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Andrea Paola Vecchiola Cardenas

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Oxidative Stress /Regulation of antioxidants; Pathogenesis of COPD and Pulmonary Fibrosis; Antiproteases and Lung Diseases; acute phase response; oxidative stress; animal models of lung disease; Distension Abdominal; Enfermedades autoinmunes; ateroesclerosis

Biología Molecular y Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
Bioquímica, UNIVERSIDAD DE CHILE. Chile, 1993

INVESTIGADOR ASOCIADO 45 horas semanales

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Not Available - Not Available

Profesor Asistente Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2006 - At present


Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome Carvajal, Cristian A; Tapia-Castillo, Alejandra; Vecchiola, Andrea.; Baudrand, Rene; Fardella, Carlos E Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)
Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division Vecchiola, Andrea.; Fuentes, Cristobal A.; Solar, Isidora; Lagos, Carlos F; Opazo, Maria Cecilia; Munoz-Durango, Natalia; Riedel, Claudia A; Owen, Gareth, I; Kalergis, Alexis M.; Fardella, Carlos E. Article ISI FRONTIERS IN ENDOCRINOLOGY (2020)
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess Tapia-Castillo, Alejandra; Guanzon, Dominic; Palma, Carlos; Lai, Andrew; Barros, Eric; Allende, Fidel; Vecchiola, Andrea.; Fardella, Carlos E.; Salomón, Carlos; Carvajal, Cristian A. Article ISI SCOPUS JOURNAL OF TRANSLATIONAL MEDICINE (2019)
EFFECTS OF MATERNAL HYPOTHYROXINEMIA OVER THE ADIPOSE TISSUE IN THE ADULT THE PROGENY Alba, Arturo; Gutierrez, Barbara; De Luca, Natalia; Vecchiola, Andrea.; Osses, Maricarmen; Gomez, Felipe; Santos, Johana; Mendez, Luis; Aguayoo, Daniel; Riedel, Claudia; Cecilia Opazo, Maria Article ISI PLACENTA (2019)
The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism Vecchiola, Andrea.; Andres Fuentes, Cristobal; Raul Barros, Eric; Martinez-Aguayo, Alejandro; Garcia, Hernan; Allende, Fidel; Solari, Sandra; Olmos, Roberto; Carvajal, Cristian; Tapia-Castillo, Alejandra; Campino, Carmen; Mikes Kalergis, Alexis; Baudrand, Rene; Enrique Fardella, Carlos Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2019)
Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects. Capponi, Valentina; Carrasco, Carmen; Macchiavello, Stefano; Undurraga, Juan; Campino, Carmen; Carvajal, Cristian; Gomez, Teresita; Weiss, Cristian; Aedo, Igor; Vecchiola, Andrea; Allende, Fidel; Solari, Sandra; Fardella, Carlos; Baudrand, René Article Neuro endocrinology letters (2018)
Gynecological-endocrinological aspects in women carriers of BRCA1/2 gene mutations. Doren, A; Vecchiola, A; Aguirre, B; Villaseca, P Article Climacteric => the journal of the International Menopause Society (2018)
Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation. Campino, Carmen; Baudrand, Rene; Valdivia, Carolina A; Carvajal, Cristian; Vecchiola, Andrea; Tapia-Castillo, Alejandra; Martínez-Aguayo, Alejandro; Garcia, Hernán; García, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal A; Lagos, Carlos F; Rojas, Maria Paulina; Muñoz, Doris; Fardella, Carlos E Article American journal of hypertension (2018)
Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children Valdivia C.; Carvajal, CA; Campino C.; Allende, F; Martinez-Aguayo, A; Baudrand R.; Vecchiola, A; Lagos, CF; Tapia-Castillo, A; Fuentes, CA; Aglony, M; Solari, S; Kalergis, AM; García H.; Owen, GI; Fardella, CE Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2016)
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension. Martinez-Aguayo, Alejandro; Campino, Carmen; Baudrand, Rene; Carvajal, Cristian A; García, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia-Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastian; Fuentes, Cristobal A; Lagos, Carlos F; Solari, Sandra; Allende, Fidel; Kalergis, Alexis M; Fardella, Carlos E Article Journal of hypertension (2016)
