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Juan Francisco Santibáñez Domínguez

Professor of Research

Institute for Medical Research

Belgrade, Serbia

Células madre mesenquimáticas; inflamación and Cancer

Bioquimica, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1990
Doctorado en Ciencias Biológicas, UNIVERSIDAD AUTONOMA DE MADRID. España, 1999

Professor of Research Full Time

Institute for Medical Reseach, University of Belgrade

Belgrade, Serbia

2008 - At present
Visiting professor Other

UNIVERSIDAD BERNARDO O'HIGGINS

Santiago, Chile

2016 - At present

profesor asistente Full Time

INTA, Universidad de Chile

Santiago, Chile

2000 - 2008
Instructor Full Time

INTA, Universidad de Chile

Santiago, Chile

1996 - 1999
Profesor de Investigacion Full Time

IMI, Universidad de Belgrado

Serbia

2008 - At present

Fundación Zanlungo

UNIVERSIDAD DE SANTIAGO DE CHILE

Chile, 1989

Estimulo académico
Abraham Stekel program

UNIVERSIDAD DE CHILE

Chile, 1992

Estimulo académico para Jovenes Investigadores
Abraham Stekel program

UNIVERSIDAD DE CHILE

Chile, 1993

Estimulo académico para Jovenes Investigadores
Abraham Stekel program

UNIVERSIDAD DE CHILE

Chile, 1994

Estimulo académico para Jovenes Investigadores
Abraham Stekel program

UNIVERSIDAD DE CHILE

Chile, 1995

Estimulo académico para Jovenes Investigadores
Beca de doctorado

Mutis (AECI/ICI)

España, 1996

Biological Doctoral program, Autonoma University /IIB Madrid, Spain
Programa de doctores extranjeros en España

Ministerio de Educación, Cultura y Deportes (MECD), Spain.

España, 2003

Estadia de instigacion en el Centro de Investigaciones Biológicas, CSIC. 18 meses
7. Fonds de la Recherche Scientifique-FNRS

Université Catholique de Louvain

Bélgica, 2007

Laboratory of Pharmacocinétique, Métabolisme, Nutrition e Toxicologie. Université Catholique de Louvain


Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: A New Target for Sepsis Gatica S.; Eltit F.; Santibanez J.F.; Varela D.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS CURRENT MOLECULAR MEDICINE (2019)
How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions Bruger, AM; Dorhoi, A; Esendagli, G; Barczyk-Kahlert, K; van der Bruggen, P; Lipoldova, M; Perecko, T; Santibanez, J; Saraiva, M; Van Ginderachter, JA; Brandau, S Article ISI CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)
Hydroxyurea-induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F-positive human erythroleukemia cells Bjelica S.; Dikli? M.; ?iki? D.; Kova?i? M.; Suboti?ki T.; Mitrovi?-Ajti? O.; Radojkovi? M.; ?oki? V.P.; Santibanez J.F. Article ISI SCOPUS FEBS JOURNAL (2019)
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDY OF NEW DINUCLEAR ZINC(II) AND NICKEL(II) OCTAAZA MACROCYCLIC COMPLEXES Krsti? M.P.; Petkovi? B.B.; Mil?i? M.; MiÅ¡i? D.; Santibanez J.F. Article ISI SCOPUS MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (2019)
Interactions among myeloid regulatory cells in cancer Umansky V.; Adema G.J.; Baran, J; Brandau S.; van Ginderachter J.A.; Hu X.; Jablonska J.; Mojsilovic S.; Papadaki H.A.; Pico de CoaÃ±a Y.; Santegoets K.C.M.; Santibanez J.F.; Serre K.; Si Y.; Sieminska I.; Velegraki M.; Fridlender Z.G. Article SCOPUS Cancer Immunology, Immunotherapy (2018)
Mesenchymal stem cells and calcium phosphate bioceramics: Implications in periodontal bone regeneration Millan C.; Vivanco J.F.; Benjumeda-Wijnhoven I.M.; Bjelica S.; Santibanez J.F. Article ISI SCOPUS (2018)
Lipopolysaccharide Can Modify Differentiation and Immunomodulatory Potential of Periodontal Ligament Stem Cells via ERK1,2 Signaling Kukolj, Tamara; Trivanovi?, Drenka; Oki? Djordjevi?, Ivana; Mojsilovi?, Slavko; Krsti?, Jelena; Obradovi?, Hristina; Jankovi?, Srdja; Santibanez, Juan Francisco; Jaukovi?, Aleksandra; Bugarski, Diana Article Journal of Cellular Physiology (2017)
Obesity: An Emerging Importance of Progenitors Trivanovi? D, Krsti? J, Santibanez JF, Jaukovi? A and Bugarski D Article Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (2017)
Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016 Cabello-Verrugio, Claudio; Simon, Felipe; Trollet, Capucine; Santibañez, Juan F. Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)
Correlation between telomere maintenance and stemness of mesenchymal stem/stromal cells Article Telomere and Telomerase (2016)
Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation Obradovi?, Hristina; Krsti?, Jelena; Kukolj, Tamara; Trivanovi?, Drenka; ?or?evi?, Ivana Oki?; Mojsilovi?, Slavko; Jaukovi?, Aleksandra; Jov?i?, Gordana; Bugarski, Diana; Santibañez, Juan Francisco Article Mediators of Inflammation (2016)
Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1 Trivanovi?, Drenka; Jaukovi?, Aleksandra; Krsti?, Jelena; Nikoli?, Srdjan; Oki? Djordjevi?, Ivana; Kukolj, Tamara; Obradovi?, Hristina; Mojsilovi?, Slavko; Ili?, Vesna; Santibanez, Juan Francisco; Bugarski, Diana Article IUBMB Life (2016)
Mesenchymal Stem Cells from Different Tissues: Immune Status and Activity Trivanovi? D, Krsti? J, Mojsilovi? S, Djordjevi? IO, Ili? V, Kukolj T, Obradovi? H, Jaukovi? A, Santibanez JF and Bugarski D Article J Immunol Infect Dis (2016)
TGF- Signalling and Its Role in Cancer Progression and Metastasis 10. Santibanez, JF; Krstic, J; Quintanilla, M; and Bernabeu, C Article eLS (2016)
The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs ?or?evi?, Ivana Oki?; Kukolj, Tamara; Krsti?, Jelena; Trivanovi?, Drenka; Obradovi?, Hristina; Santibañez, Juan F.; Mojsilovi?, Slavko; Ili?, Vesna; Bugarski, Diana; Jaukovi?, Aleksandra Article International Journal of Biochemistry and Cell Biology (2016)
The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation Trivanovi?, Drenka; Krsti?, Jelena; Djordjevi?, Ivana Oki?; Mojsilovi?, Slavko; Santibanez, Juan Francisco; Bugarski, Diana; Jaukovi?, Aleksandra Article ISI SCOPUS MEDIATORS OF INFLAMMATION (2016)
Transforming Growth Factor-Beta and Matrix Metalloproteinases Functional Interplay in Cancer; Implications in Epithelial to Mesenchymal Transition Krstic, Jelena; Santibanez, Juan F Article Cell Biology: Research & Therapy (2016)
An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling Krstic J, Obradovic H, Kukolj T, Mojsilovic S, Okic-Dordevic I, Bugarski D, Santibanez JF Article Protein Pept Lett (2015)
Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells Mojsilovi?, Slavko; Jaukovi?, Aleksandra; Santibañez, Juan F.; Bugarski, Diana Article Mediators of Inflammation (2015)
Mesenchymal stem cells of different origin: Comparative evaluation of proliferative capacity, telomere length and pluripotency marker expression Trivanovi?, Drenka; Jaukovi?, Aleksandra; Popovi?, Branka; Krsti?, Jelena; Mojsilovi?, Slavko; Oki?-Djordjevi?, Ivana; Kukolj, Tamara; Obradovi?, Hristina; Santibanez, Juan Francisco; Bugarski, Diana Article LIFE SCIENCES (2015)
Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression Krsti?, Jelena; Trivanovi?, Drenka; Mojsilovi?, Slavko; Santibanez, Juan F. Article OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction Mojsilovi?, Sonja S.; Santibanez, Juan F. Article Cell Biology International (2015)
Urokinase type plasminogen activator mediates Interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration Krsti?, Jelena; Obradovi?, Hristina; Jaukovi?, Aleksandra; Oki?-?or?evi?, Ivana; Trivanovi?, Drenka; Kukolj, Tamara; Mojsilovi?, Slavko; Ili?, Vesna; Santibañez, Juan F.; Bugarski, Diana Article Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2015)
Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro Trivanovi?, Drenka; Nikoli?, Srdjan; Krsti?, Jelena; Jaukovi?, Aleksandra; Mojsilovi?, Slavko; Ili?, Vesna; Oki?-Djordjevi?, Ivana; Santibanez, Juan Francisco; Jov?i?, Gordana; Bugarski, Diana Article Cell Biology International (2014)
Mesenchymal stem cells isolated from human periodontal ligament Mileti? M, Mojsilovi? S, Oki?-?or?evi? I, Kukolj T, Jaukovi? A, Santibanez JF, Jov?i? G, Bugarski D Article Arch Biol Sci (2014)
Novel patents and cancer therapies for transforming growth factor-beta and urokinase type plasminogen activator: potential use of their interplay in tumorigenesis Krstic J, Maslovaric I, Santibanez JF Article Recent Pat Anticancer Drug Discov (2014)
Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells Krstic, Jelena; Santibanez, Juan F. Article SCIENTIFIC WORLD JOURNAL (2014)
GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells Okic-Djordjevic I, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF, Terzic M, Vesovic D, Bugarski D. Article J BUON (2013)
In vitro effects of IL-17 on angiogenic properties of endothelial cells in relation to oxygen levels Krsti?, Jelena; Jaukovi?, Aleksandra; Mojsilovi?, Slavko; ?or?evi?, Ivana Oki?; Trivanovi?, Drenka; Ili?, Vesna; Santibañez, Juan F.; Bugarski, Diana Article Cell Biology International (2013)
Interleukin-17 modulates myoblast cell migration by inhibiting urokinase type plasminogen activator expression through p38 mitogen-activated protein kinase Koci?, Jelena; Santibañez, Juan F.; Krsti?, Aleksandra; Mojsilovi?, Slavko; Ili?, Vesna; Bugarski, Diana Article International Journal of Biochemistry and Cell Biology (2013)
Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton’s jelly Trivanovic, Drenka; Kocic, Jelena; Mojsilovic, Slavko; Krstic, Aleksandra; Ilic, Vesna; Okic-Djordjevic, Ivana; Santibanez, Juan; Jovcic, Gordana; Terzic, Milan; Bugarski, Diana Article SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO (2013)
Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells Villar, Victor; Kocic, Jelena; Santibanez, Juan F. Article SCOPUS Prostate Cancer (2013)
Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer Santibanez, Juan F. Article ISRN Dermatology (2013)
Effects of IL-17 on erythroid progenitors growth: involvement of MAPKs and GATA transcription factors Krstic A; Kocic J; Ilic V; Mojsilovic, S; Okic-Dordevic I; Trivanovic D; Santibanez, JF; Jovcic G; , Bugarski D. Article J Biol Regul Homeost Agents (2012)
Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2 Koci?, Jelena; Santibañez, Juan F.; Krsti?, Aleksandra; Mojsilovi?, Slavko; ?or?evi?, Ivana Oki?; Trivanovi?, Drenka; Ili?, Vesna; Bugarski, Diana Article Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2012)
J Biol Regul Homeost Agents Krstic A, Kocic J, Ilic V, Mojsilovic S, Okic-Dordevic I, Trivanovic D, Santibanez JF, Jovcic G, Bugarski D Article J Biol Regul Homeost Agents (2012)
SKIP Downregulation Increases TGF- β 1-Induced Matrix Metalloproteinase-9 Production in Transformed Keratinocytes Koci?, Jelena; Villar, Victor; Krsti?, Aleksandra; Santibanez, Juan F. Article SCIENTIFICA (2012)
SMAD3 is essential for transforming growth factor-beta 1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes Kocic J; Bugarski, D; Santibanez J.F. Article ISI SCOPUS European Journal of Cancer (2012)
