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Johanna Patricia Ábrigo León

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

Líneas de Investigación


- Estudio de mecanismos y vías de señalización involucradas en el desarrollo de atrofia muscular esquelética producto de enfermedades crónicas en modelos in vivo e in vitro. - Expresión, purificación y análisis termodinámicos de proteínas.

Educación

  •  Biociencias Moleculares, UNIVERSIDAD ANDRES BELLO. Chile, 2019

Experiencia Profesional

  •   Investigador post-doctoral Part Time

    Centro Interdisciplinario de Neurociencia de Valparaíso

    Valparaíso-Santiago, Chile

    2020 - At present

Premios y Distinciones

  •   Mejor tesis doctoral

    UNIVERSIDAD ANDRES BELLO

    Chile, 2019

    Premio a la mejor tesis doctoral año 2019, considerando publicaciones y logros obtenidos durante el desarrollo de la tesis.


 

Article (22)

Angiotensin (1-7) decreases myostatin-induced NF-kb signaling and skeletal muscle atrophy

Aravena J.; Abrigo J.; Gonzalez F.; Aguirre F.; Gonzalez A.; Simon F.; Cabello-verrugio C.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease

Abrigo, Johanna; Marin, Tabita; Aguirre, Francisco; Tacchi, Franco; Vilos, Cristian; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Cabello-Verrugio, Claudio

Article ISI SCOPUS
CURRENT MOLECULAR MEDICINE  (2020)

Mitochondrial Dysfunction in Skeletal Muscle Pathologies

Abrigo, Johanna; Simon, Felipe; Cabrera, Daniel; Vilos, Cristian; Cabello-Verrugio, Claudio

Article ISI SCOPUS
CURRENT PROTEIN & PEPTIDE SCIENCE  (2019)

The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Perez, Viviana; Bermedo-Garcia, Francisca; Zelada, Diego; Court, Felipe A.; Angel Perez, Miguel; Fuenzalida, Marco; Abrigo, Johanna; Cabello-Verrugio, Claudio; Moya-Alvarado, Guillermo; Carlos Tapia, Juan; Valenzuela, Vicente; Hetz, Claudio; Bronfman, Francisca C.; Pablo Henriquez, Juan

Article ISI SCOPUS
ACTA NEUROPATHOLOGICA COMMUNICATIONS  (2019)

Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia

Abrigo, Johanna; ELorza, Alvaro A.; Riedel, Claudia A; Vilos, Cristian; Simon, Felipe; Cabrera, Daniel; Estrada, Lisbell; Cabello-Verrugio, Claudio

Article ISI
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY  (2018)

Sarcopenia in a mice model of chronic liver disease=> Role of the ubiquitin-proteasome system and oxidative stress.

Fabián Campos, Johanna Ábrigo; Francisco Aguirre, Bruno Garcés; Marco Arrese, Saul Karpen; Daniel Cabrera, Marcelo Andía

Article
Pflügers Archiv - European Journal of Physiology  (2018)

Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation

Cabrera, D; Cabello-Verrugio, C; Solis, N; San Martin D.; Cofre, C; Pizarro, M; Arab, JP; Abrigo, J; Campos, F; Irigoyen, B; Carrasco-Avino, G; Bezares, K; Riquelme, V; Riquelme, A; Arrese, M; Barrera, F

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

TGF-ß requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy.

Johanna Ábrigo, Fabián Campo; Felipe Simon, Claudia Riedel; Daniel Cabrera, Cristian Vilos

Article
Journal of Biological Chemistry  (2018)

Central role of Transforming Growth Factor Type Beta 1 in skeletal muscle dysfunctions=> an update on therapeutic strategies.

Johanna Abrigo, Felipe Simon; Daniel Cabrera, Gonzalo Cordova

Article
Current Protein and Peptide Science  (2017)

The complex of PAMAM-OH dendrimer with Angiotensin (1-7) prevented the disuse-induced skeletal muscle atrophy in mice

Márquez-Miranda V.; Abrigo J.; Rivera J.C.; Araya-Durán I.; Aravena J.; Simon F.; Pacheco N.; González-Nilo F.D.; Cabello-Verrugio C.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF NANOMEDICINE  (2017)

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Morales M.G.; Abrigo, J; Acuna M.J.; Santos R.A.; Bader M.; Brandan, E.; Simon F.; Olguin, H; cabrera, D; Cabello-Verrugio C.

Article ISI SCOPUS
DISEASE MODELS & MECHANISMS  (2016)

High fat diet-induced skeletal muscle wasting is decreased by mesenchymal stem cells administration=> implications on oxidative stress, ubiquitin proteasome pathway activation, and myonuclear apoptosis.

Johanna Ábrigo, Juan Carlos Rivera; Javier Aravena, Daniel Cabrera; Felipe Simon, Fernando Ezquer

Article
Oxidative Medicine and Cellular Longevity  (2016)

New formulation based on anti-atrophic peptides and dendrimers for skeletal muscle atrophy treatment.

Valeria Márquez-Miranda, Johanna Ábrigo; Juan Carlos Rivera, Ingrid Araya-Durán; Javier Aravena, Nicolás Pacheco

Article
Nanoscale  (2016)

Transforming growth factor type beta (TGF-beta) requires reactive oxygen species to induce skeletal muscle atrophy

Abrigo, J; Rivera J.C.; Simon F.; cabrera, D; Cabello-Verrugio C.

Article ISI SCOPUS
CELLULAR SIGNALLING  (2016)

Angiotensin-(1-7) attenuates disuse-induced skeletal muscle atrophy via the Mas receptor

María Gabriela Morales, Maria Jose Acuña; Robson Santos, Michael Bader; Enrique Brandan, Felipe Simon

Article
Disease Models & Mechanisms  (2015)

Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

Cisternas, F.; Morales, MG; Meneses, C.; Simon F.; Brandan, E.; Abrigo, J; Vazquez, Y; Cabello-Verrugio, C

Article ISI
CLINICAL SCIENCE  (2015)

Apocynin inhibits the upregulation of TGF-beta(1) expression and ROS production induced by TGF-beta in skeletal muscle cells

Abrigo, J; Morales, MG; Simon F.; cabrera, D; Di CApua G; Cabello-Verrugio, C

Article ISI SCOPUS
Phytomedicine  (2015)

The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

Meneses, C.; Morales M.; Abrigo, J; Simon F.; Brandan, E.; Cabello-Verrugio, C

Article ISI SCOPUS
Pflugers Archiv European Journal of Physiology  (2015)

Transforming growth factor type beta (TGF-b) requires reactive oxygen species to induce skeletal muscle atrophy

Johanna Ábrigo, Felipe Simon

Article
Cellular Signalling  (2015)

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Morales M.G.; Abrigo, J; Meneses, C.; Cisternas, F.; Simon F.; Cabello-Verrugio C.

Article ISI SCOPUS
Histochemistry and Cell Biology  (2014)

The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-beta 1 induced by AngII in mouse skeletal muscle

Morales, MG; Abrigo, J; Meneses, C.; Simon F.; Cisternas, F.; Rivera, JC; Vazquez, Y; Cabello-Verrugio, C

Article ISI SCOPUS
CLINICAL SCIENCE  (2014)

The Ang-(1–7)/Mas-1 axis attenuates the expression and signalling of TGF-beta1 induced by AngII in mouse skeletal muscle

María Gabriela Morales, Johanna Ábrigo; Carla Meneses, Felipe Simon; Franco Cisternas, Juan Carlos Rivera

Article
Clinical Science  (2014)

Abstract (1)

Transforming growth factor type beta 1 (TGF-beta 1) induces skeletal muscle atrophy by a mechanism dependent of NADPH oxidase-induced reactive oxygen species.

Abrigo, J; Morales, MG; Simon F.; Cabello-Verrugio, C

Abstract ISI
MOLECULAR BIOLOGY OF THE CELL  (2014)

Proyecto (5)

Role of Renin angiotensin system in myogenesis and muscle regeneration=> new combined therapeutic strategies based in nanomedicine for muscular dystrophies

ECOS CONICYT (C16S02)

Proyecto
2017-2019
Personal técnico y/o de apoyo

Mechanisms involved in the cachexia induced by chronic liver diseases

FONDECYT (1161646)

Proyecto
2016-2019
Tesista

Effects of Angiotensin 1-7 in Cell Death by Apoptosis on Angiotensin II-induced Skeletal Muscle Atrophy

UNAB REGULAR (UNAB DI-281-13/R)

Proyecto
2013-2015
Personal técnico y/o de apoyo

Role of Angiotensin 1-7 on skeletal muscle wasting

Association-Francaise Contre Les Myopathies (AFM 16670)

Proyecto
2013-2016
Personal técnico y/o de apoyo

Anti-atrophic role of angiotensin 1-7 on skeletal muscle

FONDECYT (1120380)

Proyecto
2012-2016
Personal técnico y/o de apoyo

15
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

12
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

12
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

5
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

3
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

3
Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

2
Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

1
Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Nicolas Pacheco

PROFESOR ADJUNTO

CIENCIAS BIOLOGICAS

Universidad Andrés Bello

Santiago centro, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

1
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Andrea González

Docente

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

1
MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile