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Yedy Israel Jacard

Profesor Titular

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Alcoholismo, Modelos animales y estudios clinicos, Terapia Genica del alcoholismo, Neurofarmacología ,Diseño experimental, Farmacología de las adicciones, Terapia por celulas madre molecular de la dependencia al alcohol.

Bioquimica, UNIVERSITY OF TORONTO. Canada, 1965
Bioquimico, UNIVERSIDAD DE CHILE. Chile, 1962

Profesor Titular y Director Addiction Res Foundation Institute and Hospital Full Time

UNIVERSITY OF TORONTO

Medicine

Toronto, Canada

1970 - 1995
Professor and Co-Direct Alcohol Center Full Time

JEFFERSON UNIVERSITY

Medicine

Philadelphia, Estados Unidos

1994 - 2002
Profesor Titular Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1997 - At present
Profesor Titular y Dir Terapia Genica Full Time

UNIVERSIDAD DE CHILE

Ciencias Quimicas y Farmaceuticas

Santiago, Chile

1997 - 2013

Director Full Time

ADDICTION RESEARCH FOUNDATION CLINICAL INSTITUTE

Toronto, Canada

1998 - 1981
Co-Director Part Time

NIH Alcohol Research Center at Jefferson

Philadelphia, Estados Unidos

1999 - 2002
Associate Editor or Editorial Board Member Other

Addiction Biology and other Journals

Heidelberg-New Haven- Austin , Estados Unidos

1989 - At present

2016 Benjamin Erranz, Doctorado en Ciencias Biomedicas ( Director, de Doctorado Dr. Yedy Israel)

Esta tesis fue realizada en el Laboratorio de Farmacoterapia Génica bajo la dirección del Dr. Yedy Israel, quien recibió financiamiento para la realización de este proyecto del Instituto nacional de Salud de EE.UU. (Proyecto NIAAA R01-AA015421) y del Instituto de Dinámica Celular y Biotecnología (Proyecto P05-001-F), parte de la Iniciativa Científica Milenio.

Anteriores a 2016: 18 doctorados (9 en Canada o USA)

Patentes comercializadas en Canada (3 de 6).

Distinguished Research Award

Canada Pharmacological Society Upjohn Award

Canada, 1979

Animal Model of Alcoholic liver injury and treatment
Jellinek Alcoholism Award

The Jellinek International Award Foundation

Canada, 1980

Advances in the treatment of Alcoholic liver disease.
President U.S Alcoholism Research Society

U.S. Research Society on Alcoholism

Estados Unidos, 1999

Promoting Alcoholism Research
Miembro Correspondiente

Academia de Ciencias de Chile

Chile, 2001

Desarrolla en Chile el primer centro deTerapia Genica
Alcoholism Award International Society Biomed Res Alcoholism

International Society for Biomedical Reserach on Alcoholism

Estados Unidos, 2014

Alcoholism basic and clinical transference


INNATE GUT MICROBIOTA PREDISPOSES TO HIGH ALCOHOL CONSUMPTION Ezquer F, Quintanilla ME, Moya-Flores F, Morales P, Munita JM, Olivares B, Landskron G., Hermoso M, Ezquer M, Herrera-Marschitz M, Israel Y, Article ISI Scipus Addiction Bology (2021)
INTRANASAL ADMINISTRATION OF PRECONDITIONED MESENCHYMAL STEM CELL SECRETOME REDUCES OXIDATIVE STRESS, NEUROINFLAMMATION AND CELL DEATH IN HIPPOCAMPUS, ACTIVATING THE NRF2 PATHWAY, IMPROVING BEHAVIORAL AND COGNITIVE DEFICITS INDUCED BY PERINATAL ASPHYXIA Farfán N, Carril J,Redel M, Zamorano M, Araya M,Monzón, Alvarado RE,Paredes N,Tapia-Bustos A , MQuintanilla ME, zquer F, Valdés JL,Israel Y,Herrera-Marschitz, Morales MP. Article ISI Scopus INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
N-ACETYLCYSTEINE AND ACETYLSALICYLIC ACID INHIBIT ALCOHOL CONSUMPTION BY DIFFERENT MECHANISMS: COMBINED PROTECTION Quintanilla ME, Ezquer F, Morales P, Equer M, Olivares B, Santapau D, Herrera-Marschitz M Israel Y. Article ISI Scopus FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2020)
OXIDATIVE STRESS AND NEUROINFLAMMATION AS A PIVOT IN DRUG ABUSE. A FOCUS ON THE THERAPEUTIC POTENTIAL OF ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS AND BIOMOLECULES Berríos-Cárcamo P, Quezada M, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz, Israel Y, Ezquer F. Article ISI Scopus (2020)
ACTIVATION OF MITOCHONDRIAL ALDEHYDE DEHYDROGENASE (ALDH2) BY ALDA-1 REDUCES BOTH THE ACQUISITION AND MAINTENANCE OF ETHANOL INTAKE IN RATS: A DUAL MECHANISM? Rivera-Meza M, Vásquez D, Quintanilla ME, Lagos D, Rojas B, Herrera-Marschitz M, Israel Y. Article ISI Scopus NEUROPHARMACOLOGY (2019)
COMMONALITY OF ETHANOL AND NICOTINE REINFORCEMENT AND RELAPSE IN WISTAR-DERIVED UCHB RATS: INHIBITION BY N-ACETYLCYSTEINE Quintanilla ME, Morales P, Ezquer F, Ezquer M, Herrera-Marschitz M, Israel Y. Article ISI Scopus ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2018)
INTRANASAL DELIVERY OF MESENCHYMAL STEM CELL-DERIVED EXOSOMES REDUCES OXIDATIVE STRESS AND MARKEDLY INHIBITS ETHANOL CONSUMPTION AND POST-DEPRIVATION RELAPSE DRINKING Ezquer F, Quintanilla ME, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y. Article ISI Scopus ADDICTION BIOLOGY (2018)
NTRAVENOUS ADMINISTRATION OF ANTI-INFLAMMATORY MESENCHYMAL STEM CELL SPHEROIDS REDUCES CHRONIC ALCOHOL INTAKE AND ABOLISHES BINGE-DRINKING Ezquer F, Morales P, Quintanilla ME, Santapau D, Lespay-Rebolledo C, Ezquer M, Herrera-Marschitz M, Israel Y Article ISI Scopus SCIENTIFIC REPORTS (2018)
ACQUISITION, MAINTENANCE AND RELAPSE-LIKE ALCOHOL DRINKING:LESSONS FROM THE UCHB RAT LINE. Israel Y, Karahanian E, Ezquer F, Morales P, Ezquer M, Rivera-Meza M, Herrera-Marschitz M Quintanilla ME Article ISI Frontiers in Behaioral Neuroscience (2017)
ACTIVATED MESENCHYMAL STEM CELL ADMINISTRATION INHIBITS CHRONIC ALCOHOL DRINKING AND SUPPRESSES RELAPSE-LIKE DRINKING IN HIGH-ALCOHOL DRINKER RATS Ezquer F, Quintanilla ME, Morales P, Ezquer M Lespay-Rebolledo C, Herrera-Marschitz, Israel Y Article WOS ISI ADDICTION BIOLOGY (2017)
INTRACEREBRAL STEM CELL ADMINISTRATION INHIBITS RELAPSE-LIKE ALCOHOL DRINKING IN RATS Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz Article ISI and all others. Alcohol and Alcoholisml (2017)
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation Quintanilla M.E.; Rivera-Meza, M; Berríos-Cárcamo P.; Salinas-Luypaert, C; Herrera-Marschitz M.; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats Karahanian, E; Rivera-Meza, M; Tampier, L; Quintanilla M.E.; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS ADDICTION BIOLOGY (2015)
The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption Saba, LM; Flink, SC; Vanderlinden, LA; Israel, Y; Tampier, L; Colombo G.; Kiianmaa, K; Bell, RL; Printz, MP; Flodman, P; Koob, G; Richardson, HN; Lombardo, J; Hoffman, PL; Tabakoff, B Article ISI SCOPUS FEBS Journal (2015)
Fenofibrate - A lipid-lowering drug - Reduces voluntary alcohol drinking in rats Karahanian, E; Quintanilla, ME; Fernández K.; Israel, Y Article ISI SCOPUS ALCOHOL (2014)
The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats Tampier, L; Quintanilla, ME; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2013)
Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence Quintanilla M.E.; Tampier, L; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2012)
Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption? Israel, Y; Rivera-Meza, M; Quintanilla, ME; Sapag, A; Tampier, L Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2011)
Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects Karahanian, E; Quintanilla, ME; Tampier, L; Rivera-Meza, M; Bustamante D.; Gonzalez-Lira, V; Morales P.; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2011)
Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene Encina G.; Ezquer, F; Conget P.; Israel, Y Article ISI SCIELO SCOPUS Biological Research (2011)
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model Rivera-Meza, M; Quintanilla, ME; Tampier, L; Mura, CV; Sapag, A; Israel, Y Article ISI SCOPUS FASEB Journal (2010)
Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat Sapag, A; Gonzalez-Martinez, G; Lobos-Gonzalez, L; Encina G.; Tampier, L; Israel, Y; Quintanilla, ME Article ISI SCOPUS PHARMACOGENETICS AND GENOMICS (2009)
RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research Cortinez, G; Sapag, A; Israel, Y Article ISI SCOPUS ALCOHOL (2009)
Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats Bustamante D.; Quintanilla, ME; Tampier, L; Gonzalez-Lira, V; Israel, Y; Herrera-Marschitz, M Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Tolerance to disulfiram induced by chronic alcohol intake in the rat Tampier, L; Quintanilla, ME; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol Quintanilla, ME; Bustamante D.; Tampier, L; Israel, Y; Herrera-Marschitz, M Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective Quintanilla, ME; Tampier, L; Sapag, A; Gerdtzen, Z; Israel, Y Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Combined effects of aldehyde dehydrogenase variants and maternal mitochondrial genes on alcohol consumption Israel, Y; Quintanilla, ME; Sapag, A; Tampier, L Article ISI ALCOHOL RESEARCH & HEALTH (2006)
Hereditary hemochromatosis: An opportunity for gene therapy Ezquer, F; Nunez, MT; Rojas A.; Asenjo, J; Israel, Y Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA Karahanian, E; Ocaranza, P; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2005)
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis Ezquer, F; Nunez, MT; Israel, Y Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2005)
Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats Quintanilla, ME; Tampier, L; Valle-Prieto, A; Sapag, A; Israel, Y Article ISI SCOPUS FASEB JOURNAL (2005)
Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) in a Chinese population: Gender, age, culture, and genotypes of ALDH2 Luo, HR; Israel, Y; Tu, GC; Eriksson, CJP; Zhang, YP Article ISI SCOPUS Biochemical Genetics (2005)
Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides Ponnappa, BC; Israel, Y; Aini, M; Zhou F.; Russ, R; Cao, QN; Hu, YY; Rubin, R Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2005)
Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats Quintanilla, ME; Tampier, L; Sapag, A; Israel, Y Article ISI SCOPUS PHARMACOGENETICS AND GENOMICS (2005)
Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappa B cytokine gene expression, and liver injury in the rat Videla LA.; Tapia, G; Varela, P; Cornejo P.; Guerrero, J; Israel, Y; Fernández V. Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2004)
Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells Rodriguez, DA; Moncada, C; Nunez, MT; Lavandero S.; Ponnappa, BC; Israel, Y Article ISI ALCOHOL (2004)
Binding of acetaldehyde to a glutathione metabolite: Mass spectrometric characterization of an acetaldehyde-cysteinylglycine conjugate Anni, H; Pristatsky, P; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2003)
Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats Sapag, A; Tampier, L; Valle-Prieto, A; Quintanilla, ME; Moncada, C; Israel, Y Article ISI SCOPUS PHARMACOGENETICS (2003)
Use of an acetaldehyde clamp" in the determination of low-K-M aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells" Moncada, C; Fuentes N.; Lladser, A; Encina G.; Sapag, A; Karahanian, E; Israel, Y Article ISI SCOPUS ALCOHOL (2003)
Gene and antisense delivery in alcoholism research Israel, Y; Crews, FT; Thurman, RG; Tu, GC; Garver, E; Ponnappa, B; Karahanian, E; Rubin, R; Hoplight, B; Sethna, M; Hanes, R; Wilkie, MB; Wheeler, MD Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2002)
Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat Fernández V.; Videla LA.; Tapia, G; Israel, Y Article ISI SCOPUS FREE RADICAL RESEARCH (2002)
Proteomics in alcohol research Anni, H; Israel, Y Article ISI ALCOHOL RESEARCH & HEALTH (2002)
Targeting Kupffer cells with antisense oligonucleotides Ponnappa, BC; Israel, Y Article ISI FRONTIERS IN BIOSCIENCE-LANDMARK (2002)
The Research Society on Alcoholism Israel, Y; Lieber, CS Article ISI ADDICTION (2002)
Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol Garver, E; Tu, GC; Cao, QN; Aini, M; Zhou F.; Israel, Y Article ISI JOURNAL OF EXPERIMENTAL MEDICINE (2001)
In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-? in rats Ponnappa B.C.; Dey, I; Tu G.-C.; Zhou F.; Aini, M; Cao Q.-N.; Israel, Y Article SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2001)
In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats Ponnappa, BC; Dey, I; Tu, GC; Zhou F.; Aini, M; Cao, QN; Israel, Y Article ISI JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2001)
Protein binding of ?-hydroxyethyl free radicals Moncada, C; Israel, Y Article SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2001)
Protein binding of alpha-hydroxyethyl free radicals Moncada, C; Israel, Y Article ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2001)
Selection of phage-display library peptides recognizing ethanol targets on proteins Anni, H; Nikolaeva, O; Israel, Y Article ISI ALCOHOL (2001)
Paradigm to test a drug-induced aversion to ethanol Garver, E; Ross, AD; Tu, GC; Cao, QN; Zhou F.; Israel, Y Article ISI SCOPUS ALCOHOL AND ALCOHOLISM (2000)
Characterization of adducts of ethanol metabolites with cytochrome c Anni, H; Israel, Y Article Alcoholism Clinical and Experimental Research (1999)
Generation of acetate and production of ethyl-lysine in the reaction of acetaldehyde plus serum albumin Moncada, C; Israel, Y Article Alcohol (1999)
Tetranucleotide GGGA motif in primary RNA transcripts: Novel target site for antisense design Tu G.-C.; Cao Q.-N.; Zhou F.; Israel, Y Article JOURNAL OF BIOLOGICAL CHEMISTRY (1998)
ASPIRIN AND N-ACETYLCYSTEINE CO-ADMINISTRATION MARKEDLY INHIBIT CHRONIC ETHANOL INTAKE AND BLOCK RELAPSE BINGE DRINKING: ROLE OF NEUROINFLAMMATION-OXIDATIVE STRESS SELF-PERPETUATION Israel Y, Quintanilla ME, Morales P, Santapau D, Berrios-Carcamo P, Ezquer M, Herrera-Marschitz M. Article ISI Scopus ADDICTION BIOLOGY
INTRANASAL MESENCHYMAL STEM CELL SECRETOME ADMINISTRATION MARKEDLY INHIBITS ALCOHOL AND NICOTINE SELF-ADMINISTRATION AND BLOCKS RELAPSE-INTAKE: MECHANISM AND TRANSLATIONAL OPTIONS Quintanilla ME, Ezquer F, Morales P, Santapau D, Berríos-Cárcamo P, Ezquer M, Herrera-Marschitz M, Israel Y Article ISI Scopus STEM CELL RESEARCH AND THERAPY
Patents granted in the United States (three commercialized of total of six) Israel et al Article Several
Publications in Canada and United States (Total of 213 not listed) Israel et al Article Several


AN ANTICATALASE LENTIVIRAL VECTOR REDUCED ETHANOL INTAKE IN DEVELOPMENTALLY-LEAD-EXPOSED RATS Mattalloni, MS; Salinas, C; Quintanilla, ME; Herrera-Marschitz, M; Israel, Y; Cancela, LM; Rivera-Meza, M; Virgolini, MB Abstract ISI ALCOHOL AND ALCOHOLISM (2015)
FENOFIBRATE -A LIPID-LOWERING DRUG-INCREASES BLOOD ACETALDEHYDE LEVELS AND REDUCES VOLUNTARY ALCOHOL DRINKING IN RATS Karahanian, E; Rivera-Meza, M; Quintanilla, ME; Israel, Y Abstract ISI ALCOHOL AND ALCOHOLISM (2015)
A CLEAR PARADOX: AVERSIVE EFFECTS OF LIVER-GENERATED ACETALDEHYDE BUT REWARDING/REINFORCING EFFECTS OF ACETALDEHYDE GENERATED IN THE BRAIN Israel, Y; Quintanilla, ME; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)
SALSOLINOL, FREE OF ISOSALSOLINOL, EXERTS ETHANOL- LIKE MOTIVATIONAL/SENSITIZATION EFFECTS LEADING TO INCREASES IN ETHANOL INTAKE Quintanilla, ME; Rivera-Meza, M; Berrios-Carcamo, P; Bustamante D.; Buscaglia M.; Morales P.; Karahanian, E; Herrera-Marschitz, M; Israel, Y Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)
ACETALDEHYDE PROTECTS AGAINST ALCOHOLISM BUT IT ALSO PLAYS A ROLE IN THE DEVELOPMENT OF TOLERANCE AND DEPENDENCE Tampier, L; Quintanilla, ME; Rivera M.; Sapag, A; Israel, Y Abstract Alcoholism Clinical and Experimental Research (2010)
MICROINJECTION OF AN ANTI-CATALASE SHRNA-CODING LENTIVIRAL VECTOR INTO BRAIN VENTRAL TEGMENTAL AREA (VTA) VIRTUALLY ABOLISHES ETHANOL INTAKE BY RATS BRED AS HIGH ALCOHOL DRINKERS Karahanian, E; Quintanilla, ME; Tampier, L; Bustamante D.; Gonzalez-Lira, V; Morales P.; Herrera-Marschitz, M; Israel, Y Abstract Alcoholism Clinical and Experimental Research (2010)
ROLE OF ACETALDEHYDE ON THE MOTIVATIONAL PROPERTIES OF ETHANOL IN RATS BRED AS HEAVY DRINKERS Quintanilla, ME; Gonzalez-Lira, V; Bustamante D.; Tampier, L; Israel, Y; Herrera-Marschitz, M Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2010)
THE ACETALDEHYDE BURST: IT TAKES TWO TO TANGO Israel, Y; Rivera M.; Sapag, A; Quintanilla, ME; Tampier, L Abstract Alcoholism Clinical and Experimental Research (2009)
Pharmacogenetic and metabolic factors determining acetaldehyde levels and aversion to ethanol in animals and man Israel, Y; Sapag, A; Quintanilla, ME; Tampier, L; Gonzalez Mi Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
Four complex I proteins encoded in the mitochondrial genome are different in low drinker ucha and high drinker UChB rats Sapag, A; Gonzalez-Martinez, G; Encina G.; Lobos-Gonzalez, L; Quintanilla, ME; Tampier, L; Israel, Y Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2007)
Permissive and protective genes in alcoholism: Yin and Yang. Protection against alcoholism in a genetic model of alcohol dependence Israel, Y; Quintanilla, ME; Tampier, L; Ocaranza, P; Karahanian, E; Sapag, A Abstract ISI AMINO ACIDS (2007)
Autosomal and maternal genes influence alcohol intake in alcohol drinker and nondrinker rat lines: Role of the "acetaldehyde burst". Israel, Y; Quintanilla, ME; Sapag, A; Tampier, L Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2006)
Mitochondrial complex-I and aldehyde dehydrogenase (ALDH2) interactions determine an acetaldehyde burst and ethanol volition in animals: Genetic and pharmacological studies Israel, Y; Sapag, A; Quintanilla, ME; Karahanian, E; Ocaranza, P; Tampier, L Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2006)
Administration of an adenoviral vector carrying an ALDH2 antisense gene reduces ALDH2 activity and leads to an accummulation of acetaldehyde in rat hepatoma cells. Karahanian, E; Ocaranza, P; Israel, Y Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2005)
Polymorphisms in ALDH2 gene determine differences in peak acetaldehyde levels and voluntary ethanol consumption in rats. Quintanilla, ME; Templer, L; Sapag, A; Israel, Y Abstract ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2005)
Hemochromatosis: AAV coding an antisense gene against DIVIT-1 iron transporter in intestinal epithelial cells acts as RNAL and inhibits iron transport Ezquer FE; Nunez, MT; Israel, Y Abstract ISI MOLECULAR THERAPY (2004)