Expression Pattern of Scavenger Receptors and Amyloid-Î² Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer's Disease. Eugenín, Jaime; Vecchiola, Andrea; Murgas, Paola; Arroyo, Pablo; Cornejo, Francisca; von Bernhardi, Rommy Article Journal of Alzheimer's disease : JAD (2016)
Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension. Muñoz-Durango, Natalia; Fuentes, Cristóbal A; Castillo, Andrés E; González-Gómez, Luis Martín; Vecchiola, Andrea; Fardella, Carlos E; Kalergis, Alexis M Article International journal of molecular sciences (2016)
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake Tapia-Castillo, A; Carvajal, CA; Campino C.; Hill, C; Allende, F; Vecchiola, A; Carrasco C.; Bancalari, R; Valdivia C.; Lagos C.; Martinez-Aguayo, A; García H.; Aglony, M; Baudrand, RF; Kalergis, AM; Michea LF; Riedel, CA; Fardella, CE Article ISI SCOPUS American Journal of Hypertension (2015)
Identification of novel 11 beta-HSD1 inhibitors by combined ligand- and structure-based virtual screening Lagos, CF; Vecchiola, A; Allende, F; Fuentes, CA; Tichauer, JE; Valdivia C.; Solari, S; Campino C.; Tapia-Castillo, A; Baudrand R.; Villarroel P.; Cifuentes M.; Owen, GI; Carvajal, CA; Fardella, CE Article ISI MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)
LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids Allende, F; Solari, S; Campino C.; Carvajal, C. A.; Lagos, C. F.; Vecchiola, A; Valdivia C.; Baudrand R.; Owen, G. I.; Fardella C.E. Article ISI SCOPUS CHROMATOGRAPHIA (2014)
Polymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population Tapia-Castillo, A; Carvajal, CA; Campino C.; Vecchiola, A; Allende, F; Solari, S; Garcia, L.; Lavanderos, S; Valdivia C.; Fuentes C.; Lagos, CF; Martinez-Aguayo, A; Baudrand R.; Aglony, M; García H.; Fardella, CE Article ISI AMERICAN JOURNAL OF HYPERTENSION (2014)
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro Vecchiola, A; Lagos, CF; Fuentes, CA; Allende, F; Campino C.; Valdivia C.; Tapia-Castillo, A; Ogishima, T; Mukai K.; Owen, G; Solari, S; Carvajal, CA; Fardella, CE Article ISI SCOPUS Reproductive Biology and Endocrinology (2013)
PIAS gamma Enhanced SUMO-2 Modification of Nurr1 Activation-Function-1 Domain Limits Nurr1 Transcriptional Synergy Arredondo, C; Orellana M.; Vecchiola, A; Pereira, LA; Galdames L.; Andres, ME Article ISI SCOPUS PLOS ONE (2013)
Differences in acute lung response to elastase instillation in two rodent species may determine differences in severity of emphysema development Vecchiola, A; De La Llera, JF; Ramirez R.; Olmos, P; Herrera CI; Borzone, G Article ISI SCOPUS American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2011)
Differences in lung glutathione metabolism may account for rodent susceptibility in elastase-induced emphysema development Borzone, GR; Liberona, LF; Bustamante, AP; Saez CG; Olmos, PR; Vecchiola, A; Villagrán A.; Serrano, C.; Reyes, TP Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium Puebla, C; Farias M.; Gonzalez, M.; Vecchiola, A; Aguayo, C.; Krause, B; Pastor-Anglada, M; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
D-Glucose stimulation of L-arginine transport and nitric oxicle synthesis results from activation of mitogen-activated protein kinases p42/44 and smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium Vaquez, R; Farias M.; Vega, JL; Martin, RS; Vecchiola, A; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium Muñoz G.; San Martín R.; Farias M.; Cea, L; Vecchiola, A; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
PIAS gamma represses the transcriptional activation induced by the nuclear receptor Nurr1 Galleguillos D; Vecchiola, A; Fuentealba, JA; Ojeda V.; Alvarez, K; Gomez A.; Andres, ME Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Origin of collagen in restenosis post stenting. Intima or adventitia? Guarda E.; Fajuri A.,; Martínez A; Marchant, E; Vecchiola, A; VALENZUELA, E.; Lazen, R Article ISI REVISTA MEDICA DE CHILE (2001)


