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ALEJANDRA TAPIA CASTILLO

Investigador

Pontificia Universidad Católica de Chile

Santiago, Chile

Hipertensión arterial endocrina Epigenética exosomas

Doctor en ciencias e innovación en medicina, UNIVERSIDAD DEL DESARROLLO. Chile, 2019

Investigador Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2018 - 2020
Investigador Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2020 - At present

Investigador asistente Full Time

Pontificina Universidad Católica de Chile

Santiago, Chile

2013 - 2014
Investigador asistente Part Time

Millenium Institute of Immunology and Immunoterapy

Santiago, Chile

2018 - At present
Visiting Scientist Full Time

University of Queensland

Santiago, Chile

2017 - Not Available

ISE travel grant

International Society of Endocrinology

Estados Unidos, 2014

Recognition of their effectiveness in endocrine research by International Society of Endocrinology at 2014
Best Translational Study awarded

SOCHED

Chile, 2016

Best Translational Study awarded by the Chilean Society of Endocrinology and Diabetes 2016
Presidential Abstract

ENDO Society

Estados Unidos, 2016

The Presidential Poster Competition is an event where high-scoring trainees who are presenting-authors of a poster presentation compete amongst their peers.
Best published international article

SOCHED

Chile, 2016

the Best published international article granted by SOCHED at 2016.


Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism Barros, Eric R.; Rigalli, Juan Pablo; Tapia-Castillo, Alejandra; Vecchiola, Andrea; Young, Morag J.; Hoenderop, Joost G. J.; Bindels, Rene J. M.; Fardella, Carlos E.; Carvajal, Cristian A. Article ISI ENDOCRINOLOGY (2021)
Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome Carvajal, Cristian A; Tapia-Castillo, Alejandra; Vecchiola, Andrea.; Baudrand, Rene; Fardella, Carlos E Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess Tapia-Castillo, Alejandra; Guanzon, Dominic; Palma, Carlos; Lai, Andrew; Barros, Eric; Allende, Fidel; Vecchiola, Andrea.; Fardella, Carlos E.; Salomón, Carlos; Carvajal, Cristian A. Article ISI SCOPUS JOURNAL OF TRANSLATIONAL MEDICINE (2019)
The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism Vecchiola, Andrea.; Andres Fuentes, Cristobal; Raul Barros, Eric; Martinez-Aguayo, Alejandro; Garcia, Hernan; Allende, Fidel; Solari, Sandra; Olmos, Roberto; Carvajal, Cristian; Tapia-Castillo, Alejandra; Campino, Carmen; Mikes Kalergis, Alexis; Baudrand, Rene; Enrique Fardella, Carlos Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2019)
Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome Tapia-Castillo A.; Baudrand R.; Vaidya A.; Campino C.; Allende F.; Valdivia C.; Vecchiola A.; Lagos C.F.; Fuentes C.A.; solari s.; MartÃnez-Aguayo A.; GarcÃa H.; Carvajal, C. A.; Fardella C.E. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)
Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11 beta-Hydroxysteroid Dehydrogenase Type 2 Deficiency Carvajal CA, Tapia-Castillo A, Valdivia CP, Allende F, Solari S, Lagos CF, Campino C, Martínez-Aguayo A, Vecchiola A, Pinochet C, Godoy C, Iturrieta V, Baudrand R, Fardella CE. Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2018)
Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation Campino C, Baudrand R, Valdivia C, Carvajal C, Vecchiola A, Tapia-Castillo A, Martínez-Aguayo A, Garcia H, García L, Allende F, Solari S, Fuentes C, Lagos CF, Rojas MP, Muñoz D, Fardella C Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2018)
Hypertensive Patients That Respond to Aldosterone Antagonists May Have a Nonclassical 11 beta-HSD2 Deficiency Tapia-Castillo, Alejandra; Carvajal, Cristian A.; Allende, Fidel; Campino, Carmen; Fardella, Carlos E. Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2017)
Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children Valdivia C.; Carvajal, CA; Campino C.; Allende, F; Martinez-Aguayo, A; Baudrand R.; Vecchiola, A; Lagos, CF; Tapia-Castillo, A; Fuentes, CA; Aglony, M; Solari, S; Kalergis, AM; García H.; Owen, GI; Fardella, CE Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2016)
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension Martinez-Aguayo, Alejandro; Campino, Carmen; Baudrand, Rene; Carvajal, Cristian A.; García, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia-Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastian; Fuentes, Cristobal A.; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis M.; Fardella, Carlos E. Article ISI SCOPUS JOURNAL OF HYPERTENSION (2016)
Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults Campino, Carmen; Hill, Caroline; Baudrand, Rene; Mart?nez-Aguayo, Alejandro; Aglony, Marlene; Carrasco, Carmen A.; Ferrada, Clarita; Loureiro, Carolina; Vecchiola, Andrea; Bancalari, Rodrigo; Grob, Francisca; Carvajal, Cristian A.; Lagos, Carlos F.; Valdivia, Carolina; Tapia-Castillo, Alejandra; Fuentes, Cristobal A.; Mendoza, Carolina; Garcia, Hernan; Uauy, Ricardo; Fardella, Carlos E. Article ISI SCOPUS AMERICAN JOURNAL OF HYPERTENSION (2016)
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake Tapia-Castillo, A; Carvajal, CA; Campino C.; Hill, C; Allende, F; Vecchiola, A; Carrasco C.; Bancalari, R; Valdivia C.; Lagos C.; Martinez-Aguayo, A; García H.; Aglony, M; Baudrand, RF; Kalergis, AM; Michea LF; Riedel, CA; Fardella, CE Article ISI SCOPUS American Journal of Hypertension (2015)
Identification of novel 11 beta-HSD1 inhibitors by combined ligand- and structure-based virtual screening Lagos, CF; Vecchiola, A; Allende, F; Fuentes, CA; Tichauer, JE; Valdivia C.; Solari, S; Campino C.; Tapia-Castillo, A; Baudrand R.; Villarroel P.; Cifuentes M.; Owen, GI; Carvajal, CA; Fardella, CE Article ISI MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)
Polymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population Tapia-Castillo, A; Carvajal, CA; Campino C.; Vecchiola, A; Allende, F; Solari, S; Garcia, L.; Lavanderos, S; Valdivia C.; Fuentes C.; Lagos, CF; Martinez-Aguayo, A; Baudrand R.; Aglony, M; García H.; Fardella, CE Article ISI AMERICAN JOURNAL OF HYPERTENSION (2014)
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro Vecchiola, A; Lagos, CF; Fuentes, CA; Allende, F; Campino C.; Valdivia C.; Tapia-Castillo, A; Ogishima, T; Mukai K.; Owen, G; Solari, S; Carvajal, CA; Fardella, CE Article ISI SCOPUS Reproductive Biology and Endocrinology (2013)


Perfil de expresión de miRNA en exosomas urinarios en sujetos pediátricos con déficit parcial de la enzima 11βHSD2 Universidad del Desarrollo (23.400.153) Proyecto 2017-2018 Inv. Principal
Millenium institute of Immunology and immunoteraphy ICM-MINECON (09/016-F) Proyecto 2016-2021 Personal técnico y/o de apoyo
NOVEL BIOCHEMICAL AND EPIGENETIC STUDIES IN 11BETA-HYDROXYSTEROID DEHYDROGENASE 2 GENE AS A TARGET FOR ENDOCRINE HYPERTENSION. FONDECYT (1150437) Proyecto 2015-2018 Tesista
REGULACIÓN DE LA ENZIMA 11Β-HIDROXIESTEROIDE DESHIDROGENASA TIPO 2 (11ΒHSD2) POR MIRNA Y SU ASOCIACIÓN CON HIPERTENSIÓN ARTERIAL SOCHED (2015-10) Proyecto 2015-2017 Inv. Principal
SALT INTAKE IN ESSENTIAL HYPERTENSION=> STUDIES OF NEW BIOCHEMICAL AND GENETIC MECHANISMS TO IDENTIFY ITS ETIOLOGY FONDECYT (1130427) Proyecto 2013-2016 Personal técnico y/o de apoyo
PRIMARY ALDOSTERONISM AND HSD11B2 ENZYME ACTIVITY DEFECTS IN PEDIATRIC POPULATION AND ITS IMPACT ON THE GENERATION OF ENDOTHELIAL INJURY, OXIDATIVE STRESS AND ARTERIAL HYPERTENSION FONDECYT (1100356) Proyecto 2010-2013 Personal técnico y/o de apoyo