Man

David Andrés González Figueroa

Investigador postdoctoral

Institut des Neurosciences de Montpellier (INM)

Montpellier, Francia

Líneas de Investigación


- Enfermedades neurodegenerativas. - Sistema nervioso periférico y músculo esquelético. - Factores pro-fibróticos y matriz extracelular. - Dinámica de Neurofilamentos y su relación con enfermedades neurodegenerativas.

Educación

  •  Doctor en Ciencias Biológicas con mención en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018
  •  Licenciatura en Bioquímica, UNIVERSIDAD ANDRES BELLO. Chile, 2010
  •  Magíster en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
  •  Magíster en Bioquímica, UNIVERSIDAD ANDRES BELLO. Chile, 2015
  •  Bioquímico , UNIVERSIDAD ANDRES BELLO. Chile, 2015

Experiencia Académica

  •   Tesista de pregrado Full Time

    UNIVERSIDAD ANDRES BELLO

    Facultad de Ciencias de la Vida

    Santiago, Chile

    2012 - 2012

  •   Tesista de doctorado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Ciencias Biológicas

    Santiago, Chile

    2013 - 2018

  •   Investigador Postdoctoral Full Time

    Institut des Neurosciences de Montpellier

    Montpellier, Francia

    2018 - At present

Premios y Distinciones

  •   Beca Nacional de Doctorado 2013

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2013

    Beca otorgada por Conicyt para realizar el programa de Doctorado en Ciencias Biologicas con mencion en Biologia Celular y Molecular de la Pontificia Universidad Catolica de Chile

  •   Mejor Admisión al programa de Doctorado

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2013

    Mejor admisión al programa de Doctorado en Ciencias Biologicas con mencion en Biologia Celular y Molecular del ano 2013. 1er lugar dentro de 15 candidatos

  •   Beca Eventos y Cursos Cortos

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Apoyo complementario para asistir a la XIX Reunión Anual de la Sociedad de Biología Celular de Chile

  •   Beca Eventos y Cursos Cortos 2

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2016

    Beca de apoyo para asistir a la XXX Reunión Anual de la Sociedad de Biología Celular de Chile

  •   Asignación Anual para Gastos Operacionales del Proyecto de Tesis Doctoral

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2016

    Beca de apoyo para solventar gastos operacionales durante la realización de la tesis doctoral

  •   Beca de Postdoctorado de la AFM-Téléthon

    AFM-Téléthon

    Francia, 2018

    Beca para la realización de un entrenamiento postdoctoral durante 2 años en el Institut des Neurosciences de Montpellier (INM U1051)


 

Article (5)

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-beta
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model
ALS skeletal muscle shows enhanced TGF-beta signaling, fibrosis and induction of fibro/adipogenic progenitor markers
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

ConferencePoster (25)

Neurofilament aggregation in Charcot-Marie-Tooth diseases: zebrafish as a novel model to study NFs dynamics
CTGF/CCN2 inhibition improves muscle and locomotor function in an ALS mouse model
CTGF/CCN2 activity inhibition reduces fibrosis and improves muscle and locomotor function in an ALS model
Inhibition of CTGF/CCN2 improves ALS skeletal muscle phenotype and delays disease progression
A CTGF neutralizing antibody reduces fibrosis and improves locomotor function in a model of ALS
CTGF inhibition reduces fibrosis and improves muscle function in a model of ALS
Denervation-induced fibrosis is modulated by CTGF and HIF-1a
Denervation-induced fibrosis is modulated by CTGF and HIF-1alpha
Role of Connective Tissue Growth Factor (CTGF/CCN2) in the fibrosis associated to denervated skeletal muscle and ALS disease progression
Role of the matricellular protein CTGF/CCN2 in the fibrosis associated to ALS disease
Study of mutant hSOD1 overexpression in muscles cells and fibroblasts: Evaluation of pro-fibrotic factors expression and ECM deposition
Dual Role of HIF-1alpha in damaged skeletal muscle: inducer of angiogenesis and fibrosis
Fibrosis associated to skeletal muscle denervation and to Amyotrophic Lateral Sclerosis (ALS) model: Role of CTGF/CCN2
TGF-b and CTGF pro-fibrotic factors are up-regulated in transgenic ALS model and denervated muscles
Astrocytes expressing the ALS-causing mutant SOD1G93A release toxic factor(s) that trigger motoneuron death through activation of c-Abl
CTGF is up-regulated in transgenic SOD1G93A and denervated muscles
Modulation of fibrotic markers in skeletal muscle by HIF-1alpha
Reduced RECK levels improve the skeletal muscle regeneration and diminish the muscle damage and fibrosis of dystrophic mdx mice
TGF-beta signaling pathway is induced in transgenic SOD1G93A fibrotic muscles
Astrocytes expressing ALS-causing mutants SOD1 and TDP43 trigger motoneuron death through a common pathogenic pathway involving activation of c-Abl and Nav channels
RECK a novel matrix-metalloproteinase inhibitor is up-regulated in dystrophic muscles of mdx mice
ALS astrocytes release factors that trigger c-Abl phosphorylation in motoneurons: role of sodium channel activity and oxidative stress
ALS astrocytes release factors that trigger motoneuron death by increasing sodium channel activity
PSD-95 suppresses dendritic arbor development in mature hippocampal neurons by occluding synapses insertion of NR2B-NMDA receptors
Epigenetic mechanisms that control PSD95 gene expression in developing hippocampal neurons

Patent (1)

Methods for treatment of motor neuron diseases

Review (1)

CTGF/CCN2 from Skeletal Muscle to Nervous System: Impact on Neurodegenerative Diseases
30
David González

Investigador postdoctoral

Institut des Neurosciences de Montpellier (INM)

Montpellier, Francia

4
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Jennifer Faúndez

Phd(c) del programa de Doctorado Biotecnología y Bioemprendimiento

Universidad San Sebastián

Santiago, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Juan Espinoza

Encargado de Cultivo Celular y Bioterio

Universidad Bernardo O'Higgins

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile