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Rodrigo Luis Castillo Peñaloza

Profesor Asistente

University of Chile

Santiago, Chile

Cardiovascular Pathophysiology Oxidative stress markers Intermittent hypobaric hypoxia Clinical Trials

Pharmacology, UNIVERSIDAD DE CHILE. Chile, 2011
Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 2006
Fellowship Internal Medicine, UNIVERSIDAD DE CHILE. Chile, 2021

Assitant Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2012 - 2017
Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2018 - At present

Emergency Medical Doctor Part Time

Centro de Referencia de Salud

Santiago, Chile

2008 - 2012
Emergency Medical Doctor Part Time

Hospital El Carmen de Maipú

Santiago, Chile

2014 - At present
Medico Residente Unidad de Paciente Crítico Part Time

Hospital del Salvador

Santaigo, Chile

2019 - At present

Liza Mardones Lobos. Undergraduate Doctor in Veterinary Medicine. University of Chile, December, 2013
Research Unit for Medical Students, Since 2012 (Unidades de Investigación y Ayudantes Alumnos), Facultad de Medicina, Universidad de Chile.
Short Stay tutoring for International Federation of Medical Students (IFMSA)

Miguel Aguilar, MD
Master Thesis of Pathophysiology
2016 - 2018
Title: "Hipoxia hipobárica intermitente: efectos agudos y crónicos en la función, estructura y estrés oxidativo cardiovascular"

Jorge Rodriguez-Borgues., Physiotherapist
Master Thesis of Pathophysiology
2016 - 2018
Title: "Marcadores de estrés oxidativo, capacidad antioxidante y estructura pulmonar en ratas expuestas a hipoxia intermitente"

Prevention of arrhythmias Merk Award

SOCIEDAD CHILENA DE CARDIOLOGIA

Chile, 2010

Congress of Chilean Society of Cardiology, Santiago.
Jorge Mardones Restat Award

SOCIEDAD DE FARMACOLOGIA DE CHILE

Chile, 2009

The best work of PhD student
III Premio Investigación Científica Universitaria

Santander Universia

Chile, 2015

"Cardioprotección con ácidos grasos omega 3 en patologías cardiovasculares en modelos animales y humanos: del Infarto Agudo al Miocardio a la Hipoxia Hipobárica Intermitente", con la que resultó ganador en la categoría Investigador Joven de la Tercera Edición del Premio a la Investigación Científica Universitaria (PIC) entregado por Universia.


Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies Carrasco, Rodrigo; Castillo, Rodrigo L.; Gormaz, Juan G.; Carrillo, Montserrat; Thavendiranathan, Paaladinesh Article ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep Gonzalez-Candia A.; Veliz M.; Carrasco-Pozo C.; Castillo, R. L.; CÃ¡rdenas J.C.; Ebensperger G.; Reyes, R. V.; Llanos, A. J.; Herrera, E. A. Article ISI SCOPUS REDOX BIOLOGY (2019)
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep. Gonzalez-Candia A, Veliz M, Carrasco-Pozo C, Castillo RL, Cárdenas JC, Ebensperger G, Reyes RV, Llanos AJ, Herrera EA Article Redox Biology (2019)
Effects of cryopreservation on mitochondrial function and sperm quality in fish Figueroa, E.; Lee-Estevez, M.; Valdebenito, I; Watanabe, I.; Oliveira, R. P. S.; Romero, J.; Castillo, R. L.; Farias, J. G. Article ISI SCOPUS AQUACULTURE (2019)
Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa Farias, JG., Zepeda, A., Castillo, RL., Figueroa, E., Ademoyero, O.T., Pulgar, V.M. Article ISI ANDROLOGIA (2018)
Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress Aguilar, M., González-Candia, A., Rodríguez, Jorge., Carrasco-Pozo, Catalina, Cañas, Daniel., García-Herrera, Claudio., Herrera, Emilio A., Castillo, RL. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats Castillo, RL; Herrera, EA; Gonzalez-Candia, A; Reyes-Farias, M; De La Jara, N; pena, jp; Carrasco-Pozo, C Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress. Farías, Jorge G; Molina, Víctor M; Carrasco, Rodrigo A; Zepeda, Andrea B; Figueroa, Elías; Letelier, Pablo; Castillo, Rodrigo L Article Nutrients (2017)
Effects of cryopreservation on mitochondria of fish spermatozoa Elías Figueroa, Iván Valdebenito, Andrea B. Zepeda, Carolina A. Figueroa, Kelly Dumorné, Rodrigo L. Castillo, Jorge G. Farias Article Reviews in Aqcuaculture (2017)
Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2 Farías JG1, Carrasco-Pozo C2, Carrasco Loza R3, Sepúlveda N4, Álvarez P5, Quezada M6,7, Quiñones J4, Molina V8, Castillo RL7. Article ISI SCOPUS EXPERIMENTAL BIOLOGY AND MEDICINE (2017)
Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-kappa B and Nrf2 Carrasco-Pozo, C; Castillo, RL; beltran, C; Miranda A.; Fuentes, J; Gotteland M. Article ISI SCOPUS JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2016)
3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol. Carrasco-Pozo C; Gotteland M; Castillo RL; Chen C. Article Experimental Cell Research (2015)
3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic beta-cells dysfunction induced by high cholesterol Carrasco-Pozo, C; Gotteland M.; Castillo, RL; Chen C. Article ISI SCOPUS Experimental Cell Research (2015)
Molecular aspects of breast cancer resistance to drugs (Review) Calaf, GM; Zepeda, AB; Castillo, RL; Figueroa, CA; Arias, C; Figueroa, E.; Farias, JG Article ISI SCOPUS International Journal of Oncology (2015)
omega 3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats Herrera, E. A.; Farías J.G.; Gonzalez-Candia, A; Short S.E.; Carrasco-Pozo, C; Castillo, R. L. Article ISI SCOPUS Marine Drugs (2015)
Omega 3 supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats. Herrera EA; Farías JG; González-Candia A; Short SE; Carrasco-Pozo C; Castillo RL. Article Marine Drugs (2015)
Pathophysiological Approaches of Acute Respiratory Distress Syndrome: Novel Bases for Study of Lung Injury Castillo, R. L.; Carrasco Loza R.; Romero-Dapueto C. Article SCOPUS Open Respiratory Medicine Journal (2015)
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures. Herrera EA; Farías JG; Ebensperger G; Reyes RV; Llanos AJ; Castillo RL. Article Pharmacological Research (2015)
Protective effects of polyunsatutared fatty acids supplementation against testicular damage induced by intermittent hypobaric hypoxia in rats Castillo, RL; Zepeda, AB; Short, SE; Figueroa, E.; Bustos-Obregon, E; Farias, JG Article ISI SCOPUS Journal of Biomedical Science (2015)
Transfusion-Related Acute Lung Injured (TRALI): Current Concepts Alvarez, P; Carrasco, R.; Romero-Dapueto C.; Castillo, R. L. Article SCOPUS Open Respiratory Medicine Journal (2015)
Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents. Álvarez P; Tapia L; Mardones LA; Pedemonte JC; Farías JG; Castillo RL. Article Chemico-Biological Interactions (2014)
Effects of Chronic Intermittent Hypoxia and Polyunsaturated Fatty Acids on Infarct Size and Oxidative Stress Markers in Cardiac Ischemia Reperfusion Rodrigo Castillo, Jorge G. Farias, Emilio A Herrera, Pedro I Alvarez, Stefania E Short, Luis Tapia, Rodrigo Carrasco and Ramon Sotomayor Article SCOPUS Experimental and Clinical Cardiology (2014)
Omega 3 chronic supplementation attenuates myocardial ischaemia-reperfusion injury through reinforcement of antioxidant defense system in rats Castillo RL, Arias C, Farías JG. Article ISI CELL BIOCHEMISTRY AND FUNCTION (2014)
A Randomized Controlled Trial to Prevent Post-Operative Atrial Fibrillation by Antioxidant Reinforcement Rodrigo R.; Korantzopoulos, P; Cereceda, M; Asenjo R.; Zamorano J.; Villalabeitia, E; Baeza, C.; Aguayo R.; Castillo R.; Carrasco, R.; Gormaz, JG Article ISI SCOPUS Journal of the American College of Cardiology (2013)
Relationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense system Castillo, Rodrigo L.; Carrasco, Rodrigo A.; Álvarez, Pedro I; RUIZ, MAURICIO; Luchsinger, Vivian; Zunino, Enna; Martínez, María A; Avendaño, Luis F Article ISI SCIELO SCOPUS Biological Research (2013)
Effect of Carvedilol and Nebivolol on Oxidative Stress-related Parameters and Endothelial Function in Patients with Essential Hypertension Zepeda R.J.; Castillo R.; Rodrigo R.; Prieto, J. C.; Aramburu, I; Brugere, S; Galdames K.; Noriega V.; Miranda, H. F. Article ISI SCOPUS Basic & clinical pharmacology & toxicology (2012)
Antioxidant Therapy Reduces Oxidative and Inflammatory Tissue Damage in Patients Subjected to Cardiac Surgery with Extracorporeal Circulation Castillo R.; Rodrigo R.; Pérez F.; Cereceda, M; Asenjo R.; Zamorano J.; Navarrete R.; Villalabeitia, E; Sanz J.; Baeza, C.; Aguayo R. Article ISI SCOPUS Basic & clinical pharmacology & toxicology (2011)
Oxidative stress as a novel target in pediatric sepsis management Von Dessauer, B; Bongain J.; Quilodran, J; Molina, V.; Castillo R.; Rodrigo R. Article ISI SCOPUS Journal of Critical Care (2011)
Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation Rodrigo R; Vinay J; Castillo RL; Cereceda M; Asenjo R; Zamorano J; Araya J; Castillo-Koch R; Espinoza J; Larraín E. Article International Journal of Cardiology (2010)
Nueva estrategia de preacondicionamiento no hipóxico que atenúa el efecto de la Isquemia-Reperfusión en pacientes sometidos a cirugía cardíaca con circulación extracorpórea Castillo, Rodrigo; Rodrigo, Ramon; Pizarro, Rodrigo; Escobar, Matias; Cereceda, Mauricio; Asenjo, René; Larrain, Ernesto; Castillo-Koch, Rodrigo; Espinoza, Juan; Sánchez,Gina; Donoso, Paulina; Araya, Julia Article SCIELO Revista chilena de cardiología (2009)
Non-hypoxic preconditioning of myocardium against postoperative atrial fibrillation: Mechanism based on enhancement of the antioxidant defense system Rodrigo R.; Castillo R.; Cereceda, M; Asenjo R.; Zamorano J.; Araya J. Article ISI SCOPUS MEDICAL HYPOTHESES (2007)
Chronic ethanol exposure does not impair urinary acidification even under stressful conditions Rodrigo R.; Rivera G.; Castillo R.; Guichard, C Article ISI SCOPUS Medical Science Monitor (2005)
Diminution of tissue lipid peroxidation in rats is related to the in vitro antioxidant capacity of wine Rodrigo R.; Castillo R.; Carrasco, R.; Huerta, P; Moreno, M. Article ISI SCOPUS LIFE SCIENCES (2005)


Cardiac Pharmacological Preconditioning Associated with Omega 3 Supplementation: Potential Clinical Applications Castillo RL. BookReview (2017)
No Ventilatory Complications of ARDS: Difficult Weaning and Intensive Care Unit-Acquired Weakness Castillo RL & Romero-Dapueto C BookReview (2017)


Acute respiratory failure: Pathophysiological basis from a multidisciplinary clinical approach Castillo, R. L. Editorial SCOPUS Open Respiratory Medicine Journal (2015)


Molecular basis of a novel theraphy for cardioprotection through the administration of polyunsaturated fatty acids and vitamins C and E. Rodrigo Castillo P Proyecto (2011)
MOLECULAR BASIS OF A NOVEL THERAPY FOR CARDIOPROTECTION THROUGH THE ADMINISTRATION OF POLYUNSATURATED FATTY ACIDS AND VITAMINS C AND E. FONDECYT (11110426) Proyecto 2011-2013 Inv. Responsable
“CARDIOPROTECCIÓN CON ACIDOS GRASOS OMEGA 3 EN PATOLOGÍAS CARDIOVASCULARES EN MODELOS ANIMALES Y HUMANOS: Del Infarto Agudo al Miocardio a la Hipoxia Hipobárica Intermitente.” Rodrigo Castillo P.; Jorge Farías, Emilio Herrera, Catalina Carrasco-Pozo, Rodrigo Carrasco Proyecto (0)