A Deletion Encompassing Exon 2 of the ALS Gene: Analysis of a Patient with ALS Deficiency and His Family Poggi, H; Arancibia, M; Benavides, F; Lagos, C; Vecchiola, A; Dominguez-Menendez, G; Martinez-Aguayo, A Abstract ISI HORMONE RESEARCH IN PAEDIATRICS (2018)
Simvastatin Inhibits Leptin-activated Signaling Pathways That Promote Migration and Invasiveness of Ovarian Cancer Cells Cuello-Fredes, M; Kato, S; Diaz, D.; Vecchiola, A; Brañes J.; Barriga MI.; Gejman, R; Owen, GI Abstract ISI EUROPEAN JOURNAL OF CANCER (2012)
Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium Puebla, C; Farias M.; Vecchiola, A; Casanello, P; Sobrevia L. Abstract ISI PLACENTA (2007)
PIAS gamma represses NURR1-dependent transciptional activity Vecchiola, A; Andres, ME Abstract ISI PLACENTA (2006)


Pregnancy normalized familial hyperaldosteronism type I: a novel role for progesterone? Campino C.; Trejo, P.; Carvajal, CA; Vecchiola, A; Valdivia C.; Fuentes, CA; Delgado JF; Lagos, CF; Aglony, M; Carrasco C.; Martinez-Aguayo, A; García H.; Loureiro, C.; Fardella, CE Letter ISI SCOPUS Journal of Human Hypertension (2015)


ALDOSTERONE DYSREGULATION IN METABOLIC SYNDROME, OBESITY AND INFLAMMATION=> CLINICAL AND IN VITRO STUDIES. FONDECYT (1160695) Proyecto 2016-2020 Coinvestigador(a)
Nuevos Fármacos para el tratamiento de la hipertensión y el síndrome metabólico CONSORCIO-CORFO (CCM) Proyecto 2016-2018 Coinvestigador(a)
STATINS COUNTERACT THE ADIPOCYTE-CANCER CELL LOOP AND THE VICIOUS METABOLIC ORCHESTRATION INDUCED BY OBESITY IN OVARIAN CANCER=> A NOVEL STRATEGY FOR MICRO ENVIRONMENTAL THERAPY FONDECYT (1160800) Proyecto 2016-2020 Coinvestigador(a)
NOVEL BIOCHEMICAL AND EPIGENETIC STUDIES IN 11BETA-HYDROXYSTEROID DEHYDROGENASE 2 GENE AS A TARGET FOR ENDOCRINE HYPERTENSION. FONDECYT (1150437) Proyecto 2015-2018 Coinvestigador(a)
Consorcio Tecnológico en Biomedicina aplicada para el desarrollo de nuevos estrategias de prevención, diagnóstico y tratamiento de enfermedades humanas. CORFO (A) Proyecto 2014-2019 Investigador(a)
Aldosterona y sistema inmune en la génesis de la hipertensión arterial mineralocorticoídea, un estudio ex vivo e in vitro. SOCHED (2013-6) Proyecto 2013-2014 Inv. Principal
Desarrollo de Fármacos para la Hipertensión Arterial y Sindrome Metabólico FONDEF (CA12i10150) Proyecto 2013-2014 Coinvestigador(a)
SALT INTAKE IN ESSENTIAL HYPERTENSION=> STUDIES OF NEW BIOCHEMICAL AND GENETIC MECHANISMS TO IDENTIFY ITS ETIOLOGY FONDECYT (1130427) Proyecto 2013-2016 Coinvestigador(a)
SPECIES DIFFERENCES IN ACUTE LUNG INJURY BY ELASTASE. POSSIBLE ROLE FOR SPECIES DIFFERENCES IN REGULATION OF THE ACUTE PHASE RESPONSE ON THE ENSUING EMPHYSEMA DEVELOPMENT. FONDECYT (11070121) Proyecto 2007-2010 Inv. Responsable


