Man

Carlos Alberto Puebla Aracena

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Líneas de Investigación


1- Cell signaling associated with Free Fatty Acid Receptors (FFARs) 2- Señalización celular inducida por ácidos grasos libres 3- Regulation of membrane channels and hemichannels formed by connexin or pannexin proteins

Educación

  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
  •  Biologicas Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Experiencia Académica

  •   Adjunct Assistant Professor Part Time

    UNIVERSIDAD ANDRES BELLO

    Medicine

    Santiago, Chile

    2015 - 2015

  •   Assistant Professor Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Health Sciences

    Santiago, Chile

    2016 - 2019

  •   Assistant Professor Full Time

    Universidad de O'Higgins

    Health Sciences

    Rancagua, Chile

    2019 - At present

Experiencia Profesional

  •   Postdoctoral Fellowship Full Time

    Centro Interdisciplinario de Neurociencia de Valparaíso

    Valparaíso, Chile

    2011 - 2012

  •   Postdoctoral Fellowship Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2012 - 2015

  •   Postdoctoral Fellowship Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2016 - 2016

  •   Assistent Professor Full Time

    Universidad Autónoma de Chile

    Santiago, Chile

    2016 - 2019

  •   Assistent Professor Full Time

    Universidad de O'Higgins

    Rancagua, Chile

    2019 - At present

  •   Guest Associate Editor Part Time

    Frontiers in Physiology

    Suiza

    2020 - At present


 

Article (20)

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Cisterna, Bruno A.; Vargas, Aníbal A.; Puebla, Carlos; Fernández, Paola; Escamilla, Rosalba; Lagos, Carlos F; Matus, María F.; Vilos, Cristian; Cea, Luis A.; Barnafi, Esteban; Gaete, Hugo; Escobar, Daniel F.; Cardozo, Christopher P.; Sáez, Juan C.

Article SCOPUS
NATURE COMMUNICATIONS  (2020)

Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression

Ortiz, FC; Puebla, C

Article ISI SCOPUS
NEURAL REGENERATION RESEARCH  (2020)

Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells.

Cisterna, Bruno A; Arroyo, Pablo; Puebla, Carlos

Article
Frontiers in cellular neuroscience  (2019)

Regulation of Connexin-Based Channels by Fatty Acids

Puebla, Carlos; Retamal, Mauricio A.; Acuña, Rodrigo; Sáez, Juan C.

Article ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2017)

Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles

Cisterna, Bruno A.; Vargas, An?bal A.; Puebla, Carlos; S?ez, Juan C.

Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2016)

Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels

Cea, LA , ,; Balboa, E; Puebla, C; Vargas, AA; Cisterna, BA; Escamilla, R; Regueira, T; Sáez, JC

Article
Biochimica et Biophysica Acta  (2016)

Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels

Cea, Luis A.; Balboa, Elisa; Puebla, Carlos; Vargas, An?bal A.; Cisterna, Bruno A.; Escamilla, Rosalba; Regueira, Tom?s; S?ez, Juan C.

Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2016)

Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis

Cea L.A.; Puebla, C; Cisterna B.A.; Escamilla, R; Vargas A.A.; Frank, M; Martínez-Montero P.; Prior C.; Molano J.; Esteban-Rodríguez I.; Pascual, I.; Gallano, P; Lorenzo G.; Pian H.; Barrio L.C.; Willecke K.; Sáez, J.C.

Article ISI SCOPUS
CELLULAR AND MOLECULAR LIFE SCIENCES  (2016)

Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40-and Akt-dependent mechanism

Puebla, C; Cisterna B.A.; Salas D.P.; Delgado-Lopez, F; Lampe P.D.; Sáez, J.C.

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS  (2016)

Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells

Contador D.; Ezquer, F; Espinosa,M; Arango-Rodriguez, M; Puebla, C; Sobrevia L.; Conget P.

Article ISI SCOPUS
Experimental Biology and Medicine  (2015)

Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition

Salas, D.; Puebla, C; Lampe, PD; Lavandero S.; Sáez JC

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2015)

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy

Cea, LA; Cisterna, BA; Puebla, C; Frank, M; Figueroa, XF; Cardozo C.; Willecke K.; Latorre R.; Sáez JC

Article ISI SCOPUS
Proceedings of the National Academy of Sciences of the United States of America  (2013)

Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin

Salomon, C; Westermeier, F; Puebla, C; Arroyo, P; Guzman-Gutierrez, E; Pardo F.; Leiva A.; Casanello, P; Sobrevia L.

Article ISI SCOPUS
PLOS ONE  (2012)

Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes

Guzman-Gutierrez, E; Abarzua, F; Belmar C.; Nien JK; Ramirez, MA; Arroyo, P; Salomon, C; Westermeier, F; Puebla, C; Leiva A.; Casanello, P; Sobrevia L.

Article ISI SCOPUS
CURRENT VASCULAR PHARMACOLOGY  (2011)

Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

Westermeier, F; Salomon, C; Gonzalez, M.; Puebla, C; Guzman-Gutierrez, E; Cifuentes F.; Leiva A.; Casanello, P; Sobrevia L.

Article ISI SCOPUS
DIABETES  (2011)

Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes

Sobrevia L.; Salomon, C; Westermeier, F; Puebla, C; Cifuentes F.; Guzman-Gutierrez, E; Leiva A.; Casanello, P; Abarzua, F; Nien, J. K.

Article ISI SCOPUS
Placenta  (2011)

Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP alpha in human umbilical vein endothelial cells from gestational diabetes

Farias M.; Puebla, C; Westermeier, F; Jo, MJ; Pastor-Anglada, M; Casanello, P; Sobrevia L.

Article ISI SCOPUS
CARDIOVASCULAR RESEARCH  (2010)

TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium

Vega, JL; Puebla, C; Vasquez R.; Farias M.; Alarcon J.; Pastor-Anglada, M; Krause, B; Casanello, P; Sobrevia L.

Article ISI SCOPUS
CARDIOVASCULAR RESEARCH  (2009)

High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium

Puebla, C; Farias M.; Gonzalez, M.; Vecchiola, A; Aguayo, C.; Krause, B; Pastor-Anglada, M; Casanello, P; Sobrevia L.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2008)

Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endotheliurn from gestational diabetes

Farias M.; Martin, RS; Puebla, C; Pearson, JD; Casado, JF; Pastor-Anglada, M; Casanello, P; Sobrevia L.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2006)

Abstract (14)

Permeability properties of pannexin1 hemichannels activated by mechanical stress

Subiabre, M; Puebla, C; Vargas A.; Fernández P.; Sáez JC

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2014)

Denervation induces functional expression of connexin hemichannels followed by an inflammatory state in fast skeletal muscles.

Cea, LA; Cisterna, BA; Puebla, C; Sáez JC

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

Dexamethasone induces inflammation through expression of functional connexin hemichannels in skeletal muscle fibers.

Cea, LA; Puebla, C; Vargas AA; Benvenuto, MA; Frank, M; Willecke K.; Sáez JC

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2012)

INSULIN RECEPTOR A IS INVOLVED IN GESTATIONAL DIABETES-REDUCED ADENOSINE TRANSPORT VIA HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

Westermeier, F; Salomon, C; Guzman-Gutierrez, E; Puebla, C; Leiva A.; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2011)

Insulin Reverses Gestational Diabetes-Increased L-Arginine Transport Via A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium

Guzman-Gutierrez, E; Puebla, C; Salomon, C; Westermeier, F; Leiva A.; Casanello, P; Sobrevia L.

Abstract ISI
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE  (2011)

ACTIVITY AND EXPRESSION OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IS REGULATED BY D-GLUCOSE UPTAKE AND METABOLISM IN UMBILICAL VEIN ENDOTHELIUM

Puebla, C; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2010)

Expression and Activity of Human Equilibrative Nucleoside Transporter 1 Depends on D-Glucose Uptake in Umbilical Vein Endothelial Cells.

Puebla, C; Sepulveda, CA; Casanello, P; Sobrevia L.

Abstract ISI
REPRODUCTIVE SCIENCES  (2010)

HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS EXHIBIT GLUTS-LIKE TRANSPORT ACTIVITY MODULATED BY INSULIN

Sepulveda, C; Puebla, C; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2010)

Gestational diabetes mellitus is associated with NO and PKC-dependent repressor effect of hCHOP-C/EBPalpha on equilibrative nucleoside transporter 1 expression human umbilical vein endothelium

Farias M.; Puebla, C; Vega, JL; Pastor-Anglada, M; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2008)

TGF-beta 1 inhibits adenosine transport in human fetal endothelium

Vega, JL; Farias M.; Puebla, C; Casanello, P; Sobrevia L.