Transforming growth factor-β superfamily, implications in development and differentiation of stem cells Santibanez, Juan F.; Kocic, Jelena Article BioMolecular Concepts (2012)
Mesenchymal stem cell properties of dental pulp cells from deciduous teeth Nikoli? N, Krsti? A, Trivanovi? D, Mojsilovi? S, Koci? J, Santibanez JF, Jov?i? G, Bugarski D. Article Arch Biol Sci (2011)
IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation Mojsilovi?, Slavko; Krsti?, Aleksandra; Ili?, Vesna; Oki?-?or?evi?, Ivana; Koci?, Jelena; Trivanovi?, Drenka; Santibañez, Juan Francisko; Jov?i?, Gordana; Bugarski, Diana Article Cell and Tissue Research (2011)
Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines Krsti?, Milena; Sovilj, Sofija P.; Grguri?-Šipka, Sanja; Evans, Ivana Radosavljevi?; Borozan, Sun?ica; Santibanez, Juan Francisco Article EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
TGF-β/TGF-β receptor system and its role in physiological and pathological conditions Santibañez, Juan F.; Quintanilla, Miguel; Bernabeu, Carmelo Article Clinical Science (Lond) (2011)
Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice Krsti?, A.; Santibanez, J. F.; Oki?, I.; Mojsilovi?, S.; Koci?, J.; Jov?i?, G.; Milenkovi?, P.; Bugarski, D. Article Acta Physiologica (2010)
New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity Krsti?, Milena; Sovilj, Sofija P.; Grguri?-Šipka, Sanja; Radosavljevi? Evans, Ivana; Borozan, Sun?ica; Santibanez, Juan Francisco; Koci?, Jelena Article EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Rac1 modulates TGF-beta 1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes Santibanez, JF; Kocic J; Fabra, A; Cano A.; Quintanilla, M Article ISI SCOPUS FEBS Letters (2010)
ROS-NF kappa I' mediates TGF-beta 1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion Tobar, N.; Villar V.; Santibanez, JF Article ISI SCOPUS Molecular and Cellular Biochemistry (2010)
SKIP is required for TGF-beta 1-induced epithelial mesenchymal transition and migration in transformed keratinocytes Villar V.; Kocic J; Bugarski, D; Jovcic G; Santibanez, JF Article ISI SCOPUS FEBS Letters (2010)
Spred2 inhibits TGF-beta 1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition Villar V.; Kocic J; Santibanez, JF Article ISI SCOPUS International Journal of Cancer (2010)
The Role of the TGF-β Coreceptor Endoglin in Cancer Pérez-Gómez, Eduardo; del Castillo, Gaelle; Santibáñez, Juan Francisco; Lêpez-Novoa, Jose Miguel; Bernabéu, Carmelo; Quintanilla, Miguel Article SCIENTIFIC WORLD JOURNAL (2010)
The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras Santibanez, JF; Perez-Gomez, E; Fernandez-L, A; Garrido-Martin, EM; Carnero, A; Malumbres, M; Vary, CPH; Quintanilla, M; Bernabeu, C Article ISI SCOPUS Carcinogenesis (2010)
Structural Antitumoral Activity Relationships of Synthetic Chalcones Echeverria, C.; Santibanez, JF; Donoso-Tauda, O; Escobar, CA; Ramirez-Tagle, R Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2009)
RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NF kappa B-dependent mechanism Tobar, N.; Cáceres M.; Santibanez, JF; Smith, PC; Martinez, J. Article ISI SCOPUS CANCER LETTERS (2008)
Caveolin-1 interacts and cooperates with the transforming growth factor- type I receptor ALK1 in endothelial caveolae Santibanez, J. F.; Blanco, F. J.; Garrido-Martin, E. M.; Sanz-Rodriguez, F.; del Pozo, M. A.; Bernabeu, C. Article CARDIOVASCULAR RESEARCH (2007)
Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling Santibanez, JF; Letamendia, A; Perez-Barriocanal, F; Silvestri, C.; Saura, M; Vary, CPH; Lopez-Novoa, JM; Attisano, L; Bernabeu, C Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Endoglin regulates cyclooxygenase-2 expression and activity Jerkic, M; Rivas-Elena, JV; Santibanez, JF; Prieto, M; Rodriguez-Barbero, A; Perez-Barriocanal, F; Pericacho, M; Arevalo, M; Vary, CPH; Letarte, M; Bernabeu, C; Lopez-Novoa, JM Article ISI SCOPUS CIRCULATION RESEARCH (2006)
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes Eisner V.; Criollo, A; Quiroga, C; Olea Azar C.; Santibanez, JF; Troncoso R.; Chiong M.; Diaz-Araya, G; Foncea, R; Lavandero S. Article ISI SCOPUS FEBS LETTERS (2006)
JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes Santibanez, JF Article ISI SCOPUS FEBS LETTERS (2006)
Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis Santibanez, JF; Hurtado C. Article ISI SCOPUS FEBS LETTERS (2005)
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex Blanco, Francisco J.; Santibanez, Juan F.; Guerrero-Esteo, Mercedes; Langa, Carmen; Vary, Calvin P.H.; Bernabeu, Carmelo Article JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women Rodriguez, JP; Ríos S; Fernandez, M.; Santibanez, JF Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases Guerrero, J; Santibanez, JF; González A; Martinez, J. Article ISI SCOPUS EXPERIMENTAL CELL RESEARCH (2004)
Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin Smith, PC; Santibanez, JF; Morales, JP; Martinez, J. Article ISI SCOPUS JOURNAL OF PERIODONTAL RESEARCH (2004)
Cyclic AMP inhibits TGF beta 1-induced cell-scattering and invasiveness in murine-transformed keratinocytes Santibanez, JF; Olivares, D; Guerrero, J; Martinez, J. Article ISI SCOPUS INTERNATIONAL JOURNAL OF CANCER (2003)
TGF-beta(1) and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells Santibanez, JF; Quintanilla, M; Martinez, J. Article ISI SCOPUS FEBS LETTERS (2002)
Transforming growth factor-beta 1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes Santibanez, JF; Guerrero, J; Quintanilla, M; Fabra, A; Martinez, J. Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line Juretic, N; Santibanez, JF; Hurtado C.; Martinez, J. Article ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Genistein and curcumin block TGF-? 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes Santibanez J.F.; Quintanilla, M; Martinez, J. Article SCOPUS NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2000)
Genistein and curcumin block TGF-beta(1)-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes Santibanez, JF; Quintanilla, M; Martinez, J. Article ISI NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2000)
Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes Santibanez, JF; Iglesias M.; Frontelo, P; Martinez, J.; Quintanilla, M Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cells Martínez J, Fuentes M, Cambiazo V, Santibáñez JF Article Int J Cancer (1999)
Urokinase expression and binding activity associated with the transforming growth factor beta1-induced migratory and invasive phenotype of mouse epidermal keratinocytes Santibáñez JF, Iglesias M, Frontelo P, Martínez J, Quintanilla M Article J Cell Biochem. (1999)
Effect of desialylated human chorionic gonadotropin (hCG) on the bioactivity of rat Leydig cells Ronco A.M.; Tijmes M.; Santibanez J.Fco.; Moraga, P Article CELL BIOCHEMISTRY AND FUNCTION (1998)
Soluble factors secreted by PC-3 cells induce structural changes in proteoglycans produced by fetal rat osteoblasts Rodríguez JP, Santibañez JF, Martínez J Article Tumour Biol (1998)
The compound 14-keto-stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells Depix MS, Martínez J, Santibañez F, Rovirosa J, San Martín A, Maccioni RB Article Mol Cell Biochem (1998)
Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines Santibáñez JF, Navarro A, Martínez J Article Anticancer Res (1997)
Prostate-derived soluble factors block osteoblast differentiation in culture Martínez J, Silva S, Santibáñez JF Article J Cell Biochem. (1996)
Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralisation rate in fetal rat osteoblasts in culture Santibáñez JF, Silva S, Martínez J Article Br J Cancer (1996)
The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs Santibañez JF, Maccioni RB, Martínez J Article Cell Biochem Funct (1995)
Surface-associated plasminogen activation in leukemic cells: interaction with extracellular matrix Martínez J, Santibañez JF Article Eur J Cell Biol (1994)
Extracellular calcium modulates proliferation of factor dependent hemopoietic cells Martínez J, Santibañez JF. Article Cell Biochem Func (1993)
Membrane-associated procollagenase of leukemic cells is activated by urokinase-type plasminogen activator Santibañez JF, Martínez J Article Leuk Res (1993)
The antineoplastic agent estramustine and the derivative estramustine-phosphate inhibit secretion of interleukin-3 in leukemic cells. Possible roles of MAPs Martínez J, Santibáñez JF, Vial C, Maccioni RB Article Mol Cell Biochem (1992)
Binding and production of insulin-like growth factor-I in rat mammary gland Lavandero S, Santibáñez JF, Ocaranza MP, Ferreira A, Sapag-Hagar M Article Comp Biochem Physiol A Comp Physiol (1991)
Insulin-like growth factor I receptor levels during the lactogenic cycle in rat mammary gland Lavandero S, Santibáñez JF, Ocaranza MP, Sapag-Hagar M Article Biochem Soc Trans. (1990)


The TGFbeta co-receptor endoglin modulates the expression and transforming potential of H-Ras Perez-Gomez, E; Santibanez, JF; Fernandez A.; Carnero, A; Malumbres, M; Vary, CPH; Quintanilla, M; Bernabeu, C Abstract ISI EJC SUPPLEMENTS (2010)
Activation of mitogen-activated protein kinase (MAPK) pathway in mesenchymal stem cells (MSC) derived from control and osteoporotic postmenopausal women. Rodriguez, JP; Ríos S; Fernandez, M.; Pino, AM.; Hess, R; Santibanez, JF Abstract ISI JOURNAL OF BONE AND MINERAL RESEARCH (2003)
Epidermal growth factor (EGF) stimulates urokinase expression through the ERK and JNK signaling pathways in gingival fibroblasts. Smith, PC; Morales, JP; Santibanez, JF; Martinez, J. Abstract ISI JOURNAL OF DENTAL RESEARCH (2003)


Novel Patents and Cancer Therapies for Transforming Growth Factor-β and Urokinase Type Plasminogen Activator: Potential Use of Their Interplay in Tumorigenesis 4. Krsti? J, Maslovari? I, Obradovi? H, Kukolj T and Santibanez JF; Atta-ur-Rahman / Khurshid Zaman BookSection (2015)
Janus kinase 2 and transforming growth factor beta signal transduction targeted therapies in myeloproliferative neoplasms Cokic V and Santibanez JF; Prof. Atta-Ur-Rahman, FRS and Prof. M. Iqbal Choudhary BookSection (2014)
Transforming growth factor-beta regulation of urokinase type plasminogen system; mutual interactions and potential combinatory implications in oncotherapies Santibanez JF and Krstic J; Jeremiah M. Rutherford BookSection (2014)
TGF-B and MMPs: A Complex Regulatory Loop Involved in Tumor Progression 1. Quintanilla M, del Castillo G, Kocic J, Santibanez JF; Namae Oshiro and Eiko Miyagi BookSection (2011)
INTERLEUKIN-17 RECEPTOR-A 5. Mojsilovi? S, Trivanovi? D, Krsti? J and Santibanez JF; Choi, Sangdun BookSection DOI: 10.1007/978-1-4614-6438-9_101716-1


Mye-EUNITER=> European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells EU Framework Programme Horizon 2020 (Cost Action # BM1404) Proyecto 2015-2018 Investigador(a)
Determination of the mutational landscapes and clonal architecture and its application in angiogenesis and thrombosis of MPN patients Vladan Cokic; Juan Santibañez Proyecto (2014)
Regenerative and modulatory potential of mesenchymal stem cells Ministry of Science and Technological Development, Republic of Serbia (175062) Proyecto 2011-2016 Investigador(a)
Regenerative and modulatory potential of mesenchymal stem cells Diana Bugarski Proyecto (2010)
13. Cellular and molecular mechanisms involved in hematopoiesis regulation Pavle Milenkovic; Diana Bugarski; Juan F. santibáñez Proyecto (2006)
Cellular and molecular mechanisms involved in hematopoiesis regulation Ministry of Science and Technological Development, Republic of Serbia (145048) Proyecto 2006-2010 Investigador(a)
REGULACION DE LAS VIAS DE SENALIZACION DE TGF-B1,, IMPLICANCIAS EN LA PROGRESION TUMORAL. FONDECYT (1050476) Proyecto 2005-2008 Inv. Responsable
TGF-beta1 Signal transduction regulation. Implications in tumor progression Juan Santibáñez Proyecto (2005)
Estudios sobre endoglina, un co-receptor de TGF-beta implicado en la patologia humana Ministerio de Educacion y Ciencia, Plan Nacional de I+D, España (12. SAF2004-01390) Proyecto 2004-2007 Postdoctorado
ESTUDIO DE LOS MECANISMOS DE TRANSDUCCION DE SENALES INVOLUCRADAS EN LA MODULACION POR TGF-B1 DE LA PROGRESION MALIGNA EN LA CARCINOGENESIS DE PIEL DE RATON FONDECYT (3000045) Proyecto 2000-2003 Inv. Responsable
TGF-beta Signal Transduction Pathways during tumor progression of mouse skin Carcinogenesis Juan Santibáñez Proyecto (2000)
Regulation of the migratory and invasive phenotype in squamous carcinoma cells=> Role of TGF-B CICYT, España (SAF 98-0085-CO3-02) Proyecto 1998-2000 Tesista
MICROAMBIENTE CELULAR Y MOLECULAR DE LA MEDULA OSEA=> GENERADOR DE CONDICIONES PARA SUSTENTAR LOS PROCESOS HEMATOPOYETICO, OSTEOGENICO Y DE INVASION TUMORAL FONDECYT (8970028) Proyecto 1997-2000 Coinvestigador(a)
Microambiente celular y molecular de la médula ósea generador de condiciones para sustentar los procesos hematopoiético, osteogénico y de progresión tumoral Jose Minguell; Juan Santibañez Proyecto (1997)
ALTERACION DE LA FUNCION EPITELIAL INTESTINAL POR CITOQUINAS EN PATOLOGIAS INFLAMATORIAS. FONDECYT (1950256) Proyecto 1995-1998 Coinvestigador(a)
RESPUESTA CELULAR DEL TEJIDO OSEO A LA INVASION TUMORAL DE ORIGEN PROSTATICO FONDECYT (1950398) Proyecto 1995-1997 Coinvestigador(a)
ESTUDIOS DE LA FUNCION DE PROTEINAS ASOCIADAS A CITOESQUELETO EN LA INVASION TUMORAL FONDECYT (1930904) Proyecto 1993-1995 Coinvestigador(a)
Estudios de la función de proteínas asociadas a citoesqueleto en la invasión tumoral Jorge Martinez; Juan Santibánez Proyecto (1993)
ESTUDIOS DE INVASION TUMORAL FONDECYT (1911067) Proyecto 1991-1993 Coinvestigador(a)
Estudios de Invasión Tumoral Jorge Martinez; Juan Santíbañez Proyecto (1991)
Signal transduction pathways in TGF- regulation of MMP-9 in mouse Skin Carcinogenesis Juan F Santibáñez Proyecto (0)


Endothelial dysfunction in pregnancy metabolic disorders Echeverria C.; Eltit F.; Santibanez J.F.; Gatica S.; Cabello-Verrugio C.; Simon F. Review SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2019)
Transforming growth factor-, matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition Santibanez, JF; Obradovic, H; Kukolj, T; Krstic, J Review ISI DEVELOPMENTAL DYNAMICS (2018)
Transforming growth factor-beta and urokinase type plasminoge interplay in cancer Santibanez J.F.; Krsti? J. Review ISI SCOPUS (2018)
Urokinase Type Plasminogen Activator and the Molecular Mechanisms of its Regulation in Cancer Santibanez, JF Review ISI SCOPUS Protein and Peptide Letters (2017)

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Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

Institute of nutrition and food technology

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

Juan Vivanco

Profesor Asociado

Bioingeniería

UNIVERSIDAD ADOLFO IBANEZ

Viña del Mar, Chile

Rodrigo Ramírez

Director

Direccion de Investigacion y Postgrado

Universidad de Aconcagua

Santiago, Chile

Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Daniela Olivares

Asistente de Investigación

INSTITUTO DE INVESTIGACIONES AGROPECUARIAS

Santiago, Chile

Sebastián Gatica

Investigador Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Juan Francisco Santibáñez Domínguez

Líneas de Investigación

Educación

Bioquimica, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1990

Doctorado en Ciencias Biológicas, UNIVERSIDAD AUTONOMA DE MADRID. España, 1999

Experiencia Académica

Professor of Research Full Time

Visiting professor Other

Experiencia Profesional

profesor asistente Full Time

Instructor Full Time

Profesor de Investigacion Full Time

Premios y Distinciones

Fundación Zanlungo

Abraham Stekel program

Abraham Stekel program

Abraham Stekel program

Abraham Stekel program

Beca de doctorado

Programa de doctores extranjeros en España

7. Fonds de la Recherche Scientifique-FNRS

Article (85)

Abstract (3)

BookSection (5)

Proyecto (21)

Mye-EUNITER=> European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells

Regenerative and modulatory potential of mesenchymal stem cells

Cellular and molecular mechanisms involved in hematopoiesis regulation

REGULACION DE LAS VIAS DE SENALIZACION DE TGF-B1,, IMPLICANCIAS EN LA PROGRESION TUMORAL.

Estudios sobre endoglina, un co-receptor de TGF-beta implicado en la patologia humana

ESTUDIO DE LOS MECANISMOS DE TRANSDUCCION DE SENALES INVOLUCRADAS EN LA MODULACION POR TGF-B1 DE LA PROGRESION MALIGNA EN LA CARCINOGENESIS DE PIEL DE RATON

Regulation of the migratory and invasive phenotype in squamous carcinoma cells=> Role of TGF-B

MICROAMBIENTE CELULAR Y MOLECULAR DE LA MEDULA OSEA=> GENERADOR DE CONDICIONES PARA SUSTENTAR LOS PROCESOS HEMATOPOYETICO, OSTEOGENICO Y DE INVASION TUMORAL

ALTERACION DE LA FUNCION EPITELIAL INTESTINAL POR CITOQUINAS EN PATOLOGIAS INFLAMATORIAS.

RESPUESTA CELULAR DEL TEJIDO OSEO A LA INVASION TUMORAL DE ORIGEN PROSTATICO

ESTUDIOS DE LA FUNCION DE PROTEINAS ASOCIADAS A CITOESQUELETO EN LA INVASION TUMORAL

ESTUDIOS DE INVASION TUMORAL

Review (4)