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Daniel Alejandro Cabrera Garcia

Investigador Adjunto

Pontificia Universidad Catolica de Chile

santiago, Chile

Líneas de Investigación


Hepatologia; Fisiopatologia Musculo-esqueletica; Diferenciacion celular

Educación

  •  Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Doctor en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2023

Experiencia Académica

  •   Profesor Asistente Part Time

    UNIVERSIDAD BERNARDO O'HIGGINS

    Salud

    Santiago, Chile

    2011 - At present

  •   Docente Part Time

    UNIVERSIDAD DIEGO PORTALES

    Salud

    Santiago, Chile

    2010 - 2011

  •   Docente a cargo del curso "La guerra de los priones". Part Time

    PENTA-UC

    Santiago, Chile

    2011 - 2012

  •   Docente a cargo del curso "Fuerza y movimiento: Biología celular y molecular del músculo esquelético". Part Time

    PENTA-UC

    Santiago, Chile

    2010 - 2011

  •   Instructor curso Biologìa Celular Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2008 - 2009

  •   Ayudante del curso "Metabolismo". Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2004 - 2006

  •   Ayudante del curso "Genetica Molecular Avanzada". Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2004 - 2006

  •   Investigador adjunto Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2017 - At present

Experiencia Profesional

  •   Postdoctorado Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2013 - 2015

  •   Profesor asistente Part Time

    Universidad Bernardo O´Higgins

    Chile

    2013 - At present

  •   Docente a cargo del curso "La guerra de los priones". Part Time

    PENTA-UC

    Santiago, Chile

    2011 - 2012

  •   Docente a cargo del curso "Fuerza y movimiento: Biología celular y molecular del músculo esquelético". Part Time

    PENTA-UC

    Santiago, Chile

    2010 - 2011

  •   Instructor del curso "Biología Celular". Part Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2008 - 2009

  •   Ayudante del curso "Genética Molecular Avanzada". Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2004 - 2006

  •   Ayudante del curso "Metabolismo". P Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2004 - 2006

  •   Investigador adjunto Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2017 - At present

Formación de Capital Humano


Tesis postitulo en Medicina interna sub especialidad Gastroenterologia:

- Dr. Alex Ruiz (2015)
- Dr. Ricardo Cruz (2016)
- Dr. Diego San MArtin (2017)
- Dr. Rodrigo Cruz (2017)

Tesis Lic. En Biologia:

- Srta. Pamela Rojas de Santiago (2015).


Difusión y Transferencia


Patentamiento:

Daniel Cabrera, Jaime GUTIERREZ, Gabriela Morales, Claudio CABELLO-VERRUGIO, Juan Hancke y Enrique Brandan. Pharmaco-cellular therapeutic method for the treatment of muscular dystrophies. US20140271573 A1. US 14/213,403. (http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=20140271573.PGNR.)

Difusion programa Explora-Conicyt:

2009 charla “Cuerpo y movimiento” en el Liceo Nuestra Señora de la Mercedes y Colegio Alma Mater.
2012 charla “Daño y regeneración celular” y “Uso de una droga botánica para el tratamiento de la distrofia muscular de Duchenne” en el Liceo N°1 Javiera Carrera
2019 Programa Pasantías Científicas Escolares “Protagonistas de la Ciencia 2019” con alumnos del Colegio Santa María Goretti, proyecto "Señalización paracrina en modelos in vitro de enfermedad de Hígado graso no alcohólico"


Premios y Distinciones

  •   Premio Padre Hurtado

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2001

    Premio Excelencia Académica

  •   Premio Mejor Tesis

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2007

    Premio a la mejor tesis en Ciencias Biológicas

  •   Premio COPEC-UC

    FUNDACION COPEC UNIVERSIDAD CATOLICA

    Chile, 2013

    Premio a la innovacion y al patentamiento

  •   1er seleccionado Pasantìa doctoral en el extranjero

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2012

    1er seleccionado Pasantìa doctoral en la UCLA de Estados Unidos

  •   Beca Presidente de la Republica

    Gobierno de Chile

    Chile, 2001

    Premios a la excelencia académica

  •   Beca Juan Gómez Millas

    MINEDUC

    Chile, 2001

    Beca excelencia Académica

  •   Beca CONICYT

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2007

    Beca CONICYT para estudios de Doctorado

  •   Postdoctorado FONDECYT

    FONDO NACIONAL DE CIENCIA,TECNOLOGIA E INNOVACION

    Chile, 2013

    Beca para formacion post doctoral


 

Article (41)

Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles



Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2020)

Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12

Sehrawat T.S.; Simonetto, D; Yaqoob U.; Kostallari E.; Kisseleva T.; Oh Y.

Article ISI SCOPUS
JOURNAL OF HEPATOLOGY  (2020)

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease

Abrigo, Johanna; Marin, Tabita; Tacchi, Franco; Vilos, Cristian; Simon, Felipe

Article ISI SCOPUS
CURRENT MOLECULAR MEDICINE  (2020)

Intrahepatic fatty acids composition as a biomarker of NAFLD progression from steatosis to NASH by using H-1-MRS

Zacconi, F.; Gainza C.; Andia, ME

Article ISI SCOPUS
RSC ADVANCES  (2019)

Mitochondrial Dysfunction in Skeletal Muscle Pathologies

Abrigo, Johanna; Simon, Felipe; Vilos, Cristian

Article ISI SCOPUS
CURRENT PROTEIN & PEPTIDE SCIENCE  (2019)

Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients

Rolle, A; Anderson, BJ; Quezada, N; Solari, S; Allende, F; Contreras, V; Oliveros, AM; Ibacache M

Article ISI SCOPUS
BRITISH JOURNAL OF ANAESTHESIA  (2018)

Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus.

Rivera, Daniela S; Lindsay, Carolina B; Codocedo, Juan F; Carreño, Laura E; Cabrera, Daniel; Arrese, Marco A; Vio, Carlos P; Bozinovic, Francisco; Inestrosa, Nibaldo C

Article
Molecular neurobiology  (2018)

Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia.

Ábrigo, Johanna; Elorza, Alvaro A; Riedel, Claudia A; Vilos, Cristian; Simon, Felipe; Cabrera, Daniel; Estrada, Lisbell; Cabello-Verrugio, Claudio

Article
Oxidative medicine and cellular longevity  (2018)

Sarcopenia in a mice model of chronic liver disease=> role of the ubiquitin-proteasome system and oxidative stress.

Campos, Fabián; Abrigo, Johanna; Aguirre, Francisco; Garcés, Bruno; Arrese, Marco; Karpen, Saul; Cabrera, Daniel; Andía, Marcelo E; Simon, Felipe; Cabello-Verrugio, Claudio

Article
Pflugers Archiv => European journal of physiology  (2018)

Sarcopenia induction in a mouse model of chronic cholestatic liver disease: Role of the ubiquitin-proteasome system and oxidative stress

Garces, B.

Article ISI
JOURNAL OF HEPATOLOGY  (2018)

Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease=> Beneficial Hepatic and Systemic Effects of Hormone Supplementation.

Cabrera, Daniel; Cabello-Verrugio, Claudio; Solís, Nancy; San Martín, Diego; Cofré, Catalina; Pizarro, Margarita; Arab, Juan Pablo; Abrigo, Johanna; Campos, Fabián; Irigoyen, Betzabé; Carrasco-Avino, Gonzalo; Bezares, Katiuska; Riquelme, Valentina; Riquelme, Arnoldo; Arrese, Marco; Barrera, Francisco

Article
International journal of molecular sciences  (2018)

TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy.

Ábrigo, Johanna; Campos, Fabian; Simon, Felipe; Riedel, Claudia; Cabrera, Daniel; Vilos, Cristian; Cabello-Verrugio, Claudio

Article
Biological chemistry  (2018)

The pro-fibrotic connective tissue growth factor ( CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle

Goldschmeding, R

Article ISI
Journal of Cell Communication and Signaling  (2018)

Transforming Growth Factor Beta Type I Role in Neurodegeneration=> Implications for Alzheimer´s Disease.

Estrada, Lisbell D; Oliveira-Cruz, Luciana; Cabrera, Daniel

Article
Current protein & peptide science  (2018)

Triggering and resolution of inflammation in NASH.

Schuster, Susanne; Cabrera, Daniel; Arrese, Marco; Feldstein, Ariel E

Article
Nature reviews. Gastroenterology & hepatology  (2018)

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Cabrera D., Wree A., Povero D., Solís N., Hernandez A., Pizarro M., Moshage, H., Torres, J., Feldstein AE., Cabello-Verrugio C., Brandan E., Barrera F., Arab JP. and Arrese M.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2017)

Bile Acids in Cholestasis and its Treatment

Cabrera, Daniel

Article ISI SCOPUS
Annals of Hepatology  (2017)

TGF-b in HCC: When a friend Becomes an enemy?

Arrese M., Hernandez A., Astete F., Cabrera D.

Article
Current Protein and Peptide Science  (2017)

The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle



Article SCOPUS
Journal of Cell Communication and Signaling  (2017)

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Morales, MG; Abrigo, J; Bader M.; Brandan, E.; Simon, F; Olguin, H; cabrera, D

Article ISI SCOPUS
DISEASE MODELS & MECHANISMS  (2016)

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-beta) via Mas Receptor Activation



Article ISI SCOPUS
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY  (2016)

Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1.

Cabrera, Daniel; Ruiz, Alex; Cabello-Verrugio, Claudio; Brandan, Enrique; Estrada, Lisbell; Pizarro, Margarita; Solis, Nancy; Torres, Javiera; Barrera, Francisco; Arrese, Marco

Article
DIGESTIVE DISEASES AND SCIENCES  (2016)

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis



Article ISI SCOPUS
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY  (2016)

Innate Immunity and Inflammation in NAFLD/NASH

Arrese, Marco; Cabrera, Daniel; Kalergis, Alexis; Feldstein, Ariel

Article
DIGESTIVE DISEASES AND SCIENCES  (2016)

Transforming growth factor type beta (TGF-beta) requires reactive oxygen species to induce skeletal muscle atrophy

Abrigo, J; Simon, F; cabrera, D

Article ISI SCOPUS
CELLULAR SIGNALLING  (2016)

Apocynin inhibits the upregulation of TGF-beta(1) expression and ROS production induced by TGF-beta in skeletal muscle cells

Abrigo, J; Simon, F; cabrera, D; Di CApua G; Cabello-Verrugio, C

Article ISI SCOPUS
Phytomedicine  (2015)

Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis

Pizarro, M; Solís N.; Quintero, P.; Barrera F.; cabrera, D; Rojas-de Santiago, P; Arab, JP; Padilla, O; Moshage, H; Wree, A; et al.

Article ISI SCOPUS
Liver International  (2015)

NFkB inhibition by Andrographolide ameliorates inflammation and fibrogenesis through inflammasome substrate depletion in experimental Non-Alcoholic Steatohepatitis (NASH)

Cabrera, Daniel; Wree, Alex; Povero, Davide; Solis, Nancy; Pizarro, Margarita; Rojas de Santiago, Pamela; Torres, Javiera; Moshage, Han; Cabello-Verrugio, Claudio; Feldstein, Ariel; Brandan, Enrique

Article
HEPATOLOGY  (2015)

Renin‐Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

Claudio Cabello‐ Verrugio, María Gabriela Morales, Juan Carlos Rivera, Daniel Cabrera, Felipe Simon

Article
MEDICINAL RESEARCH REVIEWS  (2015)

ACE2 Is Augmented in Dystrophic Skeletal Muscle and Plays a Role in Decreasing Associated Fibrosis

Riquelme, Cecilia; Acua, Mara Jos; Torrejn, Javiera; Rebolledo, Daniela; Cabrera, Daniel; Santos, Robson A.; Brandan, Enrique; Sampaolesi, Maurilio

Article ISI SCOPUS
PLOS ONE  (2014)

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

Cabrera, Daniel; Gutiérrez, Jaime; Cabello-Verrugio, Claudio; Morales, Maria; Mezzano, Sergio; Fadic, Ricardo; Casar, Juan; Hancke, Juan L.; Brandan, Enrique

Article ISI SCOPUS
SKELETAL MUSCLE  (2014)

Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells

Gutierrez, J.; cabrera, D; Brandan, E.

Article ISI
SKELETAL MUSCLE  (2014)

Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy

Pessina P; cabrera, D; Riquelme, C; Gutierrez, J.; Serrano, AL.; Brandan, E.; Munoz-Canoves, P

Article ISI SCOPUS
SKELETAL MUSCLE  (2014)

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling

Acuña MJ; Pessina P; Olguin, H; cabrera, D; Bader M.; Munoz-Canoves, P; Santos RA; Cabello-Verrugio, C; Brandan, E.

Article ISI
HUMAN MOLECULAR GENETICS  (2014)

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

cabrera, D; Cespedes, C; Vazquez, Y; Brandan, E.; Cabello-Verrugio, C

Article ISI SCOPUS
Cell and Tissue Research  (2013)

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

Gutierrez, J.; Cabello-Verrugio, C; cabrera, D; Lipson, KE; Goldschmeding, R; Brandan, E.