Abstract ISI
PURINERGIC SIGNALLING  (2008)

The transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose rfsponses to transcription factor Sp1 and ZBP-89 in human foetal endothelium

Puebla, C; Farias M.; Vega, JL; Pastor-Anglada, M; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2008)

Transforming growth factor beta 1 is involved in the inhibitory effect of high D-glucose on human equilibrative nucleosidie transporter 1 in human fetal endothelium

Vega, JL; Farias M.; Puebla, C; Gonzalez, M.; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2008)

Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium

Puebla, C; Farias M.; Vecchiola, A; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2007)

Post-translational modulation of equilibrative nucleoside transporter 1 by D-glucose in human umbilical vein endothelium

Puebla, C; Casanello, P; Sobrevia L.

Abstract ISI
PLACENTA  (2006)

BookSection (1)

Maternal and fetal metabolic dysfunction in pregnancy diseases associated with vascular oxidative and nitrative stress

Gonzalez, Marcelo; Muñoz, Ernesto; Puebla, C; Guzman-Gutierres, Enrique; Cifuentes, Fredi; Nien, Ji Kae; Abarzua, Fernando; Leiva A.; Cassanello, Paola; Sobrevia, Paola

BookSection
 (2011)

Proyecto (7)

Role of Zonula occludens toxin in the virulence of non-toxigenic Vibrio parahaemolyticus strains

FONDECYT (1190957)

Proyecto
2019-2022
Coinvestigador(a)

REGULATION OF POTENTIATION OF SKELETAL MUSCLE CONTRACTION BY POLYUNSATURATED FATTY ACIDS

FONDECYT (11160536)

Proyecto
2016-2019
Inv. Responsable

“NEURONAL DERIVED FACTOR(S) AND MECHANISM(S) THAT REPRESS THE EXPRESSION OF NON-SELECTIVE ION CHANNELS IN NORMAL ADULT SKELETAL MUSCLES�

FONDECYT (1150291)

Proyecto
2015-2019
Coinvestigador(a)

REGULACION DEL TRANSPORTE DE GLUCOSA, A TRAVES DE SUS TRANSPORTADORES ESPECIFICOS Y HEMICANALES, POR ACIDOS GRASOS ESENCIALES EN INTESTINO DELGADO

FONDECYT (3130662)

Proyecto
2012-2015
Inv. Responsable

Beca Apoyo Realización Tesis Doctoral (Tesis=> Papel del transporte y metabolismo de D-glucosa en la expresión y actividad del transportador equilibrativo de nucleósidos 1 (hENT1) en endotelio de vena umbilical humana)

PFCHA (24090190)

Proyecto
2009-2011
Inv. Responsable

REGULACION DE LA EXPRESION Y ACTIVIDAD DE LOS TRANSPORTADORES EQUILIBRADOS DE NUCLEOSIDOS TIPO 1 (HENT1) Y 2 (HENT2) POR INSULINA EN EL ENDOTELIO MICRO Y MACROVASCULAR FETAL HUMANO EN DIABETES MELLITUS GESTACIONAL.

FONDECYT (1070865)

Proyecto
2007-2011
Tesista

Regulación transcripcional del transportador equilibrativo de nucleósidos ENT1 por D-glucosa en endotelio humano

FONDECYT (1030607)

Proyecto
2003-2007
Tesista

Review (1)

Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy

Cea L.A.; Riquelme, M. A.; Cisterna B.A.; Puebla, C; Vega, J. L.; Rovegno M.; Sáez, J.C.

Review ISI SCOPUS
Journal of Membrane Biology  (2012)

32
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

31
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

20
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

19
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

10
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

9
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

6
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

6
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

6
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

5
Francisco Westermeier

Universidad de Chile

Santiago, Chile

4
Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

3
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

3
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

3
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

2
Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

2
ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

2
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
MARCO RAMIREZ

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Daniela Salas

1
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

1
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

1
Rodrigo Acuña

Profesor Asistente Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

1
David Contador

Universidad del Desarrollo

Santiago, Chile

1
Fernando Ortiz

profesor asistente

Departmento de Biología, Facultad de Quimica y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

1
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Daniel Escobar

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile