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Alicia Susana Nogueras de Minniti

Profesor Asociado Adjunto

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Biología Celular; Neurobiología; envejecimiento y estrés oxidativo; Muscle amyloidogenic diseases using C. elegans as a model system; Role of Wnt signalling at the C. elegans neuromuscular junction; Oxidative stress and aging in C. elegans.

Biología Molecular y Celular, UNIVERSITY OF ARIZONA. Estados Unidos, 1994
Biólogo, Universidad Nacional de Córdoba. Argentina, 1989

Profesor Asociado Adjunto Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2016 - At present
Profesor Asistente Adjunto Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2009 - 2016
Investigador Asociado, Center for Aging and Regeneration (CARE) Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2009 - 2010
Investigador Asociado, Fondap Center for Cell Regulation and Pathology (CRCP) Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

S, Chile

2001 - 2008
Visiting Scholar Other

PRINCETON UNIVERSITY

Princeton, Estados Unidos

2011 - 2011
Visiting Scholar Other

University of Arizona

Tucson, Estados Unidos

2006 - 2006
Visiting Scientist Full Time

University of California Los Angeles (UCLA)

Los Angeles, Estados Unidos

2002 - 2002
Sub-directora de Carrera de Bioquímica Other

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Santiago, Chile

2018 - 2020
Investigador Asociado Other

Universidad Santo Tomás

Facultad de Ciencias

Santiago, Chile

2012 - At present

Sub-directora de Carrera de Bioquímica Other

Ponificia Universidad Católica de Chile

Santiago, Chile

2018 - 2020

Tesis de pregrado en co-tutoría:

Daniela Victoria Rebolledo Lopez, Bioquímica, PUC “Participación de cobre sobre los efectos patológicos inducidos por el péptido Abeta en Caenorhabditis elegans”. 2008.

Cristal Salcedo, Biotechnology, Escuela de Biotecnología, Universidad Santo Tomás.”Evaluación del papel de la enzima metionina sulfoxide reductase en la sinápsis neuromuscular en Caenorhabditis elegans”. 2013.

Premio de Reconocimiento a la Excelencia Docente (PRED)

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2015

El Premio de Reconocimiento a la Excelencia Docente es una iniciativa que reconoce y valora a aquellos académicos de la UC que realizan un trabajo docente de excelencia, cumpliendo con la misión de la universidad de formar profesionales de calidad. El Premio busca destacar a aquellos profesores que realizan una docencia de excelencia destacándose en el logro de todos los Principios Orientadores para una Docencia de Calidad UC.
Graduate Academic Scholarship

University of Arizona

Estados Unidos, 1989

Destaca la calidad académica de los alumnos de doctorado de la Universidad de Arizona. Est Scholarship fue recibida todos los años entre 1989 y 1994.
Premio a la Excelencia Académica

Colegio de Ingenieros de Córdoba

Argentina, 1989

Destaca a los 3 estudiantes de pregrado que se graduaron con los mejores promedios en la Facultad de Ciencias Exactas, Físicas y Naturales de la Universidad Nacional de Córdoba
Premio Universidad

Universidad Nacional de Córdoba

Chile, 1989

Destaca a los estudiantes de pregrado que se gradúan con los mejores promedio de cada carrera de la Universidad Nacional de Córdoba.


Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis Minniti, Alicia N.; Arriagada, Hector; Zuniga, Soledad; Bravo-Zehnder, Marcela; Alfaro, Ivan E.; Aldunate, Rebeca Article ISI SCOPUS AGING CELL (2019)
Age-related NMDA signaling alterations in SOD2 deficient mice Carvajal, Francisco J.; Mira, Rodrigo G.; Rovegno, Maximiliano; Minniti, Alicia N.; Cerpa, Waldo Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Peptide multifunctionalized gold nanorods decrease toxicity of beta-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease Morales-Zavala, Francisco; Arriagada, Hector; Hassan, Natalia.; Velasco, Carolina; Riveros, Ana; Álvarez, Alejandra R.; Minniti, Alicia N.; Rojas-Silva, Ximena; Muñoz, Luis L.; Vasquez, Rodrigo; Rodriguez, Katherine; Sanchez-Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Aldunate, Rebeca; Kogan Marcelo J. Article ISI SCOPUS NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)
The Protein Oxidation Repair Enzyme Methionine Sulfoxide Reductase A Modulates A beta Aggregation and Toxicity In Vivo Minniti A.N.; Arrázola M.S.; Bravo-Zehnder, M; Ramos, F; Inestrosa, N. C.; Aldunate, R Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2015)
Synaptic defects associated with s-inclusion body myositis are prevented by copper Aldunate, R; Minniti A.N.; Rebolledo, D; Inestrosa, N. C. Article ISI SCOPUS BIOMETALS (2012)
Copper Reduces A beta Oligomeric Species and Ameliorates Neuromuscular Synaptic Defects in a C. elegans Model of Inclusion Body Myositis Rebolledo, DL; Aldunate, R; Kohn R.; Neira, I; Minniti AN; Inestrosa, NC Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2011)
HID-1, a New Component of the Peptidergic Signaling Pathway Mesa R; Luo, S; Nonet M.L.; Hoover C.M.; Miller K.; Minniti A; Inestrosa, N Article ISI SCOPUS Genetics (2011)
Intracellular amyloid formation in muscle cells of A beta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification Minniti AN; Rebolledo, DL; Grez, PM; Fadic, R; Aldunate, R; Volitakis I.; Cherny, RA; Opazo C.; Masters C.; Bush, AI; Inestrosa, NC Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2009)
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans Minniti AN; Cataldo, R; Trigo, C; Vásquez, L.; Mujica, P.; Leighton F.; Inestrosa, NC; Aldunate, R Article ISI SCOPUS AGING CELL (2009)
Circadian stress tolerance in adult Caenorhabditis elegans Simonetta, SH; Romanowski A; Minniti AN; Inestrosa, NC; Golombek, DA Article ISI SCOPUS JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY (2008)
Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva Minniti AN; Labarca M.; Hurtado C.; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2004)
spe-12 encodes a sperm surface protein that promotes spermiogenesis in Caenorhabditis elegans Nance, J; Minniti, AN; Sadler, C; Ward, S Article GENETICS (1999)
Genetic and molecular analysis of spe-27, a gene required for spermiogenesis in Caenorhabditis elegans hermaphrodites Minniti, AN; Sadler, C; Ward, S Article GENETICS (1996)
The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin Varkey, JP; Muhlrad, PJ; Minniti, AN; Do, B; Ward, S Article Genes and Development (1995)
The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency Varkey, JP; Jansma, PL; Minniti, AN; Ward, S Article GENETICS


Effect of hydrogen peroxide on apoptosis in Caenorhabditis elegans dopaminergic neurons Gorenberg, E; Roadcloud, E; Quinn, T; Ortiz J.; Minniti A; Inestrosa, NC; Kohn, RE Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)


Deletion of the gene encoding for the enzyme Methionine sulphoxide reductase A increases the toxicity of A beta (1-42) in an in vivo model. Minniti A; Inestrosa, N; Aldunate, R ConferencePaper ISI NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009 (2009)
Effects of copper on A beta-induced pathological features in Caenorhabditis elegans. Minniti A; Rebolledo, D; Inestrosa, N ConferencePaper ISI NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009 (2009)
Modulation of intracellular amyloid-beta-peptide aggregation by copper in Caenorhabditis elegans Minniti A; Grez, P; Opazo C.; Volitakis I.; Cherny R.; Masters C.; Bush, A; Inestrosa, N ConferencePaper ISI New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005 (2005)


NEUROMUSCULAR AGING IN CAENORHABDITIS ELEGANS=> ROLE OF OXIDATION DAMAGE REPAIR BY METHIONINE SULFOXIDE REDUCTASE A. FONDECYT (1120213) Proyecto 2012-2015 Coinvestigador(a)
Ritmos circadianos en C. elegans Fundación Antorchas, Argentina (2004-2005) Proyecto 2004-2005 Coinvestigador(a)
Ritmos circadianos en C. elegans=> estudios comportamentales, moleculares y de desarrollo PCI (2003123) Proyecto 2003-2004 Inv. Responsable


Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle Rebolledo, DL; Minniti AN; Grez, PM; Fadic, R; Kohn R.; Inestrosa, NC Review ISI MOLECULAR NEUROBIOLOGY (2008)
Is there a role for copper in neurodegenerative diseases? Cerpa, W.; Varela-Nallar, L; Minniti A.N.; Inestrosa, N. C.; Reyes A.E. Review SCOPUS MOLECULAR ASPECTS OF MEDICINE (2005)