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Luis Fernando Larrondo Castro

Associate Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


Circadian Rhythms, fungal genetics, photobiology, fungal genomics, synthetic biology

Educación

  •  Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Experiencia Académica

  •   Postdoctoral Fellow Full Time

    DARTMOUTH COLLEGE

    Hanover, Estados Unidos

    2004 - 2009

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2009 - 2014

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2014 - At present

Experiencia Profesional

  •   Director Full Time

    Millennium Nucleus for Fungal Integrative and Synthetic Biology

    Santiago, Chile

    2013 - 2017

  •   Director Other

    Millennium Institute for Integrative Biology (iBio)

    Santiago, Chile

    2018 - At present

Formación de Capital Humano


Ph.D. THESIS DIRECTION
Vicente Rojas* 2021 (Expected)
Rodrigo Pérez * 2021 (Expected)
Verónica del Rio * 2021 (Expected)
Marlene Henroquez 2020 (Expected)
Verónica Delgado * 2020
Alejandra Goity * 2019
Felipe Muñoz * 2019
Rodrigo Diaz * 2016
Consuelo Olivares-Yañez 2015
Montserrat Hevia * 2015
Alejandro Montenegro-Montero 2014

UNDERGRADUATE THESIS DIRECTION
Cyndi Tabilo 2020 (Expected)
Andres Romero 2019
Vicente Rojas 2026 (Co-directed with Dr. Francisco Salinas)
Claudia Villegas 2015 (Co-directed with Dr. Paulina Bull)
Pilar Alessandri 2015
Hanna Muller 2015 (Co-directed with Dr. Paulo Canessa)
Alejandro Stevens-Lagos2012
Alejandra Goity 2012
Felipe Muñoz 2010 (Co-directed with Dr. Rafael Vicuna)

POSTDOCTORAL SUPERVISION
Consuelo Olivares-Yañez 2017 (Currently Young Investigator at MIISSB)
Montserrat Hevia 2015-2016 (Currently iPostdoc at UFRO)
Alejandro Montenegro-Montero 2014-2016 (Currently Editor at John Wiley & Sons, Inc.)
Veronique Hill 2014-2017 (Currently Research Assistant, Inst. Curie, France)
Francisco Salinas 2014-2017 (Currently Assistant Professor at UACH)
Paulo Canessa 2009-2015 (Currently Assistant Professor at UNAB)

EDITORIAL ACTIVITIES.
Editorial Board Member:
eLife 2019- Present
Frontiers in Microbiology 2018- Present
Biological Research 2015- Present
Fungal Biology and Biotechnology 2014- Present
Scientific Reports (Nature Publishing Group) 2014- Present
Applied and Environmental Microbiology 2009-2018

Ad Hoc reviewer for: Fungal Genetics and Biology, Eukaryotic Cell, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, New Phytologist, Microbial Biotechnology, Current Genetics, Free Radical Biology& Medicine, Applied Microbiology and Biotechnology, Plant Cell & Environment, PLoS ONE, Journal of Applied Microbiology, Marine Biotechnology, Environmental Microbiology, PloS Genetics, Trends in Plant Science, mBio, Nucleic Acid Research, Nature Protocols, Nature.


Difusión y Transferencia


- Patent application (INAPI) 201603010, “A yeast optogenetic expression system”
- Patent application (INAPI) 3363-2016, “Method for high-throughput screening of substances for the control of phytopathogenic fungi, based on genetically modified strains”


Premios y Distinciones

  •   International Research Scholars

    Howard Hughes Medical Institute

    Estados Unidos, 2017

    HHMI funds exceptionally talented scientists and educators to advance the front lines of biomedical research and train the next generation of scientific leaders.

  •   Young Affiliated member

    TWAS

    Italia, 2011

    Elected as Young Affiliated member of the Academy of Science for the Developing World (TWAS)

  •   PEW Postdoctoral Latin American Fellowship in the Biomedical Science

    THE PEW CHARITABLE TRUSTS

    Estados Unidos, 2004

    2004-2006

  •   Medalla Herman Niemeyer

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2002

    Receives the Herman Niemeyer award given by the SBBCH (Sociedad de Bioquímica y Biología Molecular de Chile) as a distinguished Ph.D. student.