Article ISI SCOPUS
Human Molecular Genetics  (2013)

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

Cabello-Verrugio, C; Morales, MG; cabrera, D; Vio C.P.; Brandan, E.

Article ISI SCOPUS
Journal of Cellular and Molecular Medicine  (2012)

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

Cabello-Verrugio, C; Santander, C; cabrera, D; Goldschmeding, R; Brandan, E.

Article ISI SCOPUS
Journal of Pathology  (2011)

Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity

Vial, C; Gutierrez, J.; Santander, C; cabrera, D; Brandan, E.

Article ISI SCOPUS
Journal of Biological Chemistry  (2011)

Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2

Mezzano, Valeria; Vial, Cecilia

Article ISI
Journal of Cell Communication and Signaling  (2007)

Increase in decorin and biglycan in Duchenne Muscular Dystrophy: role of fibroblasts as cell source of these proteoglycans in the disease

Fadic, R; Mezzano, V; Alvarez, K; cabrera, D; Holmgren, J; Brandan, E.

Article ISI SCOPUS
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE  (2006)

Abstract (4)

NFkB inhibition by Andrographolide ameliorates inflammation and fibrogenesis through inflammasome substrate depletion in experimental Non-Alcoholic Steatohepatitis (NASH)

cabrera, D; Wree, A; Povero, D; Solís N.; Pizarro, M; de Santiago, PR; Torres, J; Moshage, H; Cabello-Verrugio, C; Feldstein, AE; et al.

Abstract ISI
HEPATOLOGY  (2015)

Role of Fcgamma receptors in experimental Non-Alcoholic Steatohepatitis

cabrera, D; Jara, E; Cruz, R; Munoz-Durango, N; de Santiago, PR; Kalergis, A; Arrese, M

Abstract ISI
HEPATOLOGY  (2015)

Diet-induced nonalcoholic fatty liver disease is associated with sarcopenia and decreased serum insulin growth factor-1

Ruiz, A; cabrera, D; Quintero, P.; Pizarro, M; Solís N.; Torres, J; Cabello-Verrugio, C; Brandan, E.; Barrera F.; Arrese, M

Abstract ISI
HEPATOLOGY  (2014)

Effects of andrographolide in experimental non-alcoholic steatohepatitis

cabrera, D; Pizarro, M; Solís N.; Torres, J; Brandan, E.; Arrese, M

Abstract ISI
HEPATOLOGY  (2013)

BookWhole (1)

UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications



BookWhole SCOPUS
Handbook of Experimental Pharmacology  (2019)

ConferencePaper (1)

Hepatic Fatty Acid Profile in Mice with Nonalcoholic Fatty Liver Disease Using Magnetic Resonance Spectroscopy

Zacconi, F.

ConferencePaper ISI SCOPUS
INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS 2022, ICBHI 2022  (2019)

ConferencePoster (6)

NOVEL INSIGHTS INTO THE CROSSTALK BETWEEN MINERALOCORTICOID RECEPTOR AND EXTRACELLULAR VESICLES IN KUPFFER CELLS ACTIVATION IN NASH

Jara, Evelyn; Freire Cortes, Mariela; Leon, Jonathan

ConferencePoster
 (2019)

Chemical Hypoxia Determines Extracellular Vesicles Release from Fat-Laden Hepatocytes and Cellular Crosstalk with Hepatic Stellate Cells

Geng, Yana; Barrera, Francisco

ConferencePoster
 (2018)

Extracellular Vesicles Release from Fat-Laden Hepatocytes activates Kupffer Cells through MR activation.

Barrera, Francisco; Moshage, Han

ConferencePoster
 (2018)

Inflammasome substrate depletion by Andrographolide improves Non-Alcoholic Steatohepatitis

Povero, D; Wree, A

ConferencePoster
 (2015)

Assessment of intestinal barrier function in mice with non-alcoholic fatty liver disease subjected to intermittent hypoxia

Cruz, Rodrigo; Barrera, Francisco

ConferencePoster
 

The hypoxia-mimetic agent CoCl2 induces proinflammatory and profibrotic signals as well as inflammasome activation in liver cells

Barrera, Francisco

ConferencePoster
 

EditorialMaterial (1)

Obeticholic acid: expanding the therapeutic landscape of NASH

Arrese, M; cabrera, D; Barrera F.