Dora B. Goldstein - In Memoriam Israel, Y; Crabbe, JC; Harris, RA BiographicalItem ISI ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2012)


Activation of nuclear factor KB and TNF-alpha response to thyroid hormone-induced liver oxidative stress Fernández V.; Tapia, G; Cornejo P.; Guerrero, J; Israel, Y; Videla LA. ConferencePaper ISI XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL (2002)


PPAR? agonists reduce alcohol drinking: Do they act in the brain or in the liver? Karahanian, E; Rivera-Meza, M; Quintanilla M.E.; Muñoz D; Fernández K.; Israel, Y Letter ISI SCOPUS Alcohol and Alcoholism (2015)


The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites Israel, Y; Quintanilla, ME; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M Review ISI SCOPUS Alcoholism: Clinical and Experimental Research (2015)
Gene specific modifications unravel ethanol and acetaldehyde actions Israel, Y; Rivera-Meza, M; Karahanian, E; Quintanilla, ME; Tampier, L; Morales P.; Herrera-Marschitz, M Review ISI SCOPUS Frontiers in Behavioral Neuroscience (2013)
Genetic and Environmental Influences on Ethanol Consumption: Perspectives From Preclinical Research Pautassi, RM; Camarini, R; Quadros, IM; Miczek, KA; Israel, Y Review ISI SCOPUS Alcoholism: Clinical and Experimental Research (2010)
The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake Quintanilla, ME; Israel, Y; Sapag, A; Tampier, L Review ISI ADDICTION BIOLOGY (2006)

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Paulette Conget

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Gabriel Cortinez

Académico

Depto. Recursos Naturales y Medio Ambiente

UNIVERSIDAD DE LOS LAGOS

Puerto Montt, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

Yedy Israel Jacard

Líneas de Investigación

Educación

Bioquimica, UNIVERSITY OF TORONTO. Canada, 1965

Bioquimico, UNIVERSIDAD DE CHILE. Chile, 1962

Experiencia Académica

Profesor Titular y Director Addiction Res Foundation Institute and Hospital Full Time

Professor and Co-Direct Alcohol Center Full Time

Profesor Titular Part Time

Profesor Titular y Dir Terapia Genica Full Time

Experiencia Profesional

Director Full Time

Co-Director Part Time

Associate Editor or Editorial Board Member Other

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Distinguished Research Award

Jellinek Alcoholism Award

President U.S Alcoholism Research Society

Miembro Correspondiente

Alcoholism Award International Society Biomed Res Alcoholism

Article (59)

Abstract (16)

BiographicalItem (1)

ConferencePaper (1)

Letter (1)

Review (4)