Aldosterone Production and Signaling Dysregulation in Obesity Vecchiola, A; Lagos, CF; Carvajal, CA; Baudrand R.; Fardella, CE Review ISI SCOPUS CURRENT HYPERTENSION REPORTS (2016)
Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone Munoz-Durango, N; Vecchiola, A; Gonzalez-Gomez, LM; Simon F.; Riedel, CA; Fardella, CE; Kalergis, AM Review ISI SCOPUS BioMed Research International (2015)

Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

María Andrés

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

Carolina Serrano

Profesor Asistente Ordinario

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Pia Villarroel

Académico

Facultad de Ciencias para el Cuidado de la Salud

Universidad San Sebastián

Valdivia, Chile

Marcelo Orellana

Gestor de Innovación en áreas prioritarias

Universidad Católica de la Santísima Concepción

Concepción, Chile

José Fuentealba

Associate professor

Farmacy

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Cristóbal Herrera

Estudiante

Departamento de Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

JOSE F. DELGADO

Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Pamela Trejo

Endocrinologist

Internal Medicine

Clinica Alemana Santiago

Santiago, Chile

Arturo Alba

Asistente de gestión e investigación

FishExtend SpA

santiago, Chile

Andrea Gómez

Investigador Postdoctoral

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

Andrea Paola Vecchiola Cardenas

Líneas de Investigación

Educación

Biología Molecular y Celular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Bioquímica, UNIVERSIDAD DE CHILE. Chile, 1993

Experiencia Académica

INVESTIGADOR ASOCIADO 45 horas semanales

Experiencia Profesional

Profesor Asistente Full Time

Article (25)

Abstract (4)

Letter (1)

Proyecto (9)

ALDOSTERONE DYSREGULATION IN METABOLIC SYNDROME, OBESITY AND INFLAMMATION=> CLINICAL AND IN VITRO STUDIES.

Nuevos Fármacos para el tratamiento de la hipertensión y el síndrome metabólico

STATINS COUNTERACT THE ADIPOCYTE-CANCER CELL LOOP AND THE VICIOUS METABOLIC ORCHESTRATION INDUCED BY OBESITY IN OVARIAN CANCER=> A NOVEL STRATEGY FOR MICRO ENVIRONMENTAL THERAPY

NOVEL BIOCHEMICAL AND EPIGENETIC STUDIES IN 11BETA-HYDROXYSTEROID DEHYDROGENASE 2 GENE AS A TARGET FOR ENDOCRINE HYPERTENSION.

Consorcio Tecnológico en Biomedicina aplicada para el desarrollo de nuevos estrategias de prevención, diagnóstico y tratamiento de enfermedades humanas.

Aldosterona y sistema inmune en la génesis de la hipertensión arterial mineralocorticoídea, un estudio ex vivo e in vitro.

Desarrollo de Fármacos para la Hipertensión Arterial y Sindrome Metabólico

SALT INTAKE IN ESSENTIAL HYPERTENSION=> STUDIES OF NEW BIOCHEMICAL AND GENETIC MECHANISMS TO IDENTIFY ITS ETIOLOGY

SPECIES DIFFERENCES IN ACUTE LUNG INJURY BY ELASTASE. POSSIBLE ROLE FOR SPECIES DIFFERENCES IN REGULATION OF THE ACUTE PHASE RESPONSE ON THE ENSUING EMPHYSEMA DEVELOPMENT.

Review (2)