EditorialMaterial ISI
ANNALS OF HEPATOLOGY  (2015)

Proyecto (34)

Bile acids and extracellular vesicles as novel biomarkers to stratify the severity of alcohol­related liver disease: from binge drinking to alcoholic hepatitis



Proyecto
 (2020)

RANTES, a new myokine, participates in the chronic liver disease-associated sarcopenia.



Proyecto
 (2020)

Assessing the role of bile acids (BA) in NASH-related hepatocellular carcinoma



Proyecto
 (2019)

Dissecting therapeutic role of Growth Hormone and Insulin-like Growth Factor 1 in chronic liver disease: balancing between hepatocyte protection and oncogenic potential



Proyecto
 (2019)

Role of Angiotensin 1-7 on skeletal muscle wasting

Association-Francaise Contre Les Myopathies (AFM) (AFM 16670)

Proyecto
2017-2032
Investigador(a)

Searching for the missing link between hepatocyte injury and liver inflammation: The role of mineralocorticoid receptor in Kupffer cells activation



Proyecto
 (2017)

SEARCHING FOR THE MISSING LINK BETWEEN HEPATOCYTE INJURY AND LIVER INFLAMMATION=> THE ROLE OF MINERALOCORTICOID RECEPTOR IN KUPFFER CELLS ACTIVATION

FONDECYT (11171001)

Proyecto
2017-2019
Inv. Responsable

MECHANISMS INVOLVED IN THE CACHEXIA INDUCED BY CHRONIC LIVER DISEASES

FONDECYT (1161646)

Proyecto
2016-2020
Coinvestigador(a)

MECHANISMS INVOLVED IN THE CACHEXIA INDUCED BY CHRONIC LIVER DISEASES

FONDECYT (1161646)

Proyecto
2016-2020
Coinvestigador(a)

Evaluating somatotropic axis dysregulation and protective role of growth hormone and insulin like growth factor 1 supplementation in non-alcoholic fatty liver disease

FONDECYT (1150311)

Proyecto
2015-2019
Coinvestigador(a)

LIVER INJURY IN NON-ALCOHOLIC FATTY LIVER DISEASE=> EXPLORING NEW MODULATORS AND BIOMARKERS

FONDECYT (1150327)

Proyecto
2015-2019
Personal técnico y/o de apoyo

LIVER INJURY IN NON-ALCOHOLIC FATTY LIVER DISEASE=> EXPLORING NEW MODULATORS AND BIOMARKERS

FONDECYT (1150327)

Proyecto
2015-2019
Personal técnico y/o de apoyo

THE EFFECT OF OBESITY IN DEXMEDETOMIDINE METABOLIC CLEARANCE

FONDECYT (1150197)

Proyecto
2015-2018
Personal técnico y/o de apoyo

THE EFFECT OF OBESITY IN DEXMEDETOMIDINE METABOLIC CLEARANCE

FONDECYT (1150197)

Proyecto
2015-2018
Personal técnico y/o de apoyo

Centro de envejecimiento y regeneración

Inestrosa, Nibaldo

Proyecto
 (2014)

Angiotensina 1-7 modula la señalizacion dependiente del factor de crecimiento tipo insulinico 1 y el factor nuclear kappa b en un modelo de atrofia muscular esqueletica inducido por lipopolisacarido

Morales, Maria

Proyecto
 (2013)

Centro de Envejecimiento y Regeneración (CARE)

FONDAP (CARE Chile)

Proyecto
2013-2017
Postdoctorado

HEPATITIS C VIRUS EXPLOITS THE HEPATIC LIPID PATHWAYS=> ROLE OF NPC1L1 IN HCV INFECTION.

FONDECYT (1130357)

Proyecto
2013-2017
Personal técnico y/o de apoyo

HEPATITIS C VIRUS EXPLOITS THE HEPATIC LIPID PATHWAYS=> ROLE OF NPC1L1 IN HCV INFECTION.