Dexmedetomidine Improves Cardiovascular and Ventilatory Outcomes in Critically Ill Patients: Basic and Clinical Approaches Castillo R.L.; Ibacache M.; CortÃnez I.; Carrasco-Pozo C.; FarÃas J.G.; Carrasco R.A.; Vargas-ErrÃ¡zuriz P.; Ramos D.; Benavente R.; Torres D.H.; MÃ©ndez A. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2020)
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress Farias, JG; Herrera EA; Carrasco-Pozo, C; Sotomayor-Zarate, R; Cruz, G.; Morales P.; Castillo, RL Review ISI SCOPUS PHARMACOLOGY THERAPEUTICS (2016)
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures Herrera EA; Farias, JG; Ebensperger G.; Reyes,RV; Llanos, AR; Castillo, RL Review ISI SCOPUS Pharmacological Research (2015)
Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents Álvarez P, Tapia L, Mardones LA, Pedemonte JC, Farías JG, Castillo RL Review ISI SCOPUS CHEMICO-BIOLOGICAL INTERACTIONS (2014)
Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications Rodrigo R.; Prieto, JC; Castillo R. Review ISI SCOPUS Clinical Science (2013)
Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS Zepeda, AB; Pessoa, A.; Castillo, RL; Figueroa, CA; Pulgar VM; Farias, JG Review ISI SCOPUS Cell Biochemistry and Function (2013)
Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation Rodrigo R.; Vinay, J; Castillo R.; Cereceda, M; Asenjo R.; Zamorano J.; Araya J.; Castillo-Koch, R; Espinoza J.; Larrain, E Review ISI SCOPUS International Journal of Cardiology (2010)
Prevention of atrial fibrillation following cardiac surgery: Basis for a novel therapeutic strategy based on non-hypoxic myocardial preconditioning Rodrigo R.; Cereceda, M; Castillo R.; Asenjo R.; Zamorano J.; Araya J.; Castillo-Koch, R; Espinoza J.; Larrain, E Review ISI PHARMACOLOGY THERAPEUTICS (2008)

Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

Jorge Farias

Full Professor

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

RODRIGO CARRASCO

Miembro titular

Sociedad Chilena de Cardiologia y Cirugia Cardiovascular

Oberageri, Suiza

Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

Elías Figueroa

Associate Professor.

Department of Biological and Chemical Sciences

Catholic University of Temuco

Temuco, Chile

CONSUELO ARIAS

Docente Investigador

Kinesiología

Universidad San Sebastián

Santiago , Chile

Juan Prieto

Profesor Titular

Programa de Farmacología Molecular y Clínica

Universidad de Chile

Santiago, Chile

Rubén Aguayo

Director de Departamento Medicina Interna Occidente

Departamento de Medicina Interna Occidente

Universidad de Chile

Santiago, Chile

Alejandro Gonzalez

investigador Postdoctoral

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

Gloria Calaf

Directora Laboratorio Biología del cáncer

Universidad de Tarapacá

Arica, Chile

Ramiro Zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

Victor Molina

Nestor Sepulveda

Profesor Titular A

Producción Agropecuaria

Universidad de La Frontera

TEMUCO, Chile

German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

Caroll Beltrán

Profesor Asistente, Investigador Principal

Medicina

Universidad de Chile, Fac Medicina

SANTIAGO, Chile

mauricio Ruiz

Jefe de Sección

Medicina Norte

Hospital Clínico Universidad de Chile

Santiago, Chile

Alfonso Miranda

Stefania Short

Profesional

Ingeniería Química

Universidad de La Frontera

Temuco, Chile

VIVIAN LUCHSINGER

Profesor Asociado

Virología

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA.

Santiago, Chile

Juan Gormaz

UNIVERSIDAD DE CHILE

Santiago, Chile

Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

Juan Pedemonte

Profesor Asistente

Anestesiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

Rodrigo Luis Castillo Peñaloza

Líneas de Investigación

Educación

Pharmacology, UNIVERSIDAD DE CHILE. Chile, 2011

Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 2006

Fellowship Internal Medicine, UNIVERSIDAD DE CHILE. Chile, 2021

Experiencia Académica

Assitant Professor Full Time

Profesor Asistente Full Time

Experiencia Profesional

Emergency Medical Doctor Part Time

Emergency Medical Doctor Part Time

Medico Residente Unidad de Paciente Crítico Part Time

Formación de Capital Humano

Premios y Distinciones

Prevention of arrhythmias Merk Award

Jorge Mardones Restat Award

III Premio Investigación Científica Universitaria

Article (33)

BookReview (2)

Editorial (1)

Proyecto (3)

MOLECULAR BASIS OF A NOVEL THERAPY FOR CARDIOPROTECTION THROUGH THE ADMINISTRATION OF POLYUNSATURATED FATTY ACIDS AND VITAMINS C AND E.

Review (8)