Man

Marcelo Andrés González Ortiz

Profesor Asistente

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Líneas de Investigación


Mecanismos moleculares y celulares de regulación de la fisiología vascular placentaria humana, en condiciones saludables y de patologías, principalmente diabetes gestacional, preeclampsia y obesidad.

Educación

  •  Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 2004
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CONCEPCION

    Medicina

    CONCEPCION, Chile

    2019 - At present

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    CONCEPCION, Chile

    2009 - 2019

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad de Concepción

    Concepción, Chile

    2009 - At present

Formación de Capital Humano


Supervisión de Tesis

Magister en Fisiología Humana (UdeC): Pía Ávila, Lissette Cabrera, Iván Rodríguez, Tamara Ortiz, Sebastián Dubó, Victor Durán, Enzo Barrientos, Natalia Rodríguez, Víctor Lincoñir.

Magíster en Salud Sexual y Reproductiva (UdeC): María Fernanda Castillo (co-tutor).

Licenciatura en Bioquímica (UdeC): Natalia Vallejos, Emerita Basualto, Luz Valdivia, Astrid Haensgen, Andrea Saavedra, Roberto Villalobos, Carlos Palma, Cristina Valenzuela.

Licenciatura en Bioingeniería (UdeC): Pamela Careaga, David Gallegos, Rubén Grandón

Ingeniería Química (UdeC): María Soledad Parada (co-tutor).


Premios y Distinciones

  •   Asignación Académica

    UNIVERSIDAD DE CONCEPCION

    Chile, 2019

    Asignación al mérito académico (docencia, investigación, extensión) de acuerdo a lo realizado en los últimos 3 años del periodo.


 

Article (31)

Role of heme oxygenase 1 and human chorionic gonadotropin in pregnancy associated diseases
The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein
Pharmacological inhibition of the F-1-ATPase/P2Y(1) pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation
Transport of biodegradable polymeric particles loaded with grape seed extract across Caco-2 cell monolayers
Akt/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy
Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1.
Pro-angiogenic Role of Insulin=> From Physiology to Pathology
Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels.
Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus.
Potential benefits of physical activity during pregnancy for the reduction of gestational diabetes prevalence and oxidative stress.
Synthesis and characterization of polyhydroxybutyrate-co-hydroxyvalerate nanoparticles for encapsulation of quercetin
Biología del desarrollo vascular: Mecanismos en condiciones fisiológicas y estrés de flujo
Insulin reverses d-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells.
Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein.
Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation.
Impaired A2A adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia.
Supplementation with apple enriched with L-arginine may improve metabolic control and survival rate in alloxan-induced diabetic rats.
Biosynthesis of selenium nanoparticles by Pantoea agglomerans and their antioxidant activity
Insulin-increased L-arginine transport requires A(2A) adenosine receptors activation in human umbilical vein endothelium
L-arginine transport and nitric oxide synthesis in human endothelial progenitor cells
Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia.
Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation
A role for insulin on L-arginine transport in fetal endothelial dysfunction in hyperglycaemia
Reduced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia
High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium
Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia
Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters 1 and 2, and membrane hyperpolarization in human umbilical vein endothelium
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium

BookSection (1)

Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin

Patent (1)

PROCESO PARA OBTENER BIOLÓGICAMENTE NANOPARTÍCULAS DE SELENIO, ÚTILES EN LA SUPLEMENTACIÓN DIETARIA DE PERSONAS QUE PADECEN DEFICIENCIA DE SELENIO.

Proyecto (6)

Donut-shaped starch microparticles: preparation, characterization and applications
Caracterización de la expresión y actividad de hCATs, NADPH oxidasa y KCa en vasos sanguíneos de placenta humana proveniente de mujeres con diabetes gestacional.
Estudio de las alteraciones eléctricas y mecánicas de membrana plasmática de células endoteliales de vena umbilical humana en respuesta a la diabetes gestacional o condiciones estresantes relacionadas con la hiperglicemia.
Bio-obtención de nanopartículas de selenio encapsuladas en polisacáridos para su potencial uso como suplemento alimentario
Evaluation of novel technologies for the extraction, purification and stabilization of natural proanthocyanidins: functionalized as possible phytodrug
Regulation of expression and activity of hCAT-1 by reactive oxygen species in human endothelium exposed to insulin and high concentrations of D-glucose
11
Marcelo González

Profesor Asistente

Obstetricia y Ginecología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

1
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Paula Honorato

Colaborador docente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Claudia Radojkovic

PROFESOR ASOCIADO

DEPTO. BIOQUÍMICA CLÍNICA E INMUNOLOGÍA, FAC. FARMACIA, UNIV. CONCEPCIÓN

UNIVERSIDAD DE CONCEPCION

Concepción, Chile