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Francisco Jose Salinas Sanhueza

Profesor Asociado

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


Genómica funcional, microbiología, genética, biología molecular y optogenética en levaduras.

Educación

  •  Doctor en Microbiología, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2011
  •  Licenciatura en Ingeniería en Biotecnología, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Académica

  •   Postdoctorado Full Time

    Université de Nice

    Facultad de Medicina

    Nice, Francia

    2012 - 2014

  •   Postdoctorado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Ciencias Biológicas

    Santiago, Chile

    2014 - 2017

Experiencia Profesional

  •   Investigador asociado Full Time

    Universidad de Santiago de Chile

    Santiago, Chile

    2017 - 2019

  •   Profesor Auxiliar Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2019 - 2024

  •   Profesor Asociado Full Time

    Universidad Austral de Chile

    valdivia, Chile

    2024 - At present

Formación de Capital Humano


Director de tesis de pregrado: 8 tesis finalizadas.
Co-director de tesis de pregrado: 1 tesis finalizada.
Director de tesis de magister: 3 tesis finalizadas.
Director de tesis de doctorado: 4 tesis finalizadas.


Premios y Distinciones

  •   Mejor trabajo de incorporación

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2019

    Premio al mejor trabajo de incorporación de la Sociedad de Bioquímica y Biología Molecular de Chile (SBBMCh).


 

Article (38)

Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast

Tellini, Nicolo; Salinas, Francisco

Article ISI SCOPUS
Microbiology Spectrum  (2025)

Optogenetic Modification of Glycerol Production in Wine Yeast

Ruiz, Diego; Inzunza, Claudia; Barria, Javiera; Baeza, Camila; Molina, Antonio; Cubillos, Francisco A.; Salinas, Francisco

Article ISI SCOPUS
ACS Synthetic Biology  (2025)

Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains

Rocha, Guilherme; Salinas, Francisco

Article ISI SCOPUS
Biological Research  (2024)

Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains

Fundora, Leyanis; Khaiwal, Sakshi; Salinas, Francisco

Article ISI SCOPUS
Biological Research  (2023)

The N-Terminal Region of the BcWCL1 Photoreceptor Is Necessary for Self-Dimerization and Transcriptional Activation upon Light Stimulation in Yeast

Guerrero, Matías; Ruiz, Diego; Salinas, Francisco

Article ISI SCOPUS
International Journal of Molecular Sciences  (2023)

A Saccharomyces eubayanus haploid resource for research studies

Villegas, Claudia; Salinas, Francisco; Nespolo, Roberto F.; Cubillos, Francisco A.

Article ISI
SCIENTIFIC REPORTS  (2022)

Expanding the molecular versatility of an optogenetic switch in yeast

Inzunza, Claudia; Toro, Rodrigo; Salinas, Francisco

Article ISI
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY  (2022)

Interactions between Core Elements of the Botrytis cinerea Circadian Clock Are Modulated by Light and Different Protein Domains

Salinas, Francisco

Article ISI
JOURNAL OF FUNGI  (2022)

Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast

Salinas, Francisco

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2021)

The rise and shine of yeast optogenetics

Salinas, Francisco

Article ISI
YEAST  (2021)

Comparison of Phylogenetic Tree Topologies for Nitrogen Associated Genes Partially Reconstruct the Evolutionary History of Saccharomyces cerevisiae

Salinas, Francisco

Article ISI SCOPUS
MICROORGANISMS  (2020)

Differential Gene Expression and Allele Frequency Changes Favour Adaptation of a Heterogeneous Yeast Population to Nitrogen-Limited Fermentations

Salinas, Francisco

Article ISI
Frontiers in Microbiology  (2020)

GTR1 Affects Nitrogen Consumption and TORC1 Activity in Saccharomyces cerevisiae Under Fermentation Conditions

Salinas, Francisco

Article ISI
FRONTIERS IN GENETICS  (2020)

Total evidence or taxonomic congruence? A comparison of methods for combining biological evidence

Salinas, Francisco

Article ISI
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY  (2020)

Transcriptional Activity and Protein Levels of Horizontally Acquired Genes in Yeast Reveal Hallmarks of Adaptation to Fermentative Environments

Cubillos, Francisco A.; Salinas, Francisco

Article ISI
FRONTIERS IN GENETICS  (2020)

Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation

Cubillos, Francisco A.; Salinas, Francisco; Schacherer, Joseph

Article ISI SCOPUS
PLOS ONE  (2019)

Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains

Salinas, Francisco

Article ISI SCOPUS
YEAST  (2019)

KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae

Salinas, Francisco; Su, Ying

Article ISI SCOPUS
Frontiers in Microbiology  (2019)

Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast

Salinas, Francisco; Agosin, Eduardo

Article ISI SCOPUS
MBIO  (2018)

GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation

Tapia, Sebastián M.; Cuevas, Mara; Abarca, Valentina; Salinas, Francisco; Cubillos, Francisco A.

Article ISI SCOPUS
Frontiers in Microbiology  (2018)

Clonal Heterogeneity Influences the Fate of New Adaptive Mutations

Vázquez-García, Ignacio; Li, Jing; Fischer, Andrej; Barré, Benjamin; Hallin, Johan; Bergström, Anders; Alonso-Perez, Elisa; Warringer, Jonas; Mustonen, Ville; Liti, Gianni

Article ISI SCOPUS
CELL REPORTS  (2017)

Optogenetic switches for light-controlled gene expression in yeast

Rojas, Vicente

Article ISI SCOPUS
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY  (2017)

Extensive Recombination of a Yeast Diploid Hybrid through Meiotic Reversion

Salinas, Francisco

Article ISI
PLOS GENETICS  (2016)

Natural variation in non-coding regions underlying phenotypic diversity in budding yeast

Salinas, F; de Boer, CG; Abarca, V; García, V.; Cuevas, M; Araos S.; Martinez, C.; Cubillos, FA

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2016)

Powerful decomposition of complex traits in a diploid model

Hallin, Johan; Märtens, Kaspar; Young, Alexander I.; Zackrisson, Martin; Parts, Leopold; Warringer, Jonas; Liti, Gianni

Article ISI SCOPUS
NATURE COMMUNICATIONS  (2016)

RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast

Kessi-Pérez E.I.; Araos S.; García, V.; Salinas, F; Abarca, V; Larrondo, LF; Martinez, C.; Cubillos, F. A.

Article ISI SCOPUS
FEMS YEAST RESEARCH  (2016)

ATG18 and FAB1 Are Involved in Dehydration Stress Tolerance in Saccharomyces cerevisiae

Salinas, Francisco

Article ISI
PLOS ONE  (2015)

Concerted Evolution of Life Stage Performances Signals Recent Selection on Yeast Nitrogen Use

Salinas, Francisco

Article ISI
MOLECULAR BIOLOGY AND EVOLUTION  (2015)

A High-Definition View of Functional Genetic Variation from Natural Yeast Genomes

Bergstroem, Anders; Salinas, Francisco

Article ISI
MOLECULAR BIOLOGY AND EVOLUTION  (2014)

Mapping Genetic Variants Underlying Differences in the Central Nitrogen Metabolism in Fermenter Yeasts

Jara, M; Cubillos, FA; García, V.; Salinas, F; Aguilera, O; Liti, G; Martinez, C.

Article ISI
PLOS ONE  (2014)

High-Resolution Mapping of Complex Traits with a Four-Parent Advanced Intercross Yeast Population

Cubillos, FA; Parts, L; Salinas, F; Bergstrom, A; Scovacricchi, E; Zia, A; Illingworth, CJR; Mustonen, V; Ibstedt, S; Warringer, J; et al.

Article ISI SCOPUS
Genetics  (2013)

Identification of genes related to nitrogen uptake in wine strains of Saccharomyces cerevisiae

Contreras, A; García, V.; Salinas, F; Urzua, U; Ganga, MA; Martinez, C.

Article ISI SCOPUS
World Journal of Microbiology and Biotechnology  (2012)

The Genetic Basis of Natural Variation in Oenological Traits in Saccharomyces cerevisiae

Salinas, F; Cubillos, F. A.; Soto, D; García, V.; Bergstrom, A; Warringer, J; Ganga, MA; Louis E.J.; Liti, G; Martinez, C.

Article ISI SCOPUS
PLOS ONE  (2012)

Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis

Salinas, F; Ravanal C.; García, V.; Carrasco, C; Martinez, C.; Saavedra, J

Article ISI SCIELO SCOPUS
ELECTRONIC JOURNAL OF BIOTECHNOLOGY  (2011)

Revealing the genetic structure of a trait by sequencing a population under selection

Cubillos, Francisco A.; Jain, Kanika; Salinas, Francisco; Molin, Mikael; Quail, Michael A.

Article ISI
GENOME RESEARCH  (2011)

Genomic and phenotypic comparison between similar wine yeast strains of Saccharomyces cerevisiae from different geographic origins

Salinas, F; Mandakovic, D; Urzua, U; Massera, A; Miras, S; Combina M.; Martinez, C.

Article ISI SCOPUS
JOURNAL OF APPLIED MICROBIOLOGY  (2010)

Taqman real-time PCR for the detection and enumeration of Saccharomyces cerevisiae in wine

Salinas, F; Garrido, D; Ganga A.; Veliz, G; Martinez, C.

Article ISI SCOPUS
FOOD MICROBIOLOGY  (2009)

POLYMERASE CHAIN REACTION CONFIRMATORY METHOD FOR MICROBIOLOGICAL DETECTION OF BRETTANOMYCES BRUXELLENSIS IN WINES

Contreras, A; Salinas, F; Ganga A.; Martinez, C.

Article ISI SCOPUS
JOURNAL OF RAPID METHODS AND AUTOMATION IN MICROBIOLOGY  (2008)

Proyecto (4)

Unraveling genetic factors in alcohol yeast efficiency through multi-omics analysis

Martinez, Claudio; Salinas, Francisco

Proyecto
 (2025)

Genomic and transcriptional profiling of fermentative vigor in laboratory lager yeast hybrid

Cubillos, Francisco; Salinas, Francisco

Proyecto
 (2022)

Combining synthetic biology approaches for the reversible and simultaneous transcriptional control of multiple metabolic genes in yeast

Salinas, Francisco

Proyecto
 (2021)

Exploiting the wild genetic diversity of Saccharomyces cerevisiae for wine production

Martinez, Claudio; Salinas, Francisco

Proyecto 2020-2024
 (2020)

1
Alvaro Diaz

Profesor titular

P. UNIVERSIDAD CATÓLICA DE VALPARAÍSO

valparaiso, Chile

2
ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Eduardo Agosin

Full Professor

Chemical and Bioprocess Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
MARIA GANGA

academico jornada completa

Departamento en Ciencia y Tecnologia de los Alimentos

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

7
Verónica García

academico

DECYTAL

Universidad de Santaigo

Estación central, Chile

2
Mario Inostroza

Director

Departamento de Ingeniería Informática

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

5
Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Roberto Nespolo

Titular Professor

Instituto de Ciencias Ambientales y Evolutivas

Universidad Austral de Chile

Valdivia, Chile

1
Daniel Garrido

Associate Professor

Chemical and Bioprocess Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Carlos Villarroel

Académico

Ciencias Forestales

Universidad Católica del Maule

Talca, Chile

1
DINKA MANDAKOVIC

Associate Professor

GEMA Center

Universidad Mayor

Santiago, Chile

42
Francisco Salinas

Profesor Asociado

Instituto de Bioquímica y Microbiolgía

Universidad Austral de Chile

Valdivia, Chile

11
Francisco Cubillos

Investigador Asociado

Departamento de Biologia

Universidad de Santiago de Chile

Santiago, Chile

18
Claudio Martinez

Profesor Titular

Departamento de Ciencia y Tecnología de Alimentos

Universidad de Santiago de Chile

Santiago, Chile

2
Angela Contreras

Academica Investigadora

Ciencias Agrarias y Forestales

Universidad Católica del Maule

Talca, Chile

1
Pablo Villarreal

Investigador Postdoctoral

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

3
Manuel Villalobos

Profesor asistente

Ingeniería Informática

Universidad de Santiago de Chile

santiago, Chile

5
Jennifer Molinet

Académica Investigadora

Universidad Autónoma de Chile

Santiago, Chile

9
Eduardo Kessi

Investigador

Universidad de Santiago de Chile

Santiago, Chile

1
Matias Jara

Chief Executive Officer

Living Matter and Complex Systems

Cellter

Santiago, Chile

3
Veronica Delgado

Investigador postdoctoral

Genética Molecular y Microbiología

Instituto Milenio de Biología Integrativa (iBio)

Santiago, Chile

1
Melissa Gómez

4
Diego Ruiz

Asistente de Investigación

Instituto de Bioquímica

Universidad Austral de Chile

Valdivia, Chile