Man

José Antonio Fuentealba Evans

Associate professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Neurobiology of drug addiction. Neurochemistry and electrophysiology of amphetamine locomotor sensitization and impulsive decision-making

Educación

  •  Biological Science, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chemistry

    Santaigo, Chile

    2006 - At present

Experiencia Profesional

  •   Associate Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2006 - At present

Formación de Capital Humano


I have mentored 14 undergraduate theses and 2 Ph.D. theses (co-tutor).

Specifically in the last three years (2015 al 2017), I have mentored 4 undregraduate thesis: Leandro Montecinos Pardo: “Effect of the kappa opioid receptor antagonist nor-BNI on impulsive choice, using the delay discounting paradigm”/2017, in progress); Catalina Paz Ruiz Salazar ("Analysis of dopamine transporter activity in the dorsolateral striatum of amphetamine sensitized rats"/2017); Gladys Sepulveda Vásquez (“Effect of blockade of kappa opioid receptors in dopaminergic neurotransmission in the dorsolateral striatum of rats treated repeatedly with amphetamine”/2015); Victor Azocar Garrido "Regulation of extracellular dopamine levels in the rat dorsolateral striatum: study with microdialysis no-net flux"/2015).
I have co-tutored 2 Ph.D thesis: Macarena Vergara ("Role of dopamine receptor type 4 of the prelímbic cortex in the consolidation of fear unconditioned"/2017) and Angélica Escobar “Interaction between the D2 dopamine receptor and the kappa opioid receptor in a rat model of the obsessive-compulsive disorder”
Currently, I am mentoring 3 Ph.D. thesis : Rafael Ignacio Gatica Hernandez (“Individual differences in amphetamine sensitization: Role of dorsolateral striatum”/2015); Macarena Moreno (“Dysfunction in oxytocinergic and dopaminergic systems on impulsive choice behavior, as measured by the delay discounting task"/2016); Enzo Perez Valenzuela “Effect of repeated exposure of win 55212-2 during adolescence on striatal dopaminergic transmission in adult rats”/2016). During March to August, Enzo Perez is carried out a short stay at the laboratory of Dr. Anthony Grace, Center for Neuroscience, University of Pittsburgh, USA.

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Difusión y Transferencia


In the last three years, I have been carried out differents outreach activities aimed at school children and at the level of state agencies. I highlight two activities of high relevance for the diffusion of the neurobiology of addiction and its implication in public policies:

1-The spanish translation of the book “The Addicted Brain” by the leading researcher Dr. Michael Kuhar. (Authors: Katia Gysling, José Fuentealba, Liliana Corvalán). El Cerebro Adicto (The Addicted Brain), Ediciones UC, 2016. (ISBN Nº: 978-956-14-1804-2.
2-I have an active advisor expert of the National Service for the Prevention and Rehabilitation of Drug and Alcohol (SENDA). In 2015 I worked on the document entitled "Construction of the Alcohol Action Plan SENDA-MINSAL 2017-2020 " designed to implement public policies for the prevention and rehabilitation of alcohol consumption in the Chilean population.



 

Article (22)

High impulsive choice is accompanied by an increase in dopamine release in rat dorsolateral striatum
Adolescent exposure to WIN 55212-2 render the nigrostriatal dopaminergic pathway activated during adulthood
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
Individual Differences in Amphetamine Locomotor Sensitization are Accompanied with Changes in Dopamine Release and Firing Pattern in the Dorsolateral Striatum of Rats
Comparing dopaminergic dynamics in the dorsolateral striatum between adolescent and adult rats: Effect of an acute dose of WIN55212-2
The blocking of kappa-opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization
Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior
Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats
The expression of amphetamine sensitization is dissociable from anxiety and aversive memory: Effect of an acute injection of amphetamine
AMPHETAMINE SENSITIZATION IS ACCOMPANIED BY AN INCREASE IN PRELIMBIC CORTEX ACTIVITY
Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function
Amphetamine locomotor sensitization is accompanied with an enhanced high K+-stimulated Dopamine release in the rat medial prefrontal cortex
Clozapine pre-treatment has a protracted hypolocomotor effect on the induction and expression of amphetamine sensitization
Long-term loss of dopamine release mediated by CRF-1 receptors in the rat lateral septum after repeated cocaine administration
Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats
Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain
Repeated Treatment With the kappa-Opioid Agonist U-69593 Increases K+-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex
Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593
Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases. Stimulated dopamine extracellular levels in the rat nucleus accumbens
PIAS gamma represses the transcriptional activation induced by the nuclear receptor Nurr1
Rapid increase of Nurr1 expression in the Substantia nigra after 6-hydroxydopamine lesion in the striatum of the rat
Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis

Abstract (1)

Functional and molecular interaction between D2 and kappa opioid receptors: role in locomotor sensitization to quinpirole

BookSection (1)

Avances en neurociencias y prevención (Advances in neuroscience and prevention)

BookWhole (2)

El cerebro Adicto (Spanish translation "The addicted brain")
Bases científicas de la drogadicción (Scientific bases of drug addiction)

ConferencePaper (2)

Amphetamine-induced behavioral sensitization and the dopaminergic system
Motivated Behaviors and Neuroplasticity: Role in Addiction

ConferencePoster (14)

Increase in DA-release in the striatal pathway is associated with high impulsive choice behavior
Effect of oxytocin receptor activation in nigro-striatal pathways on impulsive choice and striatal dopamine release
Neuronal correlates in the orbitofrontal cortex, nucleus Accumbens, and dorsolateral striatum during delay discounting task
“Adolescent cannabinoid exposure increases nigrostriatal dopaminergic transmission”
Individual differences on dorsolateral striatum single unit activity during amphetamine repeated administration in freely moving rats
“Activation of OXT-R in substancia nigra pars compacta induces an increase in extracellular levels of dopamine in dorsolateral striatum”
“Adolescent exposure of WIN55212-2 increases population activity of mesolimbic and nigrostriatal dopaminergic pathways”
Effect of amphetamine sensitization on single unit activity in the rat dorsolateral striatum
A significant increase of basal dopamine extracellular leveles in the rat dorsolateral striatum accompanies the expression of amphetamine-induced sensitization: effect of the kappa-opioid receptor antagonist norBNI
Kappa opioid control on dopamine basal levels in dorsal striatum: study of no-net flux microdialysis
Single unit activity in the dorsolateral striatum of amphetamine treated rats: preliminary results"
Amphetamine sensitization is accompanied by an increase in prelimbic cortex activity.
Kappa opioids receptors blockade attenuates the expression of locomotor amphetamine sensitization
Effect of inter-trial interval extension on open arm aversion in repeated exposure to elevated plus maze

Proyecto (4)

“Cannabis, adolescence and cognition”
THE INFLUENCE OF KAPPA OPIOID SYSTEM IN AMPHETAMINE-SENSITIZATION: STUDY OF THE KAPPA OPIOID RECEPTOR ACTIVITY ON DOPAMINE NEUROTRANSMISSION IN DORSOLATERAL STRIATUM OF AMPHETAMINE-SENSITIZED RATS.
Millenium Nucleus in Stress and Addiction
STUDY OF THE NEURONAL ACTIVITY OF THE RAT MEDIAL PREFRONTAL CORTEX AFTER REPEATED TREATMENT WITH AMPHETAMINE
46
José Fuentealba

Associate professor

Farmacy

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

13
María Andrés

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

8
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Francisca Cornejo

Assistant professor

Universidad Mayor

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Montserrat Olivares

Candidata a doctor

Biología celular y molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Andrea Gómez

Investigador Postdoctoral

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile