SCOPUS NATURE COMMUNICATIONS (2020)
Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation Fernández, Gabriela; Arias-Bravo, Guisselle; Bevilacqua, Jorge A.; Castillo-Ruiz, Mario; Caviedes, Pablo; Sáez, Juan C.; Cea, Luis A. Article Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2020)
Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles Balboa, Elisa; Saavedra, Fujiko; Cea, Luis A.; Ramírez, Valeria; Escamilla, Rosalba; Vargas, Aníbal A.; Regueira, Tomás; Sáez, Juan C. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia Cea, Luis A.; Balboa, Elisa; Vargas, Anibal A.; Puebla, Carlos; Branes, Maria C.; Escamilla, Rosalba; Regueira, Tomas; Saez, Juan C Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
SEPSIS-INDUCED CHANNELOPATHY IN SKELETAL MUSCLES IS ASSOCIATED WITH EXPRESSION OF NON-SELECTIVE CHANNELS Balboa, E; Saavedra-Leiva, F; Cea, LA; Vargas, AA; Ramirez, V; Escamilla, R; Saez, JC; Regueira, T Article SHOCK (2018)
Biophysical Properties of Connexin 39 Hemichannels Expressed in HeLa Cells Anibal A. Vargas; Bruno A. Cisterna; Fujiko Saavedra; Carolina Urrutia; Luis A. Cea; Alex Vielma; Sebastian E. Gutierrez-Maldonado; Alberto J. M. Martin; Claudia Pareja-Barrueto; Yerko Escalona; Oliver Schmachtenberg; Carlos F. Lagos; Tomás Pérez-Acle; Juan C. Sáez Article FRONTIERS IN PHYSIOLOGY (2017)
On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells Vargas, AA.; Cisterna, BA.; Saavedra-Leiva, F.; Urrutia, C.; Cea, LA.; Vielma, AH.; Gutierrez-Maldonado, SE.; Martin, AJ.; Pareja-Barrueto, C.; Escalona, Y.; Schmachtenberg, O.; Lagos, CF.; Perez-Acle, T.; Sáez, JC. Article Frontiers in Physiology (2017)
Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels Balboa E.; Saavedra F.; Cea L.A.; Vargas A.A.; Ramírez V.; Escamilla R.; Sáez J.C.; Regueira T. Article SCOPUS Shock (2017)
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels Cea, Luis A.; Balboa, Elisa; Puebla, Carlos; Vargas, An?bal A.; Cisterna, Bruno A.; Escamilla, Rosalba; Regueira, Tom?s; S?ez, Juan C. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis Cea L.A.; Puebla, C; Cisterna B.A.; Escamilla, R; Vargas A.A.; Frank, M; Martínez-Montero P.; Prior C.; Molano J.; Esteban-Rodríguez I.; Pascual, I.; Gallano, P; Lorenzo G.; Pian H.; Barrio L.C.; Willecke K.; Sáez, J.C. Article ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes Cea, Luis A.; Bevilacqua, Jorge A.; Arriagada, Christian; Cárdenas, Ana María; Bigot, Anne; Mouly, Vincent; Sáez, Juan C.; Caviedes, Pablo Article ISI SCOPUS BMC CELL BIOLOGY (2016)
The absence of dysferlin induces theexpression of functional connexin-based hemichannels in human myotubes. BMC Cell Biology. Cea Luis A, Bevilacqua Jorge A, Arriagada Christian, Cárdenas Ana María, Bigot Anne, Mouly Vincent, Sáez Juan C, Caviedes Pablo Article BMC CELL BIOLOGY (2016)
Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation Riquelme, Manuel A.; Cea, Luis A.; Vega, JosÃ© L.; Puebla, Carlos; Vargas, AnÃbal A.; Shoji, Kenji F.; Subiabre, Mario; SÃ¡ez, Juan C. Article FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)
Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation. Riquelme, Manuel A; Cea, Luis A; Vega, José L; Puebla, Carlos; Vargas, Aníbal A; Shoji, Kenji F; Subiabre, Mario; Sáez, Juan C Article Frontiers in cell and developmental biology (2015)
Extracellular gentamicin reduces the activity of con nexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells Figueroa V.A.; Retamal M.A.; Cea L.A.; Salas J.D.; Vargas A.A.; Verdugo C.A.; Jara O.; Martinez A.D.; Sáez, J.C. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells. Figueroa, Vania A; Retamal, Mauricio A; Cea, Luis A; Salas, José D; Vargas, Aníbal A; Verdugo, Christian A; Jara, Oscar; Martínez, Agustín D; Sáez, Juan C Article Frontiers in cellular neuroscience (2014)
Pannexin 1 channels in skeletal muscles Cea, LA; Riquelme, MA; Vargas AA; Urrutia, C; Sáez JC Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
Pannexin 1 channels in skeletal muscles. Cea LA, Riquelme MA, Vargas AA, Urrutia C, Sáez JC. Article Frontiers in Physiology (2014)
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy Cea, LA; Cisterna, BA; Puebla, C; Frank, M; Figueroa, XF; Cardozo C.; Willecke K.; Latorre R.; Sáez JC Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2013)
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy. Cea, Luis A; Cisterna, Bruno A; Puebla, Carlos; Frank, Marina; Figueroa, Xavier F; Cardozo, Christopher; Willecke, Klaus; Latorre, Ramón; Sáez, Juan C Article Proceedings of the National Academy of Sciences of the United States of America (2013)
The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels Riquelme MA, Cea LA; Vega JL, Boric MP; Monyer H, Bennett MV; Frank M, Willecke K Article Neuropharmacology (2013)
The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels. Riquelme, Manuel A; Cea, Luis A; Vega, José L; Boric, Mauricio P; Monyer, Hannah; Bennett, Michael V L; Frank, Marina; Willecke, Klaus; Sáez, Juan C Article Neuropharmacology (2013)
Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy. Cea LA, Riquelme MA, Cisterna BA, Puebla C, Vega JL, Rovegno M, Sáez JC. Article JOURNAL OF MEMBRANE BIOLOGY (2012)
Denervation induces functional expression of connexin hemichannels followed by an inflammatory state in fast skeletal muscles. L.A. Cea, B. A. Cisterna, C. Puebla, J. C. Sáez Article MOLECULAR BIOLOGY OF THE CELL (2012)
Dexamethasone induces inflammation through expression of functional connexin hemichannels in skeletal muscle fibers. L.A. Cea, C. Puebla, A. A. Vargas, M. A. Benvenuto, M. Frank, K. Willecke, J. C. Sáez. Article MOLECULAR BIOLOGY OF THE CELL (2012)
Boldin reduces complications in diabetic rats Romina Hernandez; Luis A Cea; Alejandra Vielma; Leonardo Cigarra; Juan Carlos Saez; Mauricio P Boric; Victoria Velarde Article FASEB journal (2011)
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium Muñoz G.; San Martín R.; Farias M.; Cea, L; Vecchiola, A; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)


Denervation induces functional expression of connexin hemichannels followed by an inflammatory state in fast skeletal muscles. Cea, LA; Cisterna, BA; Puebla, C; Sáez JC Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)
Dexamethasone induces inflammation through expression of functional connexin hemichannels in skeletal muscle fibers. Cea, LA; Puebla, C; Vargas AA; Benvenuto, MA; Frank, M; Willecke K.; Sáez JC Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)
Boldin reduces complications in diabetic rats Hernández R.; Cea, LA; Vielma, A; Cigarra, L; Sáez JC; Boric, MI; Velarde, V Abstract ISI FASEB JOURNAL (2011)
Insulin increases adenosine transport via equilibrative nucleoside transporter 2 in human umbilical vein endothelium under normoxia or hypoxia. Cea, L; Casanello, P; Sobrevia L. Abstract ISI PLACENTA (2007)
Adenosine transport via Equilibrative Nucleoside Transporters 1 and 2 are not modulated by insulin in human umbilical vein endothelium under hypoxia Cea, L; Sobrevia L.; Casanello, P Abstract ISI PLACENTA (2006)
Modulation of adenosine transport by insulin in human foetal endothelium Muñoz G.; Cea, L; Casanello, P; Sobrevia L. Abstract ISI PLACENTA (2006)


EXPRESSION OF FUNCTIONAL CONNEXIN-BASED HEMICHANNELS IN SKELETAL MUSCLES OF DYSFERLIN-DEFICIENT MICE, AN ANIMAL MODEL OF DYSFERLINOPATHY, FAVORS MUSCLE DAMAGE AND DYSFUNCTION FONDECYT (11160739) Proyecto 2016-2019 Inv. Responsable
Mecanismos moleculares y celulares del daño muscular producido en disferlinopatías=> Rol de los hemicanales formados por conexinas PAI (79140023) Proyecto 2015-2017 Inv. Responsable
Mecanismos moleculares y celulares del daño muscular producido en disferlinopatías=> rol de los hemicanales formados por conexinas PAI (79140023) Proyecto 2015-2018 Inv. Responsable
CONNEXIN HEMICHANNELS AS MEDIATORS OF SARCOLEMMAL AND MITOCHONDRIAL DYSFUNCTION IN RESPIRATORY AND PERIPHERAL MUSCLE IN THE PATHOGENESIS OF SEPSIS ASSOCIATED-INTENSIVE CARE UNIT ACQUIRED WEAKNESS (ICUAW) FONDECYT (1141092) Proyecto 2014-2018 Coinvestigador(a)
Molecular and cellular mechanisms of muscular dystrophy related to mutations of dysferlin PIA (ACT-1121) Proyecto 2012-2015 Postdoctorado


Dysferlin function in skeletal muscle: Possible pathological mechanisms and therapeutical targets in dysferlinopathies Cárdenas A.M.; González-Jamett A.M.; Cea L.A.; Bevilacqua J.A.; Caviedes P. Review ISI SCOPUS EXPERIMENTAL NEUROLOGY (2016)
Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy Cea L.A.; Riquelme, M. A.; Cisterna B.A.; Puebla, C; Vega, J. L.; Rovegno M.; Sáez, J.C. Review ISI SCOPUS Journal of Membrane Biology (2012)

Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

Daniel Escobar

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Luis Andrés Cea Pisani

Líneas de Investigación

Educación

Doctor en Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012

Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Experiencia Académica

Profesor Asistente Full Time

Docente Part Time

Experiencia Profesional

Docente Part Time

Profesor Asistente Full Time

Article (27)

Abstract (6)

Proyecto (5)

EXPRESSION OF FUNCTIONAL CONNEXIN-BASED HEMICHANNELS IN SKELETAL MUSCLES OF DYSFERLIN-DEFICIENT MICE, AN ANIMAL MODEL OF DYSFERLINOPATHY, FAVORS MUSCLE DAMAGE AND DYSFUNCTION

Mecanismos moleculares y celulares del daño muscular producido en disferlinopatías=> Rol de los hemicanales formados por conexinas

Mecanismos moleculares y celulares del daño muscular producido en disferlinopatías=> rol de los hemicanales formados por conexinas

CONNEXIN HEMICHANNELS AS MEDIATORS OF SARCOLEMMAL AND MITOCHONDRIAL DYSFUNCTION IN RESPIRATORY AND PERIPHERAL MUSCLE IN THE PATHOGENESIS OF SEPSIS ASSOCIATED-INTENSIVE CARE UNIT ACQUIRED WEAKNESS (ICUAW)

Molecular and cellular mechanisms of muscular dystrophy related to mutations of dysferlin

Review (2)