FONDECYT (1130357)

Proyecto
2013-2017
Personal técnico y/o de apoyo

Hitting the brakes in the innate immune response=> synergic action of TGR5 and andrographolide in non-alcoholic steatohepatitis

FONDECYT (3140396)

Proyecto
2013-2016
Inv. Responsable

Anti-atrophic role of angiotensin 1-7 on skeletal muscle



Proyecto
 (2012)

DROGA BOTÁNICA PARA EL PARA EL TRATAMIENTO DE LA FIBROSIS CARDÍACA

FONDEF (VIU 110070)

Proyecto
2012-2012
Director(a)

EXPLORING NEW PATHOPHYSIOLOGICAL PATHWAYS IN NONALCOHOLIC FATTY LIVER DISEASE

FONDECYT (FONDECYT R)

Proyecto
2011-2014
Investigador(a)

Novel antifibrotic role of the ace2/angiotensin 1-7/mas axis in skeletal muscular dystrophies



Proyecto
 (2011)

Reduced reck levels improve the muscle cell therapy and diminish the fibrosis associated to the dystrophic muscle



Proyecto
 (2011)

Centro de Envejecimiento y Regeneración (CARE)

FONDAP (CARE Chile)

Proyecto
2008-2012
Investigador(a)

CTGF the factor involved in fibrosis development in DMD

Muscular Dystrophy Association (MDA). Estados Unidos. (MDA 2004/2007)

Proyecto
2008-2011
Investigador(a)

ENFERMEDAD RENAL CRONICA E HIPERTENSION ARTERIAL: PARTICIPACION DE CICLOOXIGENASA-2 Y ANGIOTENSINA 1-7

Vio, Carlos

Proyecto
 (2008)

Profibrotic effect of the renin-angiotensin system and connective tissue growth factor (ctgf) in dystrophic skeletal muscle



Proyecto
 (2008)

DROGA BOTANICA (BOTANICAL DRUG PARA LA FDA DE EEUU) PARA EL TRATAMIENTO EN ENFERMEDADES CRONICAS ASO CIADAS A FIBROSIS DE ALTA INCIDENCIA NACIONAL Y MUNDIAL

FONDEF (FONDEF D07)

Proyecto
2007-2010
Investigador(a)

Skeletal muscle formation, function and disease.

FONDAP (FONDAP)

Proyecto
2005-2009
Investigador(a)

DMD fibrosis=> Role of CTGF, LRP and proteoglycans

Muscular Dystrophy Association (MDA) Estados Unidos. (MDA 2004/2007)

Proyecto
2004-2007
Tesista

Expresion de moleculas de superficie celular en distrofinopatia: mdx versus duchenne

Fadic R, Ricardo

Proyecto
 (2002)

Function of proteoglycans during skeletal muscle differentiation

Howard Hughes Medical Institute (HHMI). Estados Unidos). Investigador Internacional. (HHMI 2002/2006)

Proyecto
2002-2006
Tesista

Review (3)

Central role of transforming growth factor type beta 1 in skeletal muscle dysfunctions: An update on therapeutic strategies



Review ISI SCOPUS
 (2018)

Innate Immunity and Inflammation in NAFLD/NASH

Arrese, M; cabrera, D; Kalergis, AM

Review ISI SCOPUS
DIGESTIVE DISEASES AND SCIENCES  (2016)

Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

Cabello-Verrugio, C; Rivera, JC; cabrera, D; Simon, F

Review ISI SCOPUS
Medicinal Research Reviews  (2015)

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

11
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

2
Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

20
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

3
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Luis Cortínez

Profesor Titular

DIVISIÓN DE ANESTESIOLOGÍA

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

15
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Evelyn Jara

Docente/Investigador

Ciencias Básicas

Universidad Santo Tomás

Temuco, Chile

1
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

62
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Nicolás Quezada

Adjunct Researcher

Digestive Surgery

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Carlos Sing-Long

Assistant Professor

Instituto de Ingeniería Matemática y Computacional

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jose Ignacio Vargas

Assistant Professor

GASTROENTEROLOGY

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

2
Cristian Vilos

Full Professor

Departamento de Ciencias Preclínicas

Universidad de Talca

Talca, Chile

3
María Acuña

Subdirectora de Investigación, Directora proyecto InES género UBO

Universidad Bernardo O´Higgins

Santiago, Chile

1
Victor Contreras

Director y Gestor de Proyectos

Anestesiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

1
Alejandra Hernández

Investigadora postdoctoral

Depto. Bioquímica y Biología Molecular

ACCDiS-Universidad de Chile

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Juan Arab

Assistant Professor

Gastroenterologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

5
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

2
Aline Carvalho da Silva

Assistant Professor

Universidad de Santiago de Chile

Región metropolitana, Chile

2
Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

1
Rolando Sepúlveda

Director Departamento Medicina Interna

Medicina Interna

Universidad de La Frontera

Temuco, Chile

1
francisco aguirre