  •   Aschoff's Rule

    Society for Reserach on Biological Rhythms

    Estados Unidos, 2017

    Prize given every year to a scientists who has advanced the field of chronobiology

  •   AAM

    American Academy of Microbiology

    Estados Unidos, 2020

    Elected member of the American Academy of Microbiology

  •   ACAL

    Academia de Ciencias de America Latina y el caribe

    Venezuela, 2019

    Elected Member of ACAL


 

Article (49)

A Circadian Clock in Neurospora Crassa Functions During Plant Cell Wall Deconstruction
Fungal Endophytes Exert Positive Effects on Colobanthus quitensis Under Water Stress but Neutral Under a Projected Climate Change Scenario in Antarctica
Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition in Neurospora crassa
Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains
Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast
GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation
Neurospora crassa developmental control mediated by the FLB-3 transcription factor
The developmental regulator Pcz1 affects the production of secondary metabolites in the filamentous fungus Penicillium roqueforti
Optogenetic switches for light-controlled gene expression in yeast
Spontaneous circadian rhythms in a cold-adapted natural isolate of Aureobasidium pullulans
Circadian clocks and the regulation of virulence in fungi: Getting up to speed
Daily magnesium fluxes regulate cellular timekeeping and energy balance
Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa
Natural variation in non-coding regions underlying phenotypic diversity in budding yeast
RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast
A circadian oscillator in the fungus Botrytis cinerea regulates virulence when infecting Arabidopsis thaliana
bcpmr1 encodes a P-type Ca2+/Mn2+-ATPase mediating cell-wall integrity and virulence in the phytopathogen Botrytis cinerea
Decoupling circadian clock protein turnover from circadian period determination
The bZIP Transcription Factor HAC-1 Is Involved in the Unfolded Protein Response and Is Necessary for Growth on Cellulose in Neurospora crassa
A Kinetic Study of the Effects of Light on Circadian Rhythmicity of the frq Promoter of Neurospora crassa
Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood
Bright to Dim Oscillatory Response of the Neurospora Circadian Oscillator
Circadian rhythms synchronize mitosis in Neurospora crassa
Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
Assessing the Effects of Light on Differentiation and Virulence of the Plant Pathogen Botrytis cinerea: Characterization of the White Collar Complex
Conserved RNA Helicase FRH Acts Nonenzymatically to Support the Intrinsically Disordered Neurospora Clock Protein FRQ
The Neurospora Circadian System: From Genes to Proteins and Back in Less Than 24 hours
Characterization of PIR1, a GATA family transcription factor involved in iron responses in the white-rot fungus Phanerochaete chrysosporium
Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis
High-resolution spatiotemporal analysis of gene expression in real time: In vivo analysis of circadian rhythms in Neurospora crassa using a FREQUENCY-luciferase translational reporter
The Paleozoic Origin of Enzymatic Lignin Decomposition Reconstructed from 31 Fungal Genomes
Molecular and structural modeling of the Phanerochaete flavido-alba extracellular laccase reveals its ferroxidase structure
Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion
An eleven amino acid residue deletion expands the substrate specificity of acetyl xylan esterase II (AXE II) from Penicillium purpurogenum
Functional analysis of the endoxylanase B (xynB) promoter from Penicillium purpurogenum
Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina)
Cloning and characterization of the genes encoding the high-affinity iron-uptake protein complex Fet3/Ftr1 in the basidiomycete Phanerochaete chrysosporium
Structure and transcriptional impact of divergent repetitive elements inserted within Phanerochaete chrysosporium strain RP-78 genes
Cloning and functional characterization of the gene encoding the transcription factor Ace1 in the basidiomycete Phanerochaete chrysosporium
Cloning and functional characterization of the gene encoding the transcription factor Acel in the basidiomycete Phanerochaete chrysosporium
Induction of cellular prion protein gene expression by copper in neurons
The nop gene from Phanerochaete chrysosporium encodes a peroxidase with novel structural features
Characterization of a multicopper oxidase gene cluster in Phanerochaete chrysosporium and evidence of altered splicing of the mco transcripts
Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78
A novel extracellular multicopper oxidase from Phanerochaete chrysosporium with ferroxidase activity
Heterologous expression of laccase cDNA from Ceriporiopsis subvermispora yields copper-activated apoprotein and complex isoform patterns
Enzymology and molecular genetics of the ligninolytic system of the basidiomycete Ceriporiopsis subvermispora
Isoenzyme multiplicity and characterization of recombinant manganese peroxidases from Ceriporiopsis subvermispora and Phanerochaete chrysosporium
Characterization of three new manganese peroxidase genes from the ligninolytic basidiomycete Ceriporiopsis subvermispora

BookSection (1)

Exploiting Fungal Photobiology as a Source of Novel Bio-blocks for Optogenetic Systems

BookWhole (1)

The Clock Keeps on Ticking: Emerging Roles for Circadian Regulation in the Control of Fungal Physiology and Pathogenesis

EditorialMaterial (1)

In the Driver's Seat: The Case for Transcriptional Regulation and Coupling as Relevant Determinants of the Circadian Transcriptome and Proteome in Eukaryotes

Proyecto (12)

Millennium Institute for Integrative Biology (iBIO)
A synthetic biology strategy to delve into the properties and plasticity of circadian oscillators and other transcriptional regulatory circuits
A synthetic biology strategy to delve into the properties and plasticity of circadian oscillators and other transcriptional regulatory circuits
A SYNTHETIC RED-LIGHT TOGGLE SWITCH TO CONTROL GENE EXPRESSION AND MODULATE CIRCADIAN REGULATION IN NEUROSPORA CRASSA.
DECIPHERING TRANSCRIPTIONAL REGULATORY NETWORKS IN A SIMPLE ORGANISM TO ANALYZE LIGHT- RESPONSES AND CIRCADIAN OSCILLATIONS=> AN APPROACH BASED ON COMPARATIVE GENOMIC ANALYSES AND PHYLOGENETIC FOOTPRINTING
Acquisition of a Cytation3 Cell Imaging Multi‐Mode Reader=> A platform for the development of Synthetic Biology
Environmental signals and gene expression in Neurospora crassa=> rational approach for the mapping of transcriptional networks and rewiring of key components in order to assess basic circadian principles
Millennium Nucleus for Fungal Integrative and Synthetic Biology (MN-FISB)
Millennium Nucleus for Fungal Integrative and Synthetic Biology (MN-FISB)
YEAST PLATFORMS FOR THE PRODUCTION OF NATURAL FLAVOR COMPOUNDS.
MODULATION OF BOTRYTIS CINEREA VIRULENCE FACTORS=> EVALUATING THE EFFECT OF LIGHT AND CIRCADIAN-REGULATION.
A Neurospora crassa systems-approach=> identification of molecular components involved in circadian-controlled gene expression through Forward and Reverse Genetics strategies

Review (3)

Recent Advances in the Study of the Plant Pathogenic Fungus Botrytis cinerea and its Interaction with the Environment
Environmental responses and the control of iron homeostasis in fungal systems
The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease
61
Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

15
Paulo Canessa

Assistant Professor

Facultad de Ciencias de la Vida

Universidad Andrés Bello

Santiago, Chile

10
Rubén Polanco

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO (UNAB)

SANTIAGO, Chile

5
Francisco Salinas

Profesor Auxiliar

Instituto de Bioquímica y Microbiolgía

Universidad Austral de Chile

Valdivia, Chile

4
Claudio Martinez

Profesor Titular

Departamento de Ciencia y Tecnología de Alimentos

Universidad de Santiago de Chile

Santiago, Chile

4
Alejandra Goity

Investigador postdoctoral iBio

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Francisco Melo

Profesor Titular

Genetica Molecular y Microbiologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
veronica garcia

academico

DECYTAL

Universidad de Santaigo

Estación central, Chile

3
Luis Castillo

Profesor Asociado

de Biología

UNIVERSIDAD DE LA SERENA, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

La Serena, Chile

3
Francisco Cubillos

Investigador Asociado

Departamento de Biologia

Universidad de Santiago de Chile

Santiago, Chile

3
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

3
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

3
Mario Tello

Académico

Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Veronica Delgado

Investigador postdoctoral

Genética Molecular y Microbiología

Instituto Milenio de Biología Integrativa (iBio)

Santiago, Chile

2
Renato Chavez

Full Professor

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Alexis Rivas

Investigador Postdoctoral

Instituto de Neurociencias Biomédicas

Universidad de Chile

Santiago, Chile

2
Eduardo Kessi

Investigador

Universidad de Santiago de Chile

Santiago, Chile

2
Verónica Plaza

Profesor - Investigador

Biología

Universidad de La Serena

La Serena, Chile

2
Augusto Manubens

Director

Tecnical Support

BIOSONDA S.A.

Santiago, Chile

1
Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Pedro Gundel

Titular Professor

Universidad de Talca

Talca, Chile

1
Carlos Gil

Docente Adjunto

Estudios interdisciplinarios

Universidad Mayor de Chile

Santiago de Chile, Chile

1
Daniela Seelenfreund

Profesor Asociado

Bioquímica y Biología Molecular

FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bernardo González

Full Professor

UNIVERSIDAD ADOLFO IBAÑEZ

Santiago, Chile

1
Inmaculada Vaca

Associate Professor

Chemistry Department

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jennifer Molinet

Postdoctorado

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Gloria Levican

Académica Profesora Titular

Departamento de Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

1
Raul Araya

Docente Investigador

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

1
Samuel Morales

Académico Conferenciante

Universidad de Talca

Talca